Effect of exercise intensity on weight changes and sexual hormones (androstenedione and free testosterone) in female rats with estradiol valerate-induced PCOS.

Abstract:

INTRODUCTION:Weight gain and fat accumulation are predisposing factors of PCOS. Life-style modification, including increasing physical activity, is the first line approach in managing PCOS. The objective of this study is to assess the effect of exercise intensity on weight changes, androstenedione and free testosterone level in female rats with estradiol valerate induced PCOS. METHOD AND MATERIALS:40 female Wistar rats were selected (180 ± 20 g). They had every 2 to 3 consecutive estrous cycles during 12 to 14 days. The study was approved by ethical committee of Jahrom University of Medical Sciences. The first two groups were divided into control (n = 10) and polycystic (n = 30) that were induced PCOS by estradiol valerate injection after 60 days. The polycystic groups were divided into three groups of sham (n = 10), experiment group with low-intensity exercise (pco + l.exe) (n = 10) and experiment group with moderate intensity exercise (pco + m.exe) (n = 10). Exercises were performed during 6 sessions of 60 minutes per week for 8 weeks. (Moderate intensity: 28 m/min-70%-75%VO2Max. Low intensity (20 m/min-50%-55%VO2Max) running at 0 slope, 1 h/day, 6 days/week). ANOVA and LSD test were used for data analysis. RESULTS:In the present study, no significant differences were found in the decrease of total weights of rats. And also androstenedione level changes in experiment groups were higher compared to control group but no significant differences were found, also free testosterone level was significantly higher than the observer group. CONCLUSION:According to weight changes and sexual hormones (Free testosterone and androstenedione) exercise training especially with low intensity may improve symptoms of polycystic ovary syndrome.

journal_name

J Ovarian Res

authors

Miri M,Karimi Jashni H,Alipour F

doi

10.1186/1757-2215-7-37

subject

Has Abstract

pub_date

2014-04-08 00:00:00

pages

37

issn

1757-2215

pii

1757-2215-7-37

journal_volume

7

pub_type

杂志文章
  • Proactive use of PROMs in ovarian cancer survivors: a systematic review.

    abstract:INTRODUCTION:The use of patient reported outcome measures (PROMs) has increased during the past decade, and the focus on how to use them has resulted in a more proactive application. Studies have shown that proactive use of PROMs during treatment improves patient-clinician communication, leads to better symptom managem...

    journal_title:Journal of ovarian research

    pub_type: 杂志文章,评审

    doi:10.1186/s13048-019-0538-9

    authors: Kargo AS,Coulter A,Jensen PT,Steffensen KD

    更新日期:2019-07-15 00:00:00

  • Correction to: PD-L1 expression on stromal tumor-infiltrating lymphocytes is a favorable prognostic factor in ovarian serous carcinoma.

    abstract::Following publication of the original article [1], the authors opted to correct the incorrect e-mail address of the corresponding author from 82-55-360-1850chungsu1982@gmail.com to chungsu1982@gmail.com , grant in the Acknowledgements section and Author details. Below are the updated version of the Acknowledgements an...

    journal_title:Journal of ovarian research

    pub_type: 已发布勘误

    doi:10.1186/s13048-019-0540-2

    authors: Kim KH,Choi KU,Kim A,Lee SJ,Lee JH,Suh DS,Kwon BS,Hwang C

    更新日期:2019-07-23 00:00:00

  • Nuclear survivin expression is a positive prognostic factor in taxane-platinum-treated ovarian cancer patients.

    abstract:BACKGROUND:Survivin is an inhibitor of apoptosis and a regulator of mitotic progression. TP53 protein is a negative transcriptional regulator of survivin. The aim of our study was to evaluate the clinical significance of survivin expression in advanced stages ovarian cancer with respect to the TP53 status. METHODS:Sur...

    journal_title:Journal of ovarian research

    pub_type: 杂志文章

    doi:10.1186/1757-2215-4-20

    authors: Felisiak-Golabek A,Rembiszewska A,Rzepecka IK,Szafron L,Madry R,Murawska M,Napiorkowski T,Sobiczewski P,Osuch B,Kupryjanczyk J,Polish Ovarian Cancer Study Group (POCSG).

    更新日期:2011-11-10 00:00:00

  • Rate of rebound in follicle growth after cessation of ovarian stimulation in initial non-responders: a prospective cohort study.

    abstract::Previously anecdotally observed rebounds in follicle growth after interruption of exogenous gonadotropins in absolute non-responders were the impetus for here reported study. In a prospective cohort study, we investigated 49 consecutive patients, absolutely unresponsive to maximal exogenous gonadotropin stimulation, f...

    journal_title:Journal of ovarian research

    pub_type: 杂志文章

    doi:10.1186/s13048-021-00765-5

    authors: Gleicher N,Weghofer A,Darmon SK,Barad DH

    更新日期:2021-01-09 00:00:00

  • Combined score of pretreatment platelet count and CA125 level (PLT-CA125) stratified prognosis in patients with FIGO stage IV epithelial ovarian cancer.

    abstract:BACKGROUND:The majority of death-related ovarian cancer is epithelial ovarian cancer (EOC). Regarding the Federation of Gynecology and Obstetrics (FIGO) stage IV EOC, the 5-year overall survival (OS) has not changed in last decades. Platelet (PLT) count and CA125 level are both prognostic markers that related to inflam...

    journal_title:Journal of ovarian research

    pub_type: 杂志文章

    doi:10.1186/s13048-019-0544-y

    authors: Chen JP,Huang QD,Wan T,Tu H,Gu HF,Cao JY,Liu JH

    更新日期:2019-07-31 00:00:00

  • Comparison of quartz vials with polypropylene vials for rapid cryopreservation of human ovarian tissue.

    abstract:BACKGROUND:Because higher survival of follicles during the freezing/thawing procedure improves the quality of cryopreserved tissue reimplanted after oncological therapies, defining an optimal method for human ovarian tissue cryopreservation remains a major issue in this field. One option to improve the cryopreservation...

    journal_title:Journal of ovarian research

    pub_type: 杂志文章

    doi:10.1186/s13048-016-0268-1

    authors: Scheiner D,Bracone G,Imesch P,Fink D,Hehl J,Imthurn B

    更新日期:2016-09-26 00:00:00

  • With low ovarian reserve, Highly Individualized Egg Retrieval (HIER) improves IVF results by avoiding premature luteinization.

    abstract:BACKGROUND:Highly Individualized Egg Retrieval (HIER), defined as age-specific early oocyte retrieval (ER), has been demonstrated to avoid premature luteinization in women ≥43. We here investigated whether HIER also applies to younger women with premature ovarian aging (POA), and what best lead follicle size should be ...

    journal_title:Journal of ovarian research

    pub_type: 杂志文章

    doi:10.1186/s13048-018-0398-8

    authors: Wu YG,Barad DH,Kushnir VA,Wang Q,Zhang L,Darmon SK,Albertini DF,Gleicher N

    更新日期:2018-03-16 00:00:00

  • Heart type fatty acid binding protein response and subsequent development of atherosclerosis in insulin resistant polycystic ovary syndrome patients.

    abstract:UNLABELLED: BACKGROUND:Women with polycystic ovary syndrome (PCOS) have higher risk for cardiovascular disease (CVD). Heart type fatty acid binding protein (HFABP) has been found to be predictive for myocardial ischemia.Wet ested whether HFABP is the predictor for CVD in PCOS patients, who have an increased risk of ca...

    journal_title:Journal of ovarian research

    pub_type: 杂志文章

    doi:10.1186/1757-2215-5-45

    authors: Cakir E,Ozbek M,Sahin M,Cakal E,Gungunes A,Ginis Z,Demirci T,Delibasi T

    更新日期:2012-12-18 00:00:00

  • Lnc-GULP1-2:1 affects granulosa cell proliferation by regulating COL3A1 expression and localization.

    abstract:BACKGROUNDS:Long non-coding RNA is a novel group of non-protein coding transcripts over 200 nt in length. Recent studies have found that they are widely involved in many pathological and physiological processes. In our previous study, we found that lnc-GULP1-2:1 was significantly down-regulated in the ovarian cortical ...

    journal_title:Journal of ovarian research

    pub_type: 杂志文章

    doi:10.1186/s13048-021-00769-1

    authors: Yao G,Kong Y,Yang G,Kong D,Xu Y,He J,Xu Z,Bai Y,Fan H,He Q,Sun Y

    更新日期:2021-01-20 00:00:00

  • Aurora Kinase A expression predicts platinum-resistance and adverse outcome in high-grade serous ovarian carcinoma patients.

    abstract::High-Grade Serous Ovarian Carcinoma (HGSOC) is the predominant histotype of epithelial ovarian cancer (EOC), characterized by advanced stage at diagnosis, frequent TP53 mutation, rapid progression, and high responsiveness to platinum-based-chemotherapy. To date, standard first-line-chemotherapy in advanced EOC include...

    journal_title:Journal of ovarian research

    pub_type: 杂志文章

    doi:10.1186/s13048-016-0238-7

    authors: Mignogna C,Staropoli N,Botta C,De Marco C,Rizzuto A,Morelli M,Di Cello A,Franco R,Camastra C,Presta I,Malara N,Salvino A,Tassone P,Tagliaferri P,Barni T,Donato G,Di Vito A

    更新日期:2016-05-21 00:00:00

  • Correction to: Troxerutin protects against DHT-induced polycystic ovary syndrome in rats.

    abstract::An amendment to this paper has been published and can be accessed via the original article. ...

    journal_title:Journal of ovarian research

    pub_type: 已发布勘误

    doi:10.1186/s13048-020-00733-5

    authors: Gao Z,Ma X,Liu J,Ge Y,Wang L,Fu P,Liu Z,Yao R,Yan X

    更新日期:2020-11-12 00:00:00

  • Risk factors for postoperative recurrence of ovarian endometriosis: long-term follow-up of 358 women.

    abstract:OBJECTIVE:To explore the risk factors for the recurrence of endometrioma and the risk factors for the recurrence of endometriosis-related pain after long-term follow-up. METHODS:This study retrospectively analyzed 358 women with endometriomas who had a minimum of 5-years follow up after laparoscopic endometrioma excis...

    journal_title:Journal of ovarian research

    pub_type: 杂志文章

    doi:10.1186/s13048-019-0552-y

    authors: Li XY,Chao XP,Leng JH,Zhang W,Zhang JJ,Dai Y,Shi JH,Jia SZ,Xu XX,Chen SK,Wu YS

    更新日期:2019-08-30 00:00:00

  • Effect of testosterone on the Connexin37 of sexual mature mouse cumulus oocyte complex.

    abstract:BACKGROUND:Recent researches demonstrate that pre-treatment with androgen could increase retrieved oocytes number and clinical pregnancy rate in poor ovarian response (POR) patients. In view of gap junction intercellular communication (GJIC) is important for follicular growth, and androgen plays an important role in im...

    journal_title:Journal of ovarian research

    pub_type: 杂志文章

    doi:10.1186/s13048-016-0290-3

    authors: Zhang Y,Xu Y,Kuai Y,Wang S,Xue Q,Shang J

    更新日期:2016-11-23 00:00:00

  • The aberrant upstream pathway regulations of CDK1 protein were implicated in the proliferation and apoptosis of ovarian cancer cells.

    abstract:BACKGROUND:Upregulation of Cyclin dependent kinase 1 (CDK1) protein is closely related with the prognosis of several malignant tumors. Chk1-CDC25C-CDK1 signaling and P53-P21WAF1-CDK1 signaling pathways are closely related with the cell cycle G2/M phase regulation. The present study aimed to analyze the relationship bet...

    journal_title:Journal of ovarian research

    pub_type: 杂志文章

    doi:10.1186/s13048-017-0356-x

    authors: Zhang R,Shi H,Ren F,Zhang M,Ji P,Wang W,Liu C

    更新日期:2017-09-12 00:00:00

  • Decreased ovarian function and autophagy gene methylation in aging rats.

    abstract:BACKGROUND:Degeneration of ovarian function is an obvious feature of female aging. In addition, studies have shown that autophagy decreases with age, and DNA methylation is a hallmark epigenetic pattern during aging. However, it is not clear whether the expression and DNA methylation of autophagy genes are involved in ...

    journal_title:Journal of ovarian research

    pub_type: 杂志文章

    doi:10.1186/s13048-020-0615-0

    authors: Li Q,Cai M,Wang J,Gao Q,Guo X,Jia X,Xu S,Zhu H

    更新日期:2020-02-03 00:00:00

  • Evaluation of the value of preoperative CYFRA21-1 in the diagnosis and prognosis of epithelial ovarian cancer in conjunction with CA125.

    abstract::Growing evidence indicates that the tumor biomarker cytokeratin 19 fragment (CYFRA21-1) is significant for a variety of cancers. However, its role in epithelial ovarian cancer (EOC) has rarely been reported. In this study, a receiver operating characteristic (ROC) curve was utilized to estimate the diagnostic efficien...

    journal_title:Journal of ovarian research

    pub_type: 杂志文章

    doi:10.1186/s13048-019-0587-0

    authors: Jin C,Yang M,Han X,Chu H,Zhang Y,Lu M,Wang Z,Xu X,Liu W,Wang F,Ju S

    更新日期:2019-11-25 00:00:00

  • Locally existing endothelial cells and pericytes in ovarian stroma, but not bone marrow-derived vascular progenitor cells, play a central role in neovascularization during follicular development in mice.

    abstract:BACKGROUND:Neovascularization is necessary for follicular growth. Vascularization is first observed in preantral follicles, and thereafter the vasculature markedly increases in follicles undergoing development. Neovascularization includes angiogenesis and vasculogenesis. Vasculogenesis is the formation of new blood ves...

    journal_title:Journal of ovarian research

    pub_type: 杂志文章

    doi:10.1186/1757-2215-7-10

    authors: Kizuka-Shibuya F,Tokuda N,Takagi K,Adachi Y,Lee L,Tamura I,Maekawa R,Tamura H,Suzuki T,Owada Y,Sugino N

    更新日期:2014-01-21 00:00:00

  • Increased expression of the leptin receptor in human ovaries affected by endometrioma and detection of high levels of leptin in the ovarian endometriomal fluid.

    abstract:BACKGROUND:This study was designed to investigate leptin levels in the fluid in ovarian endometriomas (OEs) and to compare the expression of leptin and its receptors (OBR) in ovarian tissue affected by endometrioma in infertile women to its expression in the normal ovarian tissue of fertile controls without endometrios...

    journal_title:Journal of ovarian research

    pub_type: 杂志文章

    doi:10.1186/1757-2215-7-2

    authors: Zendron C,Gonçalves HF,Cavalcante FS,Pereira TR,Evangelista A,Ramos CF,Oliveira MA

    更新日期:2014-01-08 00:00:00

  • Evidence of metachronous development of ovarian teratomas: a case report of bilateral mature cystic teratomas of the ovaries and systematic literature review.

    abstract:BACKGROUND:Mature cystic teratomas are usually found in the ovaries. They are bilateral in 10 to 15% of cases and multiple cystic teratomas may be present in one ovary. The aim of this study is to clarify if development of mature cystic teratomas of the ovaries in a single host is metachronous or due to autoimplant or ...

    journal_title:Journal of ovarian research

    pub_type: 杂志文章,评审

    doi:10.1186/s13048-017-0313-8

    authors: Wang WC,Lai YC

    更新日期:2017-03-14 00:00:00

  • YTHDF2, a protein repressed by miR-145, regulates proliferation, apoptosis, and migration in ovarian cancer cells.

    abstract::RNA methylation can reverse the methylation modification at the RNA level, which is an extremely important epigenetic modification. The function and mechanism of YTHDF2, as a reader of m6A modification, in epithelial ovarian cancer (EOC) have not been elucidated so far. This study aimed to investigate how YTHDF2 and m...

    journal_title:Journal of ovarian research

    pub_type: 杂志文章

    doi:10.1186/s13048-020-00717-5

    authors: Li J,Wu L,Pei M,Zhang Y

    更新日期:2020-09-18 00:00:00

  • Primary ovarian angiosarcoma: a rare and recognizable ovarian tumor.

    abstract::The diagnosis of primary angiosarcoma of ovary is still a challenge as it has no specific clinical symptoms and is easily confused with other malignant neoplasms in morphology. Here, we described a case of primary ovarian angiosarcoma and reviewed the literature. A 47-year-old female showed a left ovary mass. Grossly,...

    journal_title:Journal of ovarian research

    pub_type: 杂志文章

    doi:10.1186/s13048-021-00771-7

    authors: Ye H,Lin M,Li R,Qin S,Hou G,Chen H,Li X

    更新日期:2021-01-28 00:00:00

  • Clinical implication of the serum galectin-1 expression in epithelial ovarian cancer patients.

    abstract:BACKGROUND:galectin-1 has been implicated in tumor invasion and metastasis and is frequently over-expressed in epithelial ovarian cancer (EOC), but its potential as a biomarker remains unclear. In this novel study, we have explored the possible use of galectin-1 as a biomarker for EOC. METHODS:galectin-1 in sera was e...

    journal_title:Journal of ovarian research

    pub_type: 杂志文章

    doi:10.1186/s13048-015-0206-7

    authors: Chen L,Yao Y,Sun L,Zhou J,Liu J,Wang J,Li J,Tang J

    更新日期:2015-11-21 00:00:00

  • Decreased levels of serum glutathione peroxidase 3 are associated with papillary serous ovarian cancer and disease progression.

    abstract:BACKGROUND:Glutathione peroxidase 3 (GPX3) is a selenocysteine-containing antioxidant enzyme that reacts with hydrogen peroxide and soluble fatty acid hydroperoxides, thereby helping to maintain redox balance within cells. Serum levels of GPX3 have been found to be reduced in various cancers including prostrate, thyroi...

    journal_title:Journal of ovarian research

    pub_type: 杂志文章

    doi:10.1186/1757-2215-4-18

    authors: Agnani D,Camacho-Vanegas O,Camacho C,Lele S,Odunsi K,Cohen S,Dottino P,Martignetti JA

    更新日期:2011-10-22 00:00:00

  • Correction to: Nanog interaction with the androgen receptor signaling axis induce ovarian cancer stem cell regulation: studies based on the CRISPR/Cas9 system.

    abstract::AbstractThe original article [1] contains errors in Figs. 6 and 8. The corrected figures can be shown ahead. ...

    journal_title:Journal of ovarian research

    pub_type: 杂志文章,已发布勘误

    doi:10.1186/s13048-019-0487-3

    authors: Ling K,Jiang L,Liang S,Kwong J,Yang L,Li Y,PingYin,Deng Q,Liang Z

    更新日期:2019-01-30 00:00:00

  • Development of a multi-gene-based immune prognostic signature in ovarian Cancer.

    abstract:BACKGROUND:Various components of the immune system play a critical role in the prognosis and treatment response in ovarian cancer (OC). Immunotherapy has been recognized as a hallmark of cancer but the effect is contradictional. Reliable immune gene-based prognostic biomarkers or regulatory factors are necessary to be ...

    journal_title:Journal of ovarian research

    pub_type: 杂志文章

    doi:10.1186/s13048-021-00766-4

    authors: Cao T,Shen H

    更新日期:2021-01-28 00:00:00

  • Reliable in vitro studies require appropriate ovarian cancer cell lines.

    abstract::Ovarian cancer is the fifth most common cause of cancer death in women and the leading cause of death from gynaecological malignancies. Of the 75% women diagnosed with locally advanced or disseminated disease, only 30% will survive five years following treatment. This poor prognosis is due to the following reasons: li...

    journal_title:Journal of ovarian research

    pub_type: 杂志文章,评审

    doi:10.1186/1757-2215-7-60

    authors: Jacob F,Nixdorf S,Hacker NF,Heinzelmann-Schwarz VA

    更新日期:2014-06-07 00:00:00

  • Low dose human chorionic gonadotropin administration at the time of gonadotropin releasing-hormone agonist trigger versus 35 h later in women at high risk of developing ovarian hyperstimulation syndrome - a prospective randomized double-blind clinical tri

    abstract:BACKGROUND:Ovarian hyperstimulation syndrome remains a serious complication during in vitro fertilization cycles if high dose human chorionic gonadotropin (hCG) is used to trigger ovulation in high responder patients. Though much of this risk is mitigated with trigger using gonadotropin releasing-hormone (GnRH) agonist...

    journal_title:Journal of ovarian research

    pub_type: 杂志文章,随机对照试验

    doi:10.1186/s13048-019-0483-7

    authors: Engmann LL,Maslow BS,Kaye LA,Griffin DW,DiLuigi AJ,Schmidt DW,Grow DR,Nulsen JC,Benadiva CA

    更新日期:2019-01-26 00:00:00

  • Association between morphologic grading and implantation rate of Euploid blastocyst.

    abstract:BACKGROUND:Standard morphologic evaluation has been the most widely adopted approach to embryo selection, and remains the most common strategy.The objective of the study to determine the association between the morphologic grading and implantation rate of euploid blastocysts in single frozen-thawed embryo transfer (SET...

    journal_title:Journal of ovarian research

    pub_type: 杂志文章

    doi:10.1186/s13048-021-00770-8

    authors: Lou H,Li N,Guan Y,Zhang Y,Hao D,Cui S

    更新日期:2021-01-23 00:00:00

  • Comparative analysis of abdominal fluid cytokine levels in ovarian hyperstimulation syndrome (OHSS).

    abstract:BACKGROUND:Ovarian hyperstimulation syndrome (OHSS) is a rare, yet severe, iatrogenic complication of ovulation induction therapy during assisted reproductive procedures. Our group previously detected atypical cells in the ascitic fluid of OHSS patients, although no malignancy developed during follow up. Here, the aim ...

    journal_title:Journal of ovarian research

    pub_type: 杂志文章

    doi:10.1186/s13048-020-00624-9

    authors: Farkas B,Boldizsar F,Bohonyi N,Farkas N,Marczi S,Kovacs GL,Bodis J,Koppan M

    更新日期:2020-03-05 00:00:00

  • Prognostic analysis for Chinese patients with stage I ovarian endometrioid carcinoma.

    abstract:BACKGROUND:This study aimed to identify the clinical and pathological characteristics and the possible prognostic factors for Chinese patients with early-stage ovarian endometrioid carcinoma. METHODS:The present study reviewed the medical records of patients who received initial treatment and a postoperative pathologi...

    journal_title:Journal of ovarian research

    pub_type: 杂志文章

    doi:10.1186/s13048-017-0361-0

    authors: Zhao Y,Wang S,Qu YM,Ji YT,Shen K,Lang JH

    更新日期:2017-09-18 00:00:00