Abstract:
BACKGROUND:This study was designed to investigate leptin levels in the fluid in ovarian endometriomas (OEs) and to compare the expression of leptin and its receptors (OBR) in ovarian tissue affected by endometrioma in infertile women to its expression in the normal ovarian tissue of fertile controls without endometriosis. METHODS:In this case-control observational study, ovarian tissue, blood samples and peritoneal fluid were obtained from 20 women (10 fertile controls without endometriosis or any ovarian disease, who were undergoing tubal ligation surgery, and 10 infertile women with severe endometriosis and OE). The ovarian endometriomal fluid (EF) was aspirated, and peritoneal-implant (PI) biopsies were performed. The tissues removed during the surgeries were immediately frozen in liquid nitrogen to determine expression levels by western blot and leptin levels by ELISA. RESULTS:OBR was expressed at higher levels in the ovarian tissue affected by endometrioma than in the normal ovarian tissue (control = 0.38 ± 0.05, study = 0.60 ± 0.09, p = 0.03), but there was no significant difference in leptin levels between these groups (control = 0.57 ± 0.1, study = 0.35 ± 0.1, p = 0.18). Positive and significant correlations were observed between leptin and OBR in the OE (r = 0.85, p = 0.004) and in the PI (r = 0.87, p = 0.001). ELISA results demonstrate a greater leptin concentration within the EF compared with the serum and the PF (serum = 14.25 ± 1.63, PF = 5.98 ± 2.0, EF = 73.8 ± 16.2, p = 0.0001), but there was no correlation between these variables. A positive, significant and strong correlation was observed between PF leptin levels and the expression of leptin and OBR in PI (leptin: r = 0.78, p = 0.007/OBR: r = 0.68, p = 0.04) and between the EF leptin levels and the expression of leptin and OBR in the OE (leptin: r = 0.88, p = 0.008/OBR: r = 0.89, p = 0.005). CONCLUSIONS:These data suggest that leptin may play an important role in the physiopathology of OE through a modulatory interaction with its active receptor.
journal_name
J Ovarian Resjournal_title
Journal of ovarian researchauthors
Zendron C,Gonçalves HF,Cavalcante FS,Pereira TR,Evangelista A,Ramos CF,Oliveira MAdoi
10.1186/1757-2215-7-2subject
Has Abstractpub_date
2014-01-08 00:00:00pages
2issn
1757-2215pii
1757-2215-7-2journal_volume
7pub_type
杂志文章abstract:BACKGROUND:Wnt-inducible signaling pathway protein 2 (WISP2) is a wnt1-induced signaling pathway protein 2. Although studies indicate that WISP2 may promote the development of various tumors, its role in ovarian cancer remains unclear. The objective of the current study was to analyze the effects of WISP2 on the prolif...
journal_title:Journal of ovarian research
pub_type: 杂志文章
doi:10.1186/s13048-020-00687-8
更新日期:2020-07-25 00:00:00
abstract:BACKGROUND:The objective of this study was to build the transcriptomic profile of granulosa cells originating from follicles 6 to 9 mm in diameter in dairy cattle using microarrays. METHODS:Granulosa cells originating from three different phases of antral follicle growth were compared: growing (G), plateau (P) and atr...
journal_title:Journal of ovarian research
pub_type: 杂志文章
doi:10.1186/1757-2215-7-50
更新日期:2014-05-07 00:00:00
abstract:BACKGROUND:Whether there is a mechanistic link between FOLR1 and response to cisplatin has not been extensively examined. In this study, we determine the expression of FOLR1 in ovarian cancer and examine if FOLR1 levels influence response to cisplatin. RESULTS:(1) FOLR1 protein expression was lowest in normal ovarian ...
journal_title:Journal of ovarian research
pub_type: 杂志文章
doi:10.1186/s13048-018-0387-y
更新日期:2018-02-13 00:00:00
abstract:RATIONALE AND OBJECTIVES:To evaluate the impact of metabolic parameters in the peritoneal cavity on the likelihood of achieving complete tumor debulking in patients with ovarian and peritoneal cancers. MATERIALS AND METHODS:Forty-nine patients with ovarian and peritoneal cancers were included, who underwent pre-operat...
journal_title:Journal of ovarian research
pub_type: 杂志文章
doi:10.1186/s13048-020-00662-3
更新日期:2020-05-20 00:00:00
abstract::Both estrogens and androgens are involved in the development and normal functioning of the ovaries. It is also known that ovarian function is regulated by diet. The goal of this study was to estimate the expression of sex hormone receptors in ovaries of mice that were on a 9-month caloric restriction (alternate-day fe...
journal_title:Journal of ovarian research
pub_type: 杂志文章
doi:10.1186/s13048-015-0185-8
更新日期:2015-08-13 00:00:00
abstract:BACKGROUND:Low adiponectin levels in polycystic ovarian syndrome (PCOS) have been largely attributed to obesity which is common among these patients. In addition, evidence also suggests that low adiponectin in PCOS may be related to insulin resistance (IR) in these women. However, studies on the role of adiponectin in ...
journal_title:Journal of ovarian research
pub_type: 杂志文章
doi:10.1186/1757-2215-7-18
更新日期:2014-02-07 00:00:00
abstract:OBJECTIVE:Recently, 14-3-3 zeta protein was identified as a potential serum biomarker of epithelial ovarian cancer (EOC). The goal of this study was to investigate the clinical potential of 14-3-3 zeta protein for monitoring EOC progression compared with CA-125 and HE4. DESIGN:Prospective follow-up study. SETTING:Uni...
journal_title:Journal of ovarian research
pub_type: 杂志文章
doi:10.1186/1757-2215-6-79
更新日期:2013-11-15 00:00:00
abstract:BACKGROUND:Altered androgen hormone homeostasis and androgen receptor (AR) activity have been implicated in ovarian carcinogenesis but the relationship between AR expression in ovarian cancer and clinical outcome remains unclear. METHODS:In this study, the prognostic impact of AR expression was investigated using immu...
journal_title:Journal of ovarian research
pub_type: 杂志文章
doi:10.1186/1757-2215-3-14
更新日期:2010-06-17 00:00:00
abstract:BACKGROUND:The ST6Gal-I glycosyltransferase, which adds α2-6-linked sialic acids to N-glycosylated proteins is upregulated in a wide range of malignancies including ovarian cancer. Prior studies have shown that ST6Gal-I-mediated sialylation of select surface receptors remodels intracellular signaling to impart cancer s...
journal_title:Journal of ovarian research
pub_type: 杂志文章
doi:10.1186/s13048-019-0574-5
更新日期:2019-10-14 00:00:00
abstract:BACKGROUND:The use of long protocol during controlled ovarian stimulation for assisted reproduction attracts high dosage of gonadotropins. High dose of gonadotropins can be detrimental to oocyte development, which affects its quality and compromises the treatment outcome. Mild stimulation protocols that attract low dos...
journal_title:Journal of ovarian research
pub_type: 杂志文章
doi:10.1186/s13048-018-0408-x
更新日期:2018-05-04 00:00:00
abstract:BACKGROUND:Cell lines are very useful for both clinical and basic research. The establishment of ovarian, malignant tumor cell lines with aggressive histology is especially important. We describe the establishment and characterization of a new human clear cell carcinoma cell line of the ovary. RESULTS:The cell line HC...
journal_title:Journal of ovarian research
pub_type: 杂志文章
doi:10.1186/s13048-016-0242-y
更新日期:2016-06-04 00:00:00
abstract:BACKGROUND:The mechanisms regulating the function and regression of the corpus luteum (CL) have not yet been elucidated in detail. The regressed CL of cows was previously reported to be filled with unusual vessels like arteriovenous anastomosis (AVA); however how these vessels are being established during luteolysis re...
journal_title:Journal of ovarian research
pub_type: 杂志文章
doi:10.1186/s13048-016-0277-0
更新日期:2016-10-19 00:00:00
abstract::High-Grade Serous Ovarian Carcinoma (HGSOC) is the predominant histotype of epithelial ovarian cancer (EOC), characterized by advanced stage at diagnosis, frequent TP53 mutation, rapid progression, and high responsiveness to platinum-based-chemotherapy. To date, standard first-line-chemotherapy in advanced EOC include...
journal_title:Journal of ovarian research
pub_type: 杂志文章
doi:10.1186/s13048-016-0238-7
更新日期:2016-05-21 00:00:00
abstract::An amendment to this paper has been published and can be accessed via the original article. ...
journal_title:Journal of ovarian research
pub_type: 已发布勘误
doi:10.1186/s13048-020-00733-5
更新日期:2020-11-12 00:00:00
abstract:BACKGROUND:galectin-1 has been implicated in tumor invasion and metastasis and is frequently over-expressed in epithelial ovarian cancer (EOC), but its potential as a biomarker remains unclear. In this novel study, we have explored the possible use of galectin-1 as a biomarker for EOC. METHODS:galectin-1 in sera was e...
journal_title:Journal of ovarian research
pub_type: 杂志文章
doi:10.1186/s13048-015-0206-7
更新日期:2015-11-21 00:00:00
abstract:BACKGROUND:The prevalence of obesity is increasing worldwide and significantly affects fertility and reproduction in both men and women. Our recent study has shown that excess body fat accelerates ovarian follicle development and follicle loss in rats. The aim of the present study is to explore the effect of SIRT1 acti...
journal_title:Journal of ovarian research
pub_type: 杂志文章
doi:10.1186/s13048-014-0097-z
更新日期:2014-10-21 00:00:00
abstract:BACKGROUND:The majority of death-related ovarian cancer is epithelial ovarian cancer (EOC). Regarding the Federation of Gynecology and Obstetrics (FIGO) stage IV EOC, the 5-year overall survival (OS) has not changed in last decades. Platelet (PLT) count and CA125 level are both prognostic markers that related to inflam...
journal_title:Journal of ovarian research
pub_type: 杂志文章
doi:10.1186/s13048-019-0544-y
更新日期:2019-07-31 00:00:00
abstract:BACKGROUND:The mechanism of aggressive character of ovarian cancer and unsuccessful treatment of women with this deadly disease has been recently explained by the theory of cancer stem cells (CSCs). It has been reported that ovarian carcinogenesis and progression of disease is associated with epithelial-mesenchymal tra...
journal_title:Journal of ovarian research
pub_type: 杂志文章
doi:10.1186/s13048-017-0306-7
更新日期:2017-02-23 00:00:00
abstract:BACKGROUND:Recent researches demonstrate that pre-treatment with androgen could increase retrieved oocytes number and clinical pregnancy rate in poor ovarian response (POR) patients. In view of gap junction intercellular communication (GJIC) is important for follicular growth, and androgen plays an important role in im...
journal_title:Journal of ovarian research
pub_type: 杂志文章
doi:10.1186/s13048-016-0290-3
更新日期:2016-11-23 00:00:00
abstract:BACKGROUND:The value of this report is the identification of late recurrence with an extremely unusual combination of malignant transformation. In particular, the retroconversion of immature to mature teratoma as well as a somatic-type malignant transformation were both observed postchemotherapeutically in our case. C...
journal_title:Journal of ovarian research
pub_type: 杂志文章
doi:10.1186/s13048-018-0476-y
更新日期:2019-01-10 00:00:00
abstract:BACKGROUND:Resistance to apoptosis is a major problem in ovarian cancer (OC) and correlates with poor prognosis. Osteoprotegerin (OPG) is a soluble secreted factor that acts as a decoy receptor for receptor activator of NF-κB ligand (RANKL) and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). OPG has be...
journal_title:Journal of ovarian research
pub_type: 杂志文章
doi:10.1186/1757-2215-6-82
更新日期:2013-11-23 00:00:00
abstract:BACKGROUND:Neovascularization is necessary for follicular growth. Vascularization is first observed in preantral follicles, and thereafter the vasculature markedly increases in follicles undergoing development. Neovascularization includes angiogenesis and vasculogenesis. Vasculogenesis is the formation of new blood ves...
journal_title:Journal of ovarian research
pub_type: 杂志文章
doi:10.1186/1757-2215-7-10
更新日期:2014-01-21 00:00:00
abstract:BACKGROUND:This study was aimed to explore the role of long noncoding RNA C17orf91 and its potential mechanisms in ovarian cancer development. RESULTS:To assess its role in ovarian cancer, microarray datasets (GSE14407, GSE30587, and GSE17260) in Gene Expression Omnibus (GEO) were utilized to assess the expression and...
journal_title:Journal of ovarian research
pub_type: 杂志文章
doi:10.1186/s13048-016-0258-3
更新日期:2016-08-17 00:00:00
abstract:BACKGROUND:To investigate dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) for assessing histopathological and molecular biological features in induced rat epithelial ovarian carcinomas (EOCs). METHODS:7,12-dimethylbenz[A]anthracene (DMBA) was applied to induce EOCs in situ in 46 SD rats. Conventional MR...
journal_title:Journal of ovarian research
pub_type: 杂志文章
doi:10.1186/s13048-017-0362-z
更新日期:2017-09-26 00:00:00
abstract:BACKGROUND:The polycystic ovary syndrome (PCOS) is a complex and heterogeneous endocrine condition characterized by hyperandrogenism, hyperinsulinemia, insulin resistance and chronic anovulation. Regulation and interaction of a multitude of genes required for follicular development are found to be altered in PCOS. Micr...
journal_title:Journal of ovarian research
pub_type: 杂志文章
doi:10.1186/1757-2215-6-36
更新日期:2013-05-15 00:00:00
abstract:BACKGROUND:Glutathione peroxidase 3 (GPX3) is a selenocysteine-containing antioxidant enzyme that reacts with hydrogen peroxide and soluble fatty acid hydroperoxides, thereby helping to maintain redox balance within cells. Serum levels of GPX3 have been found to be reduced in various cancers including prostrate, thyroi...
journal_title:Journal of ovarian research
pub_type: 杂志文章
doi:10.1186/1757-2215-4-18
更新日期:2011-10-22 00:00:00
abstract::Ovarian cancer is the fifth most common cause of cancer death in women and the leading cause of death from gynaecological malignancies. Of the 75% women diagnosed with locally advanced or disseminated disease, only 30% will survive five years following treatment. This poor prognosis is due to the following reasons: li...
journal_title:Journal of ovarian research
pub_type: 杂志文章,评审
doi:10.1186/1757-2215-7-60
更新日期:2014-06-07 00:00:00
abstract:BACKGROUND:Mature cystic teratomas are usually found in the ovaries. They are bilateral in 10 to 15% of cases and multiple cystic teratomas may be present in one ovary. The aim of this study is to clarify if development of mature cystic teratomas of the ovaries in a single host is metachronous or due to autoimplant or ...
journal_title:Journal of ovarian research
pub_type: 杂志文章,评审
doi:10.1186/s13048-017-0313-8
更新日期:2017-03-14 00:00:00
abstract:BACKGROUND:Gonadoblastoma (GB) is a rare mixed germ cell-sex cord-stromal tumour, first described in humans, commonly found in dysgenetic gonads of intersex patients that have a Y chromosome. However, this entity in not recognized in the WHO classification of tumours of genital system of domestic animals. Herein, we de...
journal_title:Journal of ovarian research
pub_type: 杂志文章
doi:10.1186/s13048-019-0561-x
更新日期:2019-09-23 00:00:00
abstract:BACKGROUND:To demonstrate the use of surface-enhanced Raman spectroscopy (SERS) to determine sialic acid (SA) levels in saliva using silver nanoparticles as substrates, in adnexal mass patients scheduled for surgical intervention to remove invasive masses, with the aim to compare SA levels in benign tumor vs ovarian ca...
journal_title:Journal of ovarian research
pub_type: 杂志文章
doi:10.1186/s13048-018-0433-9
更新日期:2018-07-24 00:00:00