Abstract：
BACKGROUND:Whether there is a mechanistic link between FOLR1 and response to cisplatin has not been extensively examined. In this study, we determine the expression of FOLR1 in ovarian cancer and examine if FOLR1 levels influence response to cisplatin. RESULTS:(1) FOLR1 protein expression was lowest in normal ovarian tissue, higher in benign ovarian tumors, and highest in malignant tumors (P < 0.01). (2) FOLR1 expression was decreased in platinum drug-resistant ovarian tumors compared to sensitive tumors (P < 0.01). Consistent with this, FOLR1 expression in tumors progressing following cisplatin treatment was lower than levels in tumors in remission (P < 0.01). (3) FOLR1 was successfully overexpressed at both the mRNA and protein levels following transfection in SKOV3 cells. (4) SKOV3 cells with FOLR1 overexpression were the most sensitive to cisplatin treatment (IC50 = 3.60 μg/ml) and exhibited the highest inhibition rates in the presence of the drug (P < 0.05). (5) The rate of apoptosis of SKOV3 cells increased with cisplatin treatment in a dose- and time-dependent manner (P < 0.05). Cisplatin also induced S phase arrest in a concentration-dependent manner (P < 0.05). Apoptosis and S phase proportion were significantly altered by FOLR1 overexpression (P < 0.05). CONCLUSION:FOLR1 may be a useful biomarker for ovarian cancer, and it may be useful as a therapeutic application to improve sensitivity to cisplatin treatment.
journal_name
J Ovarian Resjournal_title
Journal of ovarian researchauthors
Huang MJ,Zhang W,Wang Q,Yang ZJ,Liao SB,Li Ldoi
10.1186/s13048-018-0387-ysubject
Has Abstractpub_date
2018-02-13 00:00:00pages
15issue
1issn
1757-2215pii
10.1186/s13048-018-0387-yjournal_volume
11pub_type
杂志文章abstract：BACKGROUND:Myo-inositol (MI), successfully used in polycystic ovary syndrome (PCOS), was administered with α-LA to exploit its action of favouring the passage of other molecules through biological barriers, and also considering its anti-inflammatory effect. METHODS:PCOS patients, according to the Rotterdam ESHRE-ASRM ...
journal_title：Journal of ovarian research
pub_type： 临床试验,杂志文章
doi：10.1186/s13048-018-0411-2
更新日期：2018-05-10 00:00:00
abstract：BACKGROUND:Neovascularization is necessary for follicular growth. Vascularization is first observed in preantral follicles, and thereafter the vasculature markedly increases in follicles undergoing development. Neovascularization includes angiogenesis and vasculogenesis. Vasculogenesis is the formation of new blood ves...
journal_title：Journal of ovarian research
pub_type： 杂志文章
doi：10.1186/1757-2215-7-10
更新日期：2014-01-21 00:00:00
abstract：BACKGROUND:Although agonistic autoantibodies against type-1 angiotensin-II receptor (AT1-AA) are frequently detected in women with preeclampsia, the clinical significance of AT1-AA in association with epithelial ovarian cancer (EOC) has not been identified. METHODS:In an attempt to clarify this issue, we measured seru...
journal_title：Journal of ovarian research
pub_type： 杂志文章
doi：10.1186/1757-2215-6-22
更新日期：2013-04-05 00:00:00
abstract：BACKGROUND:This study was aimed to explore the role of long noncoding RNA C17orf91 and its potential mechanisms in ovarian cancer development. RESULTS:To assess its role in ovarian cancer, microarray datasets (GSE14407, GSE30587, and GSE17260) in Gene Expression Omnibus (GEO) were utilized to assess the expression and...
journal_title：Journal of ovarian research
pub_type： 杂志文章
doi：10.1186/s13048-016-0258-3
更新日期：2016-08-17 00:00:00
abstract：:Infertility is a medical and social condition that affects millions of women worldwide and is today considered so far as a new disease. A considerable progress has been recently pursued in the field of the reproductive medicine and the infertility treatment may account for novel and modern procedures such as in vitro ...
journal_title：Journal of ovarian research
pub_type： 杂志文章
doi：10.1186/s13048-015-0184-9
更新日期：2015-08-07 00:00:00
abstract：UNLABELLED: BACKGROUND:To investigate the 3.0-Tesla (3 T) magnetic resonance imaging (MRI) characteristics of primary adnexal lesions for discriminating benign from malignant lesions. METHODS:One hundred thirty-nine patients with pathologically proven primary adnexal masses referred for 3 T MRI assessment preoperativ...
journal_title：Journal of ovarian research
pub_type： 杂志文章
doi：10.1186/1757-2215-5-33
更新日期：2012-11-14 00:00:00
abstract：BACKGROUND:Recent researches demonstrate that pre-treatment with androgen could increase retrieved oocytes number and clinical pregnancy rate in poor ovarian response (POR) patients. In view of gap junction intercellular communication (GJIC) is important for follicular growth, and androgen plays an important role in im...
journal_title：Journal of ovarian research
pub_type： 杂志文章
doi：10.1186/s13048-016-0290-3
更新日期：2016-11-23 00:00:00
abstract：BACKGROUND:Studies on the association between obesity and ovarian cancer survival have had conflicting results. We reviewed and quantitatively summarized the existing evidence, exploring potentially important sources of variability, such as the timing of body mass index (BMI) assessment, BMI cut points, references used...
journal_title：Journal of ovarian research
pub_type： 杂志文章,meta分析,评审
doi：10.1186/1757-2215-7-41
更新日期：2014-04-22 00:00:00
abstract：BACKGROUND:This study was designed to investigate leptin levels in the fluid in ovarian endometriomas (OEs) and to compare the expression of leptin and its receptors (OBR) in ovarian tissue affected by endometrioma in infertile women to its expression in the normal ovarian tissue of fertile controls without endometrios...
journal_title：Journal of ovarian research
pub_type： 杂志文章
doi：10.1186/1757-2215-7-2
更新日期：2014-01-08 00:00:00
abstract：:Both estrogens and androgens are involved in the development and normal functioning of the ovaries. It is also known that ovarian function is regulated by diet. The goal of this study was to estimate the expression of sex hormone receptors in ovaries of mice that were on a 9-month caloric restriction (alternate-day fe...
journal_title：Journal of ovarian research
pub_type： 杂志文章
doi：10.1186/s13048-015-0185-8
更新日期：2015-08-13 00:00:00
abstract：BACKGROUND:Degeneration of ovarian function is an obvious feature of female aging. In addition, studies have shown that autophagy decreases with age, and DNA methylation is a hallmark epigenetic pattern during aging. However, it is not clear whether the expression and DNA methylation of autophagy genes are involved in ...
journal_title：Journal of ovarian research
pub_type： 杂志文章
doi：10.1186/s13048-020-0615-0
更新日期：2020-02-03 00:00:00
abstract：BACKGROUND:Ovarian thecoma-fibroma groups (OTFG) are uncommon sex cord-stromal neoplasms. The objective of the study was to demonstrate clinical and sonographic features of OTFG and compare with surgical histopathology. METHODS:A total of 61 patients with surgically proven OTFG were enrolled in this retrospective stud...
journal_title：Journal of ovarian research
pub_type： 杂志文章
doi：10.1186/s13048-016-0291-2
更新日期：2016-11-22 00:00:00
abstract：BACKGROUND:The polycystic ovary syndrome (PCOS) affects approximately 6-10% of women of reproductive age and is characterized by chronic anovulation and hyperandrogenism. However, a comprehensive understanding of the mechanisms that dictate androgen overproduction is lacking, which may account for inconsistencies betwe...
journal_title：Journal of ovarian research
pub_type： 杂志文章
doi：10.1186/1757-2215-5-15
更新日期：2012-05-18 00:00:00
abstract：:Ovarian cystic tumors with a mural nodule are a rare entity. We report a case of a mural nodule of anaplastic spindle cell carcinoma in an ovarian mucinous cystic tumor of borderline malignancy. The patient was a 45-years-old Japanese woman who presented with an ovarian cyst. She suffered from mature cystic teratoma o...
journal_title：Journal of ovarian research
pub_type： 杂志文章
doi：10.1186/1757-2215-6-86
更新日期：2013-12-05 00:00:00
abstract：BACKGROUND:Standard morphologic evaluation has been the most widely adopted approach to embryo selection, and remains the most common strategy.The objective of the study to determine the association between the morphologic grading and implantation rate of euploid blastocysts in single frozen-thawed embryo transfer (SET...
journal_title：Journal of ovarian research
pub_type： 杂志文章
doi：10.1186/s13048-021-00770-8
更新日期：2021-01-23 00:00:00
abstract：:Ovarian cancer is the fifth most common cause of cancer death in women and the leading cause of death from gynaecological malignancies. Of the 75% women diagnosed with locally advanced or disseminated disease, only 30% will survive five years following treatment. This poor prognosis is due to the following reasons: li...
journal_title：Journal of ovarian research
pub_type： 杂志文章,评审
doi：10.1186/1757-2215-7-60
更新日期：2014-06-07 00:00:00
abstract：BACKGROUND:Resistance to apoptosis is a major problem in ovarian cancer (OC) and correlates with poor prognosis. Osteoprotegerin (OPG) is a soluble secreted factor that acts as a decoy receptor for receptor activator of NF-κB ligand (RANKL) and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). OPG has be...
journal_title：Journal of ovarian research
pub_type： 杂志文章
doi：10.1186/1757-2215-6-82
更新日期：2013-11-23 00:00:00
abstract：BACKGROUND:Ovarian cancer (OC) was the primary malignant gynecological cancer and SNARE protein is closely related with tumor progression. Here, we identified SNAP23, a member of SNARE complex, as a potential oncogene in OC. METHODS:We determined the expression of SNAP23 in OC tissues and explored the clinical signifi...
journal_title：Journal of ovarian research
pub_type： 杂志文章
doi：10.1186/s13048-016-0289-9
更新日期：2016-11-17 00:00:00
abstract：:As the human ovarian follicle enlarges in the course of a regular cycle or following controlled ovarian stimulation, the changes in its structure reveal the oocyte environment composed of cumulus oophorus cells and the follicular fluid (FF).In contrast to the dynamic nature of cells, the fluid compartment appears as a...
journal_title：Journal of ovarian research
pub_type： 杂志文章,评审
doi：10.1186/s13048-017-0342-3
更新日期：2017-07-12 00:00:00
abstract：BACKGROUND:Cell lines are very useful for both clinical and basic research. The establishment of ovarian, malignant tumor cell lines with aggressive histology is especially important. We describe the establishment and characterization of a new human clear cell carcinoma cell line of the ovary. RESULTS:The cell line HC...
journal_title：Journal of ovarian research
pub_type： 杂志文章
doi：10.1186/s13048-016-0242-y
更新日期：2016-06-04 00:00:00
abstract：BACKGROUND:To demonstrate the use of surface-enhanced Raman spectroscopy (SERS) to determine sialic acid (SA) levels in saliva using silver nanoparticles as substrates, in adnexal mass patients scheduled for surgical intervention to remove invasive masses, with the aim to compare SA levels in benign tumor vs ovarian ca...
journal_title：Journal of ovarian research
pub_type： 杂志文章
doi：10.1186/s13048-018-0433-9
更新日期：2018-07-24 00:00:00
abstract：BACKGROUND:The ST6Gal-I glycosyltransferase, which adds α2-6-linked sialic acids to N-glycosylated proteins is upregulated in a wide range of malignancies including ovarian cancer. Prior studies have shown that ST6Gal-I-mediated sialylation of select surface receptors remodels intracellular signaling to impart cancer s...
journal_title：Journal of ovarian research
pub_type： 杂志文章
doi：10.1186/s13048-019-0574-5
更新日期：2019-10-14 00:00:00
abstract：BACKGROUND:Highly Individualized Egg Retrieval (HIER), defined as age-specific early oocyte retrieval (ER), has been demonstrated to avoid premature luteinization in women ≥43. We here investigated whether HIER also applies to younger women with premature ovarian aging (POA), and what best lead follicle size should be ...
journal_title：Journal of ovarian research
pub_type： 杂志文章
doi：10.1186/s13048-018-0398-8
更新日期：2018-03-16 00:00:00
abstract：BACKGROUND:Various components of the immune system play a critical role in the prognosis and treatment response in ovarian cancer (OC). Immunotherapy has been recognized as a hallmark of cancer but the effect is contradictional. Reliable immune gene-based prognostic biomarkers or regulatory factors are necessary to be ...
journal_title：Journal of ovarian research
pub_type： 杂志文章
doi：10.1186/s13048-021-00766-4
更新日期：2021-01-28 00:00:00
abstract：BACKGROUND:The mechanisms regulating the function and regression of the corpus luteum (CL) have not yet been elucidated in detail. The regressed CL of cows was previously reported to be filled with unusual vessels like arteriovenous anastomosis (AVA); however how these vessels are being established during luteolysis re...
journal_title：Journal of ovarian research
pub_type： 杂志文章
doi：10.1186/s13048-016-0277-0
更新日期：2016-10-19 00:00:00
abstract：BACKGROUND:Hyaluronic acid is a prognostic factor in ovarian cancers. It is also a component of Hyaluronic Acid-Carboxymethyl Cellulose (HA-CMC) barrier, an anti-adhesion membrane widely used during abdominal surgeries in particular for ovarian carcinosis. 70% of patients who undergo ovarian surgery will relapse due to...
journal_title：Journal of ovarian research
pub_type： 杂志文章
doi：10.1186/1757-2215-7-40
更新日期：2014-04-16 00:00:00
abstract：BACKGROUND:The use of long protocol during controlled ovarian stimulation for assisted reproduction attracts high dosage of gonadotropins. High dose of gonadotropins can be detrimental to oocyte development, which affects its quality and compromises the treatment outcome. Mild stimulation protocols that attract low dos...
journal_title：Journal of ovarian research
pub_type： 杂志文章
doi：10.1186/s13048-018-0408-x
更新日期：2018-05-04 00:00:00
abstract：BACKGROUND:Ovarian cancer is the second most common gynecologic malignancy. As the primary imaging modality, computed tomography (CT) can provide staging information for preoperative planning and determination of surgical resectability. As a new three-dimensional postprocessing tool for CT images, cinematic rendering (...
journal_title：Journal of ovarian research
pub_type： 杂志文章
doi：10.1186/s13048-018-0461-5
更新日期：2018-09-26 00:00:00
abstract：BACKGROUND:In this study we aimed to identify a prognostic signature in BRCA1/2 mutations to predict disease progression and the efficiency of chemotherapy ovarian cancer (OV), the second most common cause of death from gynecologic cancer in women worldwide. METHODS:Univariate Cox proportional-hazards and multivariate...
journal_title：Journal of ovarian research
pub_type： 杂志文章
doi：10.1186/s13048-020-00712-w
更新日期：2020-09-19 00:00:00
abstract：BACKGROUND:It is estimated that more than 20% of ovarian cancer cases are associated with a genetic predisposition that is only partially explained by germline mutations in the BRCA1 and BRCA2 genes. Recently, several pieces of evidence showed that mutations in three genes involved in the homologous recombination DNA r...
journal_title：Journal of ovarian research
pub_type： 杂志文章,meta分析
doi：10.1186/s13048-020-00654-3
更新日期：2020-05-02 00:00:00
