Abstract:
BACKGROUND:The prevalence of obesity is increasing worldwide and significantly affects fertility and reproduction in both men and women. Our recent study has shown that excess body fat accelerates ovarian follicle development and follicle loss in rats. The aim of the present study is to explore the effect of SIRT1 activator SRT1720 on the reserve of ovarian follicle pool and ovarian lifespan of obese mice and the underlying mechanism associated with SIRT1 and mTOR signaling. METHODS:Adult female Kunming mice (n = 36) were randomly divided into three groups: the normal control (NC) group (n = 8), the caloric restriction (CR) group (fed 70% food of the NC group, n = 8) and the high-fat diet (HF) group (fed a rodent chow containing 20% fat, n = 20). After 4 months, the HF mice were further randomly divided into three groups: the control high-fat diet (CHF, n = 8) group (treated every day with an intraperitoneal injection of vehicle), the SRT1720 (SRT, n = 6) group (treated every other day with an intraperitoneal injection of SRT1720 (50 mg/kg)), the SRT1720 and nicotinamide (NAM, n = 6) group (treated every other day with an intraperitoneal injection of SRT1720 (50 mg/kg) and every day with an intraperitoneal injection of nicotinamide (100 mg/kg)). After 6 weeks of treatment, ovaries were harvested for histological and Western blotting analyses. RESULTS:The body weight, ovary weight and visceral fat in the SRT group were significantly lower than those in the CHF group at the end of treatment. Histological analysis showed that the SRT mice had significantly greater number and percentage of primordial follicles, but lower number and percentage of corpora lutea and atretic follicles than the CHF mice and NAM mice. Western blot analysis demonstrated that the levels of SIRT1, SIRT6, FOXO3a and NRF-1 protein expression significantly increased in the ovaries of SRT mice, whereas those of mTORC1, p-mTOR, p-p70S6K, NFκB and p53 decreased compared to the CHF and NAM mice. CONCLUSIONS:Our study suggests that SRT1720 may improve the follicle pool reserve in HF diet-induced obese female mice via activating SIRT1 signaling and suppressing mTOR signaling, thus extending the ovarian lifespan.
journal_name
J Ovarian Resjournal_title
Journal of ovarian researchauthors
Zhou XL,Xu JJ,Ni YH,Chen XC,Zhang HX,Zhang XM,Liu WJ,Luo LL,Fu YCdoi
10.1186/s13048-014-0097-zsubject
Has Abstractpub_date
2014-10-21 00:00:00pages
97issn
1757-2215pii
s13048-014-0097-zjournal_volume
7pub_type
杂志文章abstract::Ovarian cystic tumors with a mural nodule are a rare entity. We report a case of a mural nodule of anaplastic spindle cell carcinoma in an ovarian mucinous cystic tumor of borderline malignancy. The patient was a 45-years-old Japanese woman who presented with an ovarian cyst. She suffered from mature cystic teratoma o...
journal_title:Journal of ovarian research
pub_type: 杂志文章
doi:10.1186/1757-2215-6-86
更新日期:2013-12-05 00:00:00
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journal_title:Journal of ovarian research
pub_type: 杂志文章
doi:10.1186/1757-2215-7-50
更新日期:2014-05-07 00:00:00
abstract:BACKGROUND:Myo-inositol (MI), successfully used in polycystic ovary syndrome (PCOS), was administered with α-LA to exploit its action of favouring the passage of other molecules through biological barriers, and also considering its anti-inflammatory effect. METHODS:PCOS patients, according to the Rotterdam ESHRE-ASRM ...
journal_title:Journal of ovarian research
pub_type: 临床试验,杂志文章
doi:10.1186/s13048-018-0411-2
更新日期:2018-05-10 00:00:00
abstract:BACKGROUND:This study aimed to identify the clinical and pathological characteristics and the possible prognostic factors for Chinese patients with early-stage ovarian endometrioid carcinoma. METHODS:The present study reviewed the medical records of patients who received initial treatment and a postoperative pathologi...
journal_title:Journal of ovarian research
pub_type: 杂志文章
doi:10.1186/s13048-017-0361-0
更新日期:2017-09-18 00:00:00
abstract:BACKGROUND:Our recent study on a panel of human ovarian cancer cells revealed that SKOV-3 cells barely express the Sprouty isoform 1 (Spry1) while 1A9 cells maintain it at a level similar to normal ovarian cells. Here we investigated the functional outcomes of induced alterations in the expression of Spry1 in the two c...
journal_title:Journal of ovarian research
pub_type: 杂志文章
doi:10.1186/1757-2215-7-61
更新日期:2014-06-08 00:00:00
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journal_title:Journal of ovarian research
pub_type: 杂志文章
doi:10.1186/s13048-018-0404-1
更新日期:2018-04-10 00:00:00
abstract:BACKGROUND:The polycystic ovary syndrome (PCOS) is a complex and heterogeneous endocrine condition characterized by hyperandrogenism, hyperinsulinemia, insulin resistance and chronic anovulation. Regulation and interaction of a multitude of genes required for follicular development are found to be altered in PCOS. Micr...
journal_title:Journal of ovarian research
pub_type: 杂志文章
doi:10.1186/1757-2215-6-36
更新日期:2013-05-15 00:00:00
abstract:BACKGROUND:Resveratrol (3,5,4'-trihydroxy-trans-stilbene) is a natural antioxidant polyphenol able to exert a wide range of biological effect on several tissues. Despite its important beneficial properties, it has a low water solubility, which limits its therapeutic applications in humans. Resveratrol also acts as a ph...
journal_title:Journal of ovarian research
pub_type: 杂志文章
doi:10.1186/s13048-017-0357-9
更新日期:2017-09-15 00:00:00
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journal_title:Journal of ovarian research
pub_type: 杂志文章
doi:10.1186/s13048-015-0206-7
更新日期:2015-11-21 00:00:00
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journal_title:Journal of ovarian research
pub_type: 杂志文章,已发布勘误
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更新日期:2019-01-30 00:00:00
abstract:BACKGROUND:Ovarian hyperstimulation syndrome (OHSS) is a rare, yet severe, iatrogenic complication of ovulation induction therapy during assisted reproductive procedures. Our group previously detected atypical cells in the ascitic fluid of OHSS patients, although no malignancy developed during follow up. Here, the aim ...
journal_title:Journal of ovarian research
pub_type: 杂志文章
doi:10.1186/s13048-020-00624-9
更新日期:2020-03-05 00:00:00
abstract:BACKGROUND:This study evaluated the influence of menstrual cycle length, menstrual cycle variability and predicted luteal phase length on the success of vitrified-warmed blastocyst transfer in natural menstrual cycle using progesterone for luteal phase supplementation. METHODS:Consecutive women undergoing vitrified-wa...
journal_title:Journal of ovarian research
pub_type: 杂志文章
doi:10.1186/s13048-018-0436-6
更新日期:2018-08-02 00:00:00
abstract:BACKGROUND:Mature cystic teratomas are usually found in the ovaries. They are bilateral in 10 to 15% of cases and multiple cystic teratomas may be present in one ovary. The aim of this study is to clarify if development of mature cystic teratomas of the ovaries in a single host is metachronous or due to autoimplant or ...
journal_title:Journal of ovarian research
pub_type: 杂志文章,评审
doi:10.1186/s13048-017-0313-8
更新日期:2017-03-14 00:00:00
abstract:BACKGROUND:Ovarian cancer is the leading cause of gynecological cancer-related mortality. The novel oncogene S100A10 has been reported to be involved in cancer cell proliferation, invasion and metastasis. The role of S100A10 in ovarian cancer has not been well studied and the effect of S100A10 on chemotherapy remains u...
journal_title:Journal of ovarian research
pub_type: 杂志文章
doi:10.1186/s13048-019-0592-3
更新日期:2019-11-18 00:00:00
abstract:BACKGROUND:Hypertensive disorders of pregnancy are the most common causes of adverse maternal & perinatal outcomes. Such investigations in resource limited settings would help to have great design strategies in preventing maternal and perinatal morbidity and mortality. AIM:To determine management outcome and factor as...
journal_title:Journal of ovarian research
pub_type: 杂志文章
doi:10.1186/s13048-015-0135-5
更新日期:2015-03-15 00:00:00
abstract:BACKGROUND:Ovarian cancer is the second most common gynecologic malignancy. As the primary imaging modality, computed tomography (CT) can provide staging information for preoperative planning and determination of surgical resectability. As a new three-dimensional postprocessing tool for CT images, cinematic rendering (...
journal_title:Journal of ovarian research
pub_type: 杂志文章
doi:10.1186/s13048-018-0461-5
更新日期:2018-09-26 00:00:00
abstract:INTRODUCTION:Weight gain and fat accumulation are predisposing factors of PCOS. Life-style modification, including increasing physical activity, is the first line approach in managing PCOS. The objective of this study is to assess the effect of exercise intensity on weight changes, androstenedione and free testosterone...
journal_title:Journal of ovarian research
pub_type: 杂志文章
doi:10.1186/1757-2215-7-37
更新日期:2014-04-08 00:00:00
abstract::The original article [1] contains errors in Fig. 3C, Results and Discussion. ...
journal_title:Journal of ovarian research
pub_type: 杂志文章,已发布勘误
doi:10.1186/s13048-020-00628-5
更新日期:2020-03-13 00:00:00
abstract:BACKGROUND:Survivin is an inhibitor of apoptosis and a regulator of mitotic progression. TP53 protein is a negative transcriptional regulator of survivin. The aim of our study was to evaluate the clinical significance of survivin expression in advanced stages ovarian cancer with respect to the TP53 status. METHODS:Sur...
journal_title:Journal of ovarian research
pub_type: 杂志文章
doi:10.1186/1757-2215-4-20
更新日期:2011-11-10 00:00:00
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journal_title:Journal of ovarian research
pub_type: 杂志文章
doi:10.1186/s13048-019-0576-3
更新日期:2019-10-22 00:00:00
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pub_type: 杂志文章
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更新日期:2021-01-28 00:00:00
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pub_type: 杂志文章
doi:10.1186/s13048-018-0408-x
更新日期:2018-05-04 00:00:00
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journal_title:Journal of ovarian research
pub_type: 杂志文章
doi:10.1186/s13048-019-0568-3
更新日期:2019-09-16 00:00:00
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journal_title:Journal of ovarian research
pub_type: 杂志文章
doi:10.1186/1757-2215-6-84
更新日期:2013-11-26 00:00:00
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journal_title:Journal of ovarian research
pub_type: 杂志文章
doi:10.1186/1757-2215-7-2
更新日期:2014-01-08 00:00:00
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journal_title:Journal of ovarian research
pub_type: 已发布勘误
doi:10.1186/s13048-020-00733-5
更新日期:2020-11-12 00:00:00
abstract:BACKGROUND:Mucinous carcinomas from different organs are morphologically similar and might share similarities at the molecular and biochemical levels that may illuminate their pathogenesis and influence management. The factors involved in the pathogenesis of mucinous carcinomas remain unknown; which is likely one contr...
journal_title:Journal of ovarian research
pub_type: 杂志文章
doi:10.1186/s13048-015-0169-8
更新日期:2015-06-17 00:00:00
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journal_title:Journal of ovarian research
pub_type: 杂志文章
doi:10.1186/s13048-015-0203-x
更新日期:2015-11-14 00:00:00
abstract:BACKGROUND:Neovascularization is necessary for follicular growth. Vascularization is first observed in preantral follicles, and thereafter the vasculature markedly increases in follicles undergoing development. Neovascularization includes angiogenesis and vasculogenesis. Vasculogenesis is the formation of new blood ves...
journal_title:Journal of ovarian research
pub_type: 杂志文章
doi:10.1186/1757-2215-7-10
更新日期:2014-01-21 00:00:00
abstract:RATIONALE AND OBJECTIVES:To evaluate the impact of metabolic parameters in the peritoneal cavity on the likelihood of achieving complete tumor debulking in patients with ovarian and peritoneal cancers. MATERIALS AND METHODS:Forty-nine patients with ovarian and peritoneal cancers were included, who underwent pre-operat...
journal_title:Journal of ovarian research
pub_type: 杂志文章
doi:10.1186/s13048-020-00662-3
更新日期:2020-05-20 00:00:00