Abstract：
BACKGROUND:This study aimed to identify the clinical and pathological characteristics and the possible prognostic factors for Chinese patients with early-stage ovarian endometrioid carcinoma. METHODS:The present study reviewed the medical records of patients who received initial treatment and a postoperative pathological diagnosis of ovarian endometrioid carcinoma at our center. In all, 78 patients had stage I ovarian endometrioid carcinoma. RESULTS:In this series, the 5-year overall survival rate and 5-year disease-free survival (DFS) rates of patients with stage I ovarian endometrioid carcinoma was 98.7% and 87.2%, respectively. Univariate analysis showed the factors that influence the DFS rates include menopausal status, FIGO stage, histological grade, lymphadenectomy, cytology of ascites. Multivariate analysis showed that grade 3 and lymphadenectomy were the independent prognostic factors of DFS for Stage I ovarian endometrioid carcinoma (P = 0.0259, 0.0276 respectively). However, the coexisting endometriosis, concomitant endometrial disorders, dissection of para-aortic lymph node and more courses of thermotherapy had no influence on DFS. Besides, it was found that 19.3% of patients in this series had synchronous early stage and well-to-moderate differentiated endometrial carcinoma. CONCLUSIONS:Grade 3 and lymphadenectomy were indicated as the independent factors of DFS for stage I patients with ovarian endometrioid carcinoma. The endometrial changes should be considered seriously when fertility-sparing surgery was planned.
journal_name
J Ovarian Resjournal_title
Journal of ovarian researchauthors
Zhao Y,Wang S,Qu YM,Ji YT,Shen K,Lang JHdoi
10.1186/s13048-017-0361-0subject
Has Abstractpub_date
2017-09-18 00:00:00pages
63issue
1issn
1757-2215pii
10.1186/s13048-017-0361-0journal_volume
10pub_type
杂志文章abstract：BACKGROUND:Studies on the association between obesity and ovarian cancer survival have had conflicting results. We reviewed and quantitatively summarized the existing evidence, exploring potentially important sources of variability, such as the timing of body mass index (BMI) assessment, BMI cut points, references used...
journal_title：Journal of ovarian research
pub_type： 杂志文章,meta分析,评审
doi：10.1186/1757-2215-7-41
更新日期：2014-04-22 00:00:00
abstract：BACKGROUND:Despite advances in surgical aggressiveness and conventional chemotherapy, ovarian cancer remains the most lethal cause of gynecologic cancer mortality; consequently there is a need for new therapeutic agents and innovative treatment paradigms for the treatment of ovarian cancer. Several studies have demonst...
journal_title：Journal of ovarian research
pub_type： 杂志文章
doi：10.1186/s13048-016-0282-3
更新日期：2016-10-27 00:00:00
abstract：:Growing evidence indicates that the tumor biomarker cytokeratin 19 fragment (CYFRA21-1) is significant for a variety of cancers. However, its role in epithelial ovarian cancer (EOC) has rarely been reported. In this study, a receiver operating characteristic (ROC) curve was utilized to estimate the diagnostic efficien...
journal_title：Journal of ovarian research
pub_type： 杂志文章
doi：10.1186/s13048-019-0587-0
更新日期：2019-11-25 00:00:00
abstract：BACKGROUND:Neovascularization is necessary for follicular growth. Vascularization is first observed in preantral follicles, and thereafter the vasculature markedly increases in follicles undergoing development. Neovascularization includes angiogenesis and vasculogenesis. Vasculogenesis is the formation of new blood ves...
journal_title：Journal of ovarian research
pub_type： 杂志文章
doi：10.1186/1757-2215-7-10
更新日期：2014-01-21 00:00:00
abstract：BACKGROUND:The objective of this study was to build the transcriptomic profile of granulosa cells originating from follicles 6 to 9 mm in diameter in dairy cattle using microarrays. METHODS:Granulosa cells originating from three different phases of antral follicle growth were compared: growing (G), plateau (P) and atr...
journal_title：Journal of ovarian research
pub_type： 杂志文章
doi：10.1186/1757-2215-7-50
更新日期：2014-05-07 00:00:00
abstract：BACKGROUND:Mucinous carcinomas from different organs are morphologically similar and might share similarities at the molecular and biochemical levels that may illuminate their pathogenesis and influence management. The factors involved in the pathogenesis of mucinous carcinomas remain unknown; which is likely one contr...
journal_title：Journal of ovarian research
pub_type： 杂志文章
doi：10.1186/s13048-015-0169-8
更新日期：2015-06-17 00:00:00
abstract：BACKGROUND:The value of this report is the identification of late recurrence with an extremely unusual combination of malignant transformation. In particular, the retroconversion of immature to mature teratoma as well as a somatic-type malignant transformation were both observed postchemotherapeutically in our case. C...
journal_title：Journal of ovarian research
pub_type： 杂志文章
doi：10.1186/s13048-018-0476-y
更新日期：2019-01-10 00:00:00
abstract：BACKGROUND:Upregulation of Cyclin dependent kinase 1 (CDK1) protein is closely related with the prognosis of several malignant tumors. Chk1-CDC25C-CDK1 signaling and P53-P21WAF1-CDK1 signaling pathways are closely related with the cell cycle G2/M phase regulation. The present study aimed to analyze the relationship bet...
journal_title：Journal of ovarian research
pub_type： 杂志文章
doi：10.1186/s13048-017-0356-x
更新日期：2017-09-12 00:00:00
abstract：BACKGROUND:This study evaluated the influence of menstrual cycle length, menstrual cycle variability and predicted luteal phase length on the success of vitrified-warmed blastocyst transfer in natural menstrual cycle using progesterone for luteal phase supplementation. METHODS:Consecutive women undergoing vitrified-wa...
journal_title：Journal of ovarian research
pub_type： 杂志文章
doi：10.1186/s13048-018-0436-6
更新日期：2018-08-02 00:00:00
abstract：BACKGROUND:Degeneration of ovarian function is an obvious feature of female aging. In addition, studies have shown that autophagy decreases with age, and DNA methylation is a hallmark epigenetic pattern during aging. However, it is not clear whether the expression and DNA methylation of autophagy genes are involved in ...
journal_title：Journal of ovarian research
pub_type： 杂志文章
doi：10.1186/s13048-020-0615-0
更新日期：2020-02-03 00:00:00
abstract：BACKGROUND:Standard morphologic evaluation has been the most widely adopted approach to embryo selection, and remains the most common strategy.The objective of the study to determine the association between the morphologic grading and implantation rate of euploid blastocysts in single frozen-thawed embryo transfer (SET...
journal_title：Journal of ovarian research
pub_type： 杂志文章
doi：10.1186/s13048-021-00770-8
更新日期：2021-01-23 00:00:00
abstract：BACKGROUND:The imbalance of expression of microRNA-802 may have a significant place in tumor progression. However, the bio-function of epithelial ovarian cancer cells remains unclear. Therefore, we setup this study to explore the pathogenesis of epithelial ovarian cancer based on microRNA-802. METHODS:RT-qPCR analysis...
journal_title：Journal of ovarian research
pub_type： 杂志文章
doi：10.1186/s13048-019-0576-3
更新日期：2019-10-22 00:00:00
abstract：BACKGROUND:Epithelial ovarian cancer (EOC) is still a major gynecologic problem with poor 5 year survival rate due to distance metastases, despite routine surgery and chemotherapy. The precise underlying molecular mechanisms that trigger EOC migration and invasion are unclear. Recent studies suggest that the expression...
journal_title：Journal of ovarian research
pub_type： 杂志文章
doi：10.1186/1757-2215-6-84
更新日期：2013-11-26 00:00:00
abstract：BACKGROUND:This study aimed to examine the performance of the four risk of malignancy index (RMI) in discriminating borderline ovarian tumors (BOTs) and benign ovarian masses in daily clinical practice. METHODS:A total of 162 women with BOTs and 379 women with benign ovarian tumors diagnosed at the Second Affiliated H...
journal_title：Journal of ovarian research
pub_type： 杂志文章
doi：10.1186/s13048-019-0568-3
更新日期：2019-09-16 00:00:00
abstract：INTRODUCTION:Weight gain and fat accumulation are predisposing factors of PCOS. Life-style modification, including increasing physical activity, is the first line approach in managing PCOS. The objective of this study is to assess the effect of exercise intensity on weight changes, androstenedione and free testosterone...
journal_title：Journal of ovarian research
pub_type： 杂志文章
doi：10.1186/1757-2215-7-37
更新日期：2014-04-08 00:00:00
abstract：BACKGROUND:Highly Individualized Egg Retrieval (HIER), defined as age-specific early oocyte retrieval (ER), has been demonstrated to avoid premature luteinization in women ≥43. We here investigated whether HIER also applies to younger women with premature ovarian aging (POA), and what best lead follicle size should be ...
journal_title：Journal of ovarian research
pub_type： 杂志文章
doi：10.1186/s13048-018-0398-8
更新日期：2018-03-16 00:00:00
abstract：OBJECTIVE:To review utilisation of elective embryo cryopreservation in the expectant management of patients at risk for developing ovarian hyperstimulation syndrome (OHSS), and report on reproductive outcome following transfer of thawed embryos. MATERIALS AND METHODS:Medical records were reviewed for patients undergoi...
journal_title：Journal of ovarian research
pub_type： 杂志文章
doi：10.1186/1757-2215-1-7
更新日期：2008-11-06 00:00:00
abstract：BACKGROUND:The down-regulation of E-cadherin gene (CDH1) expression has been regarded as an important event in cancer invasion and metastasis. However, the association between CDH1 promoter methylation and ovarian cancer remains unclear. A meta-analysis was conducted to evaluate the potential role of CDH1 promoter meth...
journal_title：Journal of ovarian research
pub_type： 杂志文章,meta分析
doi：10.1186/s13048-016-0231-1
更新日期：2016-04-11 00:00:00
abstract：BACKGROUND:It is estimated that more than 20% of ovarian cancer cases are associated with a genetic predisposition that is only partially explained by germline mutations in the BRCA1 and BRCA2 genes. Recently, several pieces of evidence showed that mutations in three genes involved in the homologous recombination DNA r...
journal_title：Journal of ovarian research
pub_type： 杂志文章,meta分析
doi：10.1186/s13048-020-00654-3
更新日期：2020-05-02 00:00:00
abstract：:Previously anecdotally observed rebounds in follicle growth after interruption of exogenous gonadotropins in absolute non-responders were the impetus for here reported study. In a prospective cohort study, we investigated 49 consecutive patients, absolutely unresponsive to maximal exogenous gonadotropin stimulation, f...
journal_title：Journal of ovarian research
pub_type： 杂志文章
doi：10.1186/s13048-021-00765-5
更新日期：2021-01-09 00:00:00
abstract：BACKGROUND:We aimed to examine the expression of miR-1307 in chemosensitive and chemoresistant epithelial ovarian cancer tissues and cell lines and to analyze the clinicopathological significance of miR-1307 in ovarian cancer. METHODS:MicroRNA microarray was used to screen differentially expressed microRNAs between th...
journal_title：Journal of ovarian research
pub_type： 杂志文章
doi：10.1186/s13048-015-0143-5
更新日期：2015-04-09 00:00:00
abstract：OBJECTIVE:To explore the risk factors for the recurrence of endometrioma and the risk factors for the recurrence of endometriosis-related pain after long-term follow-up. METHODS:This study retrospectively analyzed 358 women with endometriomas who had a minimum of 5-years follow up after laparoscopic endometrioma excis...
journal_title：Journal of ovarian research
pub_type： 杂志文章
doi：10.1186/s13048-019-0552-y
更新日期：2019-08-30 00:00:00
abstract：UNLABELLED: BACKGROUND:Women with polycystic ovary syndrome (PCOS) have higher risk for cardiovascular disease (CVD). Heart type fatty acid binding protein (HFABP) has been found to be predictive for myocardial ischemia.Wet ested whether HFABP is the predictor for CVD in PCOS patients, who have an increased risk of ca...
journal_title：Journal of ovarian research
pub_type： 杂志文章
doi：10.1186/1757-2215-5-45
更新日期：2012-12-18 00:00:00
abstract：BACKGROUND:The mechanism of aggressive character of ovarian cancer and unsuccessful treatment of women with this deadly disease has been recently explained by the theory of cancer stem cells (CSCs). It has been reported that ovarian carcinogenesis and progression of disease is associated with epithelial-mesenchymal tra...
journal_title：Journal of ovarian research
pub_type： 杂志文章
doi：10.1186/s13048-017-0306-7
更新日期：2017-02-23 00:00:00
abstract：BACKGROUND:Hypertensive disorders of pregnancy are the most common causes of adverse maternal & perinatal outcomes. Such investigations in resource limited settings would help to have great design strategies in preventing maternal and perinatal morbidity and mortality. AIM:To determine management outcome and factor as...
journal_title：Journal of ovarian research
pub_type： 杂志文章
doi：10.1186/s13048-015-0135-5
更新日期：2015-03-15 00:00:00
abstract：BACKGROUND:Wnt-inducible signaling pathway protein 2 (WISP2) is a wnt1-induced signaling pathway protein 2. Although studies indicate that WISP2 may promote the development of various tumors, its role in ovarian cancer remains unclear. The objective of the current study was to analyze the effects of WISP2 on the prolif...
journal_title：Journal of ovarian research
pub_type： 杂志文章
doi：10.1186/s13048-020-00687-8
更新日期：2020-07-25 00:00:00
abstract：:We have earlier reported the presence of very small embryonic-like stem cells (VSELs) in adult mouse uterus along with slightly bigger progenitors termed endometrial stem cells (EnSCs) and their regulation by ovarian hormones thus demonstrating a crucial role played by them during proliferation, differentiation and re...
journal_title：Journal of ovarian research
pub_type： 杂志文章
doi：10.1186/s13048-017-0324-5
更新日期：2017-04-24 00:00:00
abstract：BACKGROUND:Polycystic Ovary Syndrome (PCOS) is a widespread reproductive disorder characterized by a disruption of follicular growth and anovulatory infertility. In women with PCOS, follicular growth and ovulation can be induced by subcutaneous injections of low doses of follicle stimulating hormone (FSH). The aim of t...
journal_title：Journal of ovarian research
pub_type： 杂志文章
doi：10.1186/s13048-015-0192-9
更新日期：2015-10-06 00:00:00
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journal_title：Journal of ovarian research
pub_type： 杂志文章,评审
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更新日期：2019-07-15 00:00:00
abstract：BACKGROUND:Ovarian hyperstimulation syndrome remains a serious complication during in vitro fertilization cycles if high dose human chorionic gonadotropin (hCG) is used to trigger ovulation in high responder patients. Though much of this risk is mitigated with trigger using gonadotropin releasing-hormone (GnRH) agonist...
journal_title：Journal of ovarian research
pub_type： 杂志文章,随机对照试验
doi：10.1186/s13048-019-0483-7
更新日期：2019-01-26 00:00:00
