Abstract：
BACKGROUND:Mucinous carcinomas from different organs are morphologically similar and might share similarities at the molecular and biochemical levels that may illuminate their pathogenesis and influence management. The factors involved in the pathogenesis of mucinous carcinomas remain unknown; which is likely one contributor to the current dearth of biomarkers for detection. Because zinc changes are implicated in some cancers e.g., prostate; we assessed the possibility of a similar role in mucinous carcinomas. METHODS:The goal of the current work is to study the expression of hZip1 by immunohistochemistry in mucinous carcinomas as compared with non-neoplastic epithelia and conventional carcinomas. Tissue microarray slides containing mucinous carcinomas of the ovary (n = 35), colon (n = 51), stomach (n = 32) and lung (n = 21) were used. RESULTS:hZip1 showed persistent low expression in mucinous compared to ovarian serous carcinomas and normal tissue (P < 0.05), colonic adenocarcinoma and normal mucosa (P < 0.001), and gastric adenocarcinoma and normal epithelium (P < 0.05). hZip1 also showed low expression in pulmonary mucinous carcinomas. CONCLUSIONS:hZip1 is consistently decreased in mucinous carcinomas from a variety of organs. Despite the fact that these preliminary findings are unlikely to be of much diagnostic significance, these findings suggest that hZip1 plays a fundamental role in the carcinogenesis of mucinous tumors.
journal_name
J Ovarian Resjournal_title
Journal of ovarian researchauthors
Desouki MM,Franklin RB,Costello LC,Fadare Odoi
10.1186/s13048-015-0169-8subject
Has Abstractpub_date
2015-06-17 00:00:00pages
40issn
1757-2215pii
10.1186/s13048-015-0169-8journal_volume
8pub_type
杂志文章abstract：:Previously anecdotally observed rebounds in follicle growth after interruption of exogenous gonadotropins in absolute non-responders were the impetus for here reported study. In a prospective cohort study, we investigated 49 consecutive patients, absolutely unresponsive to maximal exogenous gonadotropin stimulation, f...
journal_title：Journal of ovarian research
pub_type： 杂志文章
doi：10.1186/s13048-021-00765-5
更新日期：2021-01-09 00:00:00
abstract：BACKGROUND:It is estimated that more than 20% of ovarian cancer cases are associated with a genetic predisposition that is only partially explained by germline mutations in the BRCA1 and BRCA2 genes. Recently, several pieces of evidence showed that mutations in three genes involved in the homologous recombination DNA r...
journal_title：Journal of ovarian research
pub_type： 杂志文章,meta分析
doi：10.1186/s13048-020-00654-3
更新日期：2020-05-02 00:00:00
abstract：BACKGROUND:Despite advances in surgical aggressiveness and conventional chemotherapy, ovarian cancer remains the most lethal cause of gynecologic cancer mortality; consequently there is a need for new therapeutic agents and innovative treatment paradigms for the treatment of ovarian cancer. Several studies have demonst...
journal_title：Journal of ovarian research
pub_type： 杂志文章
doi：10.1186/s13048-016-0282-3
更新日期：2016-10-27 00:00:00
abstract：BACKGROUND:Ovarian cancer is the leading cause of gynecological cancer-related mortality. The novel oncogene S100A10 has been reported to be involved in cancer cell proliferation, invasion and metastasis. The role of S100A10 in ovarian cancer has not been well studied and the effect of S100A10 on chemotherapy remains u...
journal_title：Journal of ovarian research
pub_type： 杂志文章
doi：10.1186/s13048-019-0592-3
更新日期：2019-11-18 00:00:00
abstract：:We have earlier reported the presence of very small embryonic-like stem cells (VSELs) in adult mouse uterus along with slightly bigger progenitors termed endometrial stem cells (EnSCs) and their regulation by ovarian hormones thus demonstrating a crucial role played by them during proliferation, differentiation and re...
journal_title：Journal of ovarian research
pub_type： 杂志文章
doi：10.1186/s13048-017-0324-5
更新日期：2017-04-24 00:00:00
abstract：OBJECTIVES:Endometrioid carcinoma of the ovary is one of the most types of epithelial ovarian cancer associated to endometrioisis. Endometrioid tumors as well as endometriotic implants are characterized by the presence of epithelial cells, stromal cells, or a combination of booth, that resemble the endometrial cells, s...
journal_title：Journal of ovarian research
pub_type： 杂志文章
doi：10.1186/1757-2215-3-3
更新日期：2010-01-28 00:00:00
abstract：BACKGROUND:This study was aimed to explore the role of long noncoding RNA C17orf91 and its potential mechanisms in ovarian cancer development. RESULTS:To assess its role in ovarian cancer, microarray datasets (GSE14407, GSE30587, and GSE17260) in Gene Expression Omnibus (GEO) were utilized to assess the expression and...
journal_title：Journal of ovarian research
pub_type： 杂志文章
doi：10.1186/s13048-016-0258-3
更新日期：2016-08-17 00:00:00
abstract：BACKGROUND:Highly Individualized Egg Retrieval (HIER), defined as age-specific early oocyte retrieval (ER), has been demonstrated to avoid premature luteinization in women ≥43. We here investigated whether HIER also applies to younger women with premature ovarian aging (POA), and what best lead follicle size should be ...
journal_title：Journal of ovarian research
pub_type： 杂志文章
doi：10.1186/s13048-018-0398-8
更新日期：2018-03-16 00:00:00
abstract：OBJECTIVE:Recently, 14-3-3 zeta protein was identified as a potential serum biomarker of epithelial ovarian cancer (EOC). The goal of this study was to investigate the clinical potential of 14-3-3 zeta protein for monitoring EOC progression compared with CA-125 and HE4. DESIGN:Prospective follow-up study. SETTING:Uni...
journal_title：Journal of ovarian research
pub_type： 杂志文章
doi：10.1186/1757-2215-6-79
更新日期：2013-11-15 00:00:00
abstract：:Ovarian cystic tumors with a mural nodule are a rare entity. We report a case of a mural nodule of anaplastic spindle cell carcinoma in an ovarian mucinous cystic tumor of borderline malignancy. The patient was a 45-years-old Japanese woman who presented with an ovarian cyst. She suffered from mature cystic teratoma o...
journal_title：Journal of ovarian research
pub_type： 杂志文章
doi：10.1186/1757-2215-6-86
更新日期：2013-12-05 00:00:00
abstract：BACKGROUND:Hyaluronic acid is a prognostic factor in ovarian cancers. It is also a component of Hyaluronic Acid-Carboxymethyl Cellulose (HA-CMC) barrier, an anti-adhesion membrane widely used during abdominal surgeries in particular for ovarian carcinosis. 70% of patients who undergo ovarian surgery will relapse due to...
journal_title：Journal of ovarian research
pub_type： 杂志文章
doi：10.1186/1757-2215-7-40
更新日期：2014-04-16 00:00:00
abstract：BACKGROUND:Ovarian hyperstimulation syndrome remains a serious complication during in vitro fertilization cycles if high dose human chorionic gonadotropin (hCG) is used to trigger ovulation in high responder patients. Though much of this risk is mitigated with trigger using gonadotropin releasing-hormone (GnRH) agonist...
journal_title：Journal of ovarian research
pub_type： 杂志文章,随机对照试验
doi：10.1186/s13048-019-0483-7
更新日期：2019-01-26 00:00:00
abstract：UNLABELLED: BACKGROUND:Women with polycystic ovary syndrome (PCOS) have higher risk for cardiovascular disease (CVD). Heart type fatty acid binding protein (HFABP) has been found to be predictive for myocardial ischemia.Wet ested whether HFABP is the predictor for CVD in PCOS patients, who have an increased risk of ca...
journal_title：Journal of ovarian research
pub_type： 杂志文章
doi：10.1186/1757-2215-5-45
更新日期：2012-12-18 00:00:00
abstract：BACKGROUND:Although agonistic autoantibodies against type-1 angiotensin-II receptor (AT1-AA) are frequently detected in women with preeclampsia, the clinical significance of AT1-AA in association with epithelial ovarian cancer (EOC) has not been identified. METHODS:In an attempt to clarify this issue, we measured seru...
journal_title：Journal of ovarian research
pub_type： 杂志文章
doi：10.1186/1757-2215-6-22
更新日期：2013-04-05 00:00:00
abstract：:RNA methylation can reverse the methylation modification at the RNA level, which is an extremely important epigenetic modification. The function and mechanism of YTHDF2, as a reader of m6A modification, in epithelial ovarian cancer (EOC) have not been elucidated so far. This study aimed to investigate how YTHDF2 and m...
journal_title：Journal of ovarian research
pub_type： 杂志文章
doi：10.1186/s13048-020-00717-5
更新日期：2020-09-18 00:00:00
abstract：BACKGROUND:Ovarian cancer is the second most common gynecologic malignancy. As the primary imaging modality, computed tomography (CT) can provide staging information for preoperative planning and determination of surgical resectability. As a new three-dimensional postprocessing tool for CT images, cinematic rendering (...
journal_title：Journal of ovarian research
pub_type： 杂志文章
doi：10.1186/s13048-018-0461-5
更新日期：2018-09-26 00:00:00
abstract：BACKGROUND:Pelvic irradiation is essential for improving survival in women with pelvic malignancies despite inducing permanent ovarian damage. Ovarian transposition can be performed in premenopausal women in an attempt to preserve ovarian function. As uncertainty occurs over the proportion of women who are likely to be...
journal_title：Journal of ovarian research
pub_type： 杂志文章,meta分析,评审
doi：10.1186/1757-2215-7-69
更新日期：2014-06-25 00:00:00
abstract：BACKGROUND:To demonstrate the use of surface-enhanced Raman spectroscopy (SERS) to determine sialic acid (SA) levels in saliva using silver nanoparticles as substrates, in adnexal mass patients scheduled for surgical intervention to remove invasive masses, with the aim to compare SA levels in benign tumor vs ovarian ca...
journal_title：Journal of ovarian research
pub_type： 杂志文章
doi：10.1186/s13048-018-0433-9
更新日期：2018-07-24 00:00:00
abstract：BACKGROUND:The majority of death-related ovarian cancer is epithelial ovarian cancer (EOC). Regarding the Federation of Gynecology and Obstetrics (FIGO) stage IV EOC, the 5-year overall survival (OS) has not changed in last decades. Platelet (PLT) count and CA125 level are both prognostic markers that related to inflam...
journal_title：Journal of ovarian research
pub_type： 杂志文章
doi：10.1186/s13048-019-0544-y
更新日期：2019-07-31 00:00:00
abstract：BACKGROUND:The use of long protocol during controlled ovarian stimulation for assisted reproduction attracts high dosage of gonadotropins. High dose of gonadotropins can be detrimental to oocyte development, which affects its quality and compromises the treatment outcome. Mild stimulation protocols that attract low dos...
journal_title：Journal of ovarian research
pub_type： 杂志文章
doi：10.1186/s13048-018-0408-x
更新日期：2018-05-04 00:00:00
abstract：PURPOSE:The conversion of androgens into estrogens by aromatase is called aromatization and is inhibited by aromatase inhibitors (AIs). The aim of this article is to evaluate the use of aromatase inhibitors in gynecological diseases such as endometriosis, leiomyoma, estrogen- dependent gynecologic neoplasia and inferti...
journal_title：Journal of ovarian research
pub_type： 杂志文章,评审
doi：10.1186/s13048-015-0131-9
更新日期：2015-02-25 00:00:00
abstract：:As the human ovarian follicle enlarges in the course of a regular cycle or following controlled ovarian stimulation, the changes in its structure reveal the oocyte environment composed of cumulus oophorus cells and the follicular fluid (FF).In contrast to the dynamic nature of cells, the fluid compartment appears as a...
journal_title：Journal of ovarian research
pub_type： 杂志文章,评审
doi：10.1186/s13048-017-0342-3
更新日期：2017-07-12 00:00:00
abstract：BACKGROUND:The down-regulation of E-cadherin gene (CDH1) expression has been regarded as an important event in cancer invasion and metastasis. However, the association between CDH1 promoter methylation and ovarian cancer remains unclear. A meta-analysis was conducted to evaluate the potential role of CDH1 promoter meth...
journal_title：Journal of ovarian research
pub_type： 杂志文章,meta分析
doi：10.1186/s13048-016-0231-1
更新日期：2016-04-11 00:00:00
abstract：:Mixed germ cell tumours of the ovary are malignant neoplasms of the ovary comprising of two or more types of germ cell components. Most of the malignant mixed germ cell tumours consists of dysgerminoma accompanied by endodermal sinus tumours, immature teratoma or choriocarcinoma. There are only few case reports of mix...
journal_title：Journal of ovarian research
pub_type： 杂志文章,评审
doi：10.1186/s13048-014-0091-5
更新日期：2014-11-04 00:00:00
abstract：:Growing evidence indicates that the tumor biomarker cytokeratin 19 fragment (CYFRA21-1) is significant for a variety of cancers. However, its role in epithelial ovarian cancer (EOC) has rarely been reported. In this study, a receiver operating characteristic (ROC) curve was utilized to estimate the diagnostic efficien...
journal_title：Journal of ovarian research
pub_type： 杂志文章
doi：10.1186/s13048-019-0587-0
更新日期：2019-11-25 00:00:00
abstract：:Following publication of the original article [1], the authors opted to correct the incorrect e-mail address of the corresponding author from 82-55-360-1850chungsu1982@gmail.com to chungsu1982@gmail.com , grant in the Acknowledgements section and Author details. Below are the updated version of the Acknowledgements an...
journal_title：Journal of ovarian research
pub_type： 已发布勘误
doi：10.1186/s13048-019-0540-2
更新日期：2019-07-23 00:00:00
abstract：BACKGROUND:Upregulation of Cyclin dependent kinase 1 (CDK1) protein is closely related with the prognosis of several malignant tumors. Chk1-CDC25C-CDK1 signaling and P53-P21WAF1-CDK1 signaling pathways are closely related with the cell cycle G2/M phase regulation. The present study aimed to analyze the relationship bet...
journal_title：Journal of ovarian research
pub_type： 杂志文章
doi：10.1186/s13048-017-0356-x
更新日期：2017-09-12 00:00:00
abstract：BACKGROUND:This study aimed to examine the performance of the four risk of malignancy index (RMI) in discriminating borderline ovarian tumors (BOTs) and benign ovarian masses in daily clinical practice. METHODS:A total of 162 women with BOTs and 379 women with benign ovarian tumors diagnosed at the Second Affiliated H...
journal_title：Journal of ovarian research
pub_type： 杂志文章
doi：10.1186/s13048-019-0568-3
更新日期：2019-09-16 00:00:00
abstract：BACKGROUND:galectin-1 has been implicated in tumor invasion and metastasis and is frequently over-expressed in epithelial ovarian cancer (EOC), but its potential as a biomarker remains unclear. In this novel study, we have explored the possible use of galectin-1 as a biomarker for EOC. METHODS:galectin-1 in sera was e...
journal_title：Journal of ovarian research
pub_type： 杂志文章
doi：10.1186/s13048-015-0206-7
更新日期：2015-11-21 00:00:00
abstract：BACKGROUND:Cell lines are very useful for both clinical and basic research. The establishment of ovarian, malignant tumor cell lines with aggressive histology is especially important. We describe the establishment and characterization of a new human clear cell carcinoma cell line of the ovary. RESULTS:The cell line HC...
journal_title：Journal of ovarian research
pub_type： 杂志文章
doi：10.1186/s13048-016-0242-y
更新日期：2016-06-04 00:00:00
