Abstract:
BACKGROUND:Pelvic irradiation is essential for improving survival in women with pelvic malignancies despite inducing permanent ovarian damage. Ovarian transposition can be performed in premenopausal women in an attempt to preserve ovarian function. As uncertainty occurs over the proportion of women who are likely to benefit from the procedure, we performed a systematic review and meta-analysis of the proportion of women with ovarian function preservation, symptomatic or asymptomatic ovarian cysts and metastatic ovarian malignancy following ovarian transposition. METHODS:Medline, Embase and The Cochrane Library databases were systematically searched for articles published from January 1980 to December 2013. We computed the summary proportions for ovarian function preservation, ovarian cyst formation and metastatic ovarian disease following ovarian transposition by random effects meta-analysis with meta-regression to explore for heterogeneity by type of radiotherapy. RESULTS:Twenty four articles reporting on 892 women undergoing ovarian transposition were included. In the surgery alone group, the proportion of women with preserved ovarian function was 90% (95% CI 92-99), 87% (95% CI 79-97) of women did not develop ovarian cysts and 100% (95% CI 90-111) did not suffer metastases to the transposed ovaries. In the brachytherapy (BR)± surgery group, the proportion of women with preserved ovarian function was 94% (95% CI 79-111), 84% (95% CI 70-101) of women did not develop ovarian cysts and 100% (95% CI 85-118) did not suffer metastases to the transposed ovaries. In the external beam radiotherapy (EBRT) +surgery ± BR group, the proportion of women with preserved ovarian function was 65% (95% CI 56-74), 95% (95% CI 85-106) of women did not develop ovarian cysts and 100% (95% CI 90-112) did not suffer metastases to the transposed ovaries. Subgroup meta-analysis revealed transposition to the subcutaneous tissue being associated with higher ovarian cyst formation rate compared to the "traditional" transposition. CONCLUSION:Ovarian transposition is associated with significant preservation of ovarian function and negligible risk for metastases to the transposed ovaries despite common incidence of ovarian cysts.
journal_name
J Ovarian Resjournal_title
Journal of ovarian researchauthors
Gubbala K,Laios A,Gallos I,Pathiraja P,Haldar K,Ind Tdoi
10.1186/1757-2215-7-69subject
Has Abstractpub_date
2014-06-25 00:00:00pages
69issn
1757-2215pii
1757-2215-7-69journal_volume
7pub_type
杂志文章,meta分析,评审abstract:BACKGROUND:Upregulation of Cyclin dependent kinase 1 (CDK1) protein is closely related with the prognosis of several malignant tumors. Chk1-CDC25C-CDK1 signaling and P53-P21WAF1-CDK1 signaling pathways are closely related with the cell cycle G2/M phase regulation. The present study aimed to analyze the relationship bet...
journal_title:Journal of ovarian research
pub_type: 杂志文章
doi:10.1186/s13048-017-0356-x
更新日期:2017-09-12 00:00:00
abstract::Both estrogens and androgens are involved in the development and normal functioning of the ovaries. It is also known that ovarian function is regulated by diet. The goal of this study was to estimate the expression of sex hormone receptors in ovaries of mice that were on a 9-month caloric restriction (alternate-day fe...
journal_title:Journal of ovarian research
pub_type: 杂志文章
doi:10.1186/s13048-015-0185-8
更新日期:2015-08-13 00:00:00
abstract:BACKGROUND:This study evaluated the influence of menstrual cycle length, menstrual cycle variability and predicted luteal phase length on the success of vitrified-warmed blastocyst transfer in natural menstrual cycle using progesterone for luteal phase supplementation. METHODS:Consecutive women undergoing vitrified-wa...
journal_title:Journal of ovarian research
pub_type: 杂志文章
doi:10.1186/s13048-018-0436-6
更新日期:2018-08-02 00:00:00
abstract:BACKGROUND:Cell lines are very useful for both clinical and basic research. The establishment of ovarian, malignant tumor cell lines with aggressive histology is especially important. We describe the establishment and characterization of a new human clear cell carcinoma cell line of the ovary. RESULTS:The cell line HC...
journal_title:Journal of ovarian research
pub_type: 杂志文章
doi:10.1186/s13048-016-0242-y
更新日期:2016-06-04 00:00:00
abstract::The original article [1] contains errors in Fig. 3C, Results and Discussion. ...
journal_title:Journal of ovarian research
pub_type: 杂志文章,已发布勘误
doi:10.1186/s13048-020-00628-5
更新日期:2020-03-13 00:00:00
abstract:BACKGROUND:Polycystic Ovary Syndrome (PCOS) is a widespread reproductive disorder characterized by a disruption of follicular growth and anovulatory infertility. In women with PCOS, follicular growth and ovulation can be induced by subcutaneous injections of low doses of follicle stimulating hormone (FSH). The aim of t...
journal_title:Journal of ovarian research
pub_type: 杂志文章
doi:10.1186/s13048-015-0192-9
更新日期:2015-10-06 00:00:00
abstract::Ovarian hyperstimulation syndrome (OHSS) is a serious complication of controlled ovarian hyperstimulation (COH). The syndrome almost always presents either after hCG administration in susceptible patients or during early pregnancy. Despite many years of clinical experience, there are no precise methods to completely p...
journal_title:Journal of ovarian research
pub_type: 杂志文章
doi:10.1186/1757-2215-6-77
更新日期:2013-11-05 00:00:00
abstract::Following publication of the original article [1], the authors opted to correct the incorrect e-mail address of the corresponding author from 82-55-360-1850chungsu1982@gmail.com to chungsu1982@gmail.com , grant in the Acknowledgements section and Author details. Below are the updated version of the Acknowledgements an...
journal_title:Journal of ovarian research
pub_type: 已发布勘误
doi:10.1186/s13048-019-0540-2
更新日期:2019-07-23 00:00:00
abstract:UNLABELLED: BACKGROUND:To investigate the 3.0-Tesla (3 T) magnetic resonance imaging (MRI) characteristics of primary adnexal lesions for discriminating benign from malignant lesions. METHODS:One hundred thirty-nine patients with pathologically proven primary adnexal masses referred for 3 T MRI assessment preoperativ...
journal_title:Journal of ovarian research
pub_type: 杂志文章
doi:10.1186/1757-2215-5-33
更新日期:2012-11-14 00:00:00
abstract:BACKGROUND:In this study we aimed to identify a prognostic signature in BRCA1/2 mutations to predict disease progression and the efficiency of chemotherapy ovarian cancer (OV), the second most common cause of death from gynecologic cancer in women worldwide. METHODS:Univariate Cox proportional-hazards and multivariate...
journal_title:Journal of ovarian research
pub_type: 杂志文章
doi:10.1186/s13048-020-00712-w
更新日期:2020-09-19 00:00:00
abstract:BACKGROUND:Altered androgen hormone homeostasis and androgen receptor (AR) activity have been implicated in ovarian carcinogenesis but the relationship between AR expression in ovarian cancer and clinical outcome remains unclear. METHODS:In this study, the prognostic impact of AR expression was investigated using immu...
journal_title:Journal of ovarian research
pub_type: 杂志文章
doi:10.1186/1757-2215-3-14
更新日期:2010-06-17 00:00:00
abstract::RNA methylation can reverse the methylation modification at the RNA level, which is an extremely important epigenetic modification. The function and mechanism of YTHDF2, as a reader of m6A modification, in epithelial ovarian cancer (EOC) have not been elucidated so far. This study aimed to investigate how YTHDF2 and m...
journal_title:Journal of ovarian research
pub_type: 杂志文章
doi:10.1186/s13048-020-00717-5
更新日期:2020-09-18 00:00:00
abstract::Mixed germ cell tumours of the ovary are malignant neoplasms of the ovary comprising of two or more types of germ cell components. Most of the malignant mixed germ cell tumours consists of dysgerminoma accompanied by endodermal sinus tumours, immature teratoma or choriocarcinoma. There are only few case reports of mix...
journal_title:Journal of ovarian research
pub_type: 杂志文章,评审
doi:10.1186/s13048-014-0091-5
更新日期:2014-11-04 00:00:00
abstract:BACKGROUND:Wnt-inducible signaling pathway protein 2 (WISP2) is a wnt1-induced signaling pathway protein 2. Although studies indicate that WISP2 may promote the development of various tumors, its role in ovarian cancer remains unclear. The objective of the current study was to analyze the effects of WISP2 on the prolif...
journal_title:Journal of ovarian research
pub_type: 杂志文章
doi:10.1186/s13048-020-00687-8
更新日期:2020-07-25 00:00:00
abstract:BACKGROUND:Hyaluronic acid is a prognostic factor in ovarian cancers. It is also a component of Hyaluronic Acid-Carboxymethyl Cellulose (HA-CMC) barrier, an anti-adhesion membrane widely used during abdominal surgeries in particular for ovarian carcinosis. 70% of patients who undergo ovarian surgery will relapse due to...
journal_title:Journal of ovarian research
pub_type: 杂志文章
doi:10.1186/1757-2215-7-40
更新日期:2014-04-16 00:00:00
abstract:BACKGROUND:Ovarian cancer (OC) was the primary malignant gynecological cancer and SNARE protein is closely related with tumor progression. Here, we identified SNAP23, a member of SNARE complex, as a potential oncogene in OC. METHODS:We determined the expression of SNAP23 in OC tissues and explored the clinical signifi...
journal_title:Journal of ovarian research
pub_type: 杂志文章
doi:10.1186/s13048-016-0289-9
更新日期:2016-11-17 00:00:00
abstract:BACKGROUND:The polycystic ovary syndrome (PCOS) is a complex and heterogeneous endocrine condition characterized by hyperandrogenism, hyperinsulinemia, insulin resistance and chronic anovulation. Regulation and interaction of a multitude of genes required for follicular development are found to be altered in PCOS. Micr...
journal_title:Journal of ovarian research
pub_type: 杂志文章
doi:10.1186/1757-2215-6-36
更新日期:2013-05-15 00:00:00
abstract:BACKGROUND:It is estimated that more than 20% of ovarian cancer cases are associated with a genetic predisposition that is only partially explained by germline mutations in the BRCA1 and BRCA2 genes. Recently, several pieces of evidence showed that mutations in three genes involved in the homologous recombination DNA r...
journal_title:Journal of ovarian research
pub_type: 杂志文章,meta分析
doi:10.1186/s13048-020-00654-3
更新日期:2020-05-02 00:00:00
abstract:BACKGROUND:Mucinous carcinomas from different organs are morphologically similar and might share similarities at the molecular and biochemical levels that may illuminate their pathogenesis and influence management. The factors involved in the pathogenesis of mucinous carcinomas remain unknown; which is likely one contr...
journal_title:Journal of ovarian research
pub_type: 杂志文章
doi:10.1186/s13048-015-0169-8
更新日期:2015-06-17 00:00:00
abstract:BACKGROUND:Degeneration of ovarian function is an obvious feature of female aging. In addition, studies have shown that autophagy decreases with age, and DNA methylation is a hallmark epigenetic pattern during aging. However, it is not clear whether the expression and DNA methylation of autophagy genes are involved in ...
journal_title:Journal of ovarian research
pub_type: 杂志文章
doi:10.1186/s13048-020-0615-0
更新日期:2020-02-03 00:00:00
abstract::An amendment to this paper has been published and can be accessed via the original article. ...
journal_title:Journal of ovarian research
pub_type: 已发布勘误
doi:10.1186/s13048-020-00733-5
更新日期:2020-11-12 00:00:00
abstract:OBJECTIVE:To explore the risk factors for the recurrence of endometrioma and the risk factors for the recurrence of endometriosis-related pain after long-term follow-up. METHODS:This study retrospectively analyzed 358 women with endometriomas who had a minimum of 5-years follow up after laparoscopic endometrioma excis...
journal_title:Journal of ovarian research
pub_type: 杂志文章
doi:10.1186/s13048-019-0552-y
更新日期:2019-08-30 00:00:00
abstract:BACKGROUND:Whether there is a mechanistic link between FOLR1 and response to cisplatin has not been extensively examined. In this study, we determine the expression of FOLR1 in ovarian cancer and examine if FOLR1 levels influence response to cisplatin. RESULTS:(1) FOLR1 protein expression was lowest in normal ovarian ...
journal_title:Journal of ovarian research
pub_type: 杂志文章
doi:10.1186/s13048-018-0387-y
更新日期:2018-02-13 00:00:00
abstract:BACKGROUND:Myo-inositol (MI), successfully used in polycystic ovary syndrome (PCOS), was administered with α-LA to exploit its action of favouring the passage of other molecules through biological barriers, and also considering its anti-inflammatory effect. METHODS:PCOS patients, according to the Rotterdam ESHRE-ASRM ...
journal_title:Journal of ovarian research
pub_type: 临床试验,杂志文章
doi:10.1186/s13048-018-0411-2
更新日期:2018-05-10 00:00:00
abstract:BACKGROUND:Epithelial ovarian cancer (EOC) is still a major gynecologic problem with poor 5 year survival rate due to distance metastases, despite routine surgery and chemotherapy. The precise underlying molecular mechanisms that trigger EOC migration and invasion are unclear. Recent studies suggest that the expression...
journal_title:Journal of ovarian research
pub_type: 杂志文章
doi:10.1186/1757-2215-6-84
更新日期:2013-11-26 00:00:00
abstract:BACKGROUND:Gonadoblastoma (GB) is a rare mixed germ cell-sex cord-stromal tumour, first described in humans, commonly found in dysgenetic gonads of intersex patients that have a Y chromosome. However, this entity in not recognized in the WHO classification of tumours of genital system of domestic animals. Herein, we de...
journal_title:Journal of ovarian research
pub_type: 杂志文章
doi:10.1186/s13048-019-0561-x
更新日期:2019-09-23 00:00:00
abstract:BACKGROUND:We aimed to examine the expression of miR-1307 in chemosensitive and chemoresistant epithelial ovarian cancer tissues and cell lines and to analyze the clinicopathological significance of miR-1307 in ovarian cancer. METHODS:MicroRNA microarray was used to screen differentially expressed microRNAs between th...
journal_title:Journal of ovarian research
pub_type: 杂志文章
doi:10.1186/s13048-015-0143-5
更新日期:2015-04-09 00:00:00
abstract:OBJECTIVES:Endometrioid carcinoma of the ovary is one of the most types of epithelial ovarian cancer associated to endometrioisis. Endometrioid tumors as well as endometriotic implants are characterized by the presence of epithelial cells, stromal cells, or a combination of booth, that resemble the endometrial cells, s...
journal_title:Journal of ovarian research
pub_type: 杂志文章
doi:10.1186/1757-2215-3-3
更新日期:2010-01-28 00:00:00
abstract:BACKGROUND:Survivin is an inhibitor of apoptosis and a regulator of mitotic progression. TP53 protein is a negative transcriptional regulator of survivin. The aim of our study was to evaluate the clinical significance of survivin expression in advanced stages ovarian cancer with respect to the TP53 status. METHODS:Sur...
journal_title:Journal of ovarian research
pub_type: 杂志文章
doi:10.1186/1757-2215-4-20
更新日期:2011-11-10 00:00:00
abstract:BACKGROUND:Ovarian cancer is the leading cause of gynecological cancer-related mortality. The novel oncogene S100A10 has been reported to be involved in cancer cell proliferation, invasion and metastasis. The role of S100A10 in ovarian cancer has not been well studied and the effect of S100A10 on chemotherapy remains u...
journal_title:Journal of ovarian research
pub_type: 杂志文章
doi:10.1186/s13048-019-0592-3
更新日期:2019-11-18 00:00:00