Abstract：
UNLABELLED: BACKGROUND:To investigate the 3.0-Tesla (3 T) magnetic resonance imaging (MRI) characteristics of primary adnexal lesions for discriminating benign from malignant lesions. METHODS:One hundred thirty-nine patients with pathologically proven primary adnexal masses referred for 3 T MRI assessment preoperatively were included. Baseline characteristics, components, and conventional MRI and diffusion-weighted imaging (DWI-MRI) signals were recorded and compared. RESULTS:There were 22 ovarian cysts, 33 endometriomas, 43 benign tumors and 42 malignant tumors. When ovarian cyst and endometrioma were excluded, there were no significant differences in patients' age between benign and malignant tumor (P = 0.235). There were no significant differences (P = 0.606) in the conventional MRI signals and significant difference (P = 0.008) in DWI-MRI signal between the non-malignant and malignant lesions. There was a significant difference (P = 0.000) in the apparent diffusion coefficient values (ADCs) between the non-malignant and malignant lesions. CONCLUSIONS:3 T MRI categorized the characteristics of primary adnexal lesions. Conventional MRI signals were not useful for characterizing between benign and malignant lesions. DWI-MRI and ADCs were helpful for distinguishing malignant from benign ovarian lesions.
journal_name
J Ovarian Resjournal_title
Journal of ovarian researchauthors
Zhang H,Zhang GF,He ZY,Li ZY,Zhu M,Zhang GXdoi
10.1186/1757-2215-5-33subject
Has Abstractpub_date
2012-11-14 00:00:00pages
33issue
1issn
1757-2215pii
1757-2215-5-33journal_volume
5pub_type
杂志文章abstract：BACKGROUND:The polycystic ovary syndrome (PCOS) affects approximately 6-10% of women of reproductive age and is characterized by chronic anovulation and hyperandrogenism. However, a comprehensive understanding of the mechanisms that dictate androgen overproduction is lacking, which may account for inconsistencies betwe...
journal_title：Journal of ovarian research
pub_type： 杂志文章
doi：10.1186/1757-2215-5-15
更新日期：2012-05-18 00:00:00
abstract：BACKGROUND:It is estimated that more than 20% of ovarian cancer cases are associated with a genetic predisposition that is only partially explained by germline mutations in the BRCA1 and BRCA2 genes. Recently, several pieces of evidence showed that mutations in three genes involved in the homologous recombination DNA r...
journal_title：Journal of ovarian research
pub_type： 杂志文章,meta分析
doi：10.1186/s13048-020-00654-3
更新日期：2020-05-02 00:00:00
abstract：BACKGROUND:The mechanisms regulating the function and regression of the corpus luteum (CL) have not yet been elucidated in detail. The regressed CL of cows was previously reported to be filled with unusual vessels like arteriovenous anastomosis (AVA); however how these vessels are being established during luteolysis re...
journal_title：Journal of ovarian research
pub_type： 杂志文章
doi：10.1186/s13048-016-0277-0
更新日期：2016-10-19 00:00:00
abstract：BACKGROUND:The imbalance of expression of microRNA-802 may have a significant place in tumor progression. However, the bio-function of epithelial ovarian cancer cells remains unclear. Therefore, we setup this study to explore the pathogenesis of epithelial ovarian cancer based on microRNA-802. METHODS:RT-qPCR analysis...
journal_title：Journal of ovarian research
pub_type： 杂志文章
doi：10.1186/s13048-019-0576-3
更新日期：2019-10-22 00:00:00
abstract：BACKGROUND:Hyaluronic acid is a prognostic factor in ovarian cancers. It is also a component of Hyaluronic Acid-Carboxymethyl Cellulose (HA-CMC) barrier, an anti-adhesion membrane widely used during abdominal surgeries in particular for ovarian carcinosis. 70% of patients who undergo ovarian surgery will relapse due to...
journal_title：Journal of ovarian research
pub_type： 杂志文章
doi：10.1186/1757-2215-7-40
更新日期：2014-04-16 00:00:00
abstract：BACKGROUND:Our recent study on a panel of human ovarian cancer cells revealed that SKOV-3 cells barely express the Sprouty isoform 1 (Spry1) while 1A9 cells maintain it at a level similar to normal ovarian cells. Here we investigated the functional outcomes of induced alterations in the expression of Spry1 in the two c...
journal_title：Journal of ovarian research
pub_type： 杂志文章
doi：10.1186/1757-2215-7-61
更新日期：2014-06-08 00:00:00
abstract：OBJECTIVE:Recently, 14-3-3 zeta protein was identified as a potential serum biomarker of epithelial ovarian cancer (EOC). The goal of this study was to investigate the clinical potential of 14-3-3 zeta protein for monitoring EOC progression compared with CA-125 and HE4. DESIGN:Prospective follow-up study. SETTING:Uni...
journal_title：Journal of ovarian research
pub_type： 杂志文章
doi：10.1186/1757-2215-6-79
更新日期：2013-11-15 00:00:00
abstract：BACKGROUND:Highly Individualized Egg Retrieval (HIER), defined as age-specific early oocyte retrieval (ER), has been demonstrated to avoid premature luteinization in women ≥43. We here investigated whether HIER also applies to younger women with premature ovarian aging (POA), and what best lead follicle size should be ...
journal_title：Journal of ovarian research
pub_type： 杂志文章
doi：10.1186/s13048-018-0398-8
更新日期：2018-03-16 00:00:00
abstract：BACKGROUND:Myo-inositol (MI), successfully used in polycystic ovary syndrome (PCOS), was administered with α-LA to exploit its action of favouring the passage of other molecules through biological barriers, and also considering its anti-inflammatory effect. METHODS:PCOS patients, according to the Rotterdam ESHRE-ASRM ...
journal_title：Journal of ovarian research
pub_type： 临床试验,杂志文章
doi：10.1186/s13048-018-0411-2
更新日期：2018-05-10 00:00:00
abstract：BACKGROUND:The value of this report is the identification of late recurrence with an extremely unusual combination of malignant transformation. In particular, the retroconversion of immature to mature teratoma as well as a somatic-type malignant transformation were both observed postchemotherapeutically in our case. C...
journal_title：Journal of ovarian research
pub_type： 杂志文章
doi：10.1186/s13048-018-0476-y
更新日期：2019-01-10 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via the original article. ...
journal_title：Journal of ovarian research
pub_type： 已发布勘误
doi：10.1186/s13048-020-00733-5
更新日期：2020-11-12 00:00:00
abstract：BACKGROUND:Survivin is an inhibitor of apoptosis and a regulator of mitotic progression. TP53 protein is a negative transcriptional regulator of survivin. The aim of our study was to evaluate the clinical significance of survivin expression in advanced stages ovarian cancer with respect to the TP53 status. METHODS:Sur...
journal_title：Journal of ovarian research
pub_type： 杂志文章
doi：10.1186/1757-2215-4-20
更新日期：2011-11-10 00:00:00
abstract：BACKGROUND:The majority of death-related ovarian cancer is epithelial ovarian cancer (EOC). Regarding the Federation of Gynecology and Obstetrics (FIGO) stage IV EOC, the 5-year overall survival (OS) has not changed in last decades. Platelet (PLT) count and CA125 level are both prognostic markers that related to inflam...
journal_title：Journal of ovarian research
pub_type： 杂志文章
doi：10.1186/s13048-019-0544-y
更新日期：2019-07-31 00:00:00
abstract：BACKGROUND:Ovarian cancer is the second most common gynecologic malignancy. As the primary imaging modality, computed tomography (CT) can provide staging information for preoperative planning and determination of surgical resectability. As a new three-dimensional postprocessing tool for CT images, cinematic rendering (...
journal_title：Journal of ovarian research
pub_type： 杂志文章
doi：10.1186/s13048-018-0461-5
更新日期：2018-09-26 00:00:00
abstract：BACKGROUND:This study was designed to investigate leptin levels in the fluid in ovarian endometriomas (OEs) and to compare the expression of leptin and its receptors (OBR) in ovarian tissue affected by endometrioma in infertile women to its expression in the normal ovarian tissue of fertile controls without endometrios...
journal_title：Journal of ovarian research
pub_type： 杂志文章
doi：10.1186/1757-2215-7-2
更新日期：2014-01-08 00:00:00
abstract：:As the human ovarian follicle enlarges in the course of a regular cycle or following controlled ovarian stimulation, the changes in its structure reveal the oocyte environment composed of cumulus oophorus cells and the follicular fluid (FF).In contrast to the dynamic nature of cells, the fluid compartment appears as a...
journal_title：Journal of ovarian research
pub_type： 杂志文章,评审
doi：10.1186/s13048-017-0342-3
更新日期：2017-07-12 00:00:00
abstract：BACKGROUND:To investigate dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) for assessing histopathological and molecular biological features in induced rat epithelial ovarian carcinomas (EOCs). METHODS:7,12-dimethylbenz[A]anthracene (DMBA) was applied to induce EOCs in situ in 46 SD rats. Conventional MR...
journal_title：Journal of ovarian research
pub_type： 杂志文章
doi：10.1186/s13048-017-0362-z
更新日期：2017-09-26 00:00:00
abstract：BACKGROUND:The mechanism of aggressive character of ovarian cancer and unsuccessful treatment of women with this deadly disease has been recently explained by the theory of cancer stem cells (CSCs). It has been reported that ovarian carcinogenesis and progression of disease is associated with epithelial-mesenchymal tra...
journal_title：Journal of ovarian research
pub_type： 杂志文章
doi：10.1186/s13048-017-0306-7
更新日期：2017-02-23 00:00:00
abstract：BACKGROUND:Epithelial ovarian cancer (EOC) is still a major gynecologic problem with poor 5 year survival rate due to distance metastases, despite routine surgery and chemotherapy. The precise underlying molecular mechanisms that trigger EOC migration and invasion are unclear. Recent studies suggest that the expression...
journal_title：Journal of ovarian research
pub_type： 杂志文章
doi：10.1186/1757-2215-6-84
更新日期：2013-11-26 00:00:00
abstract：:Ovarian hyperstimulation syndrome (OHSS) is a serious complication of controlled ovarian hyperstimulation (COH). The syndrome almost always presents either after hCG administration in susceptible patients or during early pregnancy. Despite many years of clinical experience, there are no precise methods to completely p...
journal_title：Journal of ovarian research
pub_type： 杂志文章
doi：10.1186/1757-2215-6-77
更新日期：2013-11-05 00:00:00
abstract：:Both estrogens and androgens are involved in the development and normal functioning of the ovaries. It is also known that ovarian function is regulated by diet. The goal of this study was to estimate the expression of sex hormone receptors in ovaries of mice that were on a 9-month caloric restriction (alternate-day fe...
journal_title：Journal of ovarian research
pub_type： 杂志文章
doi：10.1186/s13048-015-0185-8
更新日期：2015-08-13 00:00:00
abstract：BACKGROUND:Gonadoblastoma (GB) is a rare mixed germ cell-sex cord-stromal tumour, first described in humans, commonly found in dysgenetic gonads of intersex patients that have a Y chromosome. However, this entity in not recognized in the WHO classification of tumours of genital system of domestic animals. Herein, we de...
journal_title：Journal of ovarian research
pub_type： 杂志文章
doi：10.1186/s13048-019-0561-x
更新日期：2019-09-23 00:00:00
abstract：BACKGROUND:In recent years the question of the lack of transparency in clinical research has been debated by clinicians, researchers, citizens and their representatives, authors and publishers. This is particularly important for infrequent cancers such as ovarian cancer, where treatment still gives disappointing result...
journal_title：Journal of ovarian research
pub_type： 杂志文章
doi：10.1186/s13048-018-0404-1
更新日期：2018-04-10 00:00:00
abstract：BACKGROUND:Resveratrol (3,5,4'-trihydroxy-trans-stilbene) is a natural antioxidant polyphenol able to exert a wide range of biological effect on several tissues. Despite its important beneficial properties, it has a low water solubility, which limits its therapeutic applications in humans. Resveratrol also acts as a ph...
journal_title：Journal of ovarian research
pub_type： 杂志文章
doi：10.1186/s13048-017-0357-9
更新日期：2017-09-15 00:00:00
abstract：:Currently, the world is in the seventh month of the COVID-19 pandemic. Globally, infections with novel SARS-CoV-2 virus are continuously rising with mounting numbers of deaths. International and local public health responses, almost in synchrony, imposed restrictions to minimize spread of the virus, overload of health...
journal_title：Journal of ovarian research
pub_type： 杂志文章,评审
doi：10.1186/s13048-020-00737-1
更新日期：2020-11-27 00:00:00
abstract：BACKGROUND:Degeneration of ovarian function is an obvious feature of female aging. In addition, studies have shown that autophagy decreases with age, and DNA methylation is a hallmark epigenetic pattern during aging. However, it is not clear whether the expression and DNA methylation of autophagy genes are involved in ...
journal_title：Journal of ovarian research
pub_type： 杂志文章
doi：10.1186/s13048-020-0615-0
更新日期：2020-02-03 00:00:00
abstract：:We have earlier reported the presence of very small embryonic-like stem cells (VSELs) in adult mouse uterus along with slightly bigger progenitors termed endometrial stem cells (EnSCs) and their regulation by ovarian hormones thus demonstrating a crucial role played by them during proliferation, differentiation and re...
journal_title：Journal of ovarian research
pub_type： 杂志文章
doi：10.1186/s13048-017-0324-5
更新日期：2017-04-24 00:00:00
abstract：BACKGROUND:Despite advances in surgical aggressiveness and conventional chemotherapy, ovarian cancer remains the most lethal cause of gynecologic cancer mortality; consequently there is a need for new therapeutic agents and innovative treatment paradigms for the treatment of ovarian cancer. Several studies have demonst...
journal_title：Journal of ovarian research
pub_type： 杂志文章
doi：10.1186/s13048-016-0282-3
更新日期：2016-10-27 00:00:00
abstract：BACKGROUND:The polycystic ovary syndrome (PCOS) is a complex and heterogeneous endocrine condition characterized by hyperandrogenism, hyperinsulinemia, insulin resistance and chronic anovulation. Regulation and interaction of a multitude of genes required for follicular development are found to be altered in PCOS. Micr...
journal_title：Journal of ovarian research
pub_type： 杂志文章
doi：10.1186/1757-2215-6-36
更新日期：2013-05-15 00:00:00
abstract：BACKGROUND:Various components of the immune system play a critical role in the prognosis and treatment response in ovarian cancer (OC). Immunotherapy has been recognized as a hallmark of cancer but the effect is contradictional. Reliable immune gene-based prognostic biomarkers or regulatory factors are necessary to be ...
journal_title：Journal of ovarian research
pub_type： 杂志文章
doi：10.1186/s13048-021-00766-4
更新日期：2021-01-28 00:00:00
