MiRNA-802 suppresses proliferation and migration of epithelial ovarian cancer cells by targeting YWHAZ.

Abstract:

BACKGROUND:The imbalance of expression of microRNA-802 may have a significant place in tumor progression. However, the bio-function of epithelial ovarian cancer cells remains unclear. Therefore, we setup this study to explore the pathogenesis of epithelial ovarian cancer based on microRNA-802. METHODS:RT-qPCR analysis was used to measure the expression level of microRNA802 and YWHAZ in epithelial ovarian cancer. CCK-8, colony formation, flow cytometry and transwell assay were used to detect the effects of microRNA-802 on cell proliferation, apoptosis, invasion and migration. Target gene prediction and screening, luciferase reporting experiments were applied to validate the downstream target genes of microRNA-802. The effects of microRNA-802 on the expression of YWHAZ and its biological effects were measured by Western blotting and RT-qPCR. RESULTS:Compared with normal cell lines and tissues, the expression level of microRNA-802 was obviously down-regulated in cancer related cell lines and tissues. Overexpression of microRNA-802 could obviously inhibit the invasion and proliferation and induce apoptosis. In addition, YWHAZ was the binding target protein of miR-802 for epithelial ovarian cancer cells. YWHAZ was obviously up-regulated in human epithelial ovarian cancer cells, and YWHAZ was negatively correlated with the expression of miR-802. YWHAZ can partly eliminate the inhibitory effect caused by overexpression of miR-802 on growth and metastasis of epithelial ovarian cancer cells. CONCLUSION:miR-802 can regulate the occurrence and development of epithelial ovarian cancer by targeting YWHAZ.

journal_name

J Ovarian Res

authors

Yang B,Sun L,Liang L

doi

10.1186/s13048-019-0576-3

subject

Has Abstract

pub_date

2019-10-22 00:00:00

pages

100

issue

1

issn

1757-2215

pii

10.1186/s13048-019-0576-3

journal_volume

12

pub_type

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