Abstract:
BACKGROUND:This study aimed to examine the performance of the four risk of malignancy index (RMI) in discriminating borderline ovarian tumors (BOTs) and benign ovarian masses in daily clinical practice. METHODS:A total of 162 women with BOTs and 379 women with benign ovarian tumors diagnosed at the Second Affiliated Hospital of Harbin Medical University from January 2012 to December 2016 were enrolled in this retrospective study. Also, we classified these patients into serous borderline ovarian tumor (SBOT) and mucinous borderline ovarian tumor (MBOT) subgroup. Preoperative ultrasound findings, cancer antigen 125 (CA125) and menopausal status were reviewed. The area under the curve (AUC) of receiver operator characteristic curves (ROC) and performance indices of RMI I, RMI II, RMI III and RMI IV were calculated and compared for discrimination between benign ovarian tumors and BOTs. RESULTS:RMI I had the highest AUC (0.825, 95% CI: 0.790-0.856) among the four RMIs in BOTs group. Similar results were found in SBOT (0.839, 95% CI: 0.804-0.871) and MBOT (0.791, 95% CI: 0.749-0.829) subgroups. RMI I had the highest specificity among the BOTs group (87.6, 95% CI: 83.9-90.7%), SBOT (87.6, 95% CI: 83.9-90.7%) and MBOT group (87.6, 95% CI: 83.9-90.7%). RMI II scored the highest overall in terms of sensitivity among the BOTs group (69.75, 95% CI: 62.1-76.7%), SBOT (74.34, 95% CI: 65.3-82.1%) and MBOT (59.18, 95% CI: 44.2-73.0%) group. CONCLUSION:Compared to other RMIs, RMI I was the best-performed method for differentiation of BOTs from benign ovarian tumors. At the same time, RMI I also performed best in the discrimination SBOT from benign ovarian tumors.
journal_name
J Ovarian Resjournal_title
Journal of ovarian researchauthors
Zhang S,Yu S,Hou W,Li X,Ning C,Wu Y,Zhang F,Jiao YF,Lee LTO,Sun Ldoi
10.1186/s13048-019-0568-3subject
Has Abstractpub_date
2019-09-16 00:00:00pages
87issue
1issn
1757-2215pii
10.1186/s13048-019-0568-3journal_volume
12pub_type
杂志文章abstract:BACKGROUND:Ovarian cancer (OC) was the primary malignant gynecological cancer and SNARE protein is closely related with tumor progression. Here, we identified SNAP23, a member of SNARE complex, as a potential oncogene in OC. METHODS:We determined the expression of SNAP23 in OC tissues and explored the clinical signifi...
journal_title:Journal of ovarian research
pub_type: 杂志文章
doi:10.1186/s13048-016-0289-9
更新日期:2016-11-17 00:00:00
abstract:BACKGROUND:Recent studies have shown that microRNAs may regulate the ABCB1 gene (ATP-binding cassette, sub-family B [MDR/TAP], member 1). Computational programs have predicted that the 3'-untranslated region (3'-UTR) of ABCB1 contains a potential miRNA-binding site for miR-186. Here, we investigated the role of miR-186...
journal_title:Journal of ovarian research
pub_type: 杂志文章
doi:10.1186/s13048-015-0207-6
更新日期:2015-12-02 00:00:00
abstract:BACKGROUND:Ovarian hyperstimulation syndrome remains a serious complication during in vitro fertilization cycles if high dose human chorionic gonadotropin (hCG) is used to trigger ovulation in high responder patients. Though much of this risk is mitigated with trigger using gonadotropin releasing-hormone (GnRH) agonist...
journal_title:Journal of ovarian research
pub_type: 杂志文章,随机对照试验
doi:10.1186/s13048-019-0483-7
更新日期:2019-01-26 00:00:00
abstract:BACKGROUND:Because higher survival of follicles during the freezing/thawing procedure improves the quality of cryopreserved tissue reimplanted after oncological therapies, defining an optimal method for human ovarian tissue cryopreservation remains a major issue in this field. One option to improve the cryopreservation...
journal_title:Journal of ovarian research
pub_type: 杂志文章
doi:10.1186/s13048-016-0268-1
更新日期:2016-09-26 00:00:00
abstract:BACKGROUND:The aim of this study was to evaluate the concentrations of IgG antibodies against Hsp60 and Hsp65 in sera of patients with ovarian cancer at various stages of clinical progress and for different histopathological types of disease. METHODS:Serum samples from 149 patients with ovarian carcinoma and 80 health...
journal_title:Journal of ovarian research
pub_type: 杂志文章
doi:10.1186/1757-2215-7-30
更新日期:2014-03-11 00:00:00
abstract:BACKGROUND:The imbalance of expression of microRNA-802 may have a significant place in tumor progression. However, the bio-function of epithelial ovarian cancer cells remains unclear. Therefore, we setup this study to explore the pathogenesis of epithelial ovarian cancer based on microRNA-802. METHODS:RT-qPCR analysis...
journal_title:Journal of ovarian research
pub_type: 杂志文章
doi:10.1186/s13048-019-0576-3
更新日期:2019-10-22 00:00:00
abstract:RATIONALE AND OBJECTIVES:To evaluate the impact of metabolic parameters in the peritoneal cavity on the likelihood of achieving complete tumor debulking in patients with ovarian and peritoneal cancers. MATERIALS AND METHODS:Forty-nine patients with ovarian and peritoneal cancers were included, who underwent pre-operat...
journal_title:Journal of ovarian research
pub_type: 杂志文章
doi:10.1186/s13048-020-00662-3
更新日期:2020-05-20 00:00:00
abstract:BACKGROUND:Glutathione peroxidase 3 (GPX3) is a selenocysteine-containing antioxidant enzyme that reacts with hydrogen peroxide and soluble fatty acid hydroperoxides, thereby helping to maintain redox balance within cells. Serum levels of GPX3 have been found to be reduced in various cancers including prostrate, thyroi...
journal_title:Journal of ovarian research
pub_type: 杂志文章
doi:10.1186/1757-2215-4-18
更新日期:2011-10-22 00:00:00
abstract:BACKGROUND:Ovarian hyperstimulation syndrome (OHSS) is a rare, yet severe, iatrogenic complication of ovulation induction therapy during assisted reproductive procedures. Our group previously detected atypical cells in the ascitic fluid of OHSS patients, although no malignancy developed during follow up. Here, the aim ...
journal_title:Journal of ovarian research
pub_type: 杂志文章
doi:10.1186/s13048-020-00624-9
更新日期:2020-03-05 00:00:00
abstract:INTRODUCTION:The use of patient reported outcome measures (PROMs) has increased during the past decade, and the focus on how to use them has resulted in a more proactive application. Studies have shown that proactive use of PROMs during treatment improves patient-clinician communication, leads to better symptom managem...
journal_title:Journal of ovarian research
pub_type: 杂志文章,评审
doi:10.1186/s13048-019-0538-9
更新日期:2019-07-15 00:00:00
abstract:BACKGROUND:Our recent study on a panel of human ovarian cancer cells revealed that SKOV-3 cells barely express the Sprouty isoform 1 (Spry1) while 1A9 cells maintain it at a level similar to normal ovarian cells. Here we investigated the functional outcomes of induced alterations in the expression of Spry1 in the two c...
journal_title:Journal of ovarian research
pub_type: 杂志文章
doi:10.1186/1757-2215-7-61
更新日期:2014-06-08 00:00:00
abstract:BACKGROUND:Neovascularization is necessary for follicular growth. Vascularization is first observed in preantral follicles, and thereafter the vasculature markedly increases in follicles undergoing development. Neovascularization includes angiogenesis and vasculogenesis. Vasculogenesis is the formation of new blood ves...
journal_title:Journal of ovarian research
pub_type: 杂志文章
doi:10.1186/1757-2215-7-10
更新日期:2014-01-21 00:00:00
abstract:BACKGROUND:The prevalence of obesity is increasing worldwide and significantly affects fertility and reproduction in both men and women. Our recent study has shown that excess body fat accelerates ovarian follicle development and follicle loss in rats. The aim of the present study is to explore the effect of SIRT1 acti...
journal_title:Journal of ovarian research
pub_type: 杂志文章
doi:10.1186/s13048-014-0097-z
更新日期:2014-10-21 00:00:00
abstract:OBJECTIVES:The ovarian tumor marker CA125 is expressed on human MUC16, a cell surface bound mucin that is also shed by proteolytic cleavage. Human MUC16 is overexpressed by ovarian cancer cells. MUC16 facilitates the binding of ovarian tumor cells to mesothelial cells lining the peritoneal cavity. Additionally, MUC16 a...
journal_title:Journal of ovarian research
pub_type: 杂志文章
doi:10.1186/1757-2215-2-8
更新日期:2009-06-18 00:00:00
abstract:BACKGROUND:Resistance to apoptosis is a major problem in ovarian cancer (OC) and correlates with poor prognosis. Osteoprotegerin (OPG) is a soluble secreted factor that acts as a decoy receptor for receptor activator of NF-κB ligand (RANKL) and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). OPG has be...
journal_title:Journal of ovarian research
pub_type: 杂志文章
doi:10.1186/1757-2215-6-82
更新日期:2013-11-23 00:00:00
abstract:BACKGROUND:Highly Individualized Egg Retrieval (HIER), defined as age-specific early oocyte retrieval (ER), has been demonstrated to avoid premature luteinization in women ≥43. We here investigated whether HIER also applies to younger women with premature ovarian aging (POA), and what best lead follicle size should be ...
journal_title:Journal of ovarian research
pub_type: 杂志文章
doi:10.1186/s13048-018-0398-8
更新日期:2018-03-16 00:00:00
abstract::Growing evidence indicates that the tumor biomarker cytokeratin 19 fragment (CYFRA21-1) is significant for a variety of cancers. However, its role in epithelial ovarian cancer (EOC) has rarely been reported. In this study, a receiver operating characteristic (ROC) curve was utilized to estimate the diagnostic efficien...
journal_title:Journal of ovarian research
pub_type: 杂志文章
doi:10.1186/s13048-019-0587-0
更新日期:2019-11-25 00:00:00
abstract:BACKGROUND:Various components of the immune system play a critical role in the prognosis and treatment response in ovarian cancer (OC). Immunotherapy has been recognized as a hallmark of cancer but the effect is contradictional. Reliable immune gene-based prognostic biomarkers or regulatory factors are necessary to be ...
journal_title:Journal of ovarian research
pub_type: 杂志文章
doi:10.1186/s13048-021-00766-4
更新日期:2021-01-28 00:00:00
abstract:BACKGROUND:Experience on sentinel node mapping in ovarian tumors is very limited. We evaluated the sentinel node concept in ovarian tumors using intra-operativeTc-99m-Phytate injection and lymphoscintigraphy imaging. METHODS:Thirty-five patients with a pelvic mass due to an ovarian pathology were included in the study...
journal_title:Journal of ovarian research
pub_type: 杂志文章
doi:10.1186/s13048-016-0265-4
更新日期:2016-09-07 00:00:00
abstract::RNA methylation can reverse the methylation modification at the RNA level, which is an extremely important epigenetic modification. The function and mechanism of YTHDF2, as a reader of m6A modification, in epithelial ovarian cancer (EOC) have not been elucidated so far. This study aimed to investigate how YTHDF2 and m...
journal_title:Journal of ovarian research
pub_type: 杂志文章
doi:10.1186/s13048-020-00717-5
更新日期:2020-09-18 00:00:00
abstract::Currently, the world is in the seventh month of the COVID-19 pandemic. Globally, infections with novel SARS-CoV-2 virus are continuously rising with mounting numbers of deaths. International and local public health responses, almost in synchrony, imposed restrictions to minimize spread of the virus, overload of health...
journal_title:Journal of ovarian research
pub_type: 杂志文章,评审
doi:10.1186/s13048-020-00737-1
更新日期:2020-11-27 00:00:00
abstract::Following publication of the original article [1], the authors opted to correct the incorrect e-mail address of the corresponding author from 82-55-360-1850chungsu1982@gmail.com to chungsu1982@gmail.com , grant in the Acknowledgements section and Author details. Below are the updated version of the Acknowledgements an...
journal_title:Journal of ovarian research
pub_type: 已发布勘误
doi:10.1186/s13048-019-0540-2
更新日期:2019-07-23 00:00:00
abstract:BACKGROUND:In this study we aimed to identify a prognostic signature in BRCA1/2 mutations to predict disease progression and the efficiency of chemotherapy ovarian cancer (OV), the second most common cause of death from gynecologic cancer in women worldwide. METHODS:Univariate Cox proportional-hazards and multivariate...
journal_title:Journal of ovarian research
pub_type: 杂志文章
doi:10.1186/s13048-020-00712-w
更新日期:2020-09-19 00:00:00
abstract:BACKGROUND:In recent years the question of the lack of transparency in clinical research has been debated by clinicians, researchers, citizens and their representatives, authors and publishers. This is particularly important for infrequent cancers such as ovarian cancer, where treatment still gives disappointing result...
journal_title:Journal of ovarian research
pub_type: 杂志文章
doi:10.1186/s13048-018-0404-1
更新日期:2018-04-10 00:00:00
abstract:BACKGROUND:Low adiponectin levels in polycystic ovarian syndrome (PCOS) have been largely attributed to obesity which is common among these patients. In addition, evidence also suggests that low adiponectin in PCOS may be related to insulin resistance (IR) in these women. However, studies on the role of adiponectin in ...
journal_title:Journal of ovarian research
pub_type: 杂志文章
doi:10.1186/1757-2215-7-18
更新日期:2014-02-07 00:00:00
abstract:BACKGROUND:Wnt-inducible signaling pathway protein 2 (WISP2) is a wnt1-induced signaling pathway protein 2. Although studies indicate that WISP2 may promote the development of various tumors, its role in ovarian cancer remains unclear. The objective of the current study was to analyze the effects of WISP2 on the prolif...
journal_title:Journal of ovarian research
pub_type: 杂志文章
doi:10.1186/s13048-020-00687-8
更新日期:2020-07-25 00:00:00
abstract:OBJECTIVE:Recently, 14-3-3 zeta protein was identified as a potential serum biomarker of epithelial ovarian cancer (EOC). The goal of this study was to investigate the clinical potential of 14-3-3 zeta protein for monitoring EOC progression compared with CA-125 and HE4. DESIGN:Prospective follow-up study. SETTING:Uni...
journal_title:Journal of ovarian research
pub_type: 杂志文章
doi:10.1186/1757-2215-6-79
更新日期:2013-11-15 00:00:00
abstract::AbstractThe original article [1] contains errors in Figs. 6 and 8. The corrected figures can be shown ahead. ...
journal_title:Journal of ovarian research
pub_type: 杂志文章,已发布勘误
doi:10.1186/s13048-019-0487-3
更新日期:2019-01-30 00:00:00
abstract:BACKGROUND:Although agonistic autoantibodies against type-1 angiotensin-II receptor (AT1-AA) are frequently detected in women with preeclampsia, the clinical significance of AT1-AA in association with epithelial ovarian cancer (EOC) has not been identified. METHODS:In an attempt to clarify this issue, we measured seru...
journal_title:Journal of ovarian research
pub_type: 杂志文章
doi:10.1186/1757-2215-6-22
更新日期:2013-04-05 00:00:00
abstract::We have earlier reported the presence of very small embryonic-like stem cells (VSELs) in adult mouse uterus along with slightly bigger progenitors termed endometrial stem cells (EnSCs) and their regulation by ovarian hormones thus demonstrating a crucial role played by them during proliferation, differentiation and re...
journal_title:Journal of ovarian research
pub_type: 杂志文章
doi:10.1186/s13048-017-0324-5
更新日期:2017-04-24 00:00:00