Abstract:
BACKGROUND:Epithelial ovarian cancer has the highest fatality rate of all gynecologic malignancies. Although the majority of patients achieve complete clinical response after initial cytoreductive surgery and platinum-based chemotherapy, most recur and almost all will eventually acquire platinum-resistance for which treatment options become limited. The objective of the study was to describe response and tolerability of metronomic chemotherapy regimen GFIP/BDC, a modification of the G-FLIP regimen, in patients with persistent or recurrent epithelial ovarian, fallopian tube, and primary peritoneal cancer. METHODS:A retrospective descriptive analysis of 20 patients from a single academic institution who received combination GFIP/BDC therapy from January 1, 2011 to August 31, 2016 for persistent or recurrent EOC/FT/PP. Treatment consisted of a 2-day combination of gemcitabine 300 mg, 5-fluorouracil 500 mg/m2, irinotecan 20-30 mg/m2, cisplatin 20 mg/m2, bevacizumab 4 mg/kg, docetaxel 20 mg/m2, and cyclophosphamide 200 mg/m2 administered every 14 days. Toxicities were retrospectively graded using CTCAE v4.0. RESULTS:Twenty patients were identified with a median age 57.5 years (range 32-71). A total of 85% of patients were non-Hispanic white, 90% had cancer of high-grade serous histology, and all had a GOG performance status of 0-1. Patients had received a median of 3 prior regimens and 95% were platinum-resistant. Median number of cycles of GFIP/BDC administered was 9 (range 3-48) and patients remained on treatment for a median of 5.1 months (range 1.5-24). Eleven patients (55%) experienced a partial clinical response with a median duration of 6 months (range 1.5-20). Six patients (30%) survived progression free for at least 6 months. Ten patients (50%) experienced at least one grade 3/4 adverse event. Grade 3 adverse events were hematologic (n = 5), constitutional (n = 3), gastrointestinal (n = 3), neurologic (n = 2), and vascular (n = 1). There was only one grade 4 adverse event which was severe neutropenia. Patients discontinued treatment due to disease progression 65% (n = 13), toxicity 20% (n = 4), patient preference 10% (n = 2), and 5% (n = 1) is currently on treatment. CONCLUSIONS:Selected patients with epithelial ovarian, fallopian tube or primary peritoneal cancer who have failed multiple lines of conventional cytotoxic treatment may benefit from GFIP/BDC. Toxicity might be a limiting factor for administration.
journal_name
J Ovarian Resjournal_title
Journal of ovarian researchauthors
Cohen S,Schwartz M,Dottino P,Beddoe AMdoi
10.1186/s13048-019-0506-4subject
Has Abstractpub_date
2019-04-25 00:00:00pages
36issue
1issn
1757-2215pii
10.1186/s13048-019-0506-4journal_volume
12pub_type
杂志文章abstract::The diagnosis of primary angiosarcoma of ovary is still a challenge as it has no specific clinical symptoms and is easily confused with other malignant neoplasms in morphology. Here, we described a case of primary ovarian angiosarcoma and reviewed the literature. A 47-year-old female showed a left ovary mass. Grossly,...
journal_title:Journal of ovarian research
pub_type: 杂志文章
doi:10.1186/s13048-021-00771-7
更新日期:2021-01-28 00:00:00
abstract:BACKGROUND:Ovarian cancer is the leading cause of gynecological cancer-related mortality. The novel oncogene S100A10 has been reported to be involved in cancer cell proliferation, invasion and metastasis. The role of S100A10 in ovarian cancer has not been well studied and the effect of S100A10 on chemotherapy remains u...
journal_title:Journal of ovarian research
pub_type: 杂志文章
doi:10.1186/s13048-019-0592-3
更新日期:2019-11-18 00:00:00
abstract::Previously anecdotally observed rebounds in follicle growth after interruption of exogenous gonadotropins in absolute non-responders were the impetus for here reported study. In a prospective cohort study, we investigated 49 consecutive patients, absolutely unresponsive to maximal exogenous gonadotropin stimulation, f...
journal_title:Journal of ovarian research
pub_type: 杂志文章
doi:10.1186/s13048-021-00765-5
更新日期:2021-01-09 00:00:00
abstract::Ovarian hyperstimulation syndrome (OHSS) is a serious complication of controlled ovarian hyperstimulation (COH). The syndrome almost always presents either after hCG administration in susceptible patients or during early pregnancy. Despite many years of clinical experience, there are no precise methods to completely p...
journal_title:Journal of ovarian research
pub_type: 杂志文章
doi:10.1186/1757-2215-6-77
更新日期:2013-11-05 00:00:00
abstract:BACKGROUND:This study was designed to investigate leptin levels in the fluid in ovarian endometriomas (OEs) and to compare the expression of leptin and its receptors (OBR) in ovarian tissue affected by endometrioma in infertile women to its expression in the normal ovarian tissue of fertile controls without endometrios...
journal_title:Journal of ovarian research
pub_type: 杂志文章
doi:10.1186/1757-2215-7-2
更新日期:2014-01-08 00:00:00
abstract:BACKGROUND:The down-regulation of E-cadherin gene (CDH1) expression has been regarded as an important event in cancer invasion and metastasis. However, the association between CDH1 promoter methylation and ovarian cancer remains unclear. A meta-analysis was conducted to evaluate the potential role of CDH1 promoter meth...
journal_title:Journal of ovarian research
pub_type: 杂志文章,meta分析
doi:10.1186/s13048-016-0231-1
更新日期:2016-04-11 00:00:00
abstract::Mixed germ cell tumours of the ovary are malignant neoplasms of the ovary comprising of two or more types of germ cell components. Most of the malignant mixed germ cell tumours consists of dysgerminoma accompanied by endodermal sinus tumours, immature teratoma or choriocarcinoma. There are only few case reports of mix...
journal_title:Journal of ovarian research
pub_type: 杂志文章,评审
doi:10.1186/s13048-014-0091-5
更新日期:2014-11-04 00:00:00
abstract:BACKGROUND:Our recent study on a panel of human ovarian cancer cells revealed that SKOV-3 cells barely express the Sprouty isoform 1 (Spry1) while 1A9 cells maintain it at a level similar to normal ovarian cells. Here we investigated the functional outcomes of induced alterations in the expression of Spry1 in the two c...
journal_title:Journal of ovarian research
pub_type: 杂志文章
doi:10.1186/1757-2215-7-61
更新日期:2014-06-08 00:00:00
abstract:BACKGROUND:The imbalance of expression of microRNA-802 may have a significant place in tumor progression. However, the bio-function of epithelial ovarian cancer cells remains unclear. Therefore, we setup this study to explore the pathogenesis of epithelial ovarian cancer based on microRNA-802. METHODS:RT-qPCR analysis...
journal_title:Journal of ovarian research
pub_type: 杂志文章
doi:10.1186/s13048-019-0576-3
更新日期:2019-10-22 00:00:00
abstract:BACKGROUND:Metformin decreases polycystic ovary syndrome (PCOS) symptoms, induces ovulation, and may improve developmental competence of in vitro oocyte maturation. This study was designed to define the effects of metformin on the characteristics of in vitro oocyte maturation in estradiol valerate (EV) PCOS-induced rat...
journal_title:Journal of ovarian research
pub_type: 杂志文章
doi:10.1186/s13048-015-0203-x
更新日期:2015-11-14 00:00:00
abstract:BACKGROUND:The ST6Gal-I glycosyltransferase, which adds α2-6-linked sialic acids to N-glycosylated proteins is upregulated in a wide range of malignancies including ovarian cancer. Prior studies have shown that ST6Gal-I-mediated sialylation of select surface receptors remodels intracellular signaling to impart cancer s...
journal_title:Journal of ovarian research
pub_type: 杂志文章
doi:10.1186/s13048-019-0574-5
更新日期:2019-10-14 00:00:00
abstract::The original article [1] contains errors in Fig. 3C, Results and Discussion. ...
journal_title:Journal of ovarian research
pub_type: 杂志文章,已发布勘误
doi:10.1186/s13048-020-00628-5
更新日期:2020-03-13 00:00:00
abstract:INTRODUCTION:Weight gain and fat accumulation are predisposing factors of PCOS. Life-style modification, including increasing physical activity, is the first line approach in managing PCOS. The objective of this study is to assess the effect of exercise intensity on weight changes, androstenedione and free testosterone...
journal_title:Journal of ovarian research
pub_type: 杂志文章
doi:10.1186/1757-2215-7-37
更新日期:2014-04-08 00:00:00
abstract:BACKGROUND:Hypertensive disorders of pregnancy are the most common causes of adverse maternal & perinatal outcomes. Such investigations in resource limited settings would help to have great design strategies in preventing maternal and perinatal morbidity and mortality. AIM:To determine management outcome and factor as...
journal_title:Journal of ovarian research
pub_type: 杂志文章
doi:10.1186/s13048-015-0135-5
更新日期:2015-03-15 00:00:00
abstract:BACKGROUND:We aimed to examine the expression of miR-1307 in chemosensitive and chemoresistant epithelial ovarian cancer tissues and cell lines and to analyze the clinicopathological significance of miR-1307 in ovarian cancer. METHODS:MicroRNA microarray was used to screen differentially expressed microRNAs between th...
journal_title:Journal of ovarian research
pub_type: 杂志文章
doi:10.1186/s13048-015-0143-5
更新日期:2015-04-09 00:00:00
abstract:BACKGROUND:Gonadoblastoma (GB) is a rare mixed germ cell-sex cord-stromal tumour, first described in humans, commonly found in dysgenetic gonads of intersex patients that have a Y chromosome. However, this entity in not recognized in the WHO classification of tumours of genital system of domestic animals. Herein, we de...
journal_title:Journal of ovarian research
pub_type: 杂志文章
doi:10.1186/s13048-019-0561-x
更新日期:2019-09-23 00:00:00
abstract:BACKGROUND:Recent researches demonstrate that pre-treatment with androgen could increase retrieved oocytes number and clinical pregnancy rate in poor ovarian response (POR) patients. In view of gap junction intercellular communication (GJIC) is important for follicular growth, and androgen plays an important role in im...
journal_title:Journal of ovarian research
pub_type: 杂志文章
doi:10.1186/s13048-016-0290-3
更新日期:2016-11-23 00:00:00
abstract:BACKGROUND:Upregulation of Cyclin dependent kinase 1 (CDK1) protein is closely related with the prognosis of several malignant tumors. Chk1-CDC25C-CDK1 signaling and P53-P21WAF1-CDK1 signaling pathways are closely related with the cell cycle G2/M phase regulation. The present study aimed to analyze the relationship bet...
journal_title:Journal of ovarian research
pub_type: 杂志文章
doi:10.1186/s13048-017-0356-x
更新日期:2017-09-12 00:00:00
abstract:BACKGROUND:The polycystic ovary syndrome (PCOS) is a complex and heterogeneous endocrine condition characterized by hyperandrogenism, hyperinsulinemia, insulin resistance and chronic anovulation. Regulation and interaction of a multitude of genes required for follicular development are found to be altered in PCOS. Micr...
journal_title:Journal of ovarian research
pub_type: 杂志文章
doi:10.1186/1757-2215-6-36
更新日期:2013-05-15 00:00:00
abstract:BACKGROUND:Degeneration of ovarian function is an obvious feature of female aging. In addition, studies have shown that autophagy decreases with age, and DNA methylation is a hallmark epigenetic pattern during aging. However, it is not clear whether the expression and DNA methylation of autophagy genes are involved in ...
journal_title:Journal of ovarian research
pub_type: 杂志文章
doi:10.1186/s13048-020-0615-0
更新日期:2020-02-03 00:00:00
abstract:BACKGROUND:galectin-1 has been implicated in tumor invasion and metastasis and is frequently over-expressed in epithelial ovarian cancer (EOC), but its potential as a biomarker remains unclear. In this novel study, we have explored the possible use of galectin-1 as a biomarker for EOC. METHODS:galectin-1 in sera was e...
journal_title:Journal of ovarian research
pub_type: 杂志文章
doi:10.1186/s13048-015-0206-7
更新日期:2015-11-21 00:00:00
abstract:BACKGROUND:Pelvic irradiation is essential for improving survival in women with pelvic malignancies despite inducing permanent ovarian damage. Ovarian transposition can be performed in premenopausal women in an attempt to preserve ovarian function. As uncertainty occurs over the proportion of women who are likely to be...
journal_title:Journal of ovarian research
pub_type: 杂志文章,meta分析,评审
doi:10.1186/1757-2215-7-69
更新日期:2014-06-25 00:00:00
abstract::We have earlier reported the presence of very small embryonic-like stem cells (VSELs) in adult mouse uterus along with slightly bigger progenitors termed endometrial stem cells (EnSCs) and their regulation by ovarian hormones thus demonstrating a crucial role played by them during proliferation, differentiation and re...
journal_title:Journal of ovarian research
pub_type: 杂志文章
doi:10.1186/s13048-017-0324-5
更新日期:2017-04-24 00:00:00
abstract:BACKGROUND:Ovarian cancer (OC) was the primary malignant gynecological cancer and SNARE protein is closely related with tumor progression. Here, we identified SNAP23, a member of SNARE complex, as a potential oncogene in OC. METHODS:We determined the expression of SNAP23 in OC tissues and explored the clinical signifi...
journal_title:Journal of ovarian research
pub_type: 杂志文章
doi:10.1186/s13048-016-0289-9
更新日期:2016-11-17 00:00:00
abstract::An amendment to this paper has been published and can be accessed via the original article. ...
journal_title:Journal of ovarian research
pub_type: 已发布勘误
doi:10.1186/s13048-020-00733-5
更新日期:2020-11-12 00:00:00
abstract:BACKGROUND:Resveratrol (3,5,4'-trihydroxy-trans-stilbene) is a natural antioxidant polyphenol able to exert a wide range of biological effect on several tissues. Despite its important beneficial properties, it has a low water solubility, which limits its therapeutic applications in humans. Resveratrol also acts as a ph...
journal_title:Journal of ovarian research
pub_type: 杂志文章
doi:10.1186/s13048-017-0357-9
更新日期:2017-09-15 00:00:00
abstract:BACKGROUND:Epithelial ovarian cancer (EOC) is still a major gynecologic problem with poor 5 year survival rate due to distance metastases, despite routine surgery and chemotherapy. The precise underlying molecular mechanisms that trigger EOC migration and invasion are unclear. Recent studies suggest that the expression...
journal_title:Journal of ovarian research
pub_type: 杂志文章
doi:10.1186/1757-2215-6-84
更新日期:2013-11-26 00:00:00
abstract:BACKGROUND:Glutathione peroxidase 3 (GPX3) is a selenocysteine-containing antioxidant enzyme that reacts with hydrogen peroxide and soluble fatty acid hydroperoxides, thereby helping to maintain redox balance within cells. Serum levels of GPX3 have been found to be reduced in various cancers including prostrate, thyroi...
journal_title:Journal of ovarian research
pub_type: 杂志文章
doi:10.1186/1757-2215-4-18
更新日期:2011-10-22 00:00:00
abstract:BACKGROUND:The aim of this study was to evaluate the concentrations of IgG antibodies against Hsp60 and Hsp65 in sera of patients with ovarian cancer at various stages of clinical progress and for different histopathological types of disease. METHODS:Serum samples from 149 patients with ovarian carcinoma and 80 health...
journal_title:Journal of ovarian research
pub_type: 杂志文章
doi:10.1186/1757-2215-7-30
更新日期:2014-03-11 00:00:00
abstract::AbstractThe original article [1] contains errors in Figs. 6 and 8. The corrected figures can be shown ahead. ...
journal_title:Journal of ovarian research
pub_type: 杂志文章,已发布勘误
doi:10.1186/s13048-019-0487-3
更新日期:2019-01-30 00:00:00