当前位置： SCI文献检索 > BMC Nephrology期刊下所有文献 > Interaction between acyl-ghrelin and BMI predicts clinical outcomes in hemodialysis patients.

Interaction between acyl-ghrelin and BMI predicts clinical outcomes in hemodialysis patients.

Abstract：

BACKGROUND:Ghrelin, a gastric orexigenic peptide, and body mass index (BMI) are known as inversely associated to each other and are both linked to cardiovascular (CV) risk and mortality in maintenance hemodialysis (MHD) patients. However, it is unclear whether the interaction between ghrelin and BMI is associated with a risk of all-cause and CV death in this population. METHODS:A prospective observational study was performed on 261 MHD outpatients (39% women, mean age 68.6 ± 13.6 years) recruited from October 2010 through April 2012, and were followed until November 2014 (median follow-up-28 months, interquartile range-19-34 months). We measured acyl-ghrelin (AG) levels, appetite, nutritional and inflammatory markers, prospective all-cause and cardiovascular (CV) mortality. RESULTS:During follow-up, 109 patients died, 51 due to CV causes. A significant interaction effect of high BMI and high AG (defined as levels higher than median) on all-cause mortality was found. Crude Cox HR for the product termed BMI x AG was 0.52, with a 95% confidence interval (CI): 0.29 to 0.95 (P = 0.03). Evaluating the interaction on an additive scale revealed that the combined predictive value of BMI and AG is larger than the sum of their individual predictive values (synergy index was 1.1). Across the four BMI-AG categories, the group with high BMI and high AG exhibited better all-cause and cardiovascular mortality irrespective of appetite and nutritional status (multivariable adjusted hazard ratios were 0.31, 95% CI 0.16 to 0.62, P = 0.001, and 0.35, 95% CI 0.13 to 0.91, P = 0.03, respectively). Data analyses made by dividing patients according to fat mass-AG, but not to lean body mass-AG categories, provided similar results. CONCLUSIONS:Higher AG levels enhance the favourable association between high BMI and survival in MHD patients irrespective of appetite, nutritional status and inflammation.

journal_name

BMC Nephrol

journal_title

BMC nephrology

authors

Beberashvili I,Sinuani I,Azar A,Shapiro G,Feldman L,Doenyas-Barak K,Stav K,Efrati S

doi

10.1186/s12882-017-0442-8

subject

Has Abstract

pub_date

2017-01-18 00:00:00

pages

29

issue

1

issn

1471-2369

pii

10.1186/s12882-017-0442-8

journal_volume

18

pub_type

杂志文章

相关文献

BMC Nephrology文献大全
  • Serum indoxyl sulfate is associated with mortality in hospital-acquired acute kidney injury: a prospective cohort study.

    abstract：BACKGROUND:Protein-bound uremic toxins are associated with poor outcomes in patients with chronic kidney disease. The aim of this study is to investigate the relationship between indoxyl sulfate (IS), a protein-bound solute, and 90-day mortality in patients with acute kidney injury. METHODS:Adults with hospital-acquir...

    journal_title：BMC nephrology

    pub_type： 杂志文章

    doi：10.1186/s12882-019-1238-9

    authors： Wang W,Hao G,Pan Y,Ma S,Yang T,Shi P,Zhu Q,Xie Y,Ma S,Zhang Q,Ruan H,Ding F

    更新日期：2019-02-14 00:00:00

  • Markers and risk factors for chronic kidney disease in sub-Saharan Africans: baseline levels and 12-month trajectories in newly referred patients in Cameroon.

    abstract：BACKGROUND:Little is known about the changes in disease makers and risk factors in patients with chronic kidney disease (CKD) under nephrological care in Africa. This study aimed to evaluate the baseline level of markers of CKD and their 12-month time-trend in newly referred patients in a tertiary hospital in Cameroon....

    journal_title：BMC nephrology

    pub_type： 杂志文章

    doi：10.1186/s12882-020-01760-6

    authors： Patrice HM,Pascal KA,François KF,Hilaire D,Solange DM,Gloria AE,Pierre CS

    更新日期：2020-03-18 00:00:00

  • Relationship between history of coronary heart disease at dialysis initiation and onset of events associated with heart disease: a propensity-matched analysis of a prospective cohort study.

    abstract：BACKGROUND:Chronic kidney disease (CKD) is an independent risk factor for cardiovascular disease (CVD) events, and a number of reports have shown a relationship between CKD and CVD in pre-dialysis or maintenance dialysis patients. However, few studies have reported serial observations during dialysis initiation and mai...

    journal_title：BMC nephrology

    pub_type： 临床试验,杂志文章

    doi：10.1186/s12882-017-0495-8

    authors： Inaguma D,Koide S,Takahashi K,Hayashi H,Hasegawa M,Yuzawa Y

    更新日期：2017-02-28 00:00:00

  • Association of intradialytic hypotension and convective volume in hemodiafiltration: results from a retrospective cohort study.

    abstract：BACKGROUND:Hemodiafiltration (HDF), as a convective blood purification technique, has been associated with favorable outcomes improved phosphate control, removal of middle-molecules such as Beta2-microglobulin and the occurrence of intradialytic hypotension (IDH) as compared to diffusive techniques. The aim of this ret...

    journal_title：BMC nephrology

    pub_type： 杂志文章

    doi：10.1186/1471-2369-13-106

    authors： Mora-Bravo FG,De-La-Cruz G,Rivera S,Ramírez AM,Raimann JG,Pérez-Grovas H

    更新日期：2012-09-10 00:00:00

  • The mineralocorticoid receptor antagonist eplerenone reduces renal interstitial fibrosis after long-term cyclosporine treatment in rat: antagonizing cyclosporine nephrotoxicity.

    abstract：BACKGROUND:Chronic cyclosporine-(CsA)-mediated loss of kidney function is a major clinical problem in organ transplantation. We hypothesized that the mineralocorticoid receptor antagonist eplerenone (EPL) prevents chronic CsA-induced renal interstitial volume increase, tubule loss, and functional impairment in a rat mo...

    journal_title：BMC nephrology

    pub_type： 杂志文章

    doi：10.1186/1471-2369-14-42

    authors： Nielsen FT,Jensen BL,Hansen PB,Marcussen N,Bie P

    更新日期：2013-02-20 00:00:00

  • Evaluation of potential drug- drug interactions among Palestinian hemodialysis patients.

    abstract：BACKGROUND:The aims of this study are to find the prevalence of potential drug-drug interactions (DDIs) in patients with Hemodialysis and identify factors associated with these interactions if present. METHODS:The study was an observational- retrospective cohort study that was conducted in ten hemodialysis units in th...

    journal_title：BMC nephrology

    pub_type： 杂志文章

    doi：10.1186/s12882-016-0317-4

    authors： Al-Ramahi R,Raddad AR,Rashed AO,Bsharat A,Abu-Ghazaleh D,Yasin E,Shehab O

    更新日期：2016-07-26 00:00:00

  • Gitelman-like syndrome after cisplatin therapy: a case report and literature review.

    abstract：BACKGROUND:Cisplatin is a well-known nephrotoxic antineoplastic drug. Chronic hypokalemic metabolic alkalosis with hypomagnesemia and hypocalciuria is one of the rare complications associated with its use. CASE PRESENTATION:A 42-year-old woman presented with a 20 year-history of hypokalemic metabolic alkalosis with hy...

    journal_title：BMC nephrology

    pub_type： 杂志文章,评审

    doi：10.1186/1471-2369-7-10

    authors： Panichpisal K,Angulo-Pernett F,Selhi S,Nugent KM

    更新日期：2006-05-24 00:00:00

  • Modelling the long-term benefits of tolvaptan therapy on renal function decline in autosomal dominant polycystic kidney disease: an exploratory analysis using the ADPKD outcomes model.

    abstract：BACKGROUND:The short-term efficacy of tolvaptan in patients with autosomal dominant polycystic kidney disease (ADPKD) has been demonstrated across several phase 3 trials, while the ADPKD Outcomes Model (ADPKD-OM) represents a validated approach to predict natural disease progression over a lifetime horizon. This study ...

    journal_title：BMC nephrology

    pub_type： 杂志文章,随机对照试验

    doi：10.1186/s12882-019-1290-5

    authors： Bennett H,McEwan P,Hamilton K,O'Reilly K

    更新日期：2019-04-23 00:00:00

  • The effects of 16-weeks of prebiotic supplementation and aerobic exercise training on inflammatory markers, oxidative stress, uremic toxins, and the microbiota in pre-dialysis kidney patients: a randomized controlled trial-protocol paper.

    abstract：BACKGROUND:Chronic kidney disease (CKD) is characterized by dysbiosis, elevated levels of uremic toxins, systemic inflammation, and increased markers of oxidative stress. These factors lead to an increased risk of cardiovascular disease (CVD) which is common among CKD patients. Supplementation with high amylose maize r...

    journal_title：BMC nephrology

    pub_type： 杂志文章

    doi：10.1186/s12882-020-02177-x

    authors： Headley SA,Chapman DJ,Germain MJ,Evans EE,Hutchinson J,Madsen KL,Ikizler TA,Miele EM,Kirton K,O'Neill E,Cornelius A,Martin B,Nindl B,Vaziri ND

    更新日期：2020-11-26 00:00:00

  • Serum lactate level and mortality in metformin-associated lactic acidosis requiring renal replacement therapy: a systematic review of case reports and case series.

    abstract：BACKGROUND:The current practice concerning timing, mode, and dose of renal replacement therapy (RRT) in patients with metformin-associated lactic acidosis (MALA) with renal failure remains unknown. To investigate whether serum lactate level and prescription pattern of RRT are associated with mortality in patients with ...

    journal_title：BMC nephrology

    pub_type： 杂志文章,评审

    doi：10.1186/s12882-017-0640-4

    authors： Yeh HC,Ting IW,Tsai CW,Wu JY,Kuo CC

    更新日期：2017-07-10 00:00:00

  • Post-hospitalization dialysis facility processes of care and hospital readmissions among hemodialysis patients: a retrospective cohort study.

    abstract：BACKGROUND:Both dialysis facilities and hospitals are accountable for 30-day hospital readmissions among U.S. hemodialysis patients. We examined the association of post-hospitalization processes of care at hemodialysis facilities with pulmonary edema-related and other readmissions. METHODS:In a retrospective cohort co...

    journal_title：BMC nephrology

    pub_type： 杂志文章

    doi：10.1186/s12882-018-0983-5

    authors： Plantinga LC,Masud T,Lea JP,Burkart JM,O'Donnell CM,Jaar BG

    更新日期：2018-07-31 00:00:00

  • End-stage kidney disease due to haemolytic uraemic syndrome--outcomes in 241 consecutive ANZDATA registry cases.

    abstract：BACKGROUND:The aim of this study was to investigate the characteristics and outcomes of patients receiving renal replacement therapy for end-stage kidney disease (ESKD) secondary to haemolytic uraemic syndrome (HUS). METHODS:The study included all patients with ESKD who commenced renal replacement therapy in Australia...

    journal_title：BMC nephrology

    pub_type： 杂志文章

    doi：10.1186/1471-2369-13-164

    authors： Tang W,Mohandas J,McDonald SP,Hawley CM,Badve SV,Boudville N,Brown FG,Clayton PA,Wiggins KJ,Bannister KM,Campbell SB,Johnson DW

    更新日期：2012-12-03 00:00:00

  • Treatment of chronic active antibody-mediated rejection in renal transplant recipients - a single center retrospective study.

    abstract：BACKGROUND:Chronic active antibody-mediated rejection is a major etiology of graft loss in renal transplant recipients. However, there is no consensus on the optimal treatment strategies. METHODS:Computerized records from Taichung Veterans General Hospital were collected to identify renal transplant biopsies performed...

    journal_title：BMC nephrology

    pub_type： 杂志文章

    doi：10.1186/s12882-019-1672-8

    authors： Chiu HF,Wen MC,Wu MJ,Chen CH,Yu TM,Chuang YW,Huang ST,Tsai SF,Lo YC,Ho HC,Shu KH

    更新日期：2020-01-06 00:00:00

  • Serum heat shock protein 27 levels predict cardiac mortality in hemodialysis patients.

    abstract：BACKGROUND:Decreased heat shock protein 27 (HSP27) participates in many processes that are involved in cardiovascular (CV) disease. The objective of the study was to evaluate if HSP27 level was predictive of mortality as well as to evaluate factors associated with HSP27 level in a group of patients treated with HD. ME...

    journal_title：BMC nephrology

    pub_type： 杂志文章

    doi：10.1186/s12882-018-1157-1

    authors： Jaroszyński A,Jaroszyńska A,Zaborowski T,Drelich-Zbroja A,Zapolski T,Dąbrowski W

    更新日期：2018-12-17 00:00:00

  • Seasonal variations in mortality and clinical indicators in international hemodialysis populations from the MONDO registry.

    abstract：BACKGROUND:Seasonal mortality differences have been reported in US hemodialysis (HD) patients. Here we examine the effect of seasons on mortality, clinical and laboratory parameters on a global scale. METHODS:Databases from the international Monitoring Dialysis Outcomes (MONDO) consortium were queried to identify pati...

    journal_title：BMC nephrology

    pub_type： 杂志文章

    doi：10.1186/s12882-015-0129-y

    authors： Guinsburg AM,Usvyat LA,Etter M,Xu X,Thijssen S,Marcelli D,Canaud B,Marelli C,Barth C,Wang Y,Carioni P,van der Sande FM,Kotanko P,Kooman JP,Monitoring Dialysis Outcomes (MONDO) consortium.

    更新日期：2015-08-14 00:00:00

  • Time of injury affects urinary biomarker predictive values for acute kidney injury in critically ill, non-septic patients.

    abstract：BACKGROUND:The predictive value of acute kidney injury (AKI) urinary biomarkers may depend on the time interval following tubular injury, thereby explaining in part the heterogeneous performance of these markers that has been reported in the literature. We studied the influence of timing on the predictive values of tub...

    journal_title：BMC nephrology

    pub_type： 杂志文章

    doi：10.1186/1471-2369-14-273

    authors： de Geus HR,Fortrie G,Betjes MG,van Schaik RH,Groeneveld AB

    更新日期：2013-12-09 00:00:00

  • Angiotensin converting enzyme inhibition increases ADMA concentration in patients on maintenance hemodialysis--a randomized cross-over study.

    abstract：BACKGROUND:Endothelial dysfunction occurs in patients with end-stage renal disease (ESRD) and is associated with increased cardiovascular morbidity and mortality. Asymmetric dimethylarginine (ADMA) contributes to endothelial dysfunction in ESRD. In the general population, angiotensin-converting enzyme (ACE) inhibitors ...

    journal_title：BMC nephrology

    pub_type： 杂志文章,随机对照试验

    doi：10.1186/s12882-015-0162-x

    authors： Gamboa JL,Pretorius M,Sprinkel KC,Brown NJ,Ikizler TA

    更新日期：2015-10-22 00:00:00

  • Mapping the UK renal psychosocial workforce: the first comprehensive workforce survey.

    abstract：BACKGROUND:Emerging evidence of psychosocial problems in CKD patients has led to an acceptance that a focus on the emotional wellbeing of the patient should be included in the provision of comprehensive CKD care. It is unclear if an increased attention for psychosocial needs in guidelines and policy documents has led t...

    journal_title：BMC nephrology

    pub_type： 杂志文章

    doi：10.1186/s12882-019-1287-0

    authors： Seekles ML,Ormandy P,Coyne E

    更新日期：2019-03-21 00:00:00

  • Unexpected recovery from longterm renal failure in severe diffuse proliferative lupus nephritis.

    abstract：BACKGROUND:Severe renal manifestation of systemic lupus erythematosus (SLE) is not uncommon and is associated with an indeterminate prognosis. Complete remission can be obtained, however, at least in the young when chronic lesions are absent and adequate anti-inflammatory therapy is immediately initiated. CASE PRESENT...

    journal_title：BMC nephrology

    pub_type： 杂志文章

    doi：10.1186/1471-2369-13-81

    authors： Ross S,Benz K,Sauerstein K,Amann K,Dötsch J,Dittrich K

    更新日期：2012-08-06 00:00:00

  • Vancomycin-associated acute kidney injury in Hong Kong in 2012-2016.

    abstract：BACKGROUND:To study the incidence of vancomycin-associated acute kidney injury (VA-AKI) in Hong Kong and identify risk factors for VA-AKI. METHOD:Patients with vancomycin prescription and blood level measurement in 2012-2016 were identified using the Hong Kong Hospital Authority Clinical Data Analysis and Reporting Sy...

    journal_title：BMC nephrology

    pub_type： 杂志文章

    doi：10.1186/s12882-020-1704-4

    authors： Qin X,Tsoi MF,Zhao X,Zhang L,Qi Z,Cheung BMY

    更新日期：2020-02-03 00:00:00

  • Geographic and facility variation in initial use of non-tunneled catheters for incident maintenance hemodialysis patients.

    abstract：BACKGROUND:Non-tunneled (temporary) hemodialysis catheters (NTHCs) are the least-optimal initial vascular access for incident maintenance hemodialysis patients yet little is known about factors associated with NTHC use in this context. We sought to determine factors associated with NTHC use and examine regional and fac...

    journal_title：BMC nephrology

    pub_type： 杂志文章

    doi：10.1186/s12882-016-0236-4

    authors： Clark EG,Akbari A,Hiebert B,Hiremath S,Komenda P,Lok CE,Moist LM,Schachter ME,Tangri N,Sood MM

    更新日期：2016-02-27 00:00:00

  • Mortality in dialysis patients may not be associated with ESA dose: a 2-year prospective observational study.

    abstract：BACKGROUND:Anaemia of chronic kidney disease increases the risk of death and adverse events, but can be managed using erythropoiesis stimulating agents (ESAs). However, recent evidence suggests that targeting a higher haemoglobin concentration ([Hb]) increases mortality risk, and both higher [Hb] targets and ESA doses ...

    journal_title：BMC nephrology

    pub_type： 杂志文章

    doi：10.1186/1471-2369-13-40

    authors： McMahon LP,Cai MX,Baweja S,Holt SG,Kent AB,Perkovic V,Leikis MJ,Becker GJ

    更新日期：2012-06-15 00:00:00

  • Cohort profile: Canadian study of prediction of death, dialysis and interim cardiovascular events (CanPREDDICT).

    abstract：BACKGROUND:The Canadian Study of Prediction of Death, Dialysis and Interim Cardiovascular Events (CanPREDDICT) is a large, prospective, pan-Canadian, cohort study designed to improve our understanding of determinants of renal and cardiovascular (CV) disease progression in patients with chronic kidney disease (CKD). The...

    journal_title：BMC nephrology

    pub_type： 杂志文章,多中心研究

    doi：10.1186/1471-2369-14-121

    authors： Levin A,Rigatto C,Brendan B,Madore F,Muirhead N,Holmes D,Clase CM,Tang M,Djurdjev O,CanPREDDICT investigators.

    更新日期：2013-06-11 00:00:00

  • Vitamin D receptor gene polymorphisms and susceptibility to urolithiasis: a meta-regression and meta-analysis.

    abstract：BACKGROUND:The currently available data with respect to the association between vitamin D receptor (VDR) gene polymorphism and risk to urolithiasis are inconclusive and inconsistent. Hence, an exhaustive meta-analysis can solve the discrepancies and provide a hint for upcoming investigations. Herein, a meta-analysis wa...

    journal_title：BMC nephrology

    pub_type： 杂志文章

    doi：10.1186/s12882-020-01919-1

    authors： Imani D,Razi B,Khosrojerdi A,Lorian K,Motallebnezhad M,Rezaei R,Aslani S

    更新日期：2020-07-10 00:00:00

  • Variability in monthly serum bicarbonate measures in hemodialysis patients: a cohort study.

    abstract：BACKGROUND:Some nephrologists have advocated an individualized approach to the prescription of bicarbonate hemodialysis. However, the utility of monthly serum bicarbonate levels for guiding and evaluating such treatment decisions has not been evaluated. We sought to define the variability of these measurements and to d...

    journal_title：BMC nephrology

    pub_type： 杂志文章

    doi：10.1186/s12882-015-0206-2

    authors： Patel R,Paredes W,Hall CB,Nader MA,Sapkota D,Folkert VW,Abramowitz MK

    更新日期：2015-12-21 00:00:00

  • Exclusion of pregnancy in dialysis patients: diagnostic performance of human chorionic gonadotropin.

    abstract：BACKGROUND:A positive pregnancy test in acute or chronically ill patients has implications for the use of potentially mutagenic or teratogenic products in urgent medical therapies such as the use of chemotherapies or therapies with immunosuppressants, for anesthesia, and for time-sensitive indications like urgent surge...

    journal_title：BMC nephrology

    pub_type： 杂志文章

    doi：10.1186/s12882-020-01729-5

    authors： Haninger-Vacariu N,Herkner H,Lorenz M,Säemann M,Vychytil A,Jansen M,Marculescu R,Kramar R,Sunder-Plassmann G,Schmidt A

    更新日期：2020-02-28 00:00:00

  • Effects of educational practices on the peritonitis risk in peritoneal dialysis: a retrospective cohort study with data from the French peritoneal Dialysis registry (RDPLF).

    abstract：BACKGROUND:Peritoneal dialysis (PD) is a home-based therapy performed by patients or their relatives in numerous cases, and the role of patients' educational practices in the risk of peritonitis is not well assessed. Our aim was to evaluate the effect of PD learning methods on the risk of peritonitis. METHODS:This was...

    journal_title：BMC nephrology

    pub_type： 杂志文章

    doi：10.1186/s12882-020-01867-w

    authors： Bonnal H,Bechade C,Boyer A,Lobbedez T,Guillouët S,Verger C,Ficheux M,Lanot A

    更新日期：2020-05-29 00:00:00

  • Serum galectin-9 levels are elevated in the patients with type 2 diabetes and chronic kidney disease.

    abstract：BACKGROUND:Galectin-9 (Gal-9) induces apoptosis in activated T helper 1 (TH1) cells as a ligand for T cell immunoglobulin mucin-3 (Tim-3). Gal-9 also inhibits the G1 phase cell cycle arrest and hypertrophy in db/db mice, the hallmark of early diabetic nephropathy, by reversing the high glucose-induced up-regulation of ...

    journal_title：BMC nephrology

    pub_type： 杂志文章

    doi：10.1186/1471-2369-14-23

    authors： Kurose Y,Wada J,Kanzaki M,Teshigawara S,Nakatsuka A,Murakami K,Inoue K,Terami T,Katayama A,Watanabe M,Higuchi C,Eguchi J,Miyatake N,Makino H

    更新日期：2013-01-22 00:00:00

  • A novel citrate-based protocol versus heparin anticoagulation for sustained low-efficiency dialysis in the ICU: safety, efficacy, and cost.

    abstract：BACKGROUND:The high cost, complexity of the available protocols, and metabolic complications are the major barriers that impede the clinical utilization of regional citrate anticoagulation (RCA) for sustained low efficiency dialysis (SLED) in critically ill patients. By comparing a novel protocol for SLED using 30% cit...

    journal_title：BMC nephrology

    pub_type： 杂志文章

    doi：10.1186/s12882-018-0879-4

    authors： Wen M,Küchle C,Steubl D,Satanovskji R,Heemann U,Suttmann Y,Angermann S,Kemmner S,Rehbehn L,Huber M,Hauser C,Schmaderer C,Reichelt AL,Haller B,Renders L

    更新日期：2018-04-03 00:00:00

  • Development of a health literacy questionnaire for Taiwanese hemodialysis patients.

    abstract：BACKGROUND:Dialysis has long been a critical issue in the field of nephrology, though the burden this lifesaving technology places on society can be immense. Effectively increasing the health literacy of hemodialysis patients can be beneficial for their health outcomes and self-care abilities. Thus, the aims of this st...

    journal_title：BMC nephrology

    pub_type： 杂志文章

    doi：10.1186/s12882-016-0266-y

    authors： Shih CL,Chang TH,Jensen DA,Chiu CH

    更新日期：2016-05-31 00:00:00