Abstract:
BACKGROUND:The aim of this study was to investigate the characteristics and outcomes of patients receiving renal replacement therapy for end-stage kidney disease (ESKD) secondary to haemolytic uraemic syndrome (HUS). METHODS:The study included all patients with ESKD who commenced renal replacement therapy in Australia and New Zealand between 15/5/1963 and 31/12/2010, using data from the ANZDATA Registry. HUS ESKD patients were compared with matched controls with an alternative primary renal disease using propensity scores based on age, gender and treatment era. RESULTS:Of the 58422 patients included in the study, 241 (0.4%) had ESKD secondary to HUS. HUS ESKD was independently associated with younger age, female gender and European race. Compared with matched controls, HUS ESKD was not associated with mortality on renal replacement therapy (adjusted hazard ratio [HR] 1.14, 95% CI 0.87-1.50, p = 0.34) or dialysis (HR 1.34, 95% CI 0.93-1.93, p = 0.12), but did independently predict recovery of renal function (HR 54.01, 95% CI 1.45-11.1, p = 0.008). 130 (54%) HUS patients received 166 renal allografts. Overall renal allograft survival rates were significantly lower for patients with HUS ESKD at 1 year (73% vs 91%), 5 years (62% vs 85%) and 10 years (49% vs 73%). HUS ESKD was an independent predictor of renal allograft failure (HR 2.59, 95% CI 1.70-3.95, p < 0.001). Sixteen (12%) HUS patients experienced failure of 22 renal allografts due to recurrent HUS. HUS ESKD was not independently associated with the risk of death following renal transplantation (HR 0.92, 95% CI 0.35-2.44, p = 0.87). CONCLUSIONS:HUS is an uncommon cause of ESKD, which is associated with comparable patient survival on dialysis, an increased probability of renal function recovery, comparable patient survival post-renal transplant and a heightened risk of renal transplant graft failure compared with matched ESKD controls.
journal_name
BMC Nephroljournal_title
BMC nephrologyauthors
Tang W,Mohandas J,McDonald SP,Hawley CM,Badve SV,Boudville N,Brown FG,Clayton PA,Wiggins KJ,Bannister KM,Campbell SB,Johnson DWdoi
10.1186/1471-2369-13-164subject
Has Abstractpub_date
2012-12-03 00:00:00pages
164issn
1471-2369pii
1471-2369-13-164journal_volume
13pub_type
杂志文章相关文献
BMC Nephrology文献大全abstract:BACKGROUND:Hyperchloremia is common in critically ill septic patients. The impact of hyperchloremia on the incidence of acute kidney injury (AKI) is not well studied. We investigated the association between hyperchloremia and AKI within the first 72 h of intensive care unit (ICU) admission. METHODS:6490 ICU adult pati...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-017-0750-z
更新日期:2017-12-02 00:00:00
abstract:BACKGROUND:Very less is known about health-related quality of life (HRQOL) among patients with kidney diseases in Nepal. This study examined HRQOL among haemodialysis and kidney transplant recipients in Nepal. METHODS:The Nepali version of World Health Organization Quality of Life Instruments -(WHOQOL-BREF) questionna...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-020-02085-0
更新日期:2020-10-12 00:00:00
abstract:BACKGROUND:Cryofibrinogenemia is a rare disorder that mainly affects the skin and occasionally the kidney. However, there are few published reports of cryofibrinogenemia-associated renal pathology. We therefore report a patient with cryofibrinogen-associated glomerulonephritis. Samples from this patient were examined b...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-020-1696-0
更新日期:2020-01-29 00:00:00
abstract:BACKGROUND:Several equations have been developed to estimate glomerular filtration rate (eGFR). The common equations used were derived from populations predominantly comprised of Caucasians with chronic kidney disease (CKD). Some of the equations provide a correction factor for African-Americans due to their relatively...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-017-0788-y
更新日期:2017-12-20 00:00:00
abstract:BACKGROUND:There is a perception that kidney transplant recipients transferred from pediatric centers to adult care have an increased risk of graft loss. It is not clear whether young adults transplanted in adult centers also suffer from high graft loss rates. METHODS:We examined death censored graft survival in 3 coh...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/1471-2369-12-54
更新日期:2011-10-07 00:00:00
abstract:BACKGROUND:Klotho is a transmembrane protein acting as a co-receptor for FGF-23 and thus exerts clinical actions on mineral metabolism. The association of secreted Klotho with outcomes in CKD patients is unclear. This study examined the relation between plasma Klotho and cardiovascular events in dialysis patients, acco...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-019-1391-1
更新日期:2019-06-11 00:00:00
abstract:BACKGROUND:Sclerostin is a paracrine acting factor, which is expressed in the osteocytes and articular chondrocytes. Sclerostin decreases the osteoblast-related bone formation through the inhibition of the Wnt/β-catenin pathway. Osteocytes also express the Calcium sensing receptor which is a target for cinacalcet. The ...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-016-0392-6
更新日期:2016-11-15 00:00:00
abstract:BACKGROUND:Renal proximal tubular sodium and glucose reabsorption are regulated by the sodium-glucose cotransporter (SGLT2). Changes in this transporter can play a role in hyperglycaemia and reactive oxygen species (ROS) production. We demonstrated increased glucose absorption in proximal tubule membrane vesicles and i...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-019-1490-z
更新日期:2019-08-02 00:00:00
abstract:BACKGROUND:Heavy metal poisoning can cause debilitating illness if left untreated, and its management in anuric patients poses challenges. Literature with which to guide clinical practice in this area is rather scattered. CASE PRESENTATION:We present a case of symptomatic lead and arsenic poisoning from use of Ayurved...
journal_title:BMC nephrology
pub_type: 杂志文章,评审
doi:10.1186/s12882-019-1561-1
更新日期:2019-10-17 00:00:00
abstract:BACKGROUND:Renal involvement in patients with chronic hepatitis C virus infection has been suggested to be due to a variety of immunological processes. However, the precise mechanism by which the kidneys are damaged in these patients is still unclear. CASE PRESENTATION:A 66 year old man presented with the sudden onset...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/1471-2369-4-7
更新日期:2003-08-29 00:00:00
abstract:BACKGROUND:Chronic hepatitis B virus (HBV) infection and chronic kidney disease (CKD) have high prevalences in Taiwan and worldwide. However, the association of untreated chronic hepatitis B virus (HBV) infection with chronic kidney disease (CKD) remains unclear. METHODS:This cohort study used claims data in the Taiwa...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-015-0106-5
更新日期:2015-07-22 00:00:00
abstract:BACKGROUND:Little is known about the changes in disease makers and risk factors in patients with chronic kidney disease (CKD) under nephrological care in Africa. This study aimed to evaluate the baseline level of markers of CKD and their 12-month time-trend in newly referred patients in a tertiary hospital in Cameroon....
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-020-01760-6
更新日期:2020-03-18 00:00:00
abstract:BACKGROUND:Autosomal dominant polycystic kidney disease (ADPKD) is one of the most common hereditary kidney diseases that frequently result in renal failure. In this cross-sectional observational cohort study, we evaluated urinary angiotensinogen (AGT) as a potential biomarker to assess renal function in ADPKD. METHOD...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-015-0075-8
更新日期:2015-06-20 00:00:00
abstract:BACKGROUND:Local renal ischemia is regarded as an important factor in the development of contrast-induced nephropathy (CIN). Mannose-binding lectin (MBL) is involved in the tissue damage during experimental ischemia/reperfusion injury of the kidneys. The aim of the present study was to investigate the association of MB...
journal_title:BMC nephrology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/1471-2369-13-99
更新日期:2012-09-03 00:00:00
abstract:BACKGROUND:Primary hyperoxaluria type 1 is a rare autosomal recessive disease of glyoxylate metabolism caused by a defect in the liver-specific peroxisomal enzyme alanine:glyoxylate aminotransferase (AGT) that leads to hyperoxaluria, recurrent urolithiasis, and nephrocalcinosis. METHODS:Two unrelated patients with rec...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/1471-2369-15-92
更新日期:2014-06-17 00:00:00
abstract:BACKGROUND:Cool dialysate is often recommended for prevention of intra-dialytic hypotensive episodes in maintenance hemodialysis (HD) patients. However, its effect on toxin removal is not studied. It is known that inter-compartmental resistance is the main barrier for toxin removal. Cool dialysate can potentially incre...
journal_title:BMC nephrology
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12882-015-0017-5
更新日期:2015-02-27 00:00:00
abstract:BACKGROUND:Cystinosis is a rare autosomal recessive lysosomal disorder characterized by the accumulation of cystine in lysosomes. Cystinosis is much rarer in Asian than Caucasian populations. There are only 14 patients have with cystinosis alive in Japan. Most cystinosis is the nephropathic infantile form, as indicated...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-017-0721-4
更新日期:2017-09-26 00:00:00
abstract:BACKGROUND:Despite improvement in short-term outcome of kidney transplants, the long-term survival of kidney transplants has not changed over past decades. Kidney biopsy is the gold standard of transplant pathology but it's invasive. Quantification of transplant blood flow could provide a novel non-invasive method to e...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-019-1617-2
更新日期:2019-11-27 00:00:00
abstract:BACKGROUND:Inflammatory processes are very important in the development of kidney disease. Nevertheless, the association between white blood cell (WBC) count and the risk of renal dysfunction has not been well-established, especially in subjects without chronic kidney disease (CKD). Our study investigated the associati...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-017-0608-4
更新日期:2017-06-07 00:00:00
abstract:BACKGROUND:A positive pregnancy test in acute or chronically ill patients has implications for the use of potentially mutagenic or teratogenic products in urgent medical therapies such as the use of chemotherapies or therapies with immunosuppressants, for anesthesia, and for time-sensitive indications like urgent surge...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-020-01729-5
更新日期:2020-02-28 00:00:00
abstract::Attention has recently been focused on addressing the problem of acute kidney injury in both the developed and developing world. Little information is actually available on the incidence and management of AKI in low resource settings. Thus, the paper by Bagasha in the current issue of BMC Nephrology makes an important...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/1471-2369-16-5
更新日期:2015-01-16 00:00:00
abstract:BACKGROUND:Chronic kidney disease (CKD) is characterized by dysbiosis, elevated levels of uremic toxins, systemic inflammation, and increased markers of oxidative stress. These factors lead to an increased risk of cardiovascular disease (CVD) which is common among CKD patients. Supplementation with high amylose maize r...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-020-02177-x
更新日期:2020-11-26 00:00:00
abstract:BACKGROUND:Obesity is a well-established risk factor for atherosclerosis. However, it is unknown which measure of adiposity best relates to atherosclerosis in relatively lean maintenance hemodialysis (MHD) patients. We aimed to explore and compare the associations between different adiposity indices reflecting general,...
journal_title:BMC nephrology
pub_type: 杂志文章,多中心研究
doi:10.1186/s12882-018-0996-0
更新日期:2018-08-16 00:00:00
abstract:BACKGROUND:Older patients with end-stage kidney disease (ESKD) often live with unidentified frailty and multimorbidity. Despite guideline recommendations, geriatric assessment is not part of standard clinical care, resulting in a missed opportunity to enhance (clinical) outcomes including quality of life in these patie...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-020-02206-9
更新日期:2021-01-06 00:00:00
abstract:BACKGROUND:Observational studies have demonstrated an association between nephrolithiasis and hypertension. The aim of this meta-analysis was to summarize all available evidence. METHODS:PubMed, EMBASE, the Cochrane Central Register of Controlled Trials databases, and the reference lists of relevant articles were sear...
journal_title:BMC nephrology
pub_type: 杂志文章,meta分析
doi:10.1186/s12882-017-0762-8
更新日期:2017-11-29 00:00:00
abstract:BACKGROUND:Aciduria caused by urinary excretion of acidic metabolic wastes produced in daily life is known to be augmented in patients with chronic kidney disease (CKD). To evaluate the reno-protective effect of oral alkalizing agents for the improvement of metabolic acidosis and neutralization of intratubular pH in th...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-020-01807-8
更新日期:2020-04-22 00:00:00
abstract:BACKGROUND:Emerging evidence of psychosocial problems in CKD patients has led to an acceptance that a focus on the emotional wellbeing of the patient should be included in the provision of comprehensive CKD care. It is unclear if an increased attention for psychosocial needs in guidelines and policy documents has led t...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-019-1287-0
更新日期:2019-03-21 00:00:00
abstract:BACKGROUND:Metabolic acidosis leads to chronic kidney disease (CKD) progression. The guidelines recommend a lower limit of serum bicarbonate level, but no upper limit. For serum bicarbonate level to be clinically useful as a therapeutic target marker, it is necessary to investigate the target serum bicarbonate level wi...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/1471-2369-14-4
更新日期:2013-01-09 00:00:00
abstract:BACKGROUND:Approximately 4-6% of incident end stage renal disease (ESRD) patients in the U.S. recover enough kidney function to discontinue dialysis but there is considerable geographic variation. We undertook this study to investigate whether state-level variations in renal recovery among incident ESRD patients correl...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-019-1483-y
更新日期:2019-09-02 00:00:00
abstract:BACKGROUND:Serum cystatin C (ScysC) may help predicting cardiovascular outcome not only through its ability to detect renal dysfunction but also through its potential connection to others factors that are directly related to cardiovascular diseases. We explored the potential association of ScysC with arterial stiffness...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/1471-2369-15-196
更新日期:2014-12-11 00:00:00