Abstract:
BACKGROUND:Obesity is a well-established risk factor for atherosclerosis. However, it is unknown which measure of adiposity best relates to atherosclerosis in relatively lean maintenance hemodialysis (MHD) patients. We aimed to explore and compare the associations between different adiposity indices reflecting general, abdominal, visceral adiposity and arteriosclerosis risk with atherogenic index of plasma(AIP) in relatively lean MHD patients. METHODS:We conducted a multicenter, cross-sectional study in Guizhou Province, Southwest China. General/abdominal adiposity indices like body mass index (BMI), waist circumference(WC), waist-height ratio(WHtR), conicity index (Ci) and visceral obesity indices including visceral adiposity index (VAI), lipid accumulation product (LAP) and the hypertriglyceridemic waist phenotype (HW phenotype) were recorded. Univariate and multivariate linear regression models were used. RESULTS:All adiposity indices correlated positively with AIP in univariate analysis both in men and women except for Ci. After adjustment for age and traditional atherosclerosis risk factors, BMI, WC, WHtR, VAI and LAP still had associations with AIP both in men (β = 0.265, 0.153, 0.16, 0.788 and 0.74, respectively, all P < 0.001) and women (β = 0.34,0.199, 0.21, 0.83 and 0.74, respectively, all P < 0.001). After further adjustment for BMI, associations between AIP and VAI, LAP remained significant, but associations between WC, WHtR and AIP disappeared. CONCLUSIONS:The HW phenotype, VAI, and LAP, validated and convenient markers of visceral obesity, were superior to classical anthropometric general/ abdominal adiposity indices for atherosclerosis risk assessment, especially in relatively lean MHD patients aged 40 years or older.
journal_name
BMC Nephroljournal_title
BMC nephrologyauthors
Zhou C,Peng H,Yuan J,Lin X,Zha Y,Chen Hdoi
10.1186/s12882-018-0996-0subject
Has Abstractpub_date
2018-08-16 00:00:00pages
206issue
1issn
1471-2369pii
10.1186/s12882-018-0996-0journal_volume
19pub_type
杂志文章,多中心研究相关文献
BMC Nephrology文献大全abstract:BACKGROUND:The management of proliferative lupus nephritis (LN) comprises timely and coordinated immunosuppressive therapy. This study aimed to evaluate and compare the effectiveness and safety profile of low dose mycophenolate mofetil (MMF) and cyclophosphamide (CYC) in induction therapy of LN in Nepalese population. ...
journal_title:BMC nephrology
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12882-018-0973-7
更新日期:2018-07-11 00:00:00
abstract:BACKGROUND:Bordetella pertussis infection is a known trigger of atypical hemolytic uremic syndrome (HUS). For patients suspected of having atypical HUS, prompt plasma exchange/infusion (PE/PI) or eculizumab (ECZ) treatment is recommended. CASE PRESENTATION:We report a 1-month-old female infant who was admitted with a ...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-018-1168-y
更新日期:2018-12-17 00:00:00
abstract:BACKGROUND:Diabetic nephropathy is a global common cause of chronic kidney disease and end-stage renal disease. A lot of research has been conducted in biomedical sciences, which has enhanced understanding of the pathophysiology of diabetic nephropathy and has expanded the potential available therapies. An increasing n...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-019-1590-9
更新日期:2019-10-28 00:00:00
abstract:BACKGROUND:Awareness of the spectrum of clinical manifestations of systemic lupus erythematosus (SLE), especially uncommon changes, is essential for diagnosis and effective management of patients. CASE PRESENTATION:A 26-year-old Chinese man with SLE initially manifested cutaneous papulonodular mucinosis and developed ...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-017-0458-0
更新日期:2017-02-01 00:00:00
abstract:BACKGROUND:MicroRNAs have been demonstrated to play an important role in the pathogenesis of diabetic nephropathy (DN). In this study, we investigated both the repertoire of miRNAs in the kidneys of patients with DN and their potential regulatory role in inflammation-mediated glomerular endothelial injury. METHODS:The...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/1471-2369-15-142
更新日期:2014-09-02 00:00:00
abstract:BACKGROUND:Chronic kidney disease (CKD) is an independent risk factor for cardiovascular disease (CVD) events, and a number of reports have shown a relationship between CKD and CVD in pre-dialysis or maintenance dialysis patients. However, few studies have reported serial observations during dialysis initiation and mai...
journal_title:BMC nephrology
pub_type: 临床试验,杂志文章
doi:10.1186/s12882-017-0495-8
更新日期:2017-02-28 00:00:00
abstract:BACKGROUND:Epithelioid angiomyolipoma is defined as potentially malignant mesenchymal neoplasm, characterized by proliferating epithelioid cells, whereas classic angiomyolipoma, composed of fat, smooth muscle cells and dysmorphic vessels, is defined as a potentially benign. The usual or classic angiomyolipoma is often ...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-018-0919-0
更新日期:2018-05-30 00:00:00
abstract:BACKGROUND:Cardiovascular morbidity and mortality are highly prevalent in patients with end-stage renal disease, and osteoprotegerin (OPG) may be an important link between bone loss and vascular calcification. This study was conducted to evaluate the relationship between central arterial stiffness and serum OPG levels ...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-019-1374-2
更新日期:2019-05-23 00:00:00
abstract:BACKGROUND:Chronic active antibody-mediated rejection is a major etiology of graft loss in renal transplant recipients. However, there is no consensus on the optimal treatment strategies. METHODS:Computerized records from Taichung Veterans General Hospital were collected to identify renal transplant biopsies performed...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-019-1672-8
更新日期:2020-01-06 00:00:00
abstract:BACKGROUND:Efficient and safe delivery of care to dialysis patients is essential. Concerns have been raised regarding the ability of accountable care organizations to adequately serve this high-risk population. Little is known about primary care involvement in the care of dialysis patients. This study sought to describ...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-017-0728-x
更新日期:2017-10-25 00:00:00
abstract:BACKGROUND:Renal artery stenosis is one of the secondary causes of pediatric hypertension. Cases with critical unilateral renal artery stenosis manifesting with the hyponatremic hypertensive syndrome are rare and a comprehensive description of this disorder in the pediatric population is lacking in the literature. CAS...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-019-1246-9
更新日期:2019-02-21 00:00:00
abstract:BACKGROUND:The aim of the study was to assess the association between chronic kidney disease (CKD) and obesity in predicting CKD among Chinese adults, distinguishing between 5 different adiposity indices: visceral fat index (VFI), percentage body fat (PBF), body mass index (BMI), waist circumference (WC) and waist-to-h...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-018-0837-1
更新日期:2018-02-17 00:00:00
abstract:BACKGROUND:Dose selection is an important step in pharmacokinetic (PK) studies of hemodialysis patients. We propose a simulation-based dose-selection method for PK studies of hemodialysis patients using a subpharmacological dose of oseltamivir as a model drug. METHODS:The concentrations of oseltamivir and its active m...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/1471-2369-15-46
更新日期:2014-03-17 00:00:00
abstract:BACKGROUND:Combined peritoneal dialysis (PD) and hemodialysis (HD) therapy (combined therapy) has numerous clinical benefits and should be emphasized for PD patients encountering technique failure. METHODS:This 12-year nationwide retrospective study was conducted to compare long-term outcomes (including admission and ...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-020-01989-1
更新日期:2020-08-15 00:00:00
abstract:BACKGROUND:Hepatocyte growth factor (HGF) counteracts peritoneal fibrosis in animal models and in-vitro studies, but no study explored effluent HGF in peritoneal dialysis (PD) patients with ultrafiltration failure (UFF). Our aim was to assess the relationship between effluent HGF with UF profile, free water transport (...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/1471-2369-15-201
更新日期:2014-12-17 00:00:00
abstract:BACKGROUND:Chronic Kidney Disease is a major public health problem worldwide with enormous cost burdens on health care systems in developing countries. We aimed to provide a detailed analysis of the processes and costs of haemodialysis in Sri Lanka and provide a framework for modeling similar financial audits. METHODS...
journal_title:BMC nephrology
pub_type: 杂志文章,多中心研究
doi:10.1186/1471-2369-12-42
更新日期:2011-09-06 00:00:00
abstract:BACKGROUND:This study describes chronic kidney disease of uncertain aetiology (CKDu), which cannot be attributed to diabetes, hypertension or other known aetiologies, that has emerged in the North Central region of Sri Lanka. METHODS:A cross-sectional study was conducted, to determine the prevalence of and risk factor...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/1471-2369-14-180
更新日期:2013-08-27 00:00:00
abstract:BACKGROUND:The product of the concentrations of urinary tissue inhibitor of metalloproteinases-2 and insulin-like growth factor binding protein-7 (urinary [TIMP-2] × [IGFBP-7]) has been suggested as biomarker for early detection of acute kidney injury (AKI) in various clinical settings. However, the performance of urin...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-019-1456-1
更新日期:2019-07-17 00:00:00
abstract:BACKGROUND:Serum cystatin C (ScysC) may help predicting cardiovascular outcome not only through its ability to detect renal dysfunction but also through its potential connection to others factors that are directly related to cardiovascular diseases. We explored the potential association of ScysC with arterial stiffness...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/1471-2369-15-196
更新日期:2014-12-11 00:00:00
abstract:BACKGROUND:The patient characteristics and mortality associated with autosomal dominant polycystic kidney disease (PKD) have not been characterized for a national sample of end stage renal disease (ESRD) patients on the renal transplant waiting list. METHODS:40,493 patients in the United States Renal Data System who w...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/1471-2369-3-7
更新日期:2002-08-23 00:00:00
abstract:BACKGROUND:Autosomal dominant polycystic kidney disease (ADPKD) is mainly characterised by the development and enlargement of renal cysts that lead to end-stage renal disease (ESRD) in adult patients. Other clinical manifestations of this pathology include hypertension, haematuria, abdominal pain, cardiovascular system...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-019-1540-6
更新日期:2019-09-13 00:00:00
abstract:BACKGROUND:Until now, no long-term studies relating serum albumin level to mortality rate in prevalent haemodialysis (HD) patients have been conducted. We aimed to examine the association between serum albumin level and mortality over a 5-year period. METHODS:This study included 781 patients who received maintenance H...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-016-0332-5
更新日期:2016-08-20 00:00:00
abstract:BACKGROUND:Patients with chronic kidney diseases (CKD) on haemodialysis (HD) have high morbidity and mortality rates, which are also due to the inherent risks associated with nephropathy. Non-adherence (NA) to the different demands of the treatment can have consequences for the outcome of patients undergoing HD; nevert...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-019-1573-x
更新日期:2019-11-06 00:00:00
abstract:BACKGROUND:The purpose of this study was to evaluate the feasibility of utilizing an in-vitro, closed loop hemodialysis system as a method to assess drug clearance. Secondarily, this study tested the influence of variables (blood flow rate, dialysate flow rate, and type of filter) in the hemodialysis procedure on the c...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/1471-2369-15-204
更新日期:2014-12-20 00:00:00
abstract:BACKGROUND:In patients treated by maintenance hemodialysis the relationship to survival of hemoglobin level and administered epoetin-alfa and intravenous iron is controversial. The study aim was to determine effects on patient survival of administered epoetin-alfa and intravenous iron, and of hemoglobin and variables r...
journal_title:BMC nephrology
pub_type: 杂志文章,多中心研究
doi:10.1186/1471-2369-10-6
更新日期:2009-02-26 00:00:00
abstract:BACKGROUND:Tissue derived biomarkers may offer utility as indicators of accumulated damage. Reduced thickness of retinal neuronal tissue and the vascular choroid have previously been associated with vascular damage and diabetes. We evaluated associations between retinal thickness, retinal microvascular and choroidal me...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-019-1679-1
更新日期:2020-01-31 00:00:00
abstract:BACKGROUND:Chronic hepatitis B virus (HBV) infection and chronic kidney disease (CKD) have high prevalences in Taiwan and worldwide. However, the association of untreated chronic hepatitis B virus (HBV) infection with chronic kidney disease (CKD) remains unclear. METHODS:This cohort study used claims data in the Taiwa...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-015-0106-5
更新日期:2015-07-22 00:00:00
abstract:BACKGROUND:FGF23 controls serum l,25(OH)2D3 levels and phosphate homeostasis. This study evaluates the effects of ferritin on intact PTH, FGF23, and l,25(OH)2D3 in patients with major thalassemia. It also evaluates FGF23 changes in patients with hypoparathyroidism to clarify the interaction between FGF23 and PTH in the...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-020-02101-3
更新日期:2020-11-16 00:00:00
abstract:BACKGROUND:Accurate estimation of glomerular filtration rate (GFR) is important for diagnosis and risk stratification in chronic kidney disease and for selection of living donors. Ethnic differences have required correction factors in the originally developed creatinine-based GFR estimation equations for populations ar...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-018-0813-9
更新日期:2018-02-01 00:00:00
abstract:BACKGROUND:Fabry disease (FD) is an X-linked lysosomal storage disorder caused by mutations of the GLA gene, followed by deficiency in α-galactosidase A (α-gal) activity. Nephrotic syndrome, as the renal phenotype of FD, is unusual. Here, we report the rare case of a patient with FD with nephrotic syndrome whose protei...
journal_title:BMC nephrology
pub_type: 杂志文章,评审
doi:10.1186/s12882-019-1657-7
更新日期:2019-12-17 00:00:00