Abstract：
BACKGROUND:Tissue derived biomarkers may offer utility as indicators of accumulated damage. Reduced thickness of retinal neuronal tissue and the vascular choroid have previously been associated with vascular damage and diabetes. We evaluated associations between retinal thickness, retinal microvascular and choroidal measures, and renal function in a population with a high burden of comorbidity. METHODS:Participants were recruited from nuclear cardiology or renal medicine clinics. Retinal and choroidal thickness were measured from spectral-domain optical coherence tomograms. Retinal microvascular parameters were assessed from digital fundus photographs using a semi-automated software package. MAIN OUTCOME MEASURE:Chronic kidney disease (CKD) categorised as: CKD stages 1-2, eGFR ≥60 ml/min/1.73m2; CKD stage 3, eGFR 30-59 ml/min/1.73m2, and CKD stages 4-5, eGFR ≤29 ml/min/1.73m2. RESULTS:Participants (n = 241) had a mean age of 65 years and a mean eGFR of 66.9 ml/min/1.73m2. Thirty-nine % of the cohort had diabetes and 27% were using diuretics. Thinning of the inner retina and changes to its microvascular blood supply were associated with lower eGFR and CKD stages 4 and 5, while no associations were found between the outer retinal layers or their choroidal blood supply and CKD of any stage. These associations remained following adjustment for age, mean arterial blood pressure, diabetes status, low-density lipoprotein, body mass index, and sex. CONCLUSIONS:Inner retinal thinning and retinal microvascular variation is associated with advanced CKD (stages 4 & 5) independent of important confounding factors, but not with earlier stage CKD (stage 3) and, therefore, its utility as a biomarker for early CKD is not supported in this study.
journal_name
BMC Nephroljournal_title
BMC nephrologyauthors
Paterson EN,Ravindran ML,Griffiths K,Le Velly CA,Cardwell CC,McCarter RV,Nicol P,Chhablani JK,Rasheed MA,Vupparaboina KK,MacGillivray TJ,Harbinson M,Maxwell AP,Hogg RE,McKay GJdoi
10.1186/s12882-019-1679-1subject
Has Abstractpub_date
2020-01-31 00:00:00pages
37issue
1issn
1471-2369pii
10.1186/s12882-019-1679-1journal_volume
21pub_type
杂志文章相关文献
BMC Nephrology文献大全abstract：BACKGROUND:Abdominal aortic calcification assessed by X-ray is recommended to evaluate vascular calcification in dialysis patients. It has been shown that abdominal aortic calcification score (AACS) is a predictor of adverse outcomes in hemodialysis patients, but evidence regarding its prognostic value in peritoneal di...
journal_title：BMC nephrology
pub_type： 杂志文章
doi：10.1186/s12882-020-01822-9
更新日期：2020-04-30 00:00:00
abstract：BACKGROUND:The KDIGO Clinical Practice Guidelines for Glomerulonephritis recommended tacrolimus as an alternative regimen for the initial therapy for Idiopathic membranous nephropathy (IMN), however, large observational studies evaluating tacrolimus treatment in IMN remains rare. METHODS:A total of 408 consecutive IMN...
journal_title：BMC nephrology
pub_type： 杂志文章
doi：10.1186/s12882-016-0427-z
更新日期：2017-01-05 00:00:00
abstract：BACKGROUND:Frailty is independently associated with worse health-related quality of life (HRQOL) in chronic kidney disease (CKD). However, the relationship between frailty and symptom experience is not well described in people living with CKD. This study's aim was to evaluate the relationship between frailty and sympto...
journal_title：BMC nephrology
pub_type： 杂志文章
doi：10.1186/s12882-020-02063-6
更新日期：2020-09-23 00:00:00
abstract：BACKGROUND:This study will assess measures of vascular health and inflammation in Aboriginal Australian adults with chronic kidney disease (CKD), and determine if intensive periodontal intervention improves cardiovascular health, progression of renal disease and periodontal health over a 24-month follow-up. METHODS:Th...
journal_title：BMC nephrology
pub_type： 杂志文章,随机对照试验
doi：10.1186/s12882-015-0169-3
更新日期：2015-10-31 00:00:00
abstract：BACKGROUND:Acute kidney injury (AKI) is common in hospitalized human immunodeficiency virus (HIV)-infected patients and is associated with hospital mortality. We aimed to evaluate the impact of AKI on long-term mortality of hospitalized HIV-infected patients. METHODS:Retrospective analysis of a cohort of 433 hospitali...
journal_title：BMC nephrology
pub_type： 杂志文章
doi：10.1186/1471-2369-14-32
更新日期：2013-02-11 00:00:00
abstract：BACKGROUND:Interleukin 17 is a proinflammatory cytokine involved in immune response after allograft transplantation. IL-17 family of proinflammatory cytokines includes IL-17A and IL-17F. Previous studies have demonstrated that the rs2275913 IL17A and the rs11465553 IL17F gene polymorphism are associated with kidney all...
journal_title：BMC nephrology
pub_type： 杂志文章
doi：10.1186/s12882-019-1308-z
更新日期：2019-04-08 00:00:00
abstract：BACKGROUND:Providing patient-centered care needs in patients with chronic renal failure undergoing hemodialysis is important in inspiring their confidence to continue their treatment and promote their mental and social health. Therefore, recognizing the concept of care from the viewpoint of these patients can be helpfu...
journal_title：BMC nephrology
pub_type： 杂志文章
doi：10.1186/s12882-018-1138-4
更新日期：2018-11-26 00:00:00
abstract：BACKGROUND:Anabolic-androgenic steroids and growth hormone are among the most commonly used supplements by sportsmen and sportswomen. The aim of this systematic review is to collect and report available data about renal safety of anabolic-androgenic steroids and growth hormone (GH). METHODS:The search strategy was in ...
journal_title：BMC nephrology
pub_type： 杂志文章
doi：10.1186/s12882-019-1384-0
更新日期：2019-05-31 00:00:00
abstract：BACKGROUND:Health-Related Quality of Life (HRQoL) assessment after kidney transplantation has become an important tool in evaluating outcomes. This study aims to identify the associated factors with HRQoL among a representative sample size of Kidney Transplant Recipients (KTR) at the time of their inclusion in the stud...
journal_title：BMC nephrology
pub_type： 杂志文章,多中心研究
doi：10.1186/s12882-018-0893-6
更新日期：2018-04-27 00:00:00
abstract：BACKGROUND:Sickle cell trait is not completely benign, and some renal complications can occur. The baseline rate of admission for gross hematuria in normal males carrying the sickle cell trait is 2%. CASE PRESENTATION:A 35-year-old non-smoking African man experienced a 2-week history of painless, profuse and persisten...
journal_title：BMC nephrology
pub_type： 杂志文章
doi：10.1186/s12882-018-0939-9
更新日期：2018-06-08 00:00:00
abstract：BACKGROUND:Anaemia is common in haemodialysis (HD) patients and associated with significant morbidity and mortality. Intravenous (IV) iron combined with erythropoiesis-stimulating agents (ESA) is the mainstay treatment of anaemia in these patients. The comparative efficacy and risk of adverse events with IV iron prepar...
journal_title：BMC nephrology
pub_type： 杂志文章
doi：10.1186/s12882-020-01866-x
更新日期：2020-06-03 00:00:00
abstract：BACKGROUND:Anaemia is a known risk factor for cardiovascular disease and treating anaemia in chronic kidney disease (CKD) may improve outcomes. However, little is known about the scope to improve primary care management of anaemia in CKD. METHODS:An observational study (N = 1,099,292) with a nationally representative ...
journal_title：BMC nephrology
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1186/1471-2369-14-24
更新日期：2013-01-25 00:00:00
abstract：BACKGROUND:Rehabilitation effects of exercise training on adults with chronic kidney disease (CKD) have been generally recognised; however, the effects of exercise training on proteinuria have been underexplored. Our aim was to explore the effects of exercise training on proteinuria in adult CKD patients without renal ...
journal_title：BMC nephrology
pub_type： 杂志文章
doi：10.1186/s12882-020-01816-7
更新日期：2020-05-11 00:00:00
abstract：BACKGROUND:There is limited evidence on the relationship between social support and renal outcomes in African Americans. We sought to determine the association of social support with prevalent chronic kidney disease (CKD) and kidney function decline in an African American cohort. We also examined whether age modifies t...
journal_title：BMC nephrology
pub_type： 杂志文章
doi：10.1186/s12882-019-1432-9
更新日期：2019-07-15 00:00:00
abstract：BACKGROUND:Physical activity (PA) is exceptionally low amongst the haemodialysis (HD) population, and physical inactivity is a powerful predictor of mortality, making it a prime focus for intervention. Objective measurement of PA using accelerometers is increasing, but standard reporting guidelines essential to effecti...
journal_title：BMC nephrology
pub_type： 杂志文章
doi：10.1186/s12882-019-1634-1
更新日期：2019-12-04 00:00:00
abstract：BACKGROUND:Non-tunneled (temporary) hemodialysis catheters (NTHCs) are the least-optimal initial vascular access for incident maintenance hemodialysis patients yet little is known about factors associated with NTHC use in this context. We sought to determine factors associated with NTHC use and examine regional and fac...
journal_title：BMC nephrology
pub_type： 杂志文章
doi：10.1186/s12882-016-0236-4
更新日期：2016-02-27 00:00:00
abstract：BACKGROUND:The objective of the study was to examine overall anemia management trends in non-dialysis patients with chronic kidney disease (CKD) from 2006 to 2015, and to evaluate the impact of Trial to Reduced Cardiovascular Events with Ananesp Therapy (TREAT)'s study results (October 2009) and the US Food and Drug Ad...
journal_title：BMC nephrology
pub_type： 杂志文章
doi：10.1186/s12882-018-1119-7
更新日期：2018-11-09 00:00:00
abstract：BACKGROUND:Residing remotely from health care resources appears to impact quality of care delivery. It remains unclear if there are differences in vascular access based on distance of one's residence to dialysis centre at time of dialysis initiation, and whether region or duration of pre-dialysis care are important eff...
journal_title：BMC nephrology
pub_type： 杂志文章
doi：10.1186/1471-2369-15-40
更新日期：2014-02-27 00:00:00
abstract：BACKGROUND:Kidney impairment constitutes severe risk for cardiovascular disease, stroke and all-cause mortality, and early identification and prevention of kidney impairment is critical to effective management of prognostic risk in community residents. Previous studies have validated that carotid-femoral pulse wave vel...
journal_title：BMC nephrology
pub_type： 杂志文章
doi：10.1186/s12882-018-0897-2
更新日期：2018-05-02 00:00:00
abstract：BACKGROUND:We sought to investigate the relationships among the plasma levels of carotenoids, tocopherols, endogenous antioxidants, oxidative damage and lipid profiles and their possible effects on the cardiovascular risk associated with hemodialysis (HD) patients. METHODS:The study groups were divided into HD and hea...
journal_title：BMC nephrology
pub_type： 杂志文章
doi：10.1186/1471-2369-12-59
更新日期：2011-10-26 00:00:00
abstract：BACKGROUND:The use of the Internet for searching and sharing health information and for health care interactions may have a great potential for Renal Transplant Recipients (RTR). This study aims to determine the characteristics associated with Internet and social network use in a representative sample of RTR at the tim...
journal_title：BMC nephrology
pub_type： 杂志文章,多中心研究
doi：10.1186/s12882-017-0670-y
更新日期：2017-08-03 00:00:00
abstract：BACKGROUND:Acute kidney injury (AKI) is a serious clinical problem with high rate of mortality and morbidity. Currently used prophylactic and therapeutic strategies to address AKI are limited and warrant further studies. In the present study an attempt was made to investigate the effect of quinacrine, a phospholipase A...
journal_title：BMC nephrology
pub_type： 杂志文章
doi：10.1186/s12882-017-0450-8
更新日期：2017-01-28 00:00:00
abstract：BACKGROUND:HS219 (40 mg chitosan-loaded chewing gum) is designed to bind salivary phosphorus as an add-on to available phosphorus binders. We performed a randomized, placebo-controlled, double-blind study to evaluate the efficacy and safety of HS219 in hemodialysis (HD) patients with hyperphosphatemia as an add-on to p...
journal_title：BMC nephrology
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1186/1471-2369-15-98
更新日期：2014-06-25 00:00:00
abstract：BACKGROUND:Renal injury is a serious complication after cardiac surgery and therefore, early detection and much more prediction of postoperative kidney injury is desirable. Neutrophil gelatinase-associated lipocalin (NGAL) is a predictive biomarker of acute kidney injury and may increase after cardiopulmonary bypass (C...
journal_title：BMC nephrology
pub_type： 杂志文章
doi：10.1186/s12882-017-0479-8
更新日期：2017-02-21 00:00:00
abstract：BACKGROUND:The short-term efficacy of tolvaptan in patients with autosomal dominant polycystic kidney disease (ADPKD) has been demonstrated across several phase 3 trials, while the ADPKD Outcomes Model (ADPKD-OM) represents a validated approach to predict natural disease progression over a lifetime horizon. This study ...
journal_title：BMC nephrology
pub_type： 杂志文章,随机对照试验
doi：10.1186/s12882-019-1290-5
更新日期：2019-04-23 00:00:00
abstract：BACKGROUND:Endothelial dysfunction occurs in patients with end-stage renal disease (ESRD) and is associated with increased cardiovascular morbidity and mortality. Asymmetric dimethylarginine (ADMA) contributes to endothelial dysfunction in ESRD. In the general population, angiotensin-converting enzyme (ACE) inhibitors ...
journal_title：BMC nephrology
pub_type： 杂志文章,随机对照试验
doi：10.1186/s12882-015-0162-x
更新日期：2015-10-22 00:00:00
abstract：BACKGROUND:Combined peritoneal dialysis (PD) and hemodialysis (HD) therapy (combined therapy) has numerous clinical benefits and should be emphasized for PD patients encountering technique failure. METHODS:This 12-year nationwide retrospective study was conducted to compare long-term outcomes (including admission and ...
journal_title：BMC nephrology
pub_type： 杂志文章
doi：10.1186/s12882-020-01989-1
更新日期：2020-08-15 00:00:00
abstract：BACKGROUND:Glomerular filtration rate (GFR) is the best index of renal function, but age, gender and ethnicity can putatively affect its values. The aim of this study was to establish reference values for GFR in healthy Brazilian subjects while taking these factors into account. METHODS:In this cross-sectional study, ...
journal_title：BMC nephrology
pub_type： 杂志文章
doi：10.1186/1471-2369-14-54
更新日期：2013-02-28 00:00:00
abstract：BACKGROUND:The patterns, performance characteristics, and yield of diagnostic tests ordered for the evaluation of acute kidney injury (AKI) have not been rigorously evaluated. METHODS:We characterized the frequency of AKI diagnostic testing for urine, blood, radiology, and pathology tests in all adult inpatients who w...
journal_title：BMC nephrology
pub_type： 杂志文章
doi：10.1186/s12882-016-0224-8
更新日期：2016-01-15 00:00:00
abstract：BACKGROUND:Variants in CUBN, the gene encoding cubilin, a proximal tubular transport protein, have been associated with albuminuria and vitamin B12 (B12) deficiency. We hypothesized that low levels of B12 would be associated with albuminuria in a population-based cohort. METHODS:We analyzed participants from the Frami...
journal_title：BMC nephrology
pub_type： 杂志文章
doi：10.1186/1471-2369-16-7
更新日期：2015-02-02 00:00:00
