Reference values for glomerular filtration rate in healthy Brazilian adults.

Abstract:

BACKGROUND:Glomerular filtration rate (GFR) is the best index of renal function, but age, gender and ethnicity can putatively affect its values. The aim of this study was to establish reference values for GFR in healthy Brazilian subjects while taking these factors into account. METHODS:In this cross-sectional study, GFR was measured by the 51Cr-EDTA single-injection method. GFR reference values were developed according to CLSI Guidelines for Defining, Establishing, and Verifying Reference Intervals in the Clinical Laboratory (CLSI C28 protocol). RESULTS:The age range of the 285 healthy individuals was 19 to 70  years, 57% were females, and GFR was 106 ± 18 mL/min/1.73 m(2). There was no difference between male and female GFRs (108 ± 18 vs. 104 ± 18 mL/min/1.73 m(2) respectively, P = 0.134), and reference values were therefore developed from the pooled sample. GFR values were lower in subjects aged ≥45 years as compared with those younger than 45 years (98 ± 15 vs.112 ± 18 mL/min/1.73 m(2), P < 0.001). Based on mean ± 2 SD, GFR reference values were 76 to 148 mL/min/1.73 m(2) for subjects younger than 45 years and 68 to 128 mL/min/1.73 m(2) for individuals older than 45 years, irrespective of gender. CONCLUSION:The age-adjusted reference intervals reported may be reliably adopted to evaluate kidney function, since they are based on recommended standards.

journal_name

BMC Nephrol

journal_title

BMC nephrology

authors

Soares AA,Prates AB,Weinert LS,Veronese FV,de Azevedo MJ,Silveiro SP

doi

10.1186/1471-2369-14-54

subject

Has Abstract

pub_date

2013-02-28 00:00:00

pages

54

issn

1471-2369

pii

1471-2369-14-54

journal_volume

14

pub_type

杂志文章
  • Treatment with cinacalcet increases plasma sclerostin concentration in hemodialysis patients with secondary hyperparathyroidism.

    abstract:BACKGROUND:Sclerostin is a paracrine acting factor, which is expressed in the osteocytes and articular chondrocytes. Sclerostin decreases the osteoblast-related bone formation through the inhibition of the Wnt/β-catenin pathway. Osteocytes also express the Calcium sensing receptor which is a target for cinacalcet. The ...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-016-0392-6

    authors: Kuczera P,Adamczak M,Więcek A

    更新日期:2016-11-15 00:00:00

  • Calciphylaxis epidemiology, risk factors, treatment and survival among French chronic kidney disease patients: a case-control study.

    abstract:BACKGROUND:Calcific Uremic Arteriolopathy (CUA) is a rare disease, causing painful skin ulcers in patients with end stage renal disease. Recommendations for CUA management and treatment are lacking. METHODS:We conducted a retrospective cohort study on CUA cases identified in western France, in order to describe its ma...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-020-01722-y

    authors: Gaisne R,Péré M,Menoyo V,Hourmant M,Larmet-Burgeot D

    更新日期:2020-02-26 00:00:00

  • High prevalence of undiagnosed chronic kidney disease among at-risk population in Kinshasa, the Democratic Republic of Congo.

    abstract:BACKGROUND:There is limited knowledge of Chronic Kidney Disease (CKD) among high risk populations, especially in the developing countries. We report our study of testing for CKD in at-risk subjects. METHODS:In a cross-sectional study, 527 people from primary and secondary health care areas in the city of Kinshasa were...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/1471-2369-10-18

    authors: Sumaili EK,Cohen EP,Zinga CV,Krzesinski JM,Pakasa NM,Nseka NM

    更新日期:2009-07-21 00:00:00

  • Trends in anemia care in non-dialysis-dependent chronic kidney disease (CKD) patients in the United States (2006-2015).

    abstract:BACKGROUND:The objective of the study was to examine overall anemia management trends in non-dialysis patients with chronic kidney disease (CKD) from 2006 to 2015, and to evaluate the impact of Trial to Reduced Cardiovascular Events with Ananesp Therapy (TREAT)'s study results (October 2009) and the US Food and Drug Ad...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-018-1119-7

    authors: Park H,Liu X,Henry L,Harman J,Ross EA

    更新日期:2018-11-09 00:00:00

  • The role of klotho in chronic kidney disease.

    abstract::Chronic kidney disease (CKD) is an inherently systemic disease that refers to a long-term loss of kidney function. The progression of CKD has repercussions for other organs, leading to many kinds of extrarenal complications. Intensive studies are now being undertaken to reveal the risk factors and pathophysiological m...

    journal_title:BMC nephrology

    pub_type: 杂志文章,评审

    doi:10.1186/s12882-018-1094-z

    authors: Zou D,Wu W,He Y,Ma S,Gao J

    更新日期:2018-10-22 00:00:00

  • Characteristic electron-microscopic features of cryofibrinogen-associated glomerulonephritis: a case report.

    abstract:BACKGROUND:Cryofibrinogenemia is a rare disorder that mainly affects the skin and occasionally the kidney. However, there are few published reports of cryofibrinogenemia-associated renal pathology. We therefore report a patient with cryofibrinogen-associated glomerulonephritis. Samples from this patient were examined b...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-020-1696-0

    authors: Ibuki E,Shiraishi A,Sofue T,Kushida Y,Kadota K,Honda K,Kang D,Joh K,Minamino T,Haba R

    更新日期:2020-01-29 00:00:00

  • Comparison of different anticoagulation strategies for renal replacement therapy in critically ill patients with COVID-19: a cohort study.

    abstract:BACKGROUND:Critically ill coronavirus disease 2019 (COVID-19) patients have a high risk of acute kidney injury (AKI) that requires renal replacement therapy (RRT). A state of hypercoagulability reduces circuit life spans. To maintain circuit patency and therapeutic efficiency, an optimized anticoagulation strategy is n...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-020-02150-8

    authors: Arnold F,Westermann L,Rieg S,Neumann-Haefelin E,Biever PM,Walz G,Kalbhenn J,Tanriver Y

    更新日期:2020-11-16 00:00:00

  • Perspectives and experiences of patients and healthcare professionals with geriatric assessment in chronic kidney disease: a qualitative study.

    abstract:BACKGROUND:Older patients with end-stage kidney disease (ESKD) often live with unidentified frailty and multimorbidity. Despite guideline recommendations, geriatric assessment is not part of standard clinical care, resulting in a missed opportunity to enhance (clinical) outcomes including quality of life in these patie...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-020-02206-9

    authors: Voorend CGN,Berkhout-Byrne NC,Meuleman Y,Mooijaart SP,Bos WJW,van Buren M

    更新日期:2021-01-06 00:00:00

  • The importance of iron in long-term survival of maintenance hemodialysis patients treated with epoetin-alfa and intravenous iron: analysis of 9.5 years of prospectively collected data.

    abstract:BACKGROUND:In patients treated by maintenance hemodialysis the relationship to survival of hemoglobin level and administered epoetin-alfa and intravenous iron is controversial. The study aim was to determine effects on patient survival of administered epoetin-alfa and intravenous iron, and of hemoglobin and variables r...

    journal_title:BMC nephrology

    pub_type: 杂志文章,多中心研究

    doi:10.1186/1471-2369-10-6

    authors: Pollak VE,Lorch JA,Shukla R,Satwah S

    更新日期:2009-02-26 00:00:00

  • Cohort profile: Canadian study of prediction of death, dialysis and interim cardiovascular events (CanPREDDICT).

    abstract:BACKGROUND:The Canadian Study of Prediction of Death, Dialysis and Interim Cardiovascular Events (CanPREDDICT) is a large, prospective, pan-Canadian, cohort study designed to improve our understanding of determinants of renal and cardiovascular (CV) disease progression in patients with chronic kidney disease (CKD). The...

    journal_title:BMC nephrology

    pub_type: 杂志文章,多中心研究

    doi:10.1186/1471-2369-14-121

    authors: Levin A,Rigatto C,Brendan B,Madore F,Muirhead N,Holmes D,Clase CM,Tang M,Djurdjev O,CanPREDDICT investigators.

    更新日期:2013-06-11 00:00:00

  • A need-based approach to self-management education for adults with co-morbid diabetes and chronic kidney disease.

    abstract:BACKGROUND:Self-management education needs have not been assessed in patients with complex co-morbid conditions such as diabetes and chronic kidney disease (CKD). The objectives of this study were to 1) determine the self-management education needs for patients with co-morbid diabetes and CKD and 2) co-develop an educa...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-019-1296-z

    authors: Zimbudzi E,Lo C,Kerr PG,Zoungas S

    更新日期:2019-04-02 00:00:00

  • Persistent nasal methicillin-resistant staphylococcus aureus carriage in hemodialysis outpatients: a predictor of worse outcome.

    abstract:BACKGROUND:Nasal colonization with methicillin-resistant Staphylococcus aureus (MRSA) is a well defined risk factor for subsequent bacteremia and death in various groups of patients, but its impact on outcome in patients receiving long-term hemodialysis (HD) is under debate. METHODS:This prospective interventional coh...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/1471-2369-14-93

    authors: Schmid H,Romanos A,Schiffl H,Lederer SR

    更新日期:2013-04-23 00:00:00

  • Evaluating the prevalence and opportunity for technology use in chronic kidney disease patients: a cross-sectional study.

    abstract:BACKGROUND:Chronic kidney disease (CKD) is increasing worldwide and early education to improve adherence to self-management is a key strategy to slow CKD progression. The use of the internet and mobile phone technologies (mHealth) to support patients is considered an effective tool in many other chronic disease populat...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-018-0830-8

    authors: Bonner A,Gillespie K,Campbell KL,Corones-Watkins K,Hayes B,Harvie B,Kelly JT,Havas K

    更新日期:2018-02-02 00:00:00

  • Effectiveness of immunosuppressive therapy for nephrotic syndrome in a patient with late-onset Fabry disease: a case report and literature review.

    abstract:BACKGROUND:Fabry disease (FD) is an X-linked lysosomal storage disorder caused by mutations of the GLA gene, followed by deficiency in α-galactosidase A (α-gal) activity. Nephrotic syndrome, as the renal phenotype of FD, is unusual. Here, we report the rare case of a patient with FD with nephrotic syndrome whose protei...

    journal_title:BMC nephrology

    pub_type: 杂志文章,评审

    doi:10.1186/s12882-019-1657-7

    authors: Fujisawa H,Nakayama Y,Nakao S,Yamamoto R,Kurokawa Y,Nakamura N,Nagata A,Tsukimura T,Togawa T,Sakuraba H,Fukami K

    更新日期:2019-12-17 00:00:00

  • RhoA deficiency disrupts podocyte cytoskeleton and induces podocyte apoptosis by inhibiting YAP/dendrin signal.

    abstract:BACKGROUND:Podocyte apoptosis is a major mechanism that leads to proteinuria in many kidney diseases. However, the concert mechanisms that cause podocyte apoptosis in these kidney diseases are not fully understood. RhoA is one of Rho GTPases that has been well studied and plays a key role in regulating cytoskeletal arc...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-016-0287-6

    authors: Huang Z,Zhang L,Chen Y,Zhang H,Yu C,Zhou F,Zhang Z,Jiang L,Li R,Ma J,Li Z,Lai Y,Lin T,Zhao X,Zhang Q,Zhang B,Ye Z,Liu S,Wang W,Liang X,Liao R,Shi W

    更新日期:2016-07-07 00:00:00

  • Early detection and intervention using neutrophil gelatinase-associated lipocalin (NGAL) may improve renal outcome of acute contrast media induced nephropathy: a randomized controlled trial in patients undergoing intra-arterial angiography (ANTI-CIN Study

    abstract:BACKGROUND:Patients with pre-existing impaired renal function are prone to develop acute contrast media induced nephropathy (CIN). Neutrophil gelatinase-associated lipocalin (NGAL), a new biomarker predictive for acute kidney injury (AKI), has been shown to be useful for earlier diagnosis of CIN; however, urinary NGAL ...

    journal_title:BMC nephrology

    pub_type: 杂志文章,随机对照试验

    doi:10.1186/1471-2369-12-39

    authors: Schilcher G,Ribitsch W,Otto R,Portugaller RH,Quehenberger F,Truschnig-Wilders M,Zweiker R,Stiegler P,Brodmann M,Weinhandl K,Horina JH

    更新日期:2011-08-17 00:00:00

  • Acute kidney injury in patients with myocardial infarction undergoing percutaneous coronary intervention using radial versus femoral access.

    abstract:BACKGROUND:Data on radial access (RA) as an independent risk factor for acute kidney injury (AKI) in myocardial infarction (MI) patients are conflicting. Our aim was to assess how RA influences the incidence of AKI in MI patients undergoing percutaneous coronary intervention (PCI). METHODS:Data from 3842 MI patients u...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-019-1210-8

    authors: Kanic V,Kompara G,Šuran D,Tapajner A,Naji FH,Sinkovic A

    更新日期:2019-01-30 00:00:00

  • Patient-reported non-adherence and immunosuppressant trough levels are associated with rejection after renal transplantation.

    abstract:BACKGROUND:Different measures of non-adherence to immunosuppressant (IS) medication have been found to be associated with rejection episodes after successful transplantation. The aim of the current study was to investigate whether graft rejection after renal transplantation is associated with patient-reported IS medica...

    journal_title:BMC nephrology

    pub_type: 杂志文章,多中心研究

    doi:10.1186/s12882-017-0517-6

    authors: Scheel J,Reber S,Stoessel L,Waldmann E,Jank S,Eckardt KU,Grundmann F,Vitinius F,de Zwaan M,Bertram A,Erim Y

    更新日期:2017-03-29 00:00:00

  • Clinical pharmacy activities in chronic kidney disease and end-stage renal disease patients: a systematic literature review.

    abstract:BACKGROUND:Chronic kidney disease (CKD) and end-stage renal disease (ESRD) represent worldwide health problems with an epidemic extent. Therefore, attention must be given to the optimisation of patient care, as gaps in the care of CKD and ESRD patients are well documented. As part of a multidisciplinary patient care st...

    journal_title:BMC nephrology

    pub_type: 杂志文章,评审

    doi:10.1186/1471-2369-12-35

    authors: Stemer G,Lemmens-Gruber R

    更新日期:2011-07-22 00:00:00

  • Temporal validation of the CT-PIRP prognostic model for mortality and renal replacement therapy initiation in chronic kidney disease patients.

    abstract:BACKGROUND:A classification tree model (CT-PIRP) was developed in 2013 to predict the annual renal function decline of patients with chronic kidney disease (CKD) participating in the PIRP (Progetto Insufficienza Renale Progressiva) project, which involves thirteen Nephrology Hospital Units in Emilia-Romagna (Italy). Th...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-019-1345-7

    authors: Gibertoni D,Rucci P,Mandreoli M,Corradini M,Martelli D,Russo G,Mancini E,Santoro A

    更新日期:2019-05-17 00:00:00

  • Chronic kidney disease of uncertain aetiology: prevalence and causative factors in a developing country.

    abstract:BACKGROUND:This study describes chronic kidney disease of uncertain aetiology (CKDu), which cannot be attributed to diabetes, hypertension or other known aetiologies, that has emerged in the North Central region of Sri Lanka. METHODS:A cross-sectional study was conducted, to determine the prevalence of and risk factor...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/1471-2369-14-180

    authors: Jayatilake N,Mendis S,Maheepala P,Mehta FR,CKDu National Research Project Team.

    更新日期:2013-08-27 00:00:00

  • Effect of tolvaptan on renal water and sodium excretion and blood pressure during nitric oxide inhibition: a dose-response study in healthy subjects.

    abstract:BACKGROUND:Tolvaptan is a selective vasopressin receptor antagonist. Nitric Oxide (NO) promotes renal water and sodium excretion, but the effect is unknown in the nephron's principal cells. In a dose-response study, we measured the effect of tolvaptan on renal handling of water and sodium and systemic hemodynamics, dur...

    journal_title:BMC nephrology

    pub_type: 杂志文章,随机对照试验

    doi:10.1186/s12882-017-0501-1

    authors: Al Therwani S,Rosenbæk JB,Mose FH,Bech JN,Pedersen EB

    更新日期:2017-03-13 00:00:00

  • Association between 24-hour blood pressure variability and chronic kidney disease: a cross-sectional analysis of African Americans participating in the Jackson heart study.

    abstract:BACKGROUND:Studies suggest 24-h blood pressure (BP) variability has prognostic value for cardiovascular disease. Several factors associated with high 24-h BP variability are also common among individuals with chronic kidney disease (CKD). We hypothesized 24-h BP variability would be higher for individuals with versus w...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-015-0085-6

    authors: Tanner RM,Shimbo D,Dreisbach AW,Carson AP,Fox ER,Muntner P

    更新日期:2015-06-18 00:00:00

  • Treatment of hemolytic uremic syndrome related to Bordetella pertussis infection -is plasma exchange or eculizumab use necessary?

    abstract:BACKGROUND:Bordetella pertussis infection is a known trigger of atypical hemolytic uremic syndrome (HUS). For patients suspected of having atypical HUS, prompt plasma exchange/infusion (PE/PI) or eculizumab (ECZ) treatment is recommended. CASE PRESENTATION:We report a 1-month-old female infant who was admitted with a ...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-018-1168-y

    authors: Saida K,Ogura M,Kano Y,Ishimori S,Yoshikawa T,Nagata H,Sato M,Kamei K,Ishikura K

    更新日期:2018-12-17 00:00:00

  • A model to predict disease progression in patients with autosomal dominant polycystic kidney disease (ADPKD): the ADPKD Outcomes Model.

    abstract:BACKGROUND:Autosomal dominant polycystic kidney disease (ADPKD) is the leading inheritable cause of end-stage renal disease (ESRD); however, the natural course of disease progression is heterogeneous between patients. This study aimed to develop a natural history model of ADPKD that predicted progression rates and long...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-017-0804-2

    authors: McEwan P,Bennett Wilton H,Ong ACM,Ørskov B,Sandford R,Scolari F,Cabrera MV,Walz G,O'Reilly K,Robinson P

    更新日期:2018-02-13 00:00:00

  • Diagnostic value of urine sCD163 levels for sepsis and relevant acute kidney injury: a prospective study.

    abstract:BACKGROUND:Sepsis is a common syndrome in critically ill patients and easily leads to the occurrence of acute kidney injury (AKI), with high mortality rates. This study aimed to investigate the diagnostic value of urine soluble CD163 (sCD163) for identification of sepsis, severity of sepsis, and for secondary AKI, and ...

    journal_title:BMC nephrology

    pub_type: 临床试验,杂志文章

    doi:10.1186/1471-2369-13-123

    authors: Su L,Feng L,Liu C,Jiang Z,Li M,Xiao K,Yan P,Jia Y,Feng D,Xie L

    更新日期:2012-09-26 00:00:00

  • Beyond dialysis decisions: a qualitative exploration of decision-making among culturally and linguistically diverse adults with chronic kidney disease on haemodialysis.

    abstract:BACKGROUND:To date, limited research has been dedicated to exploring the experience of decision-making for chronic kidney disease (CKD) patients who have initiated dialysis and have to make decisions in the context of managing multiple illnesses. Evidence about the experience of decision-making for minority or disadvan...

    journal_title:BMC nephrology

    pub_type: 杂志文章,多中心研究

    doi:10.1186/s12882-018-1131-y

    authors: Muscat DM,Kanagaratnam R,Shepherd HL,Sud K,McCaffery K,Webster A

    更新日期:2018-11-27 00:00:00

  • Nephrolithiasis and risk of hypertension: a meta-analysis of observational studies.

    abstract:BACKGROUND:Observational studies have demonstrated an association between nephrolithiasis and hypertension. The aim of this meta-analysis was to summarize all available evidence. METHODS:PubMed, EMBASE, the Cochrane Central Register of Controlled Trials databases, and the reference lists of relevant articles were sear...

    journal_title:BMC nephrology

    pub_type: 杂志文章,meta分析

    doi:10.1186/s12882-017-0762-8

    authors: Shang W,Li Y,Ren Y,Yang Y,Li H,Dong J

    更新日期:2017-11-29 00:00:00

  • The costs in provision of haemodialysis in a developing country: a multi-centered study.

    abstract:BACKGROUND:Chronic Kidney Disease is a major public health problem worldwide with enormous cost burdens on health care systems in developing countries. We aimed to provide a detailed analysis of the processes and costs of haemodialysis in Sri Lanka and provide a framework for modeling similar financial audits. METHODS...

    journal_title:BMC nephrology

    pub_type: 杂志文章,多中心研究

    doi:10.1186/1471-2369-12-42

    authors: Ranasinghe P,Perera YS,Makarim MF,Wijesinghe A,Wanigasuriya K

    更新日期:2011-09-06 00:00:00

  • Effects of uremic solutes on reactive oxygen species in vitro model systems as a possibility of support the renal function management.

    abstract:BACKGROUND:In view of the prevalence of oxidative stress in chronic kidney disease (CKD) patients, the loss of low-molecular-weight biomolecules by hemodialysis and the antioxidant potential of some uremic solutes that accumulate in CKD, we used in vitro model systems to test the antioxidant potential of the following ...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-015-0029-1

    authors: Assis RP,Castro JF,Gutierres VO,Arcaro CA,Brotto RS,Oliveira OM,Baviera AM,Brunetti IL

    更新日期:2015-04-11 00:00:00