The role of klotho in chronic kidney disease.

abstract：BACKGROUND:Seasonal mortality differences have been reported in US hemodialysis (HD) patients. Here we examine the effect of seasons on mortality, clinical and laboratory parameters on a global scale. METHODS:Databases from the international Monitoring Dialysis Outcomes (MONDO) consortium were queried to identify pati...

journal_title：BMC nephrology

authors： Guinsburg AM,Usvyat LA,Etter M,Xu X,Thijssen S,Marcelli D,Canaud B,Marelli C,Barth C,Wang Y,Carioni P,van der Sande FM,Kotanko P,Kooman JP,Monitoring Dialysis Outcomes (MONDO) consortium.

更新日期：2015-08-14 00:00:00

abstract：BACKGROUND:Patients with an impaired renal function show a high incidence of bone and mineral disturbances. These 'chronic kidney disease - mineral and bone disorders' (CKD-MBD) range from high turnover osteoporosis to adynamic bone disease. Currently, the histomorphometric analysis of a bone biopsy taken from the ilia...

journal_title：BMC nephrology

authors： Hiller RG,Patecki M,Neunaber C,Reifenrath J,Kielstein JT,Kielstein H

更新日期：2017-04-13 00:00:00

abstract：BACKGROUND:Renal involvement in patients with chronic hepatitis C virus infection has been suggested to be due to a variety of immunological processes. However, the precise mechanism by which the kidneys are damaged in these patients is still unclear. CASE PRESENTATION:A 66 year old man presented with the sudden onset...

journal_title：BMC nephrology

authors： Ohsawa I,Uehara Y,Hashimoto S,Endo M,Fujita T,Ohi H

更新日期：2003-08-29 00:00:00

abstract：BACKGROUND:Patients with end-stage renal disease (ESRD) exhibit a premature aging phenotype of immune system, which is recently concerned as a significant factor for increased risk of various morbidities. Nevertheless, there are few dates explicating the relevancy of T cell senescence to mortality. In this study, we pr...

journal_title：BMC nephrology

authors： Xiang F,Chen R,Cao X,Shen B,Chen X,Ding X,Zou J

更新日期：2020-07-13 00:00:00

abstract：BACKGROUND:The end stage renal disease population has a 20 fold higher incidence of cardiovascular mortality compared to the overall population. The development of reno-cardiac syndrome in these patients will result in cardiovascular events to be the cause of 50% of fatalities. There is therefore a need to research imp...

journal_title：BMC nephrology

authors： Kieswich JE,Chen J,Alliouachene S,Caton PW,McCafferty K,Thiemermann C,Yaqoob MM

更新日期：2018-12-04 00:00:00

abstract：BACKGROUND:Urinary Ca2+ excretion increases with dietary NaCl. NaCl-induced calciuria may be associated with hypertension, urinary stone formation and osteoporosis, but its mechanism and long-term effects are not fully understood. This study examined alterations in the expressions of renal Ca2+ transporters, channels a...

journal_title：BMC nephrology

authors： Yatabe MS,Yatabe J,Takano K,Murakami Y,Sakuta R,Abe S,Sanada H,Kimura J,Watanabe T

更新日期：2012-12-02 00:00:00

abstract：BACKGROUND:Cystinuria is an inherited metabolic disease that is caused by defects in two genes, SLC3A1 and SLC7A9, which result in a renal reabsorptive defect of cystine and other dibasic amino acids, including ornithine, arginine, and lysine. Patients usually present with recurrent renal calculi and may develop renal ...

journal_title：BMC nephrology

authors： Obaid A,Nashabat M,Al Fakeeh K,Al Qahtani AT,Alfadhel M

更新日期：2017-02-06 00:00:00

abstract：BACKGROUND:Several equations have been developed to estimate glomerular filtration rate (eGFR). The common equations used were derived from populations predominantly comprised of Caucasians with chronic kidney disease (CKD). Some of the equations provide a correction factor for African-Americans due to their relatively...

journal_title：BMC nephrology

authors： Omuse G,Maina D,Mwangi J,Wambua C,Kanyua A,Kagotho E,Amayo A,Ojwang P,Erasmus R

更新日期：2017-12-20 00:00:00

abstract：BACKGROUND:Physical activity (PA) is exceptionally low amongst the haemodialysis (HD) population, and physical inactivity is a powerful predictor of mortality, making it a prime focus for intervention. Objective measurement of PA using accelerometers is increasing, but standard reporting guidelines essential to effecti...

journal_title：BMC nephrology

authors： Young HML,Orme MW,Song Y,Dungey M,Burton JO,Smith AC,Singh SJ

更新日期：2019-12-04 00:00:00

abstract：BACKGROUND:Bleeding severity, anatomic location, tissue characteristics, and visibility are common challenges encountered while managing intraoperative bleeding, and conventional hemostatic measures (suture, ligature, and cautery) may sometimes be ineffective or impractical. While topical absorbable hemostats (TAH) are...

journal_title：BMC nephrology

authors： Nativ O,Patel B,Shen J,Batiller J,Horn S,Hart JC

更新日期：2012-11-08 00:00:00

abstract：BACKGROUND:Sclerostin is a paracrine acting factor, which is expressed in the osteocytes and articular chondrocytes. Sclerostin decreases the osteoblast-related bone formation through the inhibition of the Wnt/β-catenin pathway. Osteocytes also express the Calcium sensing receptor which is a target for cinacalcet. The ...

journal_title：BMC nephrology

authors： Kuczera P,Adamczak M,Więcek A

更新日期：2016-11-15 00:00:00

abstract：BACKGROUND:Canada's pandemic H1N1 influenza A (pH1N1) outbreak led to a high burden of critical illness. Our objective was to describe the incidence of AKI (acute kidney injury) in these patients and risk factors for AKI, renal replacement therapy (RRT), and mortality. METHODS:From a prospective cohort of critically i...

journal_title：BMC nephrology

authors： Bagshaw SM,Sood MM,Long J,Fowler RA,Adhikari NK,Canadian Critical Care Trials Group H1N1 Collaborative.

更新日期：2013-06-13 00:00:00

abstract：BACKGROUND:End-stage kidney disease patients undergoing haemodialysis are prescribed with multiple complex regimens and are predisposed to high risk of medication nonadherence. The aims of this study were to explore factors associated with medication adherence, and, to examine the differential perspectives on medicatio...

journal_title：BMC nephrology

authors： Ghimire S,Castelino RL,Jose MD,Zaidi STR

更新日期：2017-05-22 00:00:00

abstract：BACKGROUND:Obesity is a well-established risk factor for atherosclerosis. However, it is unknown which measure of adiposity best relates to atherosclerosis in relatively lean maintenance hemodialysis (MHD) patients. We aimed to explore and compare the associations between different adiposity indices reflecting general,...

journal_title：BMC nephrology

authors： Zhou C,Peng H,Yuan J,Lin X,Zha Y,Chen H

更新日期：2018-08-16 00:00:00

abstract：BACKGROUND:Anaemia of chronic kidney disease increases the risk of death and adverse events, but can be managed using erythropoiesis stimulating agents (ESAs). However, recent evidence suggests that targeting a higher haemoglobin concentration ([Hb]) increases mortality risk, and both higher [Hb] targets and ESA doses ...

journal_title：BMC nephrology

authors： McMahon LP,Cai MX,Baweja S,Holt SG,Kent AB,Perkovic V,Leikis MJ,Becker GJ

更新日期：2012-06-15 00:00:00

abstract：BACKGROUND:The aim of this study was to describe the findings of renal biopsies from a large nephrology center in Iasi, Romania, performed between 2005 and 2010. We compared these findings with our previous ones, from 1995 to 2004, as well as with similar reports. METHODS:We studied retrospectively 239 renal biopsies....

journal_title：BMC nephrology

authors： Volovăt C,Cãruntu I,Costin C,Stefan A,Popa R,Volovăt S,Siriopol D,Voroneanu L,Nistor I,Segall L,Covic A

更新日期：2013-07-15 00:00:00

abstract：BACKGROUND:Rehabilitation effects of exercise training on adults with chronic kidney disease (CKD) have been generally recognised; however, the effects of exercise training on proteinuria have been underexplored. Our aim was to explore the effects of exercise training on proteinuria in adult CKD patients without renal ...

journal_title：BMC nephrology

authors： Yang L,Wu X,Wang Y,Wang C,Hu R,Wu Y

更新日期：2020-05-11 00:00:00

abstract：BACKGROUND:Lupus nephritis (LN) is a severe consequence of systemic lupus erythematosus (SLE) that affects approximately 40% of patients. Pathogenic immune complexes that are characteristic of LN deposit in the kidney and activate immune mediated pathways including the complement system. Complete remission rates in LN ...

journal_title：BMC nephrology

authors： Wright RD,Bannerman F,Beresford MW,Oni L

更新日期：2020-06-30 00:00:00

abstract：BACKGROUND:Serum parathyroid hormone (PTH) levels have been reported to be associated with infectious mortality in peritoneal dialysis (PD) patients. Peritonitis is the most common and fatal infectious complication, resulting in technique failure, hospital admission and mortality. Whether PTH is associated with periton...

journal_title：BMC nephrology

authors： Yang Y,Da J,Jiang Y,Yuan J,Zha Y

更新日期：2021-01-29 00:00:00

abstract：BACKGROUND:Variants in CUBN, the gene encoding cubilin, a proximal tubular transport protein, have been associated with albuminuria and vitamin B12 (B12) deficiency. We hypothesized that low levels of B12 would be associated with albuminuria in a population-based cohort. METHODS:We analyzed participants from the Frami...

journal_title：BMC nephrology

authors： McMahon GM,Hwang SJ,Tanner RM,Jacques PF,Selhub J,Muntner P,Fox CS

更新日期：2015-02-02 00:00:00

abstract：BACKGROUND:Single nucleotide polymorphisms (SNPs) are the most common forms of sequence variations in the human genome. They contribute to the human phenotypic spectrum and are associated with variations in response to pathogens, drugs and vaccines. Recently, SNPs in three human genes involved in kidney development (RE...

journal_title：BMC nephrology

authors： Raghavendra A,Siji A,Sridhar TS,Phadke K,Vasudevan A

更新日期：2011-10-28 00:00:00

abstract：BACKGROUND:A previous cohort study indicated a significant association of lower baseline level of physical activity in hemodialysis patients with elevated risks of mortality. However, there have been no reports regarding the association between changes in physical activity over time and mortality in hemodialysis patien...

journal_title：BMC nephrology

authors： Shimoda T,Matsuzawa R,Yoneki K,Harada M,Watanabe T,Matsumoto M,Yoshida A,Takeuchi Y,Matsunaga A

更新日期：2017-05-08 00:00:00

abstract：BACKGROUND:A classification tree model (CT-PIRP) was developed in 2013 to predict the annual renal function decline of patients with chronic kidney disease (CKD) participating in the PIRP (Progetto Insufficienza Renale Progressiva) project, which involves thirteen Nephrology Hospital Units in Emilia-Romagna (Italy). Th...

journal_title：BMC nephrology

authors： Gibertoni D,Rucci P,Mandreoli M,Corradini M,Martelli D,Russo G,Mancini E,Santoro A

更新日期：2019-05-17 00:00:00

abstract：BACKGROUND:High water hardness associated with high water fluoride and the geographical distribution of Chronic Kidney Disease of unknown etiology (CKDu) in Sri Lanka are well correlated. We undertook this study to observe the effects of high water hardness with high fluoride on kidney and liver in rats and efficacy of...

journal_title：BMC nephrology

authors： Perera T,Ranasinghe S,Alles N,Waduge R

更新日期：2020-03-24 00:00:00

abstract：BACKGROUND:Little is known about the changes in disease makers and risk factors in patients with chronic kidney disease (CKD) under nephrological care in Africa. This study aimed to evaluate the baseline level of markers of CKD and their 12-month time-trend in newly referred patients in a tertiary hospital in Cameroon....

journal_title：BMC nephrology

authors： Patrice HM,Pascal KA,François KF,Hilaire D,Solange DM,Gloria AE,Pierre CS

更新日期：2020-03-18 00:00:00

abstract：BACKGROUND:Autosomal dominant polycystic kidney disease (ADPKD) is mainly characterised by the development and enlargement of renal cysts that lead to end-stage renal disease (ESRD) in adult patients. Other clinical manifestations of this pathology include hypertension, haematuria, abdominal pain, cardiovascular system...

journal_title：BMC nephrology

authors： Magistroni R,Mangolini A,Guzzo S,Testa F,Rapanà MR,Mignani R,Russo G,di Virgilio F,Aguiari G

更新日期：2019-09-13 00:00:00

abstract：BACKGROUND:Accurately determining renal function is essential for clinical management of HIV patients. Classically, it has been evaluated by estimating glomerular filtration rate (eGFR) with the MDRD-equation, but today there is evidence that the new Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation ...

journal_title：BMC nephrology

authors： Cristelli MP,Cofán F,Rico N,Trullàs JC,Manzardo C,Agüero F,Bedini JL,Moreno A,Oppenheimer F,Miro JM,CKD-H. Clinic Investigators.

更新日期：2017-02-10 00:00:00

abstract：BACKGROUND:Despite lithium being the most efficacious treatment for bipolar disorder, its use has been decreasing at least in part due to concerns about its potential to cause significant nephrotoxicity. Whilst the ability of lithium to cause nephrogenic diabetes insipidus is well established, its ability to cause chro...

journal_title：BMC nephrology

authors： Davis J,Desmond M,Berk M

更新日期：2018-11-03 00:00:00

abstract：BACKGROUND:Myeloperoxidase anti-neutrophil cytoplasmic antibody-associated glomerulonephritis (MPO-ANCA-GN) and concurrent membranous nephropathy (MN) are very rare combination. Their causal relationship has been suggested, but not determined. CASE PRESENTATION:A 73-years-old male with 5-year history of proteinuria un...

journal_title：BMC nephrology

authors： Shimada M,Fujita T,Nakamura N,Narita I,Shimaya Y,Murakami R,Yamabe H,Osawa H,Okumura K

更新日期：2013-03-28 00:00:00

abstract：BACKGROUND:Use of serum creatinine to estimate GFR may lead to underestimation of the association between self-reported frailty and kidney function. Our objectives were to evaluate the association of measured GFR (mGFR) with self-reported frailty among patients with CKD and to determine whether self-reported frailty wa...

journal_title：BMC nephrology

authors： Delgado C,Grimes BA,Glidden DV,Shlipak M,Sarnak MJ,Johansen KL

更新日期：2015-12-09 00:00:00