Abstract：
BACKGROUND:The aim of this study was to describe the findings of renal biopsies from a large nephrology center in Iasi, Romania, performed between 2005 and 2010. We compared these findings with our previous ones, from 1995 to 2004, as well as with similar reports. METHODS:We studied retrospectively 239 renal biopsies. The indications for renal biopsy were categorized into: nephrotic syndrome, acute nephritic syndrome, asymptomatic urinary abnormalities, acute kidney injury, and chronic kidney disease of unknown etiology. RESULTS:During the past 16 years, a gradual increase in the annual number of renal biopsies/per million population (p.m.p.)/year was observed, although this incidence remained lower than in other European countries. Nephrotic syndrome was the indication for renal biopsy in over 50% of cases. Glomerulonephritis (GN) was the main histological diagnosis in 91% of cases, of which 56% were primary GN and 35% were secondary GN. The frequency of various types of primary GN was: membranoproliferative GN (MPGN) - 29.3%, membranous nephropathy (MN) -27.5%, focal segmental glomerulosclerosis (FSGS) - 17.2%, mesangial GN (including IgAN) -13.7%, crescentic GN - 9.4%, and minimal change disease (MCD) - 2.5%. Compared to the previously reported period (1994-2004), we observed a significant decrease in the frequency of MPGN and significant increases in the frequency of FSGS and, particularly MN - which more than doubled. CONCLUSION:We report significant changes in the histological spectrum of GN in North-Eastern Romania in 2005-2010, compared to the previously reported 10-yrs. These changes seem to be following a trend that has also been observed in Western countries a few decades ago, and which may have a socioeconomic explanation.
journal_name
BMC Nephroljournal_title
BMC nephrologyauthors
Volovăt C,Cãruntu I,Costin C,Stefan A,Popa R,Volovăt S,Siriopol D,Voroneanu L,Nistor I,Segall L,Covic Adoi
10.1186/1471-2369-14-148subject
Has Abstractpub_date
2013-07-15 00:00:00pages
148issn
1471-2369pii
1471-2369-14-148journal_volume
14pub_type
杂志文章相关文献
BMC Nephrology文献大全abstract：BACKGROUND:Despite the urgent need for evidence to guide the end-of-life (EOL) care for patients with chronic kidney disease (CKD), we have limited knowledge of the costs and intensity of EOL care in this population. The present study examined patterns and predictors for EOL care intensity among elderly patients with C...
journal_title：BMC nephrology
pub_type： 杂志文章
doi：10.1186/s12882-017-0456-2
更新日期：2017-01-26 00:00:00
abstract：BACKGROUND:Patients with advanced chronic kidney disease (CKD) exhibit higher prevalence of coronary artery calcification (CaC) than general population. CaC has been proposed as a risk factor for mortality in end-stage CKD, but most studies in the field are based on short-term follow-up. METHODS:We conducted a cohort,...
journal_title：BMC nephrology
pub_type： 杂志文章
doi：10.1186/s12882-019-1367-1
更新日期：2019-05-28 00:00:00
abstract：BACKGROUND:Chronic Kidney Disease (CKD) is a major non-communicable chronic disease that is associated with adverse clinical and economic outcomes. Passive surveillance systems are likely to improve efforts for prevention of chronic kidney disease (CKD) and inform national service planning. This study was conducted to ...
journal_title：BMC nephrology
pub_type： 杂志文章
doi：10.1186/1471-2369-15-185
更新日期：2014-11-25 00:00:00
abstract：BACKGROUND:Precise renal histopathological diagnosis will guide therapy strategy in patients with lupus nephritis. Blood oxygen level dependent (BOLD) magnetic resonance imaging (MRI) has been applicable noninvasive technique in renal disease. This current study was performed to explore whether BOLD MRI could contribut...
journal_title：BMC nephrology
pub_type： 杂志文章
doi：10.1186/s12882-017-0787-z
更新日期：2018-02-09 00:00:00
abstract：BACKGROUND:In view of the prevalence of oxidative stress in chronic kidney disease (CKD) patients, the loss of low-molecular-weight biomolecules by hemodialysis and the antioxidant potential of some uremic solutes that accumulate in CKD, we used in vitro model systems to test the antioxidant potential of the following ...
journal_title：BMC nephrology
pub_type： 杂志文章
doi：10.1186/s12882-015-0029-1
更新日期：2015-04-11 00:00:00
abstract：BACKGROUND:Cystinosis is a rare autosomal recessive lysosomal disorder characterized by the accumulation of cystine in lysosomes. Cystinosis is much rarer in Asian than Caucasian populations. There are only 14 patients have with cystinosis alive in Japan. Most cystinosis is the nephropathic infantile form, as indicated...
journal_title：BMC nephrology
pub_type： 杂志文章
doi：10.1186/s12882-017-0721-4
更新日期：2017-09-26 00:00:00
abstract：BACKGROUND:Hemodiafiltration (HDF), as a convective blood purification technique, has been associated with favorable outcomes improved phosphate control, removal of middle-molecules such as Beta2-microglobulin and the occurrence of intradialytic hypotension (IDH) as compared to diffusive techniques. The aim of this ret...
journal_title：BMC nephrology
pub_type： 杂志文章
doi：10.1186/1471-2369-13-106
更新日期：2012-09-10 00:00:00
abstract：BACKGROUND:Depression and frailty contribute to the adverse clinical outcome of peritoneal dialysis (PD) patients. However, the interaction between depression and frailty in PD patients remains uncertain. We determined the prevalence of depression and frailty in prevalent Chinese PD patients, dissected the internal rel...
journal_title：BMC nephrology
pub_type： 杂志文章
doi：10.1186/s12882-020-01994-4
更新日期：2020-08-05 00:00:00
abstract：BACKGROUND:The patient characteristics and mortality associated with autosomal dominant polycystic kidney disease (PKD) have not been characterized for a national sample of end stage renal disease (ESRD) patients on the renal transplant waiting list. METHODS:40,493 patients in the United States Renal Data System who w...
journal_title：BMC nephrology
pub_type： 杂志文章
doi：10.1186/1471-2369-3-7
更新日期：2002-08-23 00:00:00
abstract：BACKGROUND:Experimental studies showed that 25-hydroxy-vitamin D [25(OH)D] deficiency (defined as 25-hydroxy-vitamin D < 15 ng/ml) has been associated with CKD progression. Patients with IgA nephropathy have an exceptionally high rate of severe 25(OH)D deficiency; however, it is not known whether this deficiency is a r...
journal_title：BMC nephrology
pub_type： 杂志文章
doi：10.1186/s12882-016-0378-4
更新日期：2016-11-02 00:00:00
abstract：BACKGROUND:Parents' adaptation affects the health outcomes of children with chronic kidney diseases (CKD). Identifying factors that affect parents' adaptation is necessary to understand their adaptation status. This study aims to explore factors related to the adaptation of parents who have children with CKD. METHODS:...
journal_title：BMC nephrology
pub_type： 杂志文章
doi：10.1186/s12882-020-02170-4
更新日期：2020-11-25 00:00:00
abstract：BACKGROUND:Reproductive function in women with end stage renal disease generally improves after kidney transplant. However, pregnancy remains challenging due to the risk of adverse clinical outcomes. METHODS:We searched PubMed/MEDLINE, Elsevier EMBASE, Scopus, BIOSIS Previews, ISI Science Citation Index Expanded, and ...
journal_title：BMC nephrology
pub_type： 杂志文章,meta分析
doi：10.1186/s12882-019-1213-5
更新日期：2019-01-23 00:00:00
abstract：BACKGROUND:The optimal revascularization strategy for patients with impaired glomerular filtration rate (IGFR) has not been established in acute coronary syndrome (ACS). We investigated the prognosis and impact of IGFR and invasive strategy on the cardiovascular outcomes in the ACS population. METHODS:In a Taiwan nati...
journal_title：BMC nephrology
pub_type： 杂志文章,多中心研究
doi：10.1186/1471-2369-15-66
更新日期：2014-04-23 00:00:00
abstract：BACKGROUND:MicroRNAs have been demonstrated to play an important role in the pathogenesis of diabetic nephropathy (DN). In this study, we investigated both the repertoire of miRNAs in the kidneys of patients with DN and their potential regulatory role in inflammation-mediated glomerular endothelial injury. METHODS:The...
journal_title：BMC nephrology
pub_type： 杂志文章
doi：10.1186/1471-2369-15-142
更新日期：2014-09-02 00:00:00
abstract：BACKGROUND:Frailty is independently associated with worse health-related quality of life (HRQOL) in chronic kidney disease (CKD). However, the relationship between frailty and symptom experience is not well described in people living with CKD. This study's aim was to evaluate the relationship between frailty and sympto...
journal_title：BMC nephrology
pub_type： 杂志文章
doi：10.1186/s12882-020-02063-6
更新日期：2020-09-23 00:00:00
abstract：BACKGROUND:Dementia is common in end-stage renal disease (ESRD) patients on hemodialysis (HD) and is associated with worse outcomes. This study aimed to investigate the risk of major adverse cardiac and cerebrovascular event (MACCE) in elderly patients with dementia initiating HD. METHODS:Using the database from the H...
journal_title：BMC nephrology
pub_type： 杂志文章
doi：10.1186/s12882-017-0547-0
更新日期：2017-04-06 00:00:00
abstract：BACKGROUND:Serum phosphorus control is critical for chronic kidney disease (CKD) 5D patients. Currently, clinical profile for an oral phosphorus binder in the mainland Chinese population is not available. OBJECTIVE:To establish the efficacy, safety, and tolerability of lanthanum carbonate in CKD 5D patients. DESIGN:M...
journal_title：BMC nephrology
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1186/1471-2369-14-29
更新日期：2013-02-04 00:00:00
abstract：BACKGROUND:Nephrotic syndrome (NS) is pathological condition characterized by heavy proteinuria. Our study investigates hypothesis that change in cell proliferation of proximal tubules influences primary cilia structure and function and promotes cystogenesis in congenital nephrotic syndrome of the Finnish type (CNF) an...
journal_title：BMC nephrology
pub_type： 杂志文章
doi：10.1186/1471-2369-15-3
更新日期：2014-01-08 00:00:00
abstract：:Attention has recently been focused on addressing the problem of acute kidney injury in both the developed and developing world. Little information is actually available on the incidence and management of AKI in low resource settings. Thus, the paper by Bagasha in the current issue of BMC Nephrology makes an important...
journal_title：BMC nephrology
pub_type： 杂志文章
doi：10.1186/1471-2369-16-5
更新日期：2015-01-16 00:00:00
abstract：BACKGROUND:Older patients with end-stage kidney disease (ESKD) often live with unidentified frailty and multimorbidity. Despite guideline recommendations, geriatric assessment is not part of standard clinical care, resulting in a missed opportunity to enhance (clinical) outcomes including quality of life in these patie...
journal_title：BMC nephrology
pub_type： 杂志文章
doi：10.1186/s12882-020-02206-9
更新日期：2021-01-06 00:00:00
abstract：BACKGROUND:Acute kidney injury (AKI) is common in hospitalized human immunodeficiency virus (HIV)-infected patients and is associated with hospital mortality. We aimed to evaluate the impact of AKI on long-term mortality of hospitalized HIV-infected patients. METHODS:Retrospective analysis of a cohort of 433 hospitali...
journal_title：BMC nephrology
pub_type： 杂志文章
doi：10.1186/1471-2369-14-32
更新日期：2013-02-11 00:00:00
abstract：BACKGROUND:To establish a model of chronic renal fibrosis following acute kidney injury (AKI) in BALB/c mice and to observe the effect of AKI on podocyte injury and chronic fibrosis of the kidney. Additional aims included using the model to explore the role of podocyte injury in AKI and post-injury fibrosis. METHODS:F...
journal_title：BMC nephrology
pub_type： 杂志文章
doi：10.1186/s12882-019-1298-x
更新日期：2019-03-28 00:00:00
abstract：BACKGROUND:Autosomal dominant polycystic kidney disease (ADPKD) is a hereditary disease characterized by the presence of renal cysts. Over time the expanding cysts lead to progressive renal failure. The use of tolvaptan, a V2-receptor antagonist, was recently approved in ADPKD patients. It was demonstrated that tolvapt...
journal_title：BMC nephrology
pub_type： 杂志文章
doi：10.1186/s12882-019-1612-7
更新日期：2019-11-21 00:00:00
abstract：BACKGROUND:A large body mass index (BMI) has been considered as a relative contraindication for percutaneous catheter insertion, although this technique has many advantages. Up to now, there are few studies on peritoneal catheter placement and obesity. The aim of this study was to determine whether patients with large ...
journal_title：BMC nephrology
pub_type： 杂志文章
doi：10.1186/s12882-020-01850-5
更新日期：2020-05-25 00:00:00
abstract：BACKGROUND:The current literature recognises that left ventricular hypertrophy makes a key contribution to the high rate of premature cardiovascular mortality in dialysis patients. Determining how we might intervene to ameliorate left ventricular hypertrophy in dialysis populations has become a research priority. Reduc...
journal_title：BMC nephrology
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1186/1471-2369-14-149
更新日期：2013-07-15 00:00:00
abstract：BACKGROUND:Autosomal dominant polycystic kidney disease (ADPKD) is one of the most common hereditary kidney diseases that frequently result in renal failure. In this cross-sectional observational cohort study, we evaluated urinary angiotensinogen (AGT) as a potential biomarker to assess renal function in ADPKD. METHOD...
journal_title：BMC nephrology
pub_type： 杂志文章
doi：10.1186/s12882-015-0075-8
更新日期：2015-06-20 00:00:00
abstract：BACKGROUND:A positive pregnancy test in acute or chronically ill patients has implications for the use of potentially mutagenic or teratogenic products in urgent medical therapies such as the use of chemotherapies or therapies with immunosuppressants, for anesthesia, and for time-sensitive indications like urgent surge...
journal_title：BMC nephrology
pub_type： 杂志文章
doi：10.1186/s12882-020-01729-5
更新日期：2020-02-28 00:00:00
abstract：BACKGROUND:Patients with chronic kidney disease (CKD) have a high risk of recurring thrombotic events following acute myocardial infarction (AMI). Microparticles (MPs) are circulating small vesicles shed from various cells. Platelet microparticles (PMPs) reflect platelet activation and endothelial microparticles (EMPs)...
journal_title：BMC nephrology
pub_type： 杂志文章
doi：10.1186/s12882-019-1261-x
更新日期：2019-03-01 00:00:00
abstract：BACKGROUND:The clinical consequences of starting chronic peritoneal dialysis (PD) after emergent dialysis via a temporary hemodialysis (HD) catheter has rarely been evaluated within a full spectrum of treated end-stage renal disease (ESRD). We investigated the longer-term outcomes of patients undergoing emergent-start ...
journal_title：BMC nephrology
pub_type： 杂志文章
doi：10.1186/s12882-017-0764-6
更新日期：2017-12-11 00:00:00
abstract：BACKGROUND:In patients treated by maintenance hemodialysis the relationship to survival of hemoglobin level and administered epoetin-alfa and intravenous iron is controversial. The study aim was to determine effects on patient survival of administered epoetin-alfa and intravenous iron, and of hemoglobin and variables r...
journal_title：BMC nephrology
pub_type： 杂志文章,多中心研究
doi：10.1186/1471-2369-10-6
更新日期：2009-02-26 00:00:00
