The role of podocyte damage in the etiology of ischemia-reperfusion acute kidney injury and post-injury fibrosis.

abstract：BACKGROUND:MicroRNAs have been demonstrated to play an important role in the pathogenesis of diabetic nephropathy (DN). In this study, we investigated both the repertoire of miRNAs in the kidneys of patients with DN and their potential regulatory role in inflammation-mediated glomerular endothelial injury. METHODS:The...

journal_title：BMC nephrology

authors： Huang Y,Liu Y,Li L,Su B,Yang L,Fan W,Yin Q,Chen L,Cui T,Zhang J,Lu Y,Cheng J,Fu P,Liu F

更新日期：2014-09-02 00:00:00

abstract：BACKGROUND:Urinary Ca2+ excretion increases with dietary NaCl. NaCl-induced calciuria may be associated with hypertension, urinary stone formation and osteoporosis, but its mechanism and long-term effects are not fully understood. This study examined alterations in the expressions of renal Ca2+ transporters, channels a...

journal_title：BMC nephrology

authors： Yatabe MS,Yatabe J,Takano K,Murakami Y,Sakuta R,Abe S,Sanada H,Kimura J,Watanabe T

更新日期：2012-12-02 00:00:00

abstract：BACKGROUND:Depression and frailty contribute to the adverse clinical outcome of peritoneal dialysis (PD) patients. However, the interaction between depression and frailty in PD patients remains uncertain. We determined the prevalence of depression and frailty in prevalent Chinese PD patients, dissected the internal rel...

journal_title：BMC nephrology

authors： Chan GC,Ng JK,Chow KM,Kwan BC,Kwong VW,Pang WF,Cheng PM,Law MC,Leung CB,Li PK,Szeto CC

更新日期：2020-08-05 00:00:00

abstract：BACKGROUND:Patients with advanced chronic kidney disease (CKD) exhibit higher prevalence of coronary artery calcification (CaC) than general population. CaC has been proposed as a risk factor for mortality in end-stage CKD, but most studies in the field are based on short-term follow-up. METHODS:We conducted a cohort,...

journal_title：BMC nephrology

authors： Cano-Megías M,Guisado-Vasco P,Bouarich H,de Arriba-de la Fuente G,de Sequera-Ortiz P,Álvarez-Sanz C,Rodríguez-Puyol D

更新日期：2019-05-28 00:00:00

abstract：BACKGROUND:Adherence to phosphate binder treatment is important to prevent high serum phosphate level in chronic dialysis patients. We therefore wanted to investigate patient knowledge, beliefs about and adherence to phosphate binders among these patients and assess whether one-to-one pharmacist-led education and couns...

journal_title：BMC nephrology

authors： Hjemås BJ,Bøvre K,Mathiesen L,Lindstrøm JC,Bjerknes K

更新日期：2019-05-17 00:00:00

abstract：BACKGROUND:Kidney impairment constitutes severe risk for cardiovascular disease, stroke and all-cause mortality, and early identification and prevention of kidney impairment is critical to effective management of prognostic risk in community residents. Previous studies have validated that carotid-femoral pulse wave vel...

journal_title：BMC nephrology

authors： Fu S,Guo Y,Luo L,Ye P

更新日期：2018-05-02 00:00:00

abstract：BACKGROUND:Little is known about the changes in disease makers and risk factors in patients with chronic kidney disease (CKD) under nephrological care in Africa. This study aimed to evaluate the baseline level of markers of CKD and their 12-month time-trend in newly referred patients in a tertiary hospital in Cameroon....

journal_title：BMC nephrology

authors： Patrice HM,Pascal KA,François KF,Hilaire D,Solange DM,Gloria AE,Pierre CS

更新日期：2020-03-18 00:00:00

abstract：BACKGROUND:Patients undergoing haemodialysis (HD) are at higher risk of developing worse outcomes if they contract COVID-19. In our renal service we reduced HD frequency from thrice to twice-weekly in selected patients with the primary aim of reducing COVID 19 exposure and transmission between HD patients. METHODS:Dia...

journal_title：BMC nephrology

authors： Lodge MDS,Abeygunaratne T,Alderson H,Ali I,Brown N,Chrysochou C,Donne R,Erekosima I,Evans P,Flanagan E,Gray S,Green D,Hegarty J,Hyde A,Kalra PA,Lamerton E,Lewis D,Middleton R,New D,Nipah R,O'Donoghue D,O'Riordan

更新日期：2020-12-07 00:00:00

abstract：BACKGROUND:Association between metabolic syndrome (MS) and mildly reduced estimated glomerular filtration rates (eGFRs) remains unclear. Therefore, we aimed to evaluate the association between MS and a mildly reduced eGFR in Chinese adults. METHODS:Anthropometric and biochemical examinations were performed in 2992 ind...

journal_title：BMC nephrology

authors： Hu W,Wu XJ,Ni YJ,Hao HR,Yu WN,Zhou HW

更新日期：2017-06-13 00:00:00

abstract：BACKGROUND:Cancer-related thrombotic microangiopathy (CR-TMA) is a rare entity associated with a dismal prognosis. Usually, CR-TMA is associated with mucin-producing carcinomas among which stomach, breast, prostate, lung and pancreas tumours are the most frequent. CASES PRESENTATION:We describe for the first time thre...

journal_title：BMC nephrology

authors： de Nattes T,Moreau-Grangé L,Vezzosi D,Hadoux J,Hie M,Guerrot D,Grangé S

更新日期：2020-01-30 00:00:00

abstract：BACKGROUND:Chronic kidney disease (CKD) and end-stage renal disease (ESRD) represent worldwide health problems with an epidemic extent. Therefore, attention must be given to the optimisation of patient care, as gaps in the care of CKD and ESRD patients are well documented. As part of a multidisciplinary patient care st...

journal_title：BMC nephrology

authors： Stemer G,Lemmens-Gruber R

更新日期：2011-07-22 00:00:00

abstract：BACKGROUND:The high cost, complexity of the available protocols, and metabolic complications are the major barriers that impede the clinical utilization of regional citrate anticoagulation (RCA) for sustained low efficiency dialysis (SLED) in critically ill patients. By comparing a novel protocol for SLED using 30% cit...

journal_title：BMC nephrology

authors： Wen M,Küchle C,Steubl D,Satanovskji R,Heemann U,Suttmann Y,Angermann S,Kemmner S,Rehbehn L,Huber M,Hauser C,Schmaderer C,Reichelt AL,Haller B,Renders L

更新日期：2018-04-03 00:00:00

abstract：BACKGROUND:Peripheral arterial disease (PAD) is common in patients with end-stage renal disease on hemodialysis, but is frequently underdiagnosed. The risk factors for PAD are well known within the general population, but they differ somewhat in hemodialysis patients. This study aimed to determine the prevalence of PAD...

journal_title：BMC nephrology

authors： Ašćerić RR,Dimković NB,Trajković GŽ,Ristić BS,Janković AN,Durić PS,Ilijevski NS

更新日期：2019-07-26 00:00:00

abstract：BACKGROUND:Nasal colonization with methicillin-resistant Staphylococcus aureus (MRSA) is a well defined risk factor for subsequent bacteremia and death in various groups of patients, but its impact on outcome in patients receiving long-term hemodialysis (HD) is under debate. METHODS:This prospective interventional coh...

journal_title：BMC nephrology

authors： Schmid H,Romanos A,Schiffl H,Lederer SR

更新日期：2013-04-23 00:00:00

abstract：:Chronic kidney disease (CKD) is an inherently systemic disease that refers to a long-term loss of kidney function. The progression of CKD has repercussions for other organs, leading to many kinds of extrarenal complications. Intensive studies are now being undertaken to reveal the risk factors and pathophysiological m...

journal_title：BMC nephrology

authors： Zou D,Wu W,He Y,Ma S,Gao J

更新日期：2018-10-22 00:00:00

abstract：BACKGROUND:Dietary and lifestyle factors may play an important role in the increasing prevalence of nephrolithiasis. We aimed to review and quantify the associations between lifestyle factors and incident nephrolithiasis and suggest lifestyle changes for the primary prevention of nephrolithiasis. METHODS:PubMed, EMBAS...

journal_title：BMC nephrology

authors： Lin BB,Lin ME,Huang RH,Hong YK,Lin BL,He XJ

更新日期：2020-07-11 00:00:00

abstract：BACKGROUND:Physical inactivity and sedentary behaviour (too much sitting) can contribute to renal dysfunction. However, the potential benefits of behavioural change (e.g. replacing sedentary behaviour with physical activity) on renal function are not well understood. We used isotemporal substitution to model potential ...

journal_title：BMC nephrology

authors： Kosaki K,Tanahashi K,Matsui M,Akazawa N,Osuka Y,Tanaka K,Dunstan DW,Owen N,Shibata A,Oka K,Maeda S

更新日期：2020-06-03 00:00:00

abstract：BACKGROUND:Primary hyperoxaluria type 1 is a rare autosomal recessive disease of glyoxylate metabolism caused by a defect in the liver-specific peroxisomal enzyme alanine:glyoxylate aminotransferase (AGT) that leads to hyperoxaluria, recurrent urolithiasis, and nephrocalcinosis. METHODS:Two unrelated patients with rec...

journal_title：BMC nephrology

authors： Li GM,Xu H,Shen Q,Gong YN,Fang XY,Sun L,Liu HM,An Y

更新日期：2014-06-17 00:00:00

abstract：BACKGROUND:Tolvaptan is a selective vasopressin receptor antagonist. Nitric Oxide (NO) promotes renal water and sodium excretion, but the effect is unknown in the nephron's principal cells. In a dose-response study, we measured the effect of tolvaptan on renal handling of water and sodium and systemic hemodynamics, dur...

journal_title：BMC nephrology

authors： Al Therwani S,Rosenbæk JB,Mose FH,Bech JN,Pedersen EB

更新日期：2017-03-13 00:00:00

abstract：BACKGROUND:The prevalence of chronic kidney disease (CKD) is increasing worldwide and in Africa. Health related quality of life (QOL) has become an essential outcome measure for patients with CKD and end stage renal disease (ESRD). There is growing interest worldwide in QOL of CKD patients but paucity of data in Ghana....

journal_title：BMC nephrology

authors： Tannor EK,Norman BR,Adusei KK,Sarfo FS,Davids MR,Bedu-Addo G

更新日期：2019-04-08 00:00:00

abstract：BACKGROUND:Chronic Kidney Disease (CKD) is a major non-communicable chronic disease that is associated with adverse clinical and economic outcomes. Passive surveillance systems are likely to improve efforts for prevention of chronic kidney disease (CKD) and inform national service planning. This study was conducted to ...

journal_title：BMC nephrology

authors： Stack AG,Casserly LF,Cronin CJ,Chernenko T,Cullen W,Hannigan A,Saran R,Johnson H,Browne G,Ferguson JP

更新日期：2014-11-25 00:00:00

abstract：BACKGROUND:The possibility of clearing Cell-free Plasma Hemoglobin (CPH) from human plasma may appear attractive, especially when considering the noxious effects that CPH has on the immune function and the renal damage caused by its filtration. The existence of the so-called High Cut-Off (HCO) filters, possessing pores...

journal_title：BMC nephrology

authors： Cucchiari D,Reverter E,Blasco M,Molina-Andujar A,Carpio A,Sanz M,Escorsell A,Fernández J,Poch E

更新日期：2018-10-04 00:00:00

abstract：BACKGROUND:In view of the prevalence of oxidative stress in chronic kidney disease (CKD) patients, the loss of low-molecular-weight biomolecules by hemodialysis and the antioxidant potential of some uremic solutes that accumulate in CKD, we used in vitro model systems to test the antioxidant potential of the following ...

journal_title：BMC nephrology

authors： Assis RP,Castro JF,Gutierres VO,Arcaro CA,Brotto RS,Oliveira OM,Baviera AM,Brunetti IL

更新日期：2015-04-11 00:00:00

abstract：BACKGROUND:Acute kidney injury (AKI) places a heavy burden on the healthcare system in China and is usually misdiagnosed. However, there are limited studies that have described the epidemiology and diagnosis of AKI in China. The aim of this study was to describe the incidence and diagnosis of AKI in hospitalized adult ...

journal_title：BMC nephrology

authors： Cheng X,Wu B,Liu Y,Mao H,Xing C

更新日期：2017-06-24 00:00:00

abstract：BACKGROUND:Decreased heat shock protein 27 (HSP27) participates in many processes that are involved in cardiovascular (CV) disease. The objective of the study was to evaluate if HSP27 level was predictive of mortality as well as to evaluate factors associated with HSP27 level in a group of patients treated with HD. ME...

journal_title：BMC nephrology

authors： Jaroszyński A,Jaroszyńska A,Zaborowski T,Drelich-Zbroja A,Zapolski T,Dąbrowski W

更新日期：2018-12-17 00:00:00

abstract：BACKGROUND:Variants in CUBN, the gene encoding cubilin, a proximal tubular transport protein, have been associated with albuminuria and vitamin B12 (B12) deficiency. We hypothesized that low levels of B12 would be associated with albuminuria in a population-based cohort. METHODS:We analyzed participants from the Frami...

journal_title：BMC nephrology

authors： McMahon GM,Hwang SJ,Tanner RM,Jacques PF,Selhub J,Muntner P,Fox CS

更新日期：2015-02-02 00:00:00

abstract：BACKGROUND:FGF23 controls serum l,25(OH)2D3 levels and phosphate homeostasis. This study evaluates the effects of ferritin on intact PTH, FGF23, and l,25(OH)2D3 in patients with major thalassemia. It also evaluates FGF23 changes in patients with hypoparathyroidism to clarify the interaction between FGF23 and PTH in the...

journal_title：BMC nephrology

authors： Saki F,Salehifar A,Kassaee SR,Omrani GR

更新日期：2020-11-16 00:00:00

abstract：BACKGROUND:Patients with an impaired renal function show a high incidence of bone and mineral disturbances. These 'chronic kidney disease - mineral and bone disorders' (CKD-MBD) range from high turnover osteoporosis to adynamic bone disease. Currently, the histomorphometric analysis of a bone biopsy taken from the ilia...

journal_title：BMC nephrology

authors： Hiller RG,Patecki M,Neunaber C,Reifenrath J,Kielstein JT,Kielstein H

更新日期：2017-04-13 00:00:00

abstract：:Attention has recently been focused on addressing the problem of acute kidney injury in both the developed and developing world. Little information is actually available on the incidence and management of AKI in low resource settings. Thus, the paper by Bagasha in the current issue of BMC Nephrology makes an important...

journal_title：BMC nephrology

authors： Anand S,Cruz DN,Finkelstein FO

更新日期：2015-01-16 00:00:00

abstract：BACKGROUND:Patients with chronic kidney diseases (CKD) on haemodialysis (HD) have high morbidity and mortality rates, which are also due to the inherent risks associated with nephropathy. Non-adherence (NA) to the different demands of the treatment can have consequences for the outcome of patients undergoing HD; nevert...

journal_title：BMC nephrology

authors： Dantas LGG,de Seixas Rocha M,Junior JAM,Paschoalin EL,Paschoalin SRKP,Sampaio Cruz CM

更新日期：2019-11-06 00:00:00