Abstract:
BACKGROUND:Acute kidney injury (AKI) places a heavy burden on the healthcare system in China and is usually misdiagnosed. However, there are limited studies that have described the epidemiology and diagnosis of AKI in China. The aim of this study was to describe the incidence and diagnosis of AKI in hospitalized adult patients in a tertiary teaching hospital in southeast China. METHODS:All adult patients hospitalized from October 1, 2013 to September 30, 2014 in the First Affiliated Hospital of Nanjing Medical University were screened using the Lab Administration Network. AKI definition and staging were based on the KDIGO AKI criteria. Demographic characteristics, laboratory examination, clinical data, and clinical outcomes of AKI patients were recorded and analyzed. RESULTS:The incidence of AKI was 1.6% (1401/87196). The 30-day mortality was 35.3%. AKI stage 1, 2, 3 and RRT accounted for 38.0% (532/1401), 22.0% (309/1401), 40.0% (560/1401), and 16.3% (228/1401) of patients, respectively. The Renal, other Internal Medicine, Surgery, and ICU Departments accounted for 7.4%, 37.1%, 30.1%, and 25.4% of AKI patients, respectively. The timely diagnosis rate, delayed diagnosis rate, and missed diagnosis rate were 44% (616/1401), 3.3% (46/1401), and 52.7% (739/1401), respectively. Patients hospitalized in the Renal Department had the highest AKI diagnosis rate (89.3%, 88/103), while missed diagnosis rate of the surgical patients was as high as 75.1% (317/422). Multivariable logistic regression analysis indicated that presence of tumors, higher serum albumin, and AKI stage 1 were associated with failure to timely diagnose AKI, whereas presence of chronic kidney disease, oliguria, higher blood urea nitrogen, and greater number of organ failures correlated with earlier diagnosis. CONCLUSIONS:AKI was characterized by a high incidence, high short-term mortality, and high missed diagnosis rate in hospitalized adult patients in our hospital. Interventions for improving diagnosis of AKI are urgently needed.
journal_name
BMC Nephroljournal_title
BMC nephrologyauthors
Cheng X,Wu B,Liu Y,Mao H,Xing Cdoi
10.1186/s12882-017-0622-6subject
Has Abstractpub_date
2017-06-24 00:00:00pages
203issue
1issn
1471-2369pii
10.1186/s12882-017-0622-6journal_volume
18pub_type
杂志文章相关文献
BMC Nephrology文献大全abstract::In a recent study published by the National Project Team on chronic kidney diseases of unknown origin in Sri Lanka, identified cadmium as a major risk factor but strong conclusions were not made as the identified environmental toxins were within the permissible levels.Sri Lankan food consumption pattern is different s...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-015-0211-5
更新日期:2015-12-23 00:00:00
abstract:BACKGROUND:The predictive value of acute kidney injury (AKI) urinary biomarkers may depend on the time interval following tubular injury, thereby explaining in part the heterogeneous performance of these markers that has been reported in the literature. We studied the influence of timing on the predictive values of tub...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/1471-2369-14-273
更新日期:2013-12-09 00:00:00
abstract:BACKGROUND:Transplant tourism entails movement of recipient, donor or both to a transplant centre outside their country of residence. This has been reported in many countries; and has variously been associated with organ trade. The objective of this study is to determine the frequency and pattern of transplant tourism ...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-017-0635-1
更新日期:2017-07-05 00:00:00
abstract:BACKGROUND:Sepsis is a common syndrome in critically ill patients and easily leads to the occurrence of acute kidney injury (AKI), with high mortality rates. This study aimed to investigate the diagnostic value of urine soluble CD163 (sCD163) for identification of sepsis, severity of sepsis, and for secondary AKI, and ...
journal_title:BMC nephrology
pub_type: 临床试验,杂志文章
doi:10.1186/1471-2369-13-123
更新日期:2012-09-26 00:00:00
abstract:BACKGROUND:The pathogenesis of falling is complex, and identification of risk factors may be essential for prevention. The relationship between renal disease and falls is unclear, and the goal of this study was to collect the available evidence and investigate the relationship between accidental falls and renal dysfunc...
journal_title:BMC nephrology
pub_type: 杂志文章,评审
doi:10.1186/s12882-015-0173-7
更新日期:2015-10-29 00:00:00
abstract:BACKGROUND:Whether persistent hematuria in patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) during clinical remission reflects active disease or chronic glomerular injury is uncertain. This study aimed to investigate the significance of persistent hematuria during clinical remission ...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-017-0763-7
更新日期:2017-12-06 00:00:00
abstract:BACKGROUND:There is limited evidence on the relationship between social support and renal outcomes in African Americans. We sought to determine the association of social support with prevalent chronic kidney disease (CKD) and kidney function decline in an African American cohort. We also examined whether age modifies t...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-019-1432-9
更新日期:2019-07-15 00:00:00
abstract:BACKGROUND:The objective of the study was to examine overall anemia management trends in non-dialysis patients with chronic kidney disease (CKD) from 2006 to 2015, and to evaluate the impact of Trial to Reduced Cardiovascular Events with Ananesp Therapy (TREAT)'s study results (October 2009) and the US Food and Drug Ad...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-018-1119-7
更新日期:2018-11-09 00:00:00
abstract:BACKGROUND:Until now, no long-term studies relating serum albumin level to mortality rate in prevalent haemodialysis (HD) patients have been conducted. We aimed to examine the association between serum albumin level and mortality over a 5-year period. METHODS:This study included 781 patients who received maintenance H...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-016-0332-5
更新日期:2016-08-20 00:00:00
abstract:BACKGROUND:Atypical hemolytic uremic syndrome (aHUS) is a rare, genetically-mediated systemic disease most often caused by chronic, uncontrolled complement activation that leads to systemic thrombotic microangiopathy (TMA) and renal and other end-organ damage. METHODS:The global aHUS Registry, initiated in April 2012,...
journal_title:BMC nephrology
pub_type: 杂志文章,多中心研究
doi:10.1186/s12882-015-0195-1
更新日期:2015-12-10 00:00:00
abstract:BACKGROUND:There is limited knowledge of Chronic Kidney Disease (CKD) among high risk populations, especially in the developing countries. We report our study of testing for CKD in at-risk subjects. METHODS:In a cross-sectional study, 527 people from primary and secondary health care areas in the city of Kinshasa were...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/1471-2369-10-18
更新日期:2009-07-21 00:00:00
abstract:BACKGROUND:African Americans have an increased incidence and worse prognosis with chronic kidney disease (CKD--estimated glomerular filtration rate [eGFR] <60 ml/min/1.73 m2) than their counterparts of European-descent. Inflammation has been related to renal disease in non-Hispanic whites, but there are limited data on...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/1471-2369-11-1
更新日期:2010-01-15 00:00:00
abstract:BACKGROUND:We sought to investigate the relationships among the plasma levels of carotenoids, tocopherols, endogenous antioxidants, oxidative damage and lipid profiles and their possible effects on the cardiovascular risk associated with hemodialysis (HD) patients. METHODS:The study groups were divided into HD and hea...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/1471-2369-12-59
更新日期:2011-10-26 00:00:00
abstract:BACKGROUND:Severe renal manifestation of systemic lupus erythematosus (SLE) is not uncommon and is associated with an indeterminate prognosis. Complete remission can be obtained, however, at least in the young when chronic lesions are absent and adequate anti-inflammatory therapy is immediately initiated. CASE PRESENT...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/1471-2369-13-81
更新日期:2012-08-06 00:00:00
abstract:BACKGROUND:Precise renal histopathological diagnosis will guide therapy strategy in patients with lupus nephritis. Blood oxygen level dependent (BOLD) magnetic resonance imaging (MRI) has been applicable noninvasive technique in renal disease. This current study was performed to explore whether BOLD MRI could contribut...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-017-0787-z
更新日期:2018-02-09 00:00:00
abstract:BACKGROUND:Ghrelin, a gastric orexigenic peptide, and body mass index (BMI) are known as inversely associated to each other and are both linked to cardiovascular (CV) risk and mortality in maintenance hemodialysis (MHD) patients. However, it is unclear whether the interaction between ghrelin and BMI is associated with ...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-017-0442-8
更新日期:2017-01-18 00:00:00
abstract:BACKGROUND:Fibrillary glomerulonephritis (FGN) is distinguished from amyloidosis by thicker fibrils and the lack of staining with histochemical dyes typically reactive with amyloid. However, congophilic FGN has been proposed recently and adding laser microdissection followed by mass spectrometry (LMD/MS) to conventiona...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-020-01851-4
更新日期:2020-05-24 00:00:00
abstract:BACKGROUND:Early recognition and management of chronic kidney disease (CKD) are associated with better outcomes. Internal medicine residency should prepare physicians to diagnose and manage CKD. METHODS:To examine whether residency training and program characteristics were associated with CKD knowledge and investigate...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/1471-2369-13-126
更新日期:2012-09-27 00:00:00
abstract:BACKGROUND:Periodontal disease is associated with increased mortality in the general population, however its prognostic significance in chronic kidney disease (CKD) is not known. We evaluated the joint effect of periodontal disease and CKD on all-cause and cardiovascular mortality. METHODS:Prospective observational st...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-015-0101-x
更新日期:2015-07-07 00:00:00
abstract:BACKGROUND:Sustained low efficiency dialysis (SLED) is increasingly used as a renal replacement modality in critically ill patients with acute kidney injury (AKI) and hemodynamic instability. SLED may reduce the hemodynamic perturbations of intermittent hemodialysis, while obviating the resource demands of CRRT. Althou...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-015-0123-4
更新日期:2015-08-04 00:00:00
abstract:BACKGROUND:S100A12 protein is an endogenous receptor ligand for advanced glycation end products. In this study, the plasma S100A12 level was assessed as an independent predictor of mortality, and its utility in clinical settings was examined. METHODS:In a previous cross-sectional study, plasma S100A12 levels were meas...
journal_title:BMC nephrology
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1186/1471-2369-14-16
更新日期:2013-01-16 00:00:00
abstract:BACKGROUND:The magnitude of renal function recovery after kidney donation differs in donors with a heterogeneous background. Preoperative assessment of candidates with potentially unfavorable renal functional compensation is critical when baseline kidney function is marginal. We explored the significance of preserved k...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-019-1242-0
更新日期:2019-02-08 00:00:00
abstract:BACKGROUND:Providing patient-centered care needs in patients with chronic renal failure undergoing hemodialysis is important in inspiring their confidence to continue their treatment and promote their mental and social health. Therefore, recognizing the concept of care from the viewpoint of these patients can be helpfu...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-018-1138-4
更新日期:2018-11-26 00:00:00
abstract:BACKGROUND:Urinary albumin can be measured in 24 h or spot samples. The 24 h urinary albumin excretion rate is considered the gold standard, but is cumbersome to collect. Instead, often an overnight sample is collected, and adjusted for dilution. Proxies for 24 h excretion rate have been studied in diabetics, but seldo...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/1471-2369-16-8
更新日期:2015-01-24 00:00:00
abstract:BACKGROUND:Accurately determining renal function is essential for clinical management of HIV patients. Classically, it has been evaluated by estimating glomerular filtration rate (eGFR) with the MDRD-equation, but today there is evidence that the new Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation ...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-017-0470-4
更新日期:2017-02-10 00:00:00
abstract:BACKGROUND:Pyrrolidine dithiocarbamate (PDTC) reduces renal cyst growth in a rodent model of polycystic kidney disease (PKD) but the mechanism of action is not clear. Here, we investigated the hypothesis that PDTC reduces the proliferation of cystic epithelial cells in vitro in a nuclear factor (NF)-κB-dependent manner...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-015-0193-3
更新日期:2015-12-15 00:00:00
abstract:BACKGROUND:Evidence suggests that alkaline phosphatase attenuates inflammatory response in sepsis by lipopolysaccharide detoxification and adenosine triphosphate dephosphorylation. We sought to determine changes in alkaline phosphatase (AP) activity during septic acute kidney injury (AKI) and clinical parameters associ...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-018-1028-9
更新日期:2018-09-20 00:00:00
abstract:BACKGROUND:Group A streptococcus (GAS) is an etiological agent for the immune mediated sequela post streptococcal glomerulonephritis (PSGN). In some populations PSGN is recognized as a risk factor for chronic kidney disease (CKD) and end-stage renal disease (ESRD). It was found that a significantly greater proportion o...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/1471-2369-14-101
更新日期:2013-05-06 00:00:00
abstract:BACKGROUND:Almost all cases of renal hydatid cysts need surgical intervention for treatment. We report a case of isolated renal hydatid cyst treated successfully only with medical therapy. CASE PRESENTATION:This case is a 79-year-old veterinarian presented with right flank pain, hydatiduria and positive echinococcus g...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-020-02064-5
更新日期:2020-10-08 00:00:00
abstract:BACKGROUND:Concentration of the urine is primarily regulated via vasopressin dependent aquaporin-2 water channels in the apical membrane of kidney principal cells. It is unclear whether urine concentration ability in ADPKD differs from other patients with similar degree of impaired renal function (non-ADPKD patients). ...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-020-02043-w
更新日期:2020-08-31 00:00:00