Abstract:
BACKGROUND:The predictive value of acute kidney injury (AKI) urinary biomarkers may depend on the time interval following tubular injury, thereby explaining in part the heterogeneous performance of these markers that has been reported in the literature. We studied the influence of timing on the predictive values of tubular proteins, measured before the rise of serum creatinine (SCr) in critically ill, non-septic patients. METHODS:Seven hundred adult critically ill patients were prospectively included for urine measurements at four time-points prior to the rise in serum creatinine (T = 0, -16, -20 and -24 h). Patients with sepsis and or AKI at ICU entry were excluded. The urinary excretion of the proteins, neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule-1 (KIM-1), which are up-regulated in the distal and proximal tubules, respectively, were measured as well as the constitutive cytoplasmatic enzymes, π- and α-glutathione-S-transferase (GST), which are released by the distal and proximal tubules, respectively. RESULTS:Five hundred and forty-three subjects were eligible for further analyses; however, 49 developed AKI in the first 48 h. Both NGAL (P = 0.001 at T = -24 vs. non-AKI patients) and KIM-1 (P < 0.0001 at T = 0 vs. non-AKI patients) concentrations gradually increased until AKI diagnosis, whereas π- and α-GST peaked at T = -24 before AKI (P = 0.006 and P = 0.002, respectively vs. non-AKI patients) and showed a rapid decline afterwards. The predictive values at T = -24 prior to AKI were modest for π- and α-GST, whereas NGAL sufficiently predicted AKI at T = -24 and its predictive power improved as the time interval to AKI presentation decreased (area under the receiver operating characteristic curve; AUC = 0.79, P < 0.0001). KIM-1 was a good discriminator at T = 0 only (AUC = 0.73, P < 0.0001). CONCLUSIONS:NGAL, KIM-1, pi- and alpha-GST displayed unique and mutually incomparable time dependent characteristics during the development of non-sepsis related AKI. Therefore, the time-relationship between the biomarker measurements and the injurious event influences the individual test results.
journal_name
BMC Nephroljournal_title
BMC nephrologyauthors
de Geus HR,Fortrie G,Betjes MG,van Schaik RH,Groeneveld ABdoi
10.1186/1471-2369-14-273subject
Has Abstractpub_date
2013-12-09 00:00:00pages
273issn
1471-2369pii
1471-2369-14-273journal_volume
14pub_type
杂志文章相关文献
BMC Nephrology文献大全abstract:BACKGROUND:This study aimed to compare clinical features and health-related quality of life (HRQoL) in the Chinese chronic kidney disease (CKD) 3 population and determined the necessity of the subdivision of CKD3 in Chinese patients with CKD. METHODS:Participants with stage 3 CKD (18-74 years of age) were recruited at...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-017-0725-0
更新日期:2017-10-13 00:00:00
abstract:BACKGROUND:In view of the prevalence of oxidative stress in chronic kidney disease (CKD) patients, the loss of low-molecular-weight biomolecules by hemodialysis and the antioxidant potential of some uremic solutes that accumulate in CKD, we used in vitro model systems to test the antioxidant potential of the following ...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-015-0029-1
更新日期:2015-04-11 00:00:00
abstract:BACKGROUND:Group A streptococcus (GAS) is an etiological agent for the immune mediated sequela post streptococcal glomerulonephritis (PSGN). In some populations PSGN is recognized as a risk factor for chronic kidney disease (CKD) and end-stage renal disease (ESRD). It was found that a significantly greater proportion o...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/1471-2369-14-101
更新日期:2013-05-06 00:00:00
abstract:BACKGROUND:Recently there has been a progressive loss of specialty related skills for nephrologists. Among the skills we find the kidney biopsy that has a central role in diagnosis of renal parenchymal disease. One of the causes might be the belief that the kidney biopsy should be performed only in larger Centers which...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-017-0796-y
更新日期:2018-01-15 00:00:00
abstract:BACKGROUND:Tissue derived biomarkers may offer utility as indicators of accumulated damage. Reduced thickness of retinal neuronal tissue and the vascular choroid have previously been associated with vascular damage and diabetes. We evaluated associations between retinal thickness, retinal microvascular and choroidal me...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-019-1679-1
更新日期:2020-01-31 00:00:00
abstract:BACKGROUND:Anaemia of chronic kidney disease increases the risk of death and adverse events, but can be managed using erythropoiesis stimulating agents (ESAs). However, recent evidence suggests that targeting a higher haemoglobin concentration ([Hb]) increases mortality risk, and both higher [Hb] targets and ESA doses ...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/1471-2369-13-40
更新日期:2012-06-15 00:00:00
abstract:BACKGROUND:The high cost, complexity of the available protocols, and metabolic complications are the major barriers that impede the clinical utilization of regional citrate anticoagulation (RCA) for sustained low efficiency dialysis (SLED) in critically ill patients. By comparing a novel protocol for SLED using 30% cit...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-018-0879-4
更新日期:2018-04-03 00:00:00
abstract:BACKGROUND:Until now, no long-term studies relating serum albumin level to mortality rate in prevalent haemodialysis (HD) patients have been conducted. We aimed to examine the association between serum albumin level and mortality over a 5-year period. METHODS:This study included 781 patients who received maintenance H...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-016-0332-5
更新日期:2016-08-20 00:00:00
abstract:BACKGROUND:The current literature recognises that left ventricular hypertrophy makes a key contribution to the high rate of premature cardiovascular mortality in dialysis patients. Determining how we might intervene to ameliorate left ventricular hypertrophy in dialysis populations has become a research priority. Reduc...
journal_title:BMC nephrology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/1471-2369-14-149
更新日期:2013-07-15 00:00:00
abstract:BACKGROUND:Primary hyperoxaluria type 1 is a rare autosomal recessive disease of glyoxylate metabolism caused by a defect in the liver-specific peroxisomal enzyme alanine:glyoxylate aminotransferase (AGT) that leads to hyperoxaluria, recurrent urolithiasis, and nephrocalcinosis. METHODS:Two unrelated patients with rec...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/1471-2369-15-92
更新日期:2014-06-17 00:00:00
abstract:BACKGROUND:Hypertensive nephropathy (HTN) is a kind of renal injury caused by chronic hypertension, which seriously affect people's life. The purpose of this study was to identify the potential biomarkers of HTN and understand its possible mechanisms. METHODS:The dataset numbered GSE28260 related to hypertensive and n...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-020-02142-8
更新日期:2020-11-11 00:00:00
abstract:BACKGROUND:Parents' adaptation affects the health outcomes of children with chronic kidney diseases (CKD). Identifying factors that affect parents' adaptation is necessary to understand their adaptation status. This study aims to explore factors related to the adaptation of parents who have children with CKD. METHODS:...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-020-02170-4
更新日期:2020-11-25 00:00:00
abstract:BACKGROUND:Very less is known about health-related quality of life (HRQOL) among patients with kidney diseases in Nepal. This study examined HRQOL among haemodialysis and kidney transplant recipients in Nepal. METHODS:The Nepali version of World Health Organization Quality of Life Instruments -(WHOQOL-BREF) questionna...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-020-02085-0
更新日期:2020-10-12 00:00:00
abstract:BACKGROUND:The poorly differentiated renal cell carcinoma (RCC) with rhabdomyosarcomatous sarcomatoid differentiation shows a severely aggressive biological behavior characterized by rapid disease progression. Preoperative identification of the subtype with the prognostic factors and imaging features of sarcomatoid ren...
journal_title:BMC nephrology
pub_type: 杂志文章,评审
doi:10.1186/s12882-018-0884-7
更新日期:2018-04-10 00:00:00
abstract:BACKGROUND:Galectin-9 (Gal-9) induces apoptosis in activated T helper 1 (TH1) cells as a ligand for T cell immunoglobulin mucin-3 (Tim-3). Gal-9 also inhibits the G1 phase cell cycle arrest and hypertrophy in db/db mice, the hallmark of early diabetic nephropathy, by reversing the high glucose-induced up-regulation of ...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/1471-2369-14-23
更新日期:2013-01-22 00:00:00
abstract:BACKGROUND:Patients who start renal replacement therapy (RRT) for End-Stage Kidney Disease (ESKD) without having had timely access to specialist renal services have poor outcomes. At one NHS Trust in England, a community-wide CKD management system has led to a decline in the incident rate of RRT and the lowest percenta...
journal_title:BMC nephrology
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12882-017-0522-9
更新日期:2017-04-11 00:00:00
abstract:BACKGROUND:Anabolic-androgenic steroids and growth hormone are among the most commonly used supplements by sportsmen and sportswomen. The aim of this systematic review is to collect and report available data about renal safety of anabolic-androgenic steroids and growth hormone (GH). METHODS:The search strategy was in ...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-019-1384-0
更新日期:2019-05-31 00:00:00
abstract:BACKGROUND:Patients with chronic kidney diseases (CKD) on haemodialysis (HD) have high morbidity and mortality rates, which are also due to the inherent risks associated with nephropathy. Non-adherence (NA) to the different demands of the treatment can have consequences for the outcome of patients undergoing HD; nevert...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-019-1573-x
更新日期:2019-11-06 00:00:00
abstract:BACKGROUND:Chronic cyclosporine-(CsA)-mediated loss of kidney function is a major clinical problem in organ transplantation. We hypothesized that the mineralocorticoid receptor antagonist eplerenone (EPL) prevents chronic CsA-induced renal interstitial volume increase, tubule loss, and functional impairment in a rat mo...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/1471-2369-14-42
更新日期:2013-02-20 00:00:00
abstract:BACKGROUND:Epithelioid angiomyolipoma is defined as potentially malignant mesenchymal neoplasm, characterized by proliferating epithelioid cells, whereas classic angiomyolipoma, composed of fat, smooth muscle cells and dysmorphic vessels, is defined as a potentially benign. The usual or classic angiomyolipoma is often ...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-018-0919-0
更新日期:2018-05-30 00:00:00
abstract:BACKGROUND:The Reducing Disparities in Access to kidNey Transplantation Community Study (RaDIANT) was an End-Stage Renal Disease (ESRD) Network 6-developed, dialysis facility-level randomized trial testing the effectiveness of a 1-year multicomponent education and quality improvement intervention in increasing referral...
journal_title:BMC nephrology
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12882-017-0807-z
更新日期:2018-01-15 00:00:00
abstract:BACKGROUND:Older patients with end-stage kidney disease (ESKD) often live with unidentified frailty and multimorbidity. Despite guideline recommendations, geriatric assessment is not part of standard clinical care, resulting in a missed opportunity to enhance (clinical) outcomes including quality of life in these patie...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-020-02206-9
更新日期:2021-01-06 00:00:00
abstract:BACKGROUND:Kidney injury molecule-1 (KIM-1) is a biomarker useful for detecting early tubular damage and has been recently reported as a useful marker for evaluating kidney injury in IgA nephropathy (IgAN). We therefore investigated whether treatment decreases urinary KIM-1 excretion in IgAN. METHODS:We prospectively ...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/1471-2369-14-139
更新日期:2013-07-09 00:00:00
abstract:BACKGROUND:Proteinuria after kidney transplantation portends a worse graft survival. However the magnitude of proteinuria related to patient and graft survival and its correlation with donor and recipient characteristics are poorly explored. METHODS:This study investigated the impact of post transplant proteinuria in ...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-019-1635-0
更新日期:2019-12-02 00:00:00
abstract:BACKGROUND:Sustained low efficiency dialysis (SLED) is increasingly used as a renal replacement modality in critically ill patients with acute kidney injury (AKI) and hemodynamic instability. SLED may reduce the hemodynamic perturbations of intermittent hemodialysis, while obviating the resource demands of CRRT. Althou...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-015-0123-4
更新日期:2015-08-04 00:00:00
abstract:BACKGROUND:Age and number of recipients in need of kidney re-transplantation are increasing. Re-transplantation practices and outcomes in elderly recipients are not previously explored. We aimed to retrospectively evaluate the outcomes of recipients 65 years and older receiving their second deceased donor allograft. M...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-016-0426-0
更新日期:2017-01-11 00:00:00
abstract:BACKGROUND:Seasonal mortality differences have been reported in US hemodialysis (HD) patients. Here we examine the effect of seasons on mortality, clinical and laboratory parameters on a global scale. METHODS:Databases from the international Monitoring Dialysis Outcomes (MONDO) consortium were queried to identify pati...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-015-0129-y
更新日期:2015-08-14 00:00:00
abstract:BACKGROUND:ANCA-associated vasculitis is a life-threatening, systemic autoimmune disease. There is an increased risk of organ infarction but in many cases this is asymptomatic. We described here the first reported case of PR3 vasculitis presenting with symptomatic bilateral renal wedge infarction. CASE PRESENTATION:A ...
journal_title:BMC nephrology
pub_type: 杂志文章,评审
doi:10.1186/s12882-019-1266-5
更新日期:2019-03-06 00:00:00
abstract:BACKGROUND:Hypertension is a public health problem with mostly unknown causes, and where strong hereditary genetic alterations have not been fully elucidated. However, the use of experimental models has provided valuable information. Recent evidences suggest that alterations in key nephrogenic factors, such as Wilms' t...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-016-0250-6
更新日期:2016-03-24 00:00:00
abstract:BACKGROUND:Atypical hemolytic uremic syndrome (aHUS) is a rare, genetically-mediated systemic disease most often caused by chronic, uncontrolled complement activation that leads to systemic thrombotic microangiopathy (TMA) and renal and other end-organ damage. METHODS:The global aHUS Registry, initiated in April 2012,...
journal_title:BMC nephrology
pub_type: 杂志文章,多中心研究
doi:10.1186/s12882-015-0195-1
更新日期:2015-12-10 00:00:00