Should patients older than 65 years be offered a second kidney transplant?

abstract：BACKGROUND:Chronic active antibody-mediated rejection is a major etiology of graft loss in renal transplant recipients. However, there is no consensus on the optimal treatment strategies. METHODS:Computerized records from Taichung Veterans General Hospital were collected to identify renal transplant biopsies performed...

journal_title：BMC nephrology

authors： Chiu HF,Wen MC,Wu MJ,Chen CH,Yu TM,Chuang YW,Huang ST,Tsai SF,Lo YC,Ho HC,Shu KH

更新日期：2020-01-06 00:00:00

abstract：BACKGROUND:Endothelial dysfunction occurs in patients with end-stage renal disease (ESRD) and is associated with increased cardiovascular morbidity and mortality. Asymmetric dimethylarginine (ADMA) contributes to endothelial dysfunction in ESRD. In the general population, angiotensin-converting enzyme (ACE) inhibitors ...

journal_title：BMC nephrology

authors： Gamboa JL,Pretorius M,Sprinkel KC,Brown NJ,Ikizler TA

更新日期：2015-10-22 00:00:00

abstract：BACKGROUND:There is conflicting evidence of benefit versus harm for warfarin anticoagulation in hemodialysis patients with atrial fibrillation. This equipoise may be explained by suboptimal Time in Therapeutic Range (TTR), which correlates well with thromboembolic and bleeding complications. This study aimed to compare...

journal_title：BMC nephrology

authors： Bahbahani H,AlTurki A,Dawas A,Lipman ML

更新日期：2018-01-08 00:00:00

abstract：BACKGROUND:Tolvaptan is a selective vasopressin receptor antagonist. Nitric Oxide (NO) promotes renal water and sodium excretion, but the effect is unknown in the nephron's principal cells. In a dose-response study, we measured the effect of tolvaptan on renal handling of water and sodium and systemic hemodynamics, dur...

journal_title：BMC nephrology

authors： Al Therwani S,Rosenbæk JB,Mose FH,Bech JN,Pedersen EB

更新日期：2017-03-13 00:00:00

abstract：BACKGROUND:Serum parathyroid hormone (PTH) levels have been reported to be associated with infectious mortality in peritoneal dialysis (PD) patients. Peritonitis is the most common and fatal infectious complication, resulting in technique failure, hospital admission and mortality. Whether PTH is associated with periton...

journal_title：BMC nephrology

authors： Yang Y,Da J,Jiang Y,Yuan J,Zha Y

更新日期：2021-01-29 00:00:00

abstract：BACKGROUND:Kidney injury molecule-1 (KIM-1) is a biomarker useful for detecting early tubular damage and has been recently reported as a useful marker for evaluating kidney injury in IgA nephropathy (IgAN). We therefore investigated whether treatment decreases urinary KIM-1 excretion in IgAN. METHODS:We prospectively ...

journal_title：BMC nephrology

authors： Seo MS,Park MY,Choi SJ,Jeon JS,Noh H,Kim JK,Han DC,Hwang SD,Jin SY,Kwon SH

更新日期：2013-07-09 00:00:00

abstract：BACKGROUND:Studies suggest 24-h blood pressure (BP) variability has prognostic value for cardiovascular disease. Several factors associated with high 24-h BP variability are also common among individuals with chronic kidney disease (CKD). We hypothesized 24-h BP variability would be higher for individuals with versus w...

journal_title：BMC nephrology

authors： Tanner RM,Shimbo D,Dreisbach AW,Carson AP,Fox ER,Muntner P

更新日期：2015-06-18 00:00:00

abstract：BACKGROUND:Podocyte apoptosis is a major mechanism that leads to proteinuria in many kidney diseases. However, the concert mechanisms that cause podocyte apoptosis in these kidney diseases are not fully understood. RhoA is one of Rho GTPases that has been well studied and plays a key role in regulating cytoskeletal arc...

journal_title：BMC nephrology

authors： Huang Z,Zhang L,Chen Y,Zhang H,Yu C,Zhou F,Zhang Z,Jiang L,Li R,Ma J,Li Z,Lai Y,Lin T,Zhao X,Zhang Q,Zhang B,Ye Z,Liu S,Wang W,Liang X,Liao R,Shi W

更新日期：2016-07-07 00:00:00

abstract：BACKGROUND:Patients with end-stage renal disease (ESRD) exhibit a premature aging phenotype of immune system, which is recently concerned as a significant factor for increased risk of various morbidities. Nevertheless, there are few dates explicating the relevancy of T cell senescence to mortality. In this study, we pr...

journal_title：BMC nephrology

authors： Xiang F,Chen R,Cao X,Shen B,Chen X,Ding X,Zou J

更新日期：2020-07-13 00:00:00

abstract：BACKGROUND:Bioimpedance analysis (BIA) has been reported as helpful in identifying hypervolemia. Observation data showed that hypervolemic maintenance hemodialysis (MHD) patients identified using BIA methods have higher mortality risk. However, it is not known if BIA-guided fluid management can improve MHD patients' su...

journal_title：BMC nephrology

authors： Liu L,Long G,Ren J,Li J,Xu J,Lei J,Li M,Qiu M,Yuan P,Sun W,Lin S,Liu W,Sun Y,Ma Y,Mao Y,Shen Y,Zuo L

更新日期：2012-09-25 00:00:00

abstract：BACKGROUND:Increased leucine-rich α2-glycoprotein-1 (LRG1) has been observed in various inflammatory and autoimmune diseases. We aimed to explore the expression and role of LRG1 in lupus nephritis (LN). METHODS:Plasma LRG1 (pLRG1) was measured by enzyme-linked immunosorbent assay in 101 patients with renal biopsy-prov...

journal_title：BMC nephrology

authors： Yang Y,Luo R,Cheng Y,Liu T,Dai W,Li Y,Ge S,Xu G

更新日期：2020-04-06 00:00:00

abstract：BACKGROUND:Accumulating evidence suggests that a decrease in brain-derived neurotrophic factor (BDNF) level induces a variety of psychiatric and neurological disorders. However, the expression and role of BDNF in the kidney have not been explored. The present study examined the expression of BDNF and tropomyosin-relate...

journal_title：BMC nephrology

authors： Tao YS,Piao SG,Jin YS,Jin JZ,Zheng HL,Zhao HY,Lim SW,Yang CW,Li C

更新日期：2018-03-14 00:00:00

abstract：BACKGROUND:Liddle's syndrome is a rare monogenic form of hypertension caused by truncating or missense mutations in the C termini of the epithelial sodium channel (ENaC) β or γ subunits. Patients with this syndrome present with early onset of hypertension, hypokalemia, metabolic alkalosis, hyporeninemia and hypoaldoste...

journal_title：BMC nephrology

authors： Yamaguchi E,Yoshikawa K,Nakaya I,Kato K,Miyasato Y,Nakagawa T,Kakizoe Y,Mukoyama M,Soma J

更新日期：2018-05-23 00:00:00

abstract：BACKGROUND:Urinary Ca2+ excretion increases with dietary NaCl. NaCl-induced calciuria may be associated with hypertension, urinary stone formation and osteoporosis, but its mechanism and long-term effects are not fully understood. This study examined alterations in the expressions of renal Ca2+ transporters, channels a...

journal_title：BMC nephrology

authors： Yatabe MS,Yatabe J,Takano K,Murakami Y,Sakuta R,Abe S,Sanada H,Kimura J,Watanabe T

更新日期：2012-12-02 00:00:00

abstract：BACKGROUND:As a result of difficulties related to their illness, diagnosis and treatment, patients with end-stage renal disease experience significant emotional and psychological problems, which untreated can have considerable negative impact on their health and wellbeing. Despite evidence that patients desire improved...

journal_title：BMC nephrology

authors： Taylor F,Taylor C,Baharani J,Nicholas J,Combes G

更新日期：2016-08-02 00:00:00

abstract：BACKGROUND:This study will assess measures of vascular health and inflammation in Aboriginal Australian adults with chronic kidney disease (CKD), and determine if intensive periodontal intervention improves cardiovascular health, progression of renal disease and periodontal health over a 24-month follow-up. METHODS:Th...

journal_title：BMC nephrology

authors： Jamieson L,Skilton M,Maple-Brown L,Kapellas K,Askie L,Hughes J,Arrow P,Cherian S,Fernandes D,Pawar B,Brown A,Boffa J,Hoy W,Harris D,Mueller N,Cass A

更新日期：2015-10-31 00:00:00

abstract：BACKGROUND:Residing remotely from health care resources appears to impact quality of care delivery. It remains unclear if there are differences in vascular access based on distance of one's residence to dialysis centre at time of dialysis initiation, and whether region or duration of pre-dialysis care are important eff...

journal_title：BMC nephrology

authors： Miller LM,Vercaigne LM,Moist L,Lok CE,Tangri N,Komenda P,Rigatto C,Mojica J,Sood MM

更新日期：2014-02-27 00:00:00

abstract：BACKGROUND:Inherited cystic kidney disease is a spectrum of disorders in which clusters of renal cysts develop as the result of genetic mutation. The exact methods and pipelines for defining genetic mutations of inherited cystic kidney disease are not clear at this point. This 3-year, prospective, multicenter, cohort s...

journal_title：BMC nephrology

authors： Park HC,Ryu H,Kim YC,Ahn C,Lee KB,Kim YH,Kim Y,Han S,Kim Y,Bae EH,Ma SK,Kang HG,Ahn YH,Park E,Jeong K,Lee J,Choi J,Oh KH,Oh YK

更新日期：2021-01-06 00:00:00

abstract：BACKGROUND:Hypertension is a public health problem with mostly unknown causes, and where strong hereditary genetic alterations have not been fully elucidated. However, the use of experimental models has provided valuable information. Recent evidences suggest that alterations in key nephrogenic factors, such as Wilms' t...

journal_title：BMC nephrology

authors： Mazzei L,García M,Calvo JP,Casarotto M,Fornés M,Abud MA,Cuello-Carrión D,Ferder L,Manucha W

更新日期：2016-03-24 00:00:00

abstract：BACKGROUND:TAFRO syndrome is a clinical subtype of idiopathic multicentric Castleman disease (iMCD) that is characterized by thrombocytopenia, anasarca, fever, reticulin myelofibrosis (or renal dysfunction), and organomegaly. TAFRO syndrome has only recently been described, and many clinicians are unaware of this disea...

journal_title：BMC nephrology

authors： Zhou Q,Zhang Y,Zhou G,Zhu J

更新日期：2020-11-23 00:00:00

abstract：BACKGROUND:Until now, no long-term studies relating serum albumin level to mortality rate in prevalent haemodialysis (HD) patients have been conducted. We aimed to examine the association between serum albumin level and mortality over a 5-year period. METHODS:This study included 781 patients who received maintenance H...

journal_title：BMC nephrology

authors： Chen JB,Cheng BC,Yang CH,Hua MS

更新日期：2016-08-20 00:00:00

abstract：BACKGROUND:The possibility of clearing Cell-free Plasma Hemoglobin (CPH) from human plasma may appear attractive, especially when considering the noxious effects that CPH has on the immune function and the renal damage caused by its filtration. The existence of the so-called High Cut-Off (HCO) filters, possessing pores...

journal_title：BMC nephrology

authors： Cucchiari D,Reverter E,Blasco M,Molina-Andujar A,Carpio A,Sanz M,Escorsell A,Fernández J,Poch E

更新日期：2018-10-04 00:00:00

abstract：BACKGROUND:The Reducing Disparities in Access to kidNey Transplantation Community Study (RaDIANT) was an End-Stage Renal Disease (ESRD) Network 6-developed, dialysis facility-level randomized trial testing the effectiveness of a 1-year multicomponent education and quality improvement intervention in increasing referral...

journal_title：BMC nephrology

authors： Hamoda RE,Gander JC,McPherson LJ,Arriola KJ,Cobb L,Pastan SO,Plantinga L,Browne T,Hartmann E,Mulloy L,Zayas C,Krisher J,Patzer RE

更新日期：2018-01-15 00:00:00

abstract：BACKGROUND:To study the incidence of vancomycin-associated acute kidney injury (VA-AKI) in Hong Kong and identify risk factors for VA-AKI. METHOD:Patients with vancomycin prescription and blood level measurement in 2012-2016 were identified using the Hong Kong Hospital Authority Clinical Data Analysis and Reporting Sy...

journal_title：BMC nephrology

authors： Qin X,Tsoi MF,Zhao X,Zhang L,Qi Z,Cheung BMY

更新日期：2020-02-03 00:00:00

abstract：BACKGROUND:Disagreements between clinic and ambulatory blood pressure (BP) measurements are well-described in the general population. Though hypertension is frequent in renal transplant recipients, only a few studies address the clinic-ambulatory discordance in this population. We aimed to describe the difference betwe...

journal_title：BMC nephrology

authors： Gluskin E,Tzukert K,Mor-Yosef Levi I,Gotsman O,Sagiv I,Abel R,Bloch A,Rubinger D,Aharon M,Dranitzki Elhalel M,Ben-Dov IZ

更新日期：2019-07-27 00:00:00

abstract：BACKGROUND:To assess whether serum osteoprotegerin (OPG) and/or fetuin-A predict mortality and cardiovascular (CV) morbidity and mortality in hemodialysis patients. METHODS:Multicenter, observational, prospective study that included 220 hemodialysis patients followed up for up to 6 years. Serum OPG and fetuin-A levels...

journal_title：BMC nephrology

authors： Collado S,Coll E,Nicolau C,Azqueta M,Pons M,Cruzado JM,de la Torre B,Deulofeu R,Mojal S,Pascual J,Cases A

更新日期：2017-09-07 00:00:00

abstract：BACKGROUND:Levetiracetam is a frequently used drug in the therapy of partial onset, myoclonic and generalized tonic-clonic seizures. The main route of elimination is via the kidneys, which eliminate 66% of the unchanged drug as well as 24% as inactive metabolite that stems from enzymatic hydrolysis. Therefore dose adju...

journal_title：BMC nephrology

authors： Bahte SK,Hiss M,Lichtinghagen R,Kielstein JT

更新日期：2014-04-16 00:00:00

abstract：BACKGROUND:Ongoing efforts are focused on shortening ischemia intervals as much as possible during partial nephrectomy to preserve renal function. Off-clamp partial nephrectomy (off-PN) has been a common strategy for to avoid ischemia in small renal tumors. Although studies comparing the advantages between off-PN with ...

journal_title：BMC nephrology

authors： Deng W,Liu X,Hu J,Chen L,Fu B

更新日期：2018-07-31 00:00:00

abstract：BACKGROUND:Diabetes mellitus is the leading cause of end-stage renal disease (ESRD) globally. Diabetes and human immunodeficiency virus (HIV), both prevalent in South Africa, have not been reported as significant causes of ESRD. METHODS:We evaluated chronic kidney disease (CKD) and cardiovascular disease risk factors ...

journal_title：BMC nephrology

authors： Madala ND,Thusi GP,Assounga AG,Naicker S

更新日期：2014-04-14 00:00:00

abstract：BACKGROUND:Vancomycin is the first-line antibiotic for methicillin-resistant Staphylococcus aureus and coagulase-negative strains. The risk of vancomycin-induced acute kidney injury increases with plasma vancomycin levels. Vancomycin-induced acute kidney injury is histologically characterized by acute interstitial neph...

journal_title：BMC nephrology

authors： Sawada A,Kawanishi K,Morikawa S,Nakano T,Kodama M,Mitobe M,Taneda S,Koike J,Ohara M,Nagashima Y,Nitta K,Mochizuki T

更新日期：2018-03-27 00:00:00