Genetic identification of inherited cystic kidney diseases for implementing precision medicine: a study protocol for a 3-year prospective multicenter cohort study.

abstract：BACKGROUND:Diabetic nephropathy (DN) is a primary complication of diabetes mellitus (DM). The pathology of DN is still vague, and diagnostic accuracy is not enough. This study was performed to identify miRNAs and genes that have possibilities of being used as therapeutic targets for DN in type 2 DM. METHODS:Human miRN...

journal_title：BMC nephrology

authors： Yu Y,Jia YY,Wang M,Mu L,Li HJ

更新日期：2021-01-12 00:00:00

abstract：BACKGROUND:Klotho is a transmembrane protein acting as a co-receptor for FGF-23 and thus exerts clinical actions on mineral metabolism. The association of secreted Klotho with outcomes in CKD patients is unclear. This study examined the relation between plasma Klotho and cardiovascular events in dialysis patients, acco...

journal_title：BMC nephrology

authors： Memmos E,Sarafidis P,Pateinakis P,Tsiantoulas A,Faitatzidou D,Giamalis P,Vasilikos V,Papagianni A

更新日期：2019-06-11 00:00:00

abstract：BACKGROUND:The aim of this study was to describe the findings of renal biopsies from a large nephrology center in Iasi, Romania, performed between 2005 and 2010. We compared these findings with our previous ones, from 1995 to 2004, as well as with similar reports. METHODS:We studied retrospectively 239 renal biopsies....

journal_title：BMC nephrology

authors： Volovăt C,Cãruntu I,Costin C,Stefan A,Popa R,Volovăt S,Siriopol D,Voroneanu L,Nistor I,Segall L,Covic A

更新日期：2013-07-15 00:00:00

abstract：BACKGROUND:HS219 (40 mg chitosan-loaded chewing gum) is designed to bind salivary phosphorus as an add-on to available phosphorus binders. We performed a randomized, placebo-controlled, double-blind study to evaluate the efficacy and safety of HS219 in hemodialysis (HD) patients with hyperphosphatemia as an add-on to p...

journal_title：BMC nephrology

authors： Akizawa T,Tsuruta Y,Okada Y,Miyauchi Y,Suda A,Kasahara H,Sasaki N,Maeda Y,Suzuki T,Matsui N,Niwayama J,Suzuki T,Hara H,Asano Y,Komemushi S,Fukagawa M

更新日期：2014-06-25 00:00:00

abstract：BACKGROUND:Acute kidney injury (AKI) is common in hospitalized human immunodeficiency virus (HIV)-infected patients and is associated with hospital mortality. We aimed to evaluate the impact of AKI on long-term mortality of hospitalized HIV-infected patients. METHODS:Retrospective analysis of a cohort of 433 hospitali...

journal_title：BMC nephrology

authors： Lopes JA,Melo MJ,Raimundo M,Fragoso A,Antunes F

更新日期：2013-02-11 00:00:00

abstract：BACKGROUND:Bordetella pertussis infection is a known trigger of atypical hemolytic uremic syndrome (HUS). For patients suspected of having atypical HUS, prompt plasma exchange/infusion (PE/PI) or eculizumab (ECZ) treatment is recommended. CASE PRESENTATION:We report a 1-month-old female infant who was admitted with a ...

journal_title：BMC nephrology

authors： Saida K,Ogura M,Kano Y,Ishimori S,Yoshikawa T,Nagata H,Sato M,Kamei K,Ishikura K

更新日期：2018-12-17 00:00:00

abstract：BACKGROUND:There is limited evidence on the relationship between social support and renal outcomes in African Americans. We sought to determine the association of social support with prevalent chronic kidney disease (CKD) and kidney function decline in an African American cohort. We also examined whether age modifies t...

journal_title：BMC nephrology

authors： Hall RK,Davenport CA,Sims M,Colón-Emeric C,Washington T,St Clair Russell J,Pendergast J,Bhavsar N,Scialla J,Tyson CC,Wang W,Min YI,Young B,Boulware LE,Diamantidis CJ

更新日期：2019-07-15 00:00:00

abstract：BACKGROUND:Treatment of idiopathic membranous nephropathy with nephrotic syndrome is still controversial. There is currently little known about the clinical use of renal biomarkers which may explain contradictory results obtained from clinical trials. In order to assess whether IgG-uria can predict the outcome in membr...

journal_title：BMC nephrology

authors： Bazzi C,Rizza V,Casellato D,Tofik R,Berg AL,Gallieni M,D'Amico G,Bakoush O

更新日期：2014-05-08 00:00:00

abstract：BACKGROUND:Very less is known about health-related quality of life (HRQOL) among patients with kidney diseases in Nepal. This study examined HRQOL among haemodialysis and kidney transplant recipients in Nepal. METHODS:The Nepali version of World Health Organization Quality of Life Instruments -(WHOQOL-BREF) questionna...

journal_title：BMC nephrology

authors： Ranabhat K,Khanal P,Mishra SR,Khanal A,Tripathi S,Sigdel MR

更新日期：2020-10-12 00:00:00

abstract：BACKGROUND:Transfusion patterns are not well characterized in non-dialysis (ND) chronic kidney disease (CKD) patients. This study describes the proportion of patients transfused, units of blood transfused and trigger-hemoglobin (Hb) levels for transfusions in severe anemic, ND-CKD patients in routine practice. METHODS...

journal_title：BMC nephrology

authors： Fox KM,Yee J,Cong Z,Brooks JM,Petersen J,Lamerato L,Gandra SR

更新日期：2012-01-24 00:00:00

abstract：BACKGROUND:Hyperphosphatemia is associated with vascular calcification and bone mineral disorders and is a major concern among patients with chronic kidney disease (CKD). However, the relationship between hyperphosphatemia and renal outcome in non-CKD patients has not been studied. Furthermore, the clinical implication...

journal_title：BMC nephrology

authors： Moon H,Chin HJ,Na KY,Joo KW,Kim YS,Kim S,Han SS

更新日期：2019-09-18 00:00:00

abstract：BACKGROUND:Chronic kidney disease (CKD) is increasingly being recognized as a predictor for both end-stage renal disease and cardiovascular disease. The present study, conducted on individuals from a community in Arita, Japan, was designed to evaluate biomarkers that can be used to determine the associated factors for ...

journal_title：BMC nephrology

authors： Takamatsu N,Abe H,Tominaga T,Nakahara K,Ito Y,Okumoto Y,Kim J,Kitakaze M,Doi T

更新日期：2009-10-27 00:00:00

abstract：BACKGROUND:Emerging evidence of psychosocial problems in CKD patients has led to an acceptance that a focus on the emotional wellbeing of the patient should be included in the provision of comprehensive CKD care. It is unclear if an increased attention for psychosocial needs in guidelines and policy documents has led t...

journal_title：BMC nephrology

authors： Seekles ML,Ormandy P,Coyne E

更新日期：2019-03-21 00:00:00

abstract：BACKGROUND:Patients with end-stage renal disease (ESRD) under hemodialysis (HD) are at greater risks of infectious spondylitis (IS), but there is no reliable predictor that facilitate early detection of this relatively rare and insidious disease. METHODS:A retrospective review of the medical records from patients with...

journal_title：BMC nephrology

authors： Lu KL,Huang WH,Lu YA,Lin CY,Wu HH,Hsu CW,Weng CH,Wu CY,Wu IW,Wu MY,Yen TH,Yang HY

更新日期：2019-08-16 00:00:00

abstract：BACKGROUND:Current guidelines regarding plasma-sampling techniques for glomerular filtration rate (GFR) determination are inconsistent. Single-sample methods are commonly believed not to be precise enough to meet clinical demands. The present study compared the agreement between single- and dual- plasma sampling method...

journal_title：BMC nephrology

authors： Zhang Y,Sui Z,Yu Z,Li TF,Feng WY,Zuo L

更新日期：2018-07-11 00:00:00

abstract：BACKGROUND:Single nucleotide polymorphisms (SNPs) are the most common forms of sequence variations in the human genome. They contribute to the human phenotypic spectrum and are associated with variations in response to pathogens, drugs and vaccines. Recently, SNPs in three human genes involved in kidney development (RE...

journal_title：BMC nephrology

authors： Raghavendra A,Siji A,Sridhar TS,Phadke K,Vasudevan A

更新日期：2011-10-28 00:00:00

abstract：BACKGROUND:Serum cystatin C (ScysC) may help predicting cardiovascular outcome not only through its ability to detect renal dysfunction but also through its potential connection to others factors that are directly related to cardiovascular diseases. We explored the potential association of ScysC with arterial stiffness...

journal_title：BMC nephrology

authors： Dinic M,Maillard N,Thibaudin D,Jannot M,Masson I,Alamartine E,Mariat C

更新日期：2014-12-11 00:00:00

abstract：BACKGROUND:Increased leucine-rich α2-glycoprotein-1 (LRG1) has been observed in various inflammatory and autoimmune diseases. We aimed to explore the expression and role of LRG1 in lupus nephritis (LN). METHODS:Plasma LRG1 (pLRG1) was measured by enzyme-linked immunosorbent assay in 101 patients with renal biopsy-prov...

journal_title：BMC nephrology

authors： Yang Y,Luo R,Cheng Y,Liu T,Dai W,Li Y,Ge S,Xu G

更新日期：2020-04-06 00:00:00

abstract：BACKGROUND:Patients undergoing liver transplantation with preexisting renal dysfunction are prone to further renal impairment with the early postoperative use of Calcineurin-inhibitors. However, there is only little scientific evidence for the safety and efficacy of de novo CNI free "bottom-up" regimens in patients wit...

journal_title：BMC nephrology

authors： Schnitzbauer AA,Scherer MN,Rochon J,Sothmann J,Farkas SA,Loss M,Geissler EK,Obed A,Schlitt HJ

更新日期：2010-09-14 00:00:00

abstract：BACKGROUND:Canada's pandemic H1N1 influenza A (pH1N1) outbreak led to a high burden of critical illness. Our objective was to describe the incidence of AKI (acute kidney injury) in these patients and risk factors for AKI, renal replacement therapy (RRT), and mortality. METHODS:From a prospective cohort of critically i...

journal_title：BMC nephrology

authors： Bagshaw SM,Sood MM,Long J,Fowler RA,Adhikari NK,Canadian Critical Care Trials Group H1N1 Collaborative.

更新日期：2013-06-13 00:00:00

abstract：BACKGROUND:Atypical hemolytic uremic syndrome (aHUS) is a rare, genetically-mediated systemic disease most often caused by chronic, uncontrolled complement activation that leads to systemic thrombotic microangiopathy (TMA) and renal and other end-organ damage. METHODS:The global aHUS Registry, initiated in April 2012,...

journal_title：BMC nephrology

authors： Licht C,Ardissino G,Ariceta G,Cohen D,Cole JA,Gasteyger C,Greenbaum LA,Johnson S,Ogawa M,Schaefer F,Vande Walle J,Frémeaux-Bacchi V

更新日期：2015-12-10 00:00:00

abstract：BACKGROUND:Ongoing efforts are focused on shortening ischemia intervals as much as possible during partial nephrectomy to preserve renal function. Off-clamp partial nephrectomy (off-PN) has been a common strategy for to avoid ischemia in small renal tumors. Although studies comparing the advantages between off-PN with ...

journal_title：BMC nephrology

authors： Deng W,Liu X,Hu J,Chen L,Fu B

更新日期：2018-07-31 00:00:00

abstract：BACKGROUND:About 1% of patients admitted to the Emergency Department (ED) have hypernatremia, a condition associated with a mortality rate of 20 to 60%. Management recommendations originate from intensive care unit studies, in which patients and medical diseases differ from those in ED. METHODS:We retrospectively stud...

journal_title：BMC nephrology

authors： Bataille S,Baralla C,Torro D,Buffat C,Berland Y,Alazia M,Loundou A,Michelet P,Vacher-Coponat H

更新日期：2014-02-21 00:00:00

abstract：BACKGROUND:Annual decline in kidney function is a widely applied surrogate outcome of renal failure. It is important to understand the relationships between known risk factors and the annual decline in estimated glomerular filtration rate (eGFR) according to baseline age; however, these remain unclear. METHODS:A commu...

journal_title：BMC nephrology

authors： Toyama T,Kitagawa K,Oshima M,Kitajima S,Hara A,Iwata Y,Sakai N,Shimizu M,Hashiba A,Furuichi K,Wada T

更新日期：2020-11-13 00:00:00

abstract：BACKGROUND:The possibility of clearing Cell-free Plasma Hemoglobin (CPH) from human plasma may appear attractive, especially when considering the noxious effects that CPH has on the immune function and the renal damage caused by its filtration. The existence of the so-called High Cut-Off (HCO) filters, possessing pores...

journal_title：BMC nephrology

authors： Cucchiari D,Reverter E,Blasco M,Molina-Andujar A,Carpio A,Sanz M,Escorsell A,Fernández J,Poch E

更新日期：2018-10-04 00:00:00

abstract：BACKGROUND:Diet can markedly affect acid-base status and it significantly influences chronic kidney disease (CKD) and its progression. The relationship of dietary acid load (DAL) and CKD has not been assessed on a population level. We examined the association of estimated net acid excretion (NAE(es)) with CKD; and soci...

journal_title：BMC nephrology

authors： Banerjee T,Crews DC,Wesson DE,Tilea A,Saran R,Rios Burrows N,Williams DE,Powe NR,Centers for Disease Control and Prevention Chronic Kidney Disease Surveillance Team.

更新日期：2014-08-24 00:00:00

abstract：BACKGROUND:Stage 5 chronic kidney disease (CKD-5) patients on haemodialysis (HD) are at high risk of accidental falls. Previous research has shown that frailty is one of the primary contributors to the increased risk of falling in this clinical population. However, HD patients often present with abnormalities of cardio...

journal_title：BMC nephrology

authors： Zanotto T,Mercer TH,van der Linden ML,Rush R,Traynor JP,Petrie CJ,Doyle A,Chalmers K,Allan N,Shilliday I,Koufaki P

更新日期：2020-03-14 00:00:00

abstract：BACKGROUND:Peritoneal dialysis (PD) is a home-based therapy performed by patients or their relatives in numerous cases, and the role of patients' educational practices in the risk of peritonitis is not well assessed. Our aim was to evaluate the effect of PD learning methods on the risk of peritonitis. METHODS:This was...

journal_title：BMC nephrology

authors： Bonnal H,Bechade C,Boyer A,Lobbedez T,Guillouët S,Verger C,Ficheux M,Lanot A

更新日期：2020-05-29 00:00:00

abstract：BACKGROUND:Anaemia is common in haemodialysis (HD) patients and associated with significant morbidity and mortality. Intravenous (IV) iron combined with erythropoiesis-stimulating agents (ESA) is the mainstay treatment of anaemia in these patients. The comparative efficacy and risk of adverse events with IV iron prepar...

journal_title：BMC nephrology

authors： Jesus-Silva JA,Lamplugh A,Dhada S,Burton JO,Bhandari S

更新日期：2020-06-03 00:00:00

abstract：BACKGROUND:Accurate estimation of glomerular filtration rate (GFR) is important for diagnosis and risk stratification in chronic kidney disease and for selection of living donors. Ethnic differences have required correction factors in the originally developed creatinine-based GFR estimation equations for populations ar...

journal_title：BMC nephrology

authors： Kumar V,Yadav AK,Yasuda Y,Horio M,Kumar V,Sahni N,Gupta KL,Matsuo S,Kohli HS,Jha V

更新日期：2018-02-01 00:00:00