PTGER3 and MMP-2 play potential roles in diabetic nephropathy via competing endogenous RNA mechanisms.

abstract：BACKGROUND:Corticosteroids are widely used to reduce the urine protein levels of patients with immunoglobulin A nephropathy (IgAN). However, their potential preventive effects on end-stage kidney disease (ESKD) are unclear. METHODS:We previously performed a large-scale, long-term multicenter cohort study of patients w...

journal_title：BMC nephrology

authors： Tsunoda R,Usui J,Hoshino J,Fujii T,Suzuki S,Takaichi K,Ubara Y,Yamagata K

更新日期：2018-09-06 00:00:00

abstract：BACKGROUND:Liddle's syndrome is a rare monogenic form of hypertension caused by truncating or missense mutations in the C termini of the epithelial sodium channel (ENaC) β or γ subunits. Patients with this syndrome present with early onset of hypertension, hypokalemia, metabolic alkalosis, hyporeninemia and hypoaldoste...

journal_title：BMC nephrology

authors： Yamaguchi E,Yoshikawa K,Nakaya I,Kato K,Miyasato Y,Nakagawa T,Kakizoe Y,Mukoyama M,Soma J

更新日期：2018-05-23 00:00:00

abstract：BACKGROUND:Nasal colonization with methicillin-resistant Staphylococcus aureus (MRSA) is a well defined risk factor for subsequent bacteremia and death in various groups of patients, but its impact on outcome in patients receiving long-term hemodialysis (HD) is under debate. METHODS:This prospective interventional coh...

journal_title：BMC nephrology

authors： Schmid H,Romanos A,Schiffl H,Lederer SR

更新日期：2013-04-23 00:00:00

abstract：BACKGROUND:Rehabilitation effects of exercise training on adults with chronic kidney disease (CKD) have been generally recognised; however, the effects of exercise training on proteinuria have been underexplored. Our aim was to explore the effects of exercise training on proteinuria in adult CKD patients without renal ...

journal_title：BMC nephrology

authors： Yang L,Wu X,Wang Y,Wang C,Hu R,Wu Y

更新日期：2020-05-11 00:00:00

abstract：BACKGROUND:This is the first study that has examined non-cardiac incidental findings in research cardiac computed tomography (CT) of hemodialysis patients and their relationship with patient characteristics. METHODS:We performed a cross-sectional analysis in the Predictors of Arrhythmic and Cardiovascular Events in En...

journal_title：BMC nephrology

authors： Jaar BG,Zhang L,Chembrovich SV,Sozio SM,Shafi T,Scialla JJ,Tomaselli GF,Lima JA,Kao WH,Parekh RS,Meoni LA

更新日期：2014-05-01 00:00:00

abstract：BACKGROUND:The short-term efficacy of tolvaptan in patients with autosomal dominant polycystic kidney disease (ADPKD) has been demonstrated across several phase 3 trials, while the ADPKD Outcomes Model (ADPKD-OM) represents a validated approach to predict natural disease progression over a lifetime horizon. This study ...

journal_title：BMC nephrology

authors： Bennett H,McEwan P,Hamilton K,O'Reilly K

更新日期：2019-04-23 00:00:00

abstract：BACKGROUND:Several equations have been developed to estimate glomerular filtration rate (eGFR). The common equations used were derived from populations predominantly comprised of Caucasians with chronic kidney disease (CKD). Some of the equations provide a correction factor for African-Americans due to their relatively...

journal_title：BMC nephrology

authors： Omuse G,Maina D,Mwangi J,Wambua C,Kanyua A,Kagotho E,Amayo A,Ojwang P,Erasmus R

更新日期：2017-12-20 00:00:00

abstract：BACKGROUND:Anaemia is common in haemodialysis (HD) patients and associated with significant morbidity and mortality. Intravenous (IV) iron combined with erythropoiesis-stimulating agents (ESA) is the mainstay treatment of anaemia in these patients. The comparative efficacy and risk of adverse events with IV iron prepar...

journal_title：BMC nephrology

authors： Jesus-Silva JA,Lamplugh A,Dhada S,Burton JO,Bhandari S

更新日期：2020-06-03 00:00:00

abstract：BACKGROUND:Galectin-9 (Gal-9) induces apoptosis in activated T helper 1 (TH1) cells as a ligand for T cell immunoglobulin mucin-3 (Tim-3). Gal-9 also inhibits the G1 phase cell cycle arrest and hypertrophy in db/db mice, the hallmark of early diabetic nephropathy, by reversing the high glucose-induced up-regulation of ...

journal_title：BMC nephrology

authors： Kurose Y,Wada J,Kanzaki M,Teshigawara S,Nakatsuka A,Murakami K,Inoue K,Terami T,Katayama A,Watanabe M,Higuchi C,Eguchi J,Miyatake N,Makino H

更新日期：2013-01-22 00:00:00

abstract：BACKGROUND:Stage 5 chronic kidney disease (CKD-5) patients on haemodialysis (HD) are at high risk of accidental falls. Previous research has shown that frailty is one of the primary contributors to the increased risk of falling in this clinical population. However, HD patients often present with abnormalities of cardio...

journal_title：BMC nephrology

authors： Zanotto T,Mercer TH,van der Linden ML,Rush R,Traynor JP,Petrie CJ,Doyle A,Chalmers K,Allan N,Shilliday I,Koufaki P

更新日期：2020-03-14 00:00:00

abstract：BACKGROUND:There is limited knowledge of Chronic Kidney Disease (CKD) among high risk populations, especially in the developing countries. We report our study of testing for CKD in at-risk subjects. METHODS:In a cross-sectional study, 527 people from primary and secondary health care areas in the city of Kinshasa were...

journal_title：BMC nephrology

authors： Sumaili EK,Cohen EP,Zinga CV,Krzesinski JM,Pakasa NM,Nseka NM

更新日期：2009-07-21 00:00:00

abstract：BACKGROUND:Despite the urgent need for evidence to guide the end-of-life (EOL) care for patients with chronic kidney disease (CKD), we have limited knowledge of the costs and intensity of EOL care in this population. The present study examined patterns and predictors for EOL care intensity among elderly patients with C...

journal_title：BMC nephrology

authors： Chen B,Fan VY,Chou YJ,Kuo CC

更新日期：2017-01-26 00:00:00

abstract：BACKGROUND:Chronic kidney disease (CKD) is increasing worldwide and early education to improve adherence to self-management is a key strategy to slow CKD progression. The use of the internet and mobile phone technologies (mHealth) to support patients is considered an effective tool in many other chronic disease populat...

journal_title：BMC nephrology

authors： Bonner A,Gillespie K,Campbell KL,Corones-Watkins K,Hayes B,Harvie B,Kelly JT,Havas K

更新日期：2018-02-02 00:00:00

abstract：BACKGROUND:Abdominal aortic calcification assessed by X-ray is recommended to evaluate vascular calcification in dialysis patients. It has been shown that abdominal aortic calcification score (AACS) is a predictor of adverse outcomes in hemodialysis patients, but evidence regarding its prognostic value in peritoneal di...

journal_title：BMC nephrology

authors： Ma D,Yan H,Yang X,Yu Z,Ni Z,Fang W

更新日期：2020-04-30 00:00:00

abstract：BACKGROUND:Acute kidney injury (AKI) is a serious clinical problem with high rate of mortality and morbidity. Currently used prophylactic and therapeutic strategies to address AKI are limited and warrant further studies. In the present study an attempt was made to investigate the effect of quinacrine, a phospholipase A...

journal_title：BMC nephrology

authors： Al Asmari AK,Al Sadoon KT,Obaid AA,Yesunayagam D,Tariq M

更新日期：2017-01-28 00:00:00

abstract：BACKGROUND:To assess whether serum osteoprotegerin (OPG) and/or fetuin-A predict mortality and cardiovascular (CV) morbidity and mortality in hemodialysis patients. METHODS:Multicenter, observational, prospective study that included 220 hemodialysis patients followed up for up to 6 years. Serum OPG and fetuin-A levels...

journal_title：BMC nephrology

authors： Collado S,Coll E,Nicolau C,Azqueta M,Pons M,Cruzado JM,de la Torre B,Deulofeu R,Mojal S,Pascual J,Cases A

更新日期：2017-09-07 00:00:00

abstract：BACKGROUND:The patterns, performance characteristics, and yield of diagnostic tests ordered for the evaluation of acute kidney injury (AKI) have not been rigorously evaluated. METHODS:We characterized the frequency of AKI diagnostic testing for urine, blood, radiology, and pathology tests in all adult inpatients who w...

journal_title：BMC nephrology

authors： Leaf DE,Srivastava A,Zeng X,McMahon GM,Croy HE,Mendu ML,Kachalia A,Waikar SS

更新日期：2016-01-15 00:00:00

abstract：BACKGROUND:Although hemodialysis (HD) adequacy, single-pool Kt/Vurea (spKt/V), is inversely correlated with body size, each is known to affect patient survival in the same direction. Therefore, we sought to examine the relationship between HD adequacy and mortality according to body mass index (BMI) in HD patients and ...

journal_title：BMC nephrology

authors： Hong WP,Lee YJ

更新日期：2019-10-22 00:00:00

abstract：BACKGROUND:Diabetic nephropathy is a global common cause of chronic kidney disease and end-stage renal disease. A lot of research has been conducted in biomedical sciences, which has enhanced understanding of the pathophysiology of diabetic nephropathy and has expanded the potential available therapies. An increasing n...

journal_title：BMC nephrology

authors： De la Cruz-Cano E,Jiménez-González CDC,Morales-García V,Pineda-Pérez C,Tejas-Juárez JG,Rendón-Gandarilla FJ,Jiménez-Morales S,Díaz-Gandarilla JA

更新日期：2019-10-28 00:00:00

abstract：BACKGROUND:Acute kidney injury (AKI) is a common clinical problem. Studies have documented the incidence of AKI in a variety of populations but to date we do not believe the real incidence of AKI has been accurately documented in a district general hospital setting.The aim here was to describe the detected incidence of...

journal_title：BMC nephrology

authors： Bedford M,Stevens PE,Wheeler TW,Farmer CK

更新日期：2014-06-21 00:00:00

abstract：BACKGROUND:The end stage renal disease population has a 20 fold higher incidence of cardiovascular mortality compared to the overall population. The development of reno-cardiac syndrome in these patients will result in cardiovascular events to be the cause of 50% of fatalities. There is therefore a need to research imp...

journal_title：BMC nephrology

authors： Kieswich JE,Chen J,Alliouachene S,Caton PW,McCafferty K,Thiemermann C,Yaqoob MM

更新日期：2018-12-04 00:00:00

abstract：BACKGROUND:Gitelman syndrome (GS) is an autosomal recessive inherited salt-losing tubulopathy (SLT). Here, we describe, for the first time, a case of GS without Gitelman-like features and with concomitant kidney stones, cysts and diabetic nephropathy (DN). CASE PRESENTATION:We described a male patient had a 19-year hi...

journal_title：BMC nephrology

authors： Chen Q,Wang X,Min J,Wang L,Mou L

更新日期：2021-01-07 00:00:00

abstract：BACKGROUND:Patients undergoing liver transplantation with preexisting renal dysfunction are prone to further renal impairment with the early postoperative use of Calcineurin-inhibitors. However, there is only little scientific evidence for the safety and efficacy of de novo CNI free "bottom-up" regimens in patients wit...

journal_title：BMC nephrology

authors： Schnitzbauer AA,Scherer MN,Rochon J,Sothmann J,Farkas SA,Loss M,Geissler EK,Obed A,Schlitt HJ

更新日期：2010-09-14 00:00:00

abstract：BACKGROUND:Group A streptococcus (GAS) is an etiological agent for the immune mediated sequela post streptococcal glomerulonephritis (PSGN). In some populations PSGN is recognized as a risk factor for chronic kidney disease (CKD) and end-stage renal disease (ESRD). It was found that a significantly greater proportion o...

journal_title：BMC nephrology

authors： Karmarkar MG,Hule GP,Hase NK,Mehta PR,Walter SR,Sriprakash KS

更新日期：2013-05-06 00:00:00

abstract：BACKGROUND:Canada's pandemic H1N1 influenza A (pH1N1) outbreak led to a high burden of critical illness. Our objective was to describe the incidence of AKI (acute kidney injury) in these patients and risk factors for AKI, renal replacement therapy (RRT), and mortality. METHODS:From a prospective cohort of critically i...

journal_title：BMC nephrology

authors： Bagshaw SM,Sood MM,Long J,Fowler RA,Adhikari NK,Canadian Critical Care Trials Group H1N1 Collaborative.

更新日期：2013-06-13 00:00:00

abstract：BACKGROUND:Adult patients with minimal change nephrotic syndrome (MCNS) are often associated with acute kidney injury (AKI). To assess the mechanisms of AKI, we examined whether tubular cell injuries unique to MCNS patients exist. METHODS:We performed a retrospective analysis of clinical data and tubular cell changes ...

journal_title：BMC nephrology

authors： Fujigaki Y,Tamura Y,Nagura M,Arai S,Ota T,Shibata S,Kondo F,Yamaguchi Y,Uchida S

更新日期：2017-11-28 00:00:00

abstract：BACKGROUND:Renal involvement in patients with chronic hepatitis C virus infection has been suggested to be due to a variety of immunological processes. However, the precise mechanism by which the kidneys are damaged in these patients is still unclear. CASE PRESENTATION:A 66 year old man presented with the sudden onset...

journal_title：BMC nephrology

authors： Ohsawa I,Uehara Y,Hashimoto S,Endo M,Fujita T,Ohi H

更新日期：2003-08-29 00:00:00

abstract：BACKGROUND:There is limited evidence on the relationship between social support and renal outcomes in African Americans. We sought to determine the association of social support with prevalent chronic kidney disease (CKD) and kidney function decline in an African American cohort. We also examined whether age modifies t...

journal_title：BMC nephrology

authors： Hall RK,Davenport CA,Sims M,Colón-Emeric C,Washington T,St Clair Russell J,Pendergast J,Bhavsar N,Scialla J,Tyson CC,Wang W,Min YI,Young B,Boulware LE,Diamantidis CJ

更新日期：2019-07-15 00:00:00

abstract：BACKGROUND:Increased leucine-rich α2-glycoprotein-1 (LRG1) has been observed in various inflammatory and autoimmune diseases. We aimed to explore the expression and role of LRG1 in lupus nephritis (LN). METHODS:Plasma LRG1 (pLRG1) was measured by enzyme-linked immunosorbent assay in 101 patients with renal biopsy-prov...

journal_title：BMC nephrology

authors： Yang Y,Luo R,Cheng Y,Liu T,Dai W,Li Y,Ge S,Xu G

更新日期：2020-04-06 00:00:00

abstract：BACKGROUND:There is a lack of online, evidence-based information and resources to support home-based care of childhood CKD stages 3-5. METHODS:Qualitative interviews were undertaken with parents, patients and professionals to explore their views on content of the proposed online parent information and support (OPIS) w...

journal_title：BMC nephrology

authors： Swallow VM,Hall AG,Carolan I,Santacroce S,Webb NJ,Smith T,Hanif N

更新日期：2014-02-18 00:00:00