Abstract:
BACKGROUND:Renal involvement in patients with chronic hepatitis C virus infection has been suggested to be due to a variety of immunological processes. However, the precise mechanism by which the kidneys are damaged in these patients is still unclear. CASE PRESENTATION:A 66 year old man presented with the sudden onset of autoimmune hemolytic anemia. Concomitant with a worsening of hemolysis, his initially mild proteinuria and hemoglobinuria progressed. On admission, laboratory tests revealed that he was positive for hepatitis C virus in his blood, though his liver function tests were all normal. The patient displayed cryoglobulinemia and hypocomplementemia with cold activation, and exhibited a biological false positive of syphilic test. Renal biopsy specimens showed signs of immune complex type nephropathy with hemosiderin deposition in the tubular epithelial cells. CONCLUSIONS:The renal histological findings in this case are consistent with the deposition of immune complexes and hemolytic products, which might have occurred as a result of the patient's underlying autoimmune imbalance, autoimmune hemolytic anemia, and chronic hepatitis C virus infection.
journal_name
BMC Nephroljournal_title
BMC nephrologyauthors
Ohsawa I,Uehara Y,Hashimoto S,Endo M,Fujita T,Ohi Hdoi
10.1186/1471-2369-4-7keywords:
subject
Has Abstractpub_date
2003-08-29 00:00:00pages
7issn
1471-2369pii
1471-2369-4-7journal_volume
4pub_type
杂志文章相关文献
BMC Nephrology文献大全abstract:BACKGROUND:The high cost, complexity of the available protocols, and metabolic complications are the major barriers that impede the clinical utilization of regional citrate anticoagulation (RCA) for sustained low efficiency dialysis (SLED) in critically ill patients. By comparing a novel protocol for SLED using 30% cit...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-018-0879-4
更新日期:2018-04-03 00:00:00
abstract:BACKGROUND:Immunoglobulin light chains are classified as middle molecule uremic toxins able to interact with B lymphocyte membranes leading to the activation of transmembrane signaling. The ensuing impairment of neutrophil function can contribute to the chronic inflammation state of uremic patients, and the increased r...
journal_title:BMC nephrology
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12882-016-0405-5
更新日期:2016-11-25 00:00:00
abstract:BACKGROUND:Previous studies have not described the relationship between reducing radial artery diameter as well as increasing age and functional maturation of the radio-cephalic arteriovenous fistula (RCAVF) and no data identify these as linear relationship. The objective of this study was to perform trend analysis to ...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-020-01883-w
更新日期:2020-06-22 00:00:00
abstract:BACKGROUND:Hypertension is a public health problem with mostly unknown causes, and where strong hereditary genetic alterations have not been fully elucidated. However, the use of experimental models has provided valuable information. Recent evidences suggest that alterations in key nephrogenic factors, such as Wilms' t...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-016-0250-6
更新日期:2016-03-24 00:00:00
abstract:BACKGROUND:Cardiovascular morbidity and mortality are highly prevalent in patients with end-stage renal disease, and osteoprotegerin (OPG) may be an important link between bone loss and vascular calcification. This study was conducted to evaluate the relationship between central arterial stiffness and serum OPG levels ...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-019-1374-2
更新日期:2019-05-23 00:00:00
abstract:BACKGROUND:Thermometers that measure core (internal) body temperature are the gold standard for monitoring temperature. Despite that most modern hemodialysis machines are equipped with an internal blood monitor that measures core body temperature, current practice is to use peripheral thermometers. A better understandi...
journal_title:BMC nephrology
pub_type: 杂志文章,多中心研究
doi:10.1186/s12882-018-0938-x
更新日期:2018-06-14 00:00:00
abstract:BACKGROUND:Sclerostin is a paracrine acting factor, which is expressed in the osteocytes and articular chondrocytes. Sclerostin decreases the osteoblast-related bone formation through the inhibition of the Wnt/β-catenin pathway. Osteocytes also express the Calcium sensing receptor which is a target for cinacalcet. The ...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-016-0392-6
更新日期:2016-11-15 00:00:00
abstract:BACKGROUND:In a recent study we demonstrated that low birth weight (LBW) was associated with increased risk of progressive IgA nephropathy (IgAN). In the present study we investigate whether this could be explained by differences in glomerular morphological parameters. METHODS:The Medical Birth Registry of Norway has ...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-018-1070-7
更新日期:2018-10-22 00:00:00
abstract:BACKGROUND:The current practice concerning timing, mode, and dose of renal replacement therapy (RRT) in patients with metformin-associated lactic acidosis (MALA) with renal failure remains unknown. To investigate whether serum lactate level and prescription pattern of RRT are associated with mortality in patients with ...
journal_title:BMC nephrology
pub_type: 杂志文章,评审
doi:10.1186/s12882-017-0640-4
更新日期:2017-07-10 00:00:00
abstract:BACKGROUND:Bordetella pertussis infection is a known trigger of atypical hemolytic uremic syndrome (HUS). For patients suspected of having atypical HUS, prompt plasma exchange/infusion (PE/PI) or eculizumab (ECZ) treatment is recommended. CASE PRESENTATION:We report a 1-month-old female infant who was admitted with a ...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-018-1168-y
更新日期:2018-12-17 00:00:00
abstract:BACKGROUND:There is a marked paucity of data concerning AKI in Sub-Saharan Africa, where there is a substantial burden of trauma and HIV. METHODS:Prospective data was collected on all patients admitted to a multi-disciplinary ICU in South Africa during 2017. Development of AKI (before or during ICU admission) was reco...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-019-1620-7
更新日期:2019-12-10 00:00:00
abstract:BACKGROUND:Frailty is independently associated with worse health-related quality of life (HRQOL) in chronic kidney disease (CKD). However, the relationship between frailty and symptom experience is not well described in people living with CKD. This study's aim was to evaluate the relationship between frailty and sympto...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-020-02063-6
更新日期:2020-09-23 00:00:00
abstract:BACKGROUND:Bioimpedance analysis (BIA) has been reported as helpful in identifying hypervolemia. Observation data showed that hypervolemic maintenance hemodialysis (MHD) patients identified using BIA methods have higher mortality risk. However, it is not known if BIA-guided fluid management can improve MHD patients' su...
journal_title:BMC nephrology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/1471-2369-13-120
更新日期:2012-09-25 00:00:00
abstract:BACKGROUND:Chronic Kidney Disease is a major public health problem worldwide with enormous cost burdens on health care systems in developing countries. We aimed to provide a detailed analysis of the processes and costs of haemodialysis in Sri Lanka and provide a framework for modeling similar financial audits. METHODS...
journal_title:BMC nephrology
pub_type: 杂志文章,多中心研究
doi:10.1186/1471-2369-12-42
更新日期:2011-09-06 00:00:00
abstract:BACKGROUND:Adult patients with minimal change nephrotic syndrome (MCNS) are often associated with acute kidney injury (AKI). To assess the mechanisms of AKI, we examined whether tubular cell injuries unique to MCNS patients exist. METHODS:We performed a retrospective analysis of clinical data and tubular cell changes ...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-017-0756-6
更新日期:2017-11-28 00:00:00
abstract:BACKGROUND:Anaemia is common in haemodialysis (HD) patients and associated with significant morbidity and mortality. Intravenous (IV) iron combined with erythropoiesis-stimulating agents (ESA) is the mainstay treatment of anaemia in these patients. The comparative efficacy and risk of adverse events with IV iron prepar...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-020-01866-x
更新日期:2020-06-03 00:00:00
abstract:BACKGROUND:Physical activity (PA) is exceptionally low amongst the haemodialysis (HD) population, and physical inactivity is a powerful predictor of mortality, making it a prime focus for intervention. Objective measurement of PA using accelerometers is increasing, but standard reporting guidelines essential to effecti...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-019-1634-1
更新日期:2019-12-04 00:00:00
abstract:BACKGROUND:Little is known about the changes in disease makers and risk factors in patients with chronic kidney disease (CKD) under nephrological care in Africa. This study aimed to evaluate the baseline level of markers of CKD and their 12-month time-trend in newly referred patients in a tertiary hospital in Cameroon....
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-020-01760-6
更新日期:2020-03-18 00:00:00
abstract:BACKGROUND:The KDIGO Clinical Practice Guidelines for Glomerulonephritis recommended tacrolimus as an alternative regimen for the initial therapy for Idiopathic membranous nephropathy (IMN), however, large observational studies evaluating tacrolimus treatment in IMN remains rare. METHODS:A total of 408 consecutive IMN...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-016-0427-z
更新日期:2017-01-05 00:00:00
abstract:BACKGROUND:Renal proximal tubular sodium and glucose reabsorption are regulated by the sodium-glucose cotransporter (SGLT2). Changes in this transporter can play a role in hyperglycaemia and reactive oxygen species (ROS) production. We demonstrated increased glucose absorption in proximal tubule membrane vesicles and i...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-019-1490-z
更新日期:2019-08-02 00:00:00
abstract:BACKGROUND:End-Stage Renal disease (ESRD) is associated with increased morbidity and mortality. We assessed the occurrence, time-trend and determinants of fatal outcomes of haemodialysis-treated ESRD patients over a 10-year period in a major referral hospital in Cameroon. METHODS:Medical records of ESRD patients who s...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-016-0377-5
更新日期:2016-11-03 00:00:00
abstract:BACKGROUND:This study aimed to compare clinical features and health-related quality of life (HRQoL) in the Chinese chronic kidney disease (CKD) 3 population and determined the necessity of the subdivision of CKD3 in Chinese patients with CKD. METHODS:Participants with stage 3 CKD (18-74 years of age) were recruited at...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-017-0725-0
更新日期:2017-10-13 00:00:00
abstract:BACKGROUND:Transfusion patterns are not well characterized in non-dialysis (ND) chronic kidney disease (CKD) patients. This study describes the proportion of patients transfused, units of blood transfused and trigger-hemoglobin (Hb) levels for transfusions in severe anemic, ND-CKD patients in routine practice. METHODS...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/1471-2369-13-5
更新日期:2012-01-24 00:00:00
abstract:BACKGROUND:Diabetes mellitus is the leading cause of end-stage renal disease (ESRD) globally. Diabetes and human immunodeficiency virus (HIV), both prevalent in South Africa, have not been reported as significant causes of ESRD. METHODS:We evaluated chronic kidney disease (CKD) and cardiovascular disease risk factors ...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/1471-2369-15-61
更新日期:2014-04-14 00:00:00
abstract:BACKGROUND:Gitelman syndrome (GS) is an autosomal recessive inherited salt-losing tubulopathy (SLT). Here, we describe, for the first time, a case of GS without Gitelman-like features and with concomitant kidney stones, cysts and diabetic nephropathy (DN). CASE PRESENTATION:We described a male patient had a 19-year hi...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-020-02211-y
更新日期:2021-01-07 00:00:00
abstract:BACKGROUND:Kidney impairment constitutes severe risk for cardiovascular disease, stroke and all-cause mortality, and early identification and prevention of kidney impairment is critical to effective management of prognostic risk in community residents. Previous studies have validated that carotid-femoral pulse wave vel...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-018-0897-2
更新日期:2018-05-02 00:00:00
abstract:BACKGROUND:Proteinuria after kidney transplantation portends a worse graft survival. However the magnitude of proteinuria related to patient and graft survival and its correlation with donor and recipient characteristics are poorly explored. METHODS:This study investigated the impact of post transplant proteinuria in ...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-019-1635-0
更新日期:2019-12-02 00:00:00
abstract:BACKGROUND:Chronic Kidney Disease (CKD) is a major non-communicable chronic disease that is associated with adverse clinical and economic outcomes. Passive surveillance systems are likely to improve efforts for prevention of chronic kidney disease (CKD) and inform national service planning. This study was conducted to ...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/1471-2369-15-185
更新日期:2014-11-25 00:00:00
abstract:BACKGROUND:About 1% of patients admitted to the Emergency Department (ED) have hypernatremia, a condition associated with a mortality rate of 20 to 60%. Management recommendations originate from intensive care unit studies, in which patients and medical diseases differ from those in ED. METHODS:We retrospectively stud...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/1471-2369-15-37
更新日期:2014-02-21 00:00:00
abstract:BACKGROUND:The extent to which smoking contributes to adverse outcomes among men and women of all ages undergoing dialysis is uncertain. The objective of this study was to determine the differential impact of smoking on risks of mortality and kidney transplantation by age and by sex at dialysis initiation. METHODS:We ...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-016-0311-x
更新日期:2016-07-26 00:00:00