Autoimmune hemolytic anemia occurred prior to evident nephropathy in a patient with chronic hepatitis C virus infection: case report.

Abstract:

BACKGROUND:Renal involvement in patients with chronic hepatitis C virus infection has been suggested to be due to a variety of immunological processes. However, the precise mechanism by which the kidneys are damaged in these patients is still unclear. CASE PRESENTATION:A 66 year old man presented with the sudden onset of autoimmune hemolytic anemia. Concomitant with a worsening of hemolysis, his initially mild proteinuria and hemoglobinuria progressed. On admission, laboratory tests revealed that he was positive for hepatitis C virus in his blood, though his liver function tests were all normal. The patient displayed cryoglobulinemia and hypocomplementemia with cold activation, and exhibited a biological false positive of syphilic test. Renal biopsy specimens showed signs of immune complex type nephropathy with hemosiderin deposition in the tubular epithelial cells. CONCLUSIONS:The renal histological findings in this case are consistent with the deposition of immune complexes and hemolytic products, which might have occurred as a result of the patient's underlying autoimmune imbalance, autoimmune hemolytic anemia, and chronic hepatitis C virus infection.

journal_name

BMC Nephrol

journal_title

BMC nephrology

authors

Ohsawa I,Uehara Y,Hashimoto S,Endo M,Fujita T,Ohi H

doi

10.1186/1471-2369-4-7

keywords:

subject

Has Abstract

pub_date

2003-08-29 00:00:00

pages

7

issn

1471-2369

pii

1471-2369-4-7

journal_volume

4

pub_type

杂志文章
  • A novel citrate-based protocol versus heparin anticoagulation for sustained low-efficiency dialysis in the ICU: safety, efficacy, and cost.

    abstract:BACKGROUND:The high cost, complexity of the available protocols, and metabolic complications are the major barriers that impede the clinical utilization of regional citrate anticoagulation (RCA) for sustained low efficiency dialysis (SLED) in critically ill patients. By comparing a novel protocol for SLED using 30% cit...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-018-0879-4

    authors: Wen M,Küchle C,Steubl D,Satanovskji R,Heemann U,Suttmann Y,Angermann S,Kemmner S,Rehbehn L,Huber M,Hauser C,Schmaderer C,Reichelt AL,Haller B,Renders L

    更新日期:2018-04-03 00:00:00

  • Removal of free light chains in hemodialysis patients without multiple myeloma: a crossover comparison of three different dialyzers.

    abstract:BACKGROUND:Immunoglobulin light chains are classified as middle molecule uremic toxins able to interact with B lymphocyte membranes leading to the activation of transmembrane signaling. The ensuing impairment of neutrophil function can contribute to the chronic inflammation state of uremic patients, and the increased r...

    journal_title:BMC nephrology

    pub_type: 杂志文章,随机对照试验

    doi:10.1186/s12882-016-0405-5

    authors: Donati G,Moretti MI,Baraldi O,Spazzoli A,Capelli I,Comai G,Marchetti A,Sarma M,Mancini R,La Manna G

    更新日期:2016-11-25 00:00:00

  • Radial artery diameterand and age related functional maturation of the radio-cephalic arteriovenous fistula.

    abstract:BACKGROUND:Previous studies have not described the relationship between reducing radial artery diameter as well as increasing age and functional maturation of the radio-cephalic arteriovenous fistula (RCAVF) and no data identify these as linear relationship. The objective of this study was to perform trend analysis to ...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-020-01883-w

    authors: Wan ZM,Hu B,Lai QQ,Gao XJ,Tu B,Zhou Y,Zhao WB

    更新日期:2020-06-22 00:00:00

  • Changes in renal WT-1 expression preceding hypertension development.

    abstract:BACKGROUND:Hypertension is a public health problem with mostly unknown causes, and where strong hereditary genetic alterations have not been fully elucidated. However, the use of experimental models has provided valuable information. Recent evidences suggest that alterations in key nephrogenic factors, such as Wilms' t...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-016-0250-6

    authors: Mazzei L,García M,Calvo JP,Casarotto M,Fornés M,Abud MA,Cuello-Carrión D,Ferder L,Manucha W

    更新日期:2016-03-24 00:00:00

  • Serum osteoprotegerin is an independent marker of central arterial stiffness as assessed using carotid-femoral pulse wave velocity in hemodialysis patients: a cross sectional study.

    abstract:BACKGROUND:Cardiovascular morbidity and mortality are highly prevalent in patients with end-stage renal disease, and osteoprotegerin (OPG) may be an important link between bone loss and vascular calcification. This study was conducted to evaluate the relationship between central arterial stiffness and serum OPG levels ...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-019-1374-2

    authors: Hou JS,Lin YL,Wang CH,Lai YH,Kuo CH,Subeq YM,Hsu BG

    更新日期:2019-05-23 00:00:00

  • A comparison of temporal artery thermometers with internal blood monitors to measure body temperature during hemodialysis.

    abstract:BACKGROUND:Thermometers that measure core (internal) body temperature are the gold standard for monitoring temperature. Despite that most modern hemodialysis machines are equipped with an internal blood monitor that measures core body temperature, current practice is to use peripheral thermometers. A better understandi...

    journal_title:BMC nephrology

    pub_type: 杂志文章,多中心研究

    doi:10.1186/s12882-018-0938-x

    authors: Lunney M,Tonelli B,Lewis R,Wiebe N,Thomas C,MacRae J,Tonelli M

    更新日期:2018-06-14 00:00:00

  • Treatment with cinacalcet increases plasma sclerostin concentration in hemodialysis patients with secondary hyperparathyroidism.

    abstract:BACKGROUND:Sclerostin is a paracrine acting factor, which is expressed in the osteocytes and articular chondrocytes. Sclerostin decreases the osteoblast-related bone formation through the inhibition of the Wnt/β-catenin pathway. Osteocytes also express the Calcium sensing receptor which is a target for cinacalcet. The ...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-016-0392-6

    authors: Kuczera P,Adamczak M,Więcek A

    更新日期:2016-11-15 00:00:00

  • Low birth weight associates with glomerular area in young male IgA nephropathy patients.

    abstract:BACKGROUND:In a recent study we demonstrated that low birth weight (LBW) was associated with increased risk of progressive IgA nephropathy (IgAN). In the present study we investigate whether this could be explained by differences in glomerular morphological parameters. METHODS:The Medical Birth Registry of Norway has ...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-018-1070-7

    authors: Ruggajo P,Leh S,Svarstad E,Marti HP,Vikse BE

    更新日期:2018-10-22 00:00:00

  • Serum lactate level and mortality in metformin-associated lactic acidosis requiring renal replacement therapy: a systematic review of case reports and case series.

    abstract:BACKGROUND:The current practice concerning timing, mode, and dose of renal replacement therapy (RRT) in patients with metformin-associated lactic acidosis (MALA) with renal failure remains unknown. To investigate whether serum lactate level and prescription pattern of RRT are associated with mortality in patients with ...

    journal_title:BMC nephrology

    pub_type: 杂志文章,评审

    doi:10.1186/s12882-017-0640-4

    authors: Yeh HC,Ting IW,Tsai CW,Wu JY,Kuo CC

    更新日期:2017-07-10 00:00:00

  • Treatment of hemolytic uremic syndrome related to Bordetella pertussis infection -is plasma exchange or eculizumab use necessary?

    abstract:BACKGROUND:Bordetella pertussis infection is a known trigger of atypical hemolytic uremic syndrome (HUS). For patients suspected of having atypical HUS, prompt plasma exchange/infusion (PE/PI) or eculizumab (ECZ) treatment is recommended. CASE PRESENTATION:We report a 1-month-old female infant who was admitted with a ...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-018-1168-y

    authors: Saida K,Ogura M,Kano Y,Ishimori S,Yoshikawa T,Nagata H,Sato M,Kamei K,Ishikura K

    更新日期:2018-12-17 00:00:00

  • Risk factors and outcomes of acute kidney injury in South African critically ill adults: a prospective cohort study.

    abstract:BACKGROUND:There is a marked paucity of data concerning AKI in Sub-Saharan Africa, where there is a substantial burden of trauma and HIV. METHODS:Prospective data was collected on all patients admitted to a multi-disciplinary ICU in South Africa during 2017. Development of AKI (before or during ICU admission) was reco...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-019-1620-7

    authors: Aylward RE,van der Merwe E,Pazi S,van Niekerk M,Ensor J,Baker D,Freercks RJ

    更新日期:2019-12-10 00:00:00

  • Symptom-burden in people living with frailty and chronic kidney disease.

    abstract:BACKGROUND:Frailty is independently associated with worse health-related quality of life (HRQOL) in chronic kidney disease (CKD). However, the relationship between frailty and symptom experience is not well described in people living with CKD. This study's aim was to evaluate the relationship between frailty and sympto...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-020-02063-6

    authors: Nixon AC,Wilkinson TJ,Young HML,Taal MW,Pendleton N,Mitra S,Brady ME,Dhaygude AP,Smith AC

    更新日期:2020-09-23 00:00:00

  • A randomized controlled trial of long term effect of BCM guided fluid management in MHD patients (BOCOMO study): rationales and study design.

    abstract:BACKGROUND:Bioimpedance analysis (BIA) has been reported as helpful in identifying hypervolemia. Observation data showed that hypervolemic maintenance hemodialysis (MHD) patients identified using BIA methods have higher mortality risk. However, it is not known if BIA-guided fluid management can improve MHD patients' su...

    journal_title:BMC nephrology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1186/1471-2369-13-120

    authors: Liu L,Long G,Ren J,Li J,Xu J,Lei J,Li M,Qiu M,Yuan P,Sun W,Lin S,Liu W,Sun Y,Ma Y,Mao Y,Shen Y,Zuo L

    更新日期:2012-09-25 00:00:00

  • The costs in provision of haemodialysis in a developing country: a multi-centered study.

    abstract:BACKGROUND:Chronic Kidney Disease is a major public health problem worldwide with enormous cost burdens on health care systems in developing countries. We aimed to provide a detailed analysis of the processes and costs of haemodialysis in Sri Lanka and provide a framework for modeling similar financial audits. METHODS...

    journal_title:BMC nephrology

    pub_type: 杂志文章,多中心研究

    doi:10.1186/1471-2369-12-42

    authors: Ranasinghe P,Perera YS,Makarim MF,Wijesinghe A,Wanigasuriya K

    更新日期:2011-09-06 00:00:00

  • Unique proximal tubular cell injury and the development of acute kidney injury in adult patients with minimal change nephrotic syndrome.

    abstract:BACKGROUND:Adult patients with minimal change nephrotic syndrome (MCNS) are often associated with acute kidney injury (AKI). To assess the mechanisms of AKI, we examined whether tubular cell injuries unique to MCNS patients exist. METHODS:We performed a retrospective analysis of clinical data and tubular cell changes ...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-017-0756-6

    authors: Fujigaki Y,Tamura Y,Nagura M,Arai S,Ota T,Shibata S,Kondo F,Yamaguchi Y,Uchida S

    更新日期:2017-11-28 00:00:00

  • Conversion of haemodialysis patients from iron sucrose to iron isomaltoside: a real-world experience.

    abstract:BACKGROUND:Anaemia is common in haemodialysis (HD) patients and associated with significant morbidity and mortality. Intravenous (IV) iron combined with erythropoiesis-stimulating agents (ESA) is the mainstay treatment of anaemia in these patients. The comparative efficacy and risk of adverse events with IV iron prepar...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-020-01866-x

    authors: Jesus-Silva JA,Lamplugh A,Dhada S,Burton JO,Bhandari S

    更新日期:2020-06-03 00:00:00

  • Standardising the measurement of physical activity in people receiving haemodialysis: considerations for research and practice.

    abstract:BACKGROUND:Physical activity (PA) is exceptionally low amongst the haemodialysis (HD) population, and physical inactivity is a powerful predictor of mortality, making it a prime focus for intervention. Objective measurement of PA using accelerometers is increasing, but standard reporting guidelines essential to effecti...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-019-1634-1

    authors: Young HML,Orme MW,Song Y,Dungey M,Burton JO,Smith AC,Singh SJ

    更新日期:2019-12-04 00:00:00

  • Markers and risk factors for chronic kidney disease in sub-Saharan Africans: baseline levels and 12-month trajectories in newly referred patients in Cameroon.

    abstract:BACKGROUND:Little is known about the changes in disease makers and risk factors in patients with chronic kidney disease (CKD) under nephrological care in Africa. This study aimed to evaluate the baseline level of markers of CKD and their 12-month time-trend in newly referred patients in a tertiary hospital in Cameroon....

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-020-01760-6

    authors: Patrice HM,Pascal KA,François KF,Hilaire D,Solange DM,Gloria AE,Pierre CS

    更新日期:2020-03-18 00:00:00

  • Evaluating tacrolimus treatment in idiopathic membranous nephropathy in a cohort of 408 patients.

    abstract:BACKGROUND:The KDIGO Clinical Practice Guidelines for Glomerulonephritis recommended tacrolimus as an alternative regimen for the initial therapy for Idiopathic membranous nephropathy (IMN), however, large observational studies evaluating tacrolimus treatment in IMN remains rare. METHODS:A total of 408 consecutive IMN...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-016-0427-z

    authors: Qin HZ,Liu L,Liang SS,Shi JS,Zheng CX,Hou Q,Lu YH,Le WB

    更新日期:2017-01-05 00:00:00

  • Role of sodium/glucose cotransporter inhibition on a rat model of angiotensin II-dependent kidney damage.

    abstract:BACKGROUND:Renal proximal tubular sodium and glucose reabsorption are regulated by the sodium-glucose cotransporter (SGLT2). Changes in this transporter can play a role in hyperglycaemia and reactive oxygen species (ROS) production. We demonstrated increased glucose absorption in proximal tubule membrane vesicles and i...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-019-1490-z

    authors: Reyes-Pardo H,Bautista R,Vargas-Robles H,Rios A,Sánchez D,Escalante B

    更新日期:2019-08-02 00:00:00

  • Fatal outcomes among patients on maintenance haemodialysis in sub-Saharan Africa: a 10-year audit from the Douala General Hospital in Cameroon.

    abstract:BACKGROUND:End-Stage Renal disease (ESRD) is associated with increased morbidity and mortality. We assessed the occurrence, time-trend and determinants of fatal outcomes of haemodialysis-treated ESRD patients over a 10-year period in a major referral hospital in Cameroon. METHODS:Medical records of ESRD patients who s...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-016-0377-5

    authors: Halle MP,Ashuntantang G,Kaze FF,Takongue C,Kengne AP

    更新日期:2016-11-03 00:00:00

  • Clinical features and CKD-related quality of life in patients with CKD G3a and CKD G3b in China: results from the Chinese Cohort Study of Chronic Kidney Disease (C-STRIDE).

    abstract:BACKGROUND:This study aimed to compare clinical features and health-related quality of life (HRQoL) in the Chinese chronic kidney disease (CKD) 3 population and determined the necessity of the subdivision of CKD3 in Chinese patients with CKD. METHODS:Participants with stage 3 CKD (18-74 years of age) were recruited at...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-017-0725-0

    authors: Peng Z,Wang J,Yuan Q,Xiao X,Xu H,Xie Y,Wang W,Huang L,Zhong Y,Ao X,Zhang L,Zhao M,Tao L,Zhou Q,C-STRIDE study group.

    更新日期:2017-10-13 00:00:00

  • Transfusion burden in non-dialysis chronic kidney disease patients with persistent anemia treated in routine clinical practice: a retrospective observational study.

    abstract:BACKGROUND:Transfusion patterns are not well characterized in non-dialysis (ND) chronic kidney disease (CKD) patients. This study describes the proportion of patients transfused, units of blood transfused and trigger-hemoglobin (Hb) levels for transfusions in severe anemic, ND-CKD patients in routine practice. METHODS...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/1471-2369-13-5

    authors: Fox KM,Yee J,Cong Z,Brooks JM,Petersen J,Lamerato L,Gandra SR

    更新日期:2012-01-24 00:00:00

  • Characteristics of South African patients presenting with kidney disease in rural KwaZulu-Natal: a cross sectional study.

    abstract:BACKGROUND:Diabetes mellitus is the leading cause of end-stage renal disease (ESRD) globally. Diabetes and human immunodeficiency virus (HIV), both prevalent in South Africa, have not been reported as significant causes of ESRD. METHODS:We evaluated chronic kidney disease (CKD) and cardiovascular disease risk factors ...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/1471-2369-15-61

    authors: Madala ND,Thusi GP,Assounga AG,Naicker S

    更新日期:2014-04-14 00:00:00

  • Kidney stones and moderate proteinuria as the rare manifestations of Gitelman syndrome.

    abstract:BACKGROUND:Gitelman syndrome (GS) is an autosomal recessive inherited salt-losing tubulopathy (SLT). Here, we describe, for the first time, a case of GS without Gitelman-like features and with concomitant kidney stones, cysts and diabetic nephropathy (DN). CASE PRESENTATION:We described a male patient had a 19-year hi...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-020-02211-y

    authors: Chen Q,Wang X,Min J,Wang L,Mou L

    更新日期:2021-01-07 00:00:00

  • Association of arterial stiffness and central hemodynamics with moderately reduced glomerular filtration rate in Chinese middle-aged and elderly community residents: a cross-sectional analysis.

    abstract:BACKGROUND:Kidney impairment constitutes severe risk for cardiovascular disease, stroke and all-cause mortality, and early identification and prevention of kidney impairment is critical to effective management of prognostic risk in community residents. Previous studies have validated that carotid-femoral pulse wave vel...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-018-0897-2

    authors: Fu S,Guo Y,Luo L,Ye P

    更新日期:2018-05-02 00:00:00

  • Relationship between early proteinuria and long term outcome of kidney transplanted patients from different decades of donor age.

    abstract:BACKGROUND:Proteinuria after kidney transplantation portends a worse graft survival. However the magnitude of proteinuria related to patient and graft survival and its correlation with donor and recipient characteristics are poorly explored. METHODS:This study investigated the impact of post transplant proteinuria in ...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-019-1635-0

    authors: Diena D,Messina M,De Biase C,Fop F,Scardino E,Rossetti MM,Barreca A,Verri A,Biancone L

    更新日期:2019-12-02 00:00:00

  • Prevalence and variation of Chronic Kidney Disease in the Irish health system: initial findings from the National Kidney Disease Surveillance Programme.

    abstract:BACKGROUND:Chronic Kidney Disease (CKD) is a major non-communicable chronic disease that is associated with adverse clinical and economic outcomes. Passive surveillance systems are likely to improve efforts for prevention of chronic kidney disease (CKD) and inform national service planning. This study was conducted to ...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/1471-2369-15-185

    authors: Stack AG,Casserly LF,Cronin CJ,Chernenko T,Cullen W,Hannigan A,Saran R,Johnson H,Browne G,Ferguson JP

    更新日期:2014-11-25 00:00:00

  • Undercorrection of hypernatremia is frequent and associated with mortality.

    abstract:BACKGROUND:About 1% of patients admitted to the Emergency Department (ED) have hypernatremia, a condition associated with a mortality rate of 20 to 60%. Management recommendations originate from intensive care unit studies, in which patients and medical diseases differ from those in ED. METHODS:We retrospectively stud...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/1471-2369-15-37

    authors: Bataille S,Baralla C,Torro D,Buffat C,Berland Y,Alazia M,Loundou A,Michelet P,Vacher-Coponat H

    更新日期:2014-02-21 00:00:00

  • Differential impact of smoking on mortality and kidney transplantation among adult Men and Women undergoing dialysis.

    abstract:BACKGROUND:The extent to which smoking contributes to adverse outcomes among men and women of all ages undergoing dialysis is uncertain. The objective of this study was to determine the differential impact of smoking on risks of mortality and kidney transplantation by age and by sex at dialysis initiation. METHODS:We ...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-016-0311-x

    authors: Stack AG,Yermak D,Roche DG,Ferguson JP,Elsayed M,Mohammed W,Casserly LF,Walsh SR,Cronin CJ

    更新日期:2016-07-26 00:00:00