Abstract:
BACKGROUND:There is a marked paucity of data concerning AKI in Sub-Saharan Africa, where there is a substantial burden of trauma and HIV. METHODS:Prospective data was collected on all patients admitted to a multi-disciplinary ICU in South Africa during 2017. Development of AKI (before or during ICU admission) was recorded and renal recovery 90 days after ICU discharge was determined. RESULTS:Of 849 admissions, the mean age was 42.5 years and mean SAPS 3 score was 48.1. Comorbidities included hypertension (30.5%), HIV (32.6%), diabetes (13.3%), CKD (7.8%) and active tuberculosis (6.2%). The most common reason for admission was trauma (26%). AKI developed in 497 (58.5%). Male gender, illness severity, length of stay, vasopressor drugs and sepsis were independently associated with AKI. AKI was associated with a higher in-hospital mortality rate of 31.8% vs 7.23% in those without AKI. Age, active tuberculosis, higher SAPS 3 score, mechanical ventilation, vasopressor support and sepsis were associated with an increased adjusted odds ratio for death. HIV was not independently associated with AKI or hospital mortality. CKD developed in 14 of 110 (12.7%) patients with stage 3 AKI; none were dialysis-dependent. CONCLUSIONS:In this large prospective multidisciplinary ICU cohort of younger patients, AKI was common, often associated with trauma in addition to traditional risk factors and was associated with good functional renal recovery at 90 days in most survivors. Although the HIV prevalence was high and associated with higher mortality, this was related to the severity of illness and not to HIV status per se.
journal_name
BMC Nephroljournal_title
BMC nephrologyauthors
Aylward RE,van der Merwe E,Pazi S,van Niekerk M,Ensor J,Baker D,Freercks RJdoi
10.1186/s12882-019-1620-7subject
Has Abstractpub_date
2019-12-10 00:00:00pages
460issue
1issn
1471-2369pii
10.1186/s12882-019-1620-7journal_volume
20pub_type
杂志文章相关文献
BMC Nephrology文献大全abstract:BACKGROUND:Diabetic nephropathy is a global common cause of chronic kidney disease and end-stage renal disease. A lot of research has been conducted in biomedical sciences, which has enhanced understanding of the pathophysiology of diabetic nephropathy and has expanded the potential available therapies. An increasing n...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-019-1590-9
更新日期:2019-10-28 00:00:00
abstract:BACKGROUND:Accurate estimation of glomerular filtration rate (GFR) is important for diagnosis and risk stratification in chronic kidney disease and for selection of living donors. Ethnic differences have required correction factors in the originally developed creatinine-based GFR estimation equations for populations ar...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-018-0813-9
更新日期:2018-02-01 00:00:00
abstract:BACKGROUND:Tissue derived biomarkers may offer utility as indicators of accumulated damage. Reduced thickness of retinal neuronal tissue and the vascular choroid have previously been associated with vascular damage and diabetes. We evaluated associations between retinal thickness, retinal microvascular and choroidal me...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-019-1679-1
更新日期:2020-01-31 00:00:00
abstract:BACKGROUND:During continuous venovenous haemofiltration (CVVH), regional anticoagulation with citrate may be superior to heparin in terms of biocompatibility, since heparin as opposed to citrate may activate complement (reflected by circulating C5a) and induce neutrophil degranulation in the filter and myeloperoxidase ...
journal_title:BMC nephrology
pub_type: 杂志文章,随机对照试验
doi:10.1186/1471-2369-15-19
更新日期:2014-01-17 00:00:00
abstract:BACKGROUND:Kidney impairment constitutes severe risk for cardiovascular disease, stroke and all-cause mortality, and early identification and prevention of kidney impairment is critical to effective management of prognostic risk in community residents. Previous studies have validated that carotid-femoral pulse wave vel...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-018-0897-2
更新日期:2018-05-02 00:00:00
abstract:BACKGROUND:Klotho is a transmembrane protein acting as a co-receptor for FGF-23 and thus exerts clinical actions on mineral metabolism. The association of secreted Klotho with outcomes in CKD patients is unclear. This study examined the relation between plasma Klotho and cardiovascular events in dialysis patients, acco...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-019-1391-1
更新日期:2019-06-11 00:00:00
abstract:BACKGROUND:Peritoneal dialysis (PD) is a home-based therapy performed by patients or their relatives in numerous cases, and the role of patients' educational practices in the risk of peritonitis is not well assessed. Our aim was to evaluate the effect of PD learning methods on the risk of peritonitis. METHODS:This was...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-020-01867-w
更新日期:2020-05-29 00:00:00
abstract:BACKGROUND:The clinical consequences of starting chronic peritoneal dialysis (PD) after emergent dialysis via a temporary hemodialysis (HD) catheter has rarely been evaluated within a full spectrum of treated end-stage renal disease (ESRD). We investigated the longer-term outcomes of patients undergoing emergent-start ...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-017-0764-6
更新日期:2017-12-11 00:00:00
abstract:BACKGROUND:The presence of glutathione transferase (GST) M1 null genotype (GSTM1-null) in end-stage renal disease (ESRD) patients is associated with lower overall survival rate in comparison to those with GSTM1-active variants. We examined association between GSTM1 and GSTT1 deletion polymorphisms as well as SNPs in GS...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/1471-2369-15-12
更新日期:2014-01-14 00:00:00
abstract:BACKGROUND:Patients with diabetes and chronic kidney disease (CKD) are a complex subset of the growing number of patients with diabetes, due to multi-morbidity. Gaps between recommended and received care for diabetes and chronic kidney disease (CKD) are evident despite promulgation of guidelines. Here, we document gaps...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-017-0493-x
更新日期:2017-02-28 00:00:00
abstract:BACKGROUND:Renal involvement in patients with chronic hepatitis C virus infection has been suggested to be due to a variety of immunological processes. However, the precise mechanism by which the kidneys are damaged in these patients is still unclear. CASE PRESENTATION:A 66 year old man presented with the sudden onset...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/1471-2369-4-7
更新日期:2003-08-29 00:00:00
abstract:BACKGROUND:Cystinuria is an inherited metabolic disease that is caused by defects in two genes, SLC3A1 and SLC7A9, which result in a renal reabsorptive defect of cystine and other dibasic amino acids, including ornithine, arginine, and lysine. Patients usually present with recurrent renal calculi and may develop renal ...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-017-0469-x
更新日期:2017-02-06 00:00:00
abstract:BACKGROUND:Lower serum bicarbonate, mainly due to the modern Western-style diet, and renal hyperfiltration (RHF) are both independently associated with higher mortality in the general population with preserved renal function. The objective of this study was to evaluate the association between serum bicarbonate and RHF....
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-015-0218-y
更新日期:2016-01-06 00:00:00
abstract:BACKGROUND:The aim of this study was to describe the findings of renal biopsies from a large nephrology center in Iasi, Romania, performed between 2005 and 2010. We compared these findings with our previous ones, from 1995 to 2004, as well as with similar reports. METHODS:We studied retrospectively 239 renal biopsies....
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/1471-2369-14-148
更新日期:2013-07-15 00:00:00
abstract:BACKGROUND:Multiple factors influence timing of dialysis initiation. The impact of supply of nephrology workforce on timing and incidence of dialysis initiation is not well known. METHODS:We determined the number of pediatric and adult nephrologists in each state using data from the American Medical Association and Am...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/1471-2369-16-2
更新日期:2015-01-15 00:00:00
abstract:BACKGROUND:Echocardiographic characteristics across the spectrum of chronic kidney disease (CKD) have not been well described. We assessed the echocardiographic characteristics of patients with preserved renal function and mild or moderate CKD referred for echocardiography and determined whether echocardiographic param...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-018-0975-5
更新日期:2018-07-11 00:00:00
abstract:BACKGROUND:TAFRO syndrome is a clinical subtype of idiopathic multicentric Castleman disease (iMCD) that is characterized by thrombocytopenia, anasarca, fever, reticulin myelofibrosis (or renal dysfunction), and organomegaly. TAFRO syndrome has only recently been described, and many clinicians are unaware of this disea...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-020-02119-7
更新日期:2020-11-23 00:00:00
abstract:BACKGROUND:In patients with autosomal dominant polycystic kidney disease (ADPKD), malnutrition may develop as renal function declines and the abdominal organs become enlarged. We investigated the relationship of intra-abdominal mass with nutritional status. METHODS:This cross-sectional study was performed at a tertiar...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-016-0434-0
更新日期:2017-01-14 00:00:00
abstract:BACKGROUND:Decreased heat shock protein 27 (HSP27) participates in many processes that are involved in cardiovascular (CV) disease. The objective of the study was to evaluate if HSP27 level was predictive of mortality as well as to evaluate factors associated with HSP27 level in a group of patients treated with HD. ME...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-018-1157-1
更新日期:2018-12-17 00:00:00
abstract:BACKGROUND:Early preparation for renal replacement therapy (RRT) is recommended for patients with advanced chronic kidney disease (CKD), yet many patients initiate RRT urgently and/or are inadequately prepared. METHODS:We conducted audio-recorded, qualitative, directed telephone interviews of nephrology health care pr...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-015-0020-x
更新日期:2015-03-28 00:00:00
abstract:BACKGROUND:In a previous study we showed that troponin I (TnI) > 0.42 ng/mL predicted the need of dialysis in a group of 29 septic patients admitted to the intensive care unit (ICU). We aimed to confirm such finding in a larger independent sample. METHODS:All septic patients admitted to an ICU from March 2016 to Febru...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-018-1129-5
更新日期:2018-11-20 00:00:00
abstract:BACKGROUND:Chronic kidney disease (CKD) is an independent risk factor for cardiovascular disease (CVD) events, and a number of reports have shown a relationship between CKD and CVD in pre-dialysis or maintenance dialysis patients. However, few studies have reported serial observations during dialysis initiation and mai...
journal_title:BMC nephrology
pub_type: 临床试验,杂志文章
doi:10.1186/s12882-017-0495-8
更新日期:2017-02-28 00:00:00
abstract:BACKGROUND:Chronic kidney disease (CKD) is characterized by dysbiosis, elevated levels of uremic toxins, systemic inflammation, and increased markers of oxidative stress. These factors lead to an increased risk of cardiovascular disease (CVD) which is common among CKD patients. Supplementation with high amylose maize r...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-020-02177-x
更新日期:2020-11-26 00:00:00
abstract:BACKGROUND:Anabolic-androgenic steroids and growth hormone are among the most commonly used supplements by sportsmen and sportswomen. The aim of this systematic review is to collect and report available data about renal safety of anabolic-androgenic steroids and growth hormone (GH). METHODS:The search strategy was in ...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-019-1384-0
更新日期:2019-05-31 00:00:00
abstract:BACKGROUND:The magnitude of renal function recovery after kidney donation differs in donors with a heterogeneous background. Preoperative assessment of candidates with potentially unfavorable renal functional compensation is critical when baseline kidney function is marginal. We explored the significance of preserved k...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-019-1242-0
更新日期:2019-02-08 00:00:00
abstract:BACKGROUND:Rehabilitation effects of exercise training on adults with chronic kidney disease (CKD) have been generally recognised; however, the effects of exercise training on proteinuria have been underexplored. Our aim was to explore the effects of exercise training on proteinuria in adult CKD patients without renal ...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-020-01816-7
更新日期:2020-05-11 00:00:00
abstract:BACKGROUND:Hyperchloremia is common in critically ill septic patients. The impact of hyperchloremia on the incidence of acute kidney injury (AKI) is not well studied. We investigated the association between hyperchloremia and AKI within the first 72 h of intensive care unit (ICU) admission. METHODS:6490 ICU adult pati...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-017-0750-z
更新日期:2017-12-02 00:00:00
abstract:BACKGROUND:To establish a model of chronic renal fibrosis following acute kidney injury (AKI) in BALB/c mice and to observe the effect of AKI on podocyte injury and chronic fibrosis of the kidney. Additional aims included using the model to explore the role of podocyte injury in AKI and post-injury fibrosis. METHODS:F...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-019-1298-x
更新日期:2019-03-28 00:00:00
abstract:BACKGROUND:Abdominal aortic calcification assessed by X-ray is recommended to evaluate vascular calcification in dialysis patients. It has been shown that abdominal aortic calcification score (AACS) is a predictor of adverse outcomes in hemodialysis patients, but evidence regarding its prognostic value in peritoneal di...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-020-01822-9
更新日期:2020-04-30 00:00:00
abstract:BACKGROUND:Frailty is independently associated with worse health-related quality of life (HRQOL) in chronic kidney disease (CKD). However, the relationship between frailty and symptom experience is not well described in people living with CKD. This study's aim was to evaluate the relationship between frailty and sympto...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-020-02063-6
更新日期:2020-09-23 00:00:00