Abstract:
BACKGROUND:Chronic kidney disease (CKD) is characterized by dysbiosis, elevated levels of uremic toxins, systemic inflammation, and increased markers of oxidative stress. These factors lead to an increased risk of cardiovascular disease (CVD) which is common among CKD patients. Supplementation with high amylose maize resistant starch type 2 (RS-2) can change the composition of the gut microbiota, and reduce markers of inflammation and oxidative stress in patients with end-stage renal disease. However, the impact of RS-2 supplementation has not been extensively studied in CKD patients not on dialysis. Aerobic exercise training lowers certain markers of inflammation in CKD patients. Whether combining aerobic training along with RS-2 supplementation has an additive effect on the aforementioned biomarkers in predialysis CKD patients has not been previously investigated. METHODS:The study is being conducted as a 16-week, double-blind, placebo controlled, parallel arm, randomized controlled trial. Sixty stage 3-4 CKD patients (ages of 30-75 years) are being randomized to one of four groups: RS-2 & usual care, RS-2 & aerobic exercise, placebo (cornstarch) & usual care and placebo & exercise. Patients attend four testing sessions: Two baseline (BL) sessions with follow up visits 8 (wk8) and 16 weeks (wk16) later. Fasting blood samples, resting brachial and central blood pressures, and arterial stiffness are collected at BL, wk8 and wk16. A stool sample is collected for analysis of microbial composition and peak oxygen uptake is assessed at BL and wk16. Blood samples will be assayed for p-cresyl sulphate and indoxyl sulphate, c-reactive protein, tumor necrosis factor α, interleukin 6, interleukin 10, monocyte chemoattractant protein 1, malondialdehyde, 8-isoprostanes F2a, endothelin-1 and nitrate/nitrite. Following BL, subjects are randomized to their group. Individuals randomized to conditions involving exercise will attend three supervised moderate intensity (55-65% peak oxygen uptake) aerobic training sessions (treadmills, bikes or elliptical machine) per week for 16 weeks. DISCUSSION:This study has the potential to yield information about the effect of RS-2 supplementation on key biomarkers believed to impact upon the development of CVD in patients with CKD. We are examining whether there is an additive effect of exercise training and RS-2 supplementation on these key variables. TRIAL REGISTRATION:Clinicaltrials.gov Trial registration# NCT03689569 . 9/28/2018, retrospectively registered.
journal_name
BMC Nephroljournal_title
BMC nephrologyauthors
Headley SA,Chapman DJ,Germain MJ,Evans EE,Hutchinson J,Madsen KL,Ikizler TA,Miele EM,Kirton K,O'Neill E,Cornelius A,Martin B,Nindl B,Vaziri NDdoi
10.1186/s12882-020-02177-xsubject
Has Abstractpub_date
2020-11-26 00:00:00pages
517issue
1issn
1471-2369pii
10.1186/s12882-020-02177-xjournal_volume
21pub_type
杂志文章相关文献
BMC Nephrology文献大全abstract:BACKGROUND:Chronic kidney disease (CKD) is increasingly being recognized as a predictor for both end-stage renal disease and cardiovascular disease. The present study, conducted on individuals from a community in Arita, Japan, was designed to evaluate biomarkers that can be used to determine the associated factors for ...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/1471-2369-10-34
更新日期:2009-10-27 00:00:00
abstract:BACKGROUND:Despite lithium being the most efficacious treatment for bipolar disorder, its use has been decreasing at least in part due to concerns about its potential to cause significant nephrotoxicity. Whilst the ability of lithium to cause nephrogenic diabetes insipidus is well established, its ability to cause chro...
journal_title:BMC nephrology
pub_type: 杂志文章,评审
doi:10.1186/s12882-018-1101-4
更新日期:2018-11-03 00:00:00
abstract:BACKGROUND:Despite improvement in short-term outcome of kidney transplants, the long-term survival of kidney transplants has not changed over past decades. Kidney biopsy is the gold standard of transplant pathology but it's invasive. Quantification of transplant blood flow could provide a novel non-invasive method to e...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-019-1617-2
更新日期:2019-11-27 00:00:00
abstract:BACKGROUND:IgA nephropathy (IgAN) is the most common glomerulonephritis worldwide and is an important cause of end-stage renal disease (ESRD). Exploring novel biomarkers is necessary for predicting the disease activity and progression of IgAN patients. The present study sought to investigate the value of serum C4 for p...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-019-1420-0
更新日期:2019-07-04 00:00:00
abstract:BACKGROUND:Chronic kidney disease (CKD) with edema is a common clinical problem resulting from defects in water and solute excretion. Furosemide is the drug of choice for treatment. In theory, good perfusion and albumin are required for the furosemide to be secreted at the tubular lumen. Thus, in the situation of low g...
journal_title:BMC nephrology
pub_type: 杂志文章,随机对照试验
doi:10.1186/1471-2369-13-92
更新日期:2012-08-29 00:00:00
abstract:BACKGROUND:Hyperphosphatemia is associated with vascular calcification and bone mineral disorders and is a major concern among patients with chronic kidney disease (CKD). However, the relationship between hyperphosphatemia and renal outcome in non-CKD patients has not been studied. Furthermore, the clinical implication...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-019-1556-y
更新日期:2019-09-18 00:00:00
abstract:BACKGROUND:Occurrence of cardiovascular disease (CVD) in the setting of chronic kidney disease (CKD) can be described as a "cruel alliance", with CVD responsible for about half of all deaths among CKD patients. Chronic kidney disease patients are more likely to die from CVD than progress to end stage kidney disease (ES...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-019-1583-8
更新日期:2019-10-30 00:00:00
abstract:BACKGROUND:Cystinuria is an inherited metabolic disease that is caused by defects in two genes, SLC3A1 and SLC7A9, which result in a renal reabsorptive defect of cystine and other dibasic amino acids, including ornithine, arginine, and lysine. Patients usually present with recurrent renal calculi and may develop renal ...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-017-0469-x
更新日期:2017-02-06 00:00:00
abstract:BACKGROUND:Lower serum bicarbonate, mainly due to the modern Western-style diet, and renal hyperfiltration (RHF) are both independently associated with higher mortality in the general population with preserved renal function. The objective of this study was to evaluate the association between serum bicarbonate and RHF....
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-015-0218-y
更新日期:2016-01-06 00:00:00
abstract:BACKGROUND:Anabolic-androgenic steroids and growth hormone are among the most commonly used supplements by sportsmen and sportswomen. The aim of this systematic review is to collect and report available data about renal safety of anabolic-androgenic steroids and growth hormone (GH). METHODS:The search strategy was in ...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-019-1384-0
更新日期:2019-05-31 00:00:00
abstract:BACKGROUND:Frailty is independently associated with worse health-related quality of life (HRQOL) in chronic kidney disease (CKD). However, the relationship between frailty and symptom experience is not well described in people living with CKD. This study's aim was to evaluate the relationship between frailty and sympto...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-020-02063-6
更新日期:2020-09-23 00:00:00
abstract:BACKGROUND:Use of serum creatinine to estimate GFR may lead to underestimation of the association between self-reported frailty and kidney function. Our objectives were to evaluate the association of measured GFR (mGFR) with self-reported frailty among patients with CKD and to determine whether self-reported frailty wa...
journal_title:BMC nephrology
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1186/s12882-015-0202-6
更新日期:2015-12-09 00:00:00
abstract:BACKGROUND:Levetiracetam is a frequently used drug in the therapy of partial onset, myoclonic and generalized tonic-clonic seizures. The main route of elimination is via the kidneys, which eliminate 66% of the unchanged drug as well as 24% as inactive metabolite that stems from enzymatic hydrolysis. Therefore dose adju...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/1471-2369-15-49
更新日期:2014-04-16 00:00:00
abstract:BACKGROUND:Transplant tourism entails movement of recipient, donor or both to a transplant centre outside their country of residence. This has been reported in many countries; and has variously been associated with organ trade. The objective of this study is to determine the frequency and pattern of transplant tourism ...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-017-0635-1
更新日期:2017-07-05 00:00:00
abstract:BACKGROUND:Despite the urgent need for evidence to guide the end-of-life (EOL) care for patients with chronic kidney disease (CKD), we have limited knowledge of the costs and intensity of EOL care in this population. The present study examined patterns and predictors for EOL care intensity among elderly patients with C...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-017-0456-2
更新日期:2017-01-26 00:00:00
abstract:BACKGROUND:Metabolic acidosis leads to chronic kidney disease (CKD) progression. The guidelines recommend a lower limit of serum bicarbonate level, but no upper limit. For serum bicarbonate level to be clinically useful as a therapeutic target marker, it is necessary to investigate the target serum bicarbonate level wi...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/1471-2369-14-4
更新日期:2013-01-09 00:00:00
abstract:BACKGROUND:Metabolic syndrome (MetS) has been established as a risk for cardiovascular diseases and mortality in hemodialysis patients. Energy intake (EI) is an important nutritional therapy for preventing MetS. We examined the association of self-reported dietary EI with metabolic abnormalities and MetS among hemodial...
journal_title:BMC nephrology
pub_type: 杂志文章,多中心研究
doi:10.1186/s12882-018-1041-z
更新日期:2018-09-19 00:00:00
abstract:BACKGROUND:Physical inactivity and sedentary behaviour (too much sitting) can contribute to renal dysfunction. However, the potential benefits of behavioural change (e.g. replacing sedentary behaviour with physical activity) on renal function are not well understood. We used isotemporal substitution to model potential ...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-020-01869-8
更新日期:2020-06-03 00:00:00
abstract:BACKGROUND:Calcific Uremic Arteriolopathy (CUA) is a rare disease, causing painful skin ulcers in patients with end stage renal disease. Recommendations for CUA management and treatment are lacking. METHODS:We conducted a retrospective cohort study on CUA cases identified in western France, in order to describe its ma...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-020-01722-y
更新日期:2020-02-26 00:00:00
abstract:BACKGROUND:The aim of the study was to assess the association between chronic kidney disease (CKD) and obesity in predicting CKD among Chinese adults, distinguishing between 5 different adiposity indices: visceral fat index (VFI), percentage body fat (PBF), body mass index (BMI), waist circumference (WC) and waist-to-h...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-018-0837-1
更新日期:2018-02-17 00:00:00
abstract:BACKGROUND:Chronic kidney disease (CKD) is global health concern and priority. It is the 12th leading cause of death worldwide. Protein Energy Wasting occurs in 20-25% of patients with chronic kidney disease and can lead to a high morbidity and mortality rate. We determined the prevalence of protein energy wasting and ...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-018-0920-7
更新日期:2018-06-14 00:00:00
abstract:BACKGROUND:Podocyte apoptosis is a major mechanism that leads to proteinuria in many kidney diseases. However, the concert mechanisms that cause podocyte apoptosis in these kidney diseases are not fully understood. RhoA is one of Rho GTPases that has been well studied and plays a key role in regulating cytoskeletal arc...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-016-0287-6
更新日期:2016-07-07 00:00:00
abstract:BACKGROUND:For chronic hemodialysis, the ideal permanent vascular access is the arteriovenous fistula (AVF). Temporary catheters should be reserved for acute dialysis needs. The AVF is associated with lower infection rates, better clinical results, and a higher quality of life and survival when compared to temporary ca...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/1471-2369-12-63
更新日期:2011-11-17 00:00:00
abstract:BACKGROUND:Adult patients with minimal change nephrotic syndrome (MCNS) are often associated with acute kidney injury (AKI). To assess the mechanisms of AKI, we examined whether tubular cell injuries unique to MCNS patients exist. METHODS:We performed a retrospective analysis of clinical data and tubular cell changes ...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-017-0756-6
更新日期:2017-11-28 00:00:00
abstract:BACKGROUND:MicroRNAs have been demonstrated to play an important role in the pathogenesis of diabetic nephropathy (DN). In this study, we investigated both the repertoire of miRNAs in the kidneys of patients with DN and their potential regulatory role in inflammation-mediated glomerular endothelial injury. METHODS:The...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/1471-2369-15-142
更新日期:2014-09-02 00:00:00
abstract:BACKGROUND:Gitelman syndrome (GS) is an autosomal recessive inherited salt-losing tubulopathy (SLT). Here, we describe, for the first time, a case of GS without Gitelman-like features and with concomitant kidney stones, cysts and diabetic nephropathy (DN). CASE PRESENTATION:We described a male patient had a 19-year hi...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-020-02211-y
更新日期:2021-01-07 00:00:00
abstract:BACKGROUND:Kidney injury molecule-1 (KIM-1) is a biomarker useful for detecting early tubular damage and has been recently reported as a useful marker for evaluating kidney injury in IgA nephropathy (IgAN). We therefore investigated whether treatment decreases urinary KIM-1 excretion in IgAN. METHODS:We prospectively ...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/1471-2369-14-139
更新日期:2013-07-09 00:00:00
abstract:BACKGROUND:Older patients with end-stage kidney disease (ESKD) often live with unidentified frailty and multimorbidity. Despite guideline recommendations, geriatric assessment is not part of standard clinical care, resulting in a missed opportunity to enhance (clinical) outcomes including quality of life in these patie...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-020-02206-9
更新日期:2021-01-06 00:00:00
abstract:BACKGROUND:Renal infarction (RI) is a rare disease with poor prognosis. Appropriate secondary prevention treatment is essential and requires an exhaustive etiological assessment. We aimed to determine whether invasive endovascular explorations may improve the diagnostic process and change the secondary prevention treat...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-020-01929-z
更新日期:2020-07-14 00:00:00
abstract:BACKGROUND:Recently there has been a progressive loss of specialty related skills for nephrologists. Among the skills we find the kidney biopsy that has a central role in diagnosis of renal parenchymal disease. One of the causes might be the belief that the kidney biopsy should be performed only in larger Centers which...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-017-0796-y
更新日期:2018-01-15 00:00:00