Arg913Gln variation of SLC12A3 gene is associated with diabetic nephropathy in type 2 diabetes and Gitelman syndrome: a systematic review.

Abstract:

BACKGROUND:Diabetic nephropathy is a global common cause of chronic kidney disease and end-stage renal disease. A lot of research has been conducted in biomedical sciences, which has enhanced understanding of the pathophysiology of diabetic nephropathy and has expanded the potential available therapies. An increasing number of evidence suggests that genetic alterations play a major role in development and progression of diabetic nephropathy. This systematic review was focused on searching an association between Arg913Gln variation in SLC12A3 gene with diabetic nephropathy in individuals with Type 2 Diabetes and Gitelman Syndrome. METHODS:An extensive systematic review of the literature was completed using PubMed, EBSCO and Cochrane Library, from their inception to January 2018. The PRISMA guidelines were followed and the search strategy ensured that all possible studies were identified to compile the review. Inclusion criteria for this review were: 1) Studies that analyzed the SLC12A3 gene in individuals with Type 2 Diabetes and Gitelman Syndrome. 2) Use of at least one analysis investigating the association between the Arg913Gln variation of SLC12A3 gene with diabetic nephropathy. 3) Use of a case-control or follow-up design. 4) Investigation of type 2 diabetes mellitus in individuals with Gitelman's syndrome, with a history of diabetic nephropathy. RESULTS:The included studies comprised 2106 individuals with diabetic nephropathy. This review shows a significant genetic association in most studies in the Arg913Gln variation of SLC12A3 gene with the diabetic nephropathy, pointing out that the mutations of this gene could be a key predictor of end-stage renal disease. CONCLUSIONS:The results showed in this systematic review contribute to better understanding of the association between the Arg913Gln variation of SLC12A3 gene with the pathogenesis of diabetic nephropathy in individuals with T2DM and GS.

journal_name

BMC Nephrol

journal_title

BMC nephrology

authors

De la Cruz-Cano E,Jiménez-González CDC,Morales-García V,Pineda-Pérez C,Tejas-Juárez JG,Rendón-Gandarilla FJ,Jiménez-Morales S,Díaz-Gandarilla JA

doi

10.1186/s12882-019-1590-9

subject

Has Abstract

pub_date

2019-10-28 00:00:00

pages

393

issue

1

issn

1471-2369

pii

10.1186/s12882-019-1590-9

journal_volume

20

pub_type

杂志文章
  • Association of anaemia in primary care patients with chronic kidney disease: cross sectional study of quality improvement in chronic kidney disease (QICKD) trial data.

    abstract:BACKGROUND:Anaemia is a known risk factor for cardiovascular disease and treating anaemia in chronic kidney disease (CKD) may improve outcomes. However, little is known about the scope to improve primary care management of anaemia in CKD. METHODS:An observational study (N = 1,099,292) with a nationally representative ...

    journal_title:BMC nephrology

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1186/1471-2369-14-24

    authors: Dmitrieva O,de Lusignan S,Macdougall IC,Gallagher H,Tomson C,Harris K,Desombre T,Goldsmith D

    更新日期:2013-01-25 00:00:00

  • Medical treatment for an isolated renal multilocular hydatid cyst in an elderly: a case report.

    abstract:BACKGROUND:Almost all cases of renal hydatid cysts need surgical intervention for treatment. We report a case of isolated renal hydatid cyst treated successfully only with medical therapy. CASE PRESENTATION:This case is a 79-year-old veterinarian presented with right flank pain, hydatiduria and positive echinococcus g...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-020-02064-5

    authors: Moghtadaie A,Yazdi SAM,Mohraz M,Asefi H,Razeghi E

    更新日期:2020-10-08 00:00:00

  • A novel simple experimental model for low-osmolar contrast-induced acute kidney injury using different definitions based on the levels of serum creatinine and cystatin C.

    abstract:BACKGROUND:It remained lack of a kind of contrast-induced acute kidney injury (CI-AKI) model which was widely used in clinical practice and comparable to CI-AKI in humans. METHODS:Fifty Sprague-Dawley rats were divided into five groups of 10 rats each: (1) sham group (normal saline [NS] + NS); (2) NS plus low osmolali...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-019-1436-5

    authors: Liu YH,Xue JH,Wu DX,Bei WJ,Wang K,Liu Y,Chen JY,Tan N

    更新日期:2019-07-04 00:00:00

  • A prospective observational study comparing a non-operator dependent automatic PWV analyser to pulse pressure, in assessing arterial stiffness in hemodialysis.

    abstract:BACKGROUND:Chronic kidney disease (CKD) accelerates vascular stiffening related to age. Arterial stiffness may be evaluated measuring the carotid-femoral pulse wave velocity (PWV) or more simply, as recommended by KDOQI, monitoring pulse pressure (PP). Both correlate to survival and incidence of cardiovascular disease....

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-015-0058-9

    authors: Salvadé I,Schätti-Stählin S,Violetti E,Schönholzer C,Cereghetti C,Zwahlen H,Berwert L,Burnier M,Gabutti L

    更新日期:2015-04-23 00:00:00

  • Impact of impaired glomerular filtration rate and revascularization strategy on one-year cardiovascular events in acute coronary syndrome: data from Taiwan acute coronary syndrome full spectrum registry.

    abstract:BACKGROUND:The optimal revascularization strategy for patients with impaired glomerular filtration rate (IGFR) has not been established in acute coronary syndrome (ACS). We investigated the prognosis and impact of IGFR and invasive strategy on the cardiovascular outcomes in the ACS population. METHODS:In a Taiwan nati...

    journal_title:BMC nephrology

    pub_type: 杂志文章,多中心研究

    doi:10.1186/1471-2369-15-66

    authors: Lin TH,Hsin HT,Wang CL,Lai WT,Li AH,Kuo CT,Hwang JJ,Chiang FT,Chang SC,Chang CJ,Taiwan ACS Full Spectrum Registry Investigators.

    更新日期:2014-04-23 00:00:00

  • Urine concentration ability is reduced to the same degree in adult dominant polycystic kidney disease compared with other chronic kidney diseases in the same CKD-stage and lower THAN in healthy control subjects - a CASE control study.

    abstract:BACKGROUND:Concentration of the urine is primarily regulated via vasopressin dependent aquaporin-2 water channels in the apical membrane of kidney principal cells. It is unclear whether urine concentration ability in ADPKD differs from other patients with similar degree of impaired renal function (non-ADPKD patients). ...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-020-02043-w

    authors: Malmberg MH,Mose FH,Pedersen EB,Bech JN

    更新日期:2020-08-31 00:00:00

  • High prevalence of non-steroidal anti-inflammatory drug use among acute kidney injury survivors in the southern community cohort study.

    abstract:BACKGROUND:Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used and have been linked to acute kidney injury (AKI), chronic kidney disease (CKD) and cardiovascular disease (CVD). Patients who survive an AKI episode are at risk for future adverse kidney and cardiovascular outcomes. The objective of our study wa...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-016-0411-7

    authors: Lipworth L,Abdel-Kader K,Morse J,Stewart TG,Kabagambe EK,Parr SK,Birdwell KA,Matheny ME,Hung AM,Blot WJ,Ikizler TA,Siew ED

    更新日期:2016-11-24 00:00:00

  • Corticosteroids pulse therapy and oral corticosteroids therapy for IgA nephropathy patients with advanced chronic kidney disease: results of a multicenter, large-scale, long-term observational cohort study.

    abstract:BACKGROUND:Corticosteroids are widely used to reduce the urine protein levels of patients with immunoglobulin A nephropathy (IgAN). However, their potential preventive effects on end-stage kidney disease (ESKD) are unclear. METHODS:We previously performed a large-scale, long-term multicenter cohort study of patients w...

    journal_title:BMC nephrology

    pub_type: 杂志文章,多中心研究

    doi:10.1186/s12882-018-1019-x

    authors: Tsunoda R,Usui J,Hoshino J,Fujii T,Suzuki S,Takaichi K,Ubara Y,Yamagata K

    更新日期:2018-09-06 00:00:00

  • Outcomes of sustained low efficiency dialysis versus continuous renal replacement therapy in critically ill adults with acute kidney injury: a cohort study.

    abstract:BACKGROUND:Sustained low efficiency dialysis (SLED) is increasingly used as a renal replacement modality in critically ill patients with acute kidney injury (AKI) and hemodynamic instability. SLED may reduce the hemodynamic perturbations of intermittent hemodialysis, while obviating the resource demands of CRRT. Althou...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-015-0123-4

    authors: Kitchlu A,Adhikari N,Burns KE,Friedrich JO,Garg AX,Klein D,Richardson RM,Wald R

    更新日期:2015-08-04 00:00:00

  • Renal disease and accidental falls: a review of published evidence.

    abstract:BACKGROUND:The pathogenesis of falling is complex, and identification of risk factors may be essential for prevention. The relationship between renal disease and falls is unclear, and the goal of this study was to collect the available evidence and investigate the relationship between accidental falls and renal dysfunc...

    journal_title:BMC nephrology

    pub_type: 杂志文章,评审

    doi:10.1186/s12882-015-0173-7

    authors: López-Soto PJ,De Giorgi A,Senno E,Tiseo R,Ferraresi A,Canella C,Rodríguez-Borrego MA,Manfredini R,Fabbian F

    更新日期:2015-10-29 00:00:00

  • Do oral aluminium phosphate binders cause accumulation of aluminium to toxic levels?

    abstract:BACKGROUND:Aluminium (Al) toxicity was frequent in the 1980s in patients ingesting Al containing phosphate binders (Alucaps) whilst having HD using water potentially contaminated with Al. The aim of this study was to determine the risk of Al toxicity in HD patients receiving Alucaps but never exposed to contaminated di...

    journal_title:BMC nephrology

    pub_type: 临床试验,杂志文章

    doi:10.1186/1471-2369-12-55

    authors: Pepper R,Campbell N,Yaqoob MM,Roberts NB,Fan SL

    更新日期:2011-10-12 00:00:00

  • Acute bilateral emphysematous pyelonephritis successfully managed by medical therapy alone: a case report and review of the literature.

    abstract:BACKGROUND:Bilateral emphysematous pyelonephritis is a life threatening condition usually occurring in diabetics. Management of this condition has traditionally been aggressive and surgery is considered mandatory. However, this is itself a hazardous intervention in a septic, unstable patient with circulatory or liver f...

    journal_title:BMC nephrology

    pub_type: 杂志文章,评审

    doi:10.1186/1471-2369-3-4

    authors: Flores G,Nellen H,Magaña F,Calleja J

    更新日期:2002-06-03 00:00:00

  • A novel citrate-based protocol versus heparin anticoagulation for sustained low-efficiency dialysis in the ICU: safety, efficacy, and cost.

    abstract:BACKGROUND:The high cost, complexity of the available protocols, and metabolic complications are the major barriers that impede the clinical utilization of regional citrate anticoagulation (RCA) for sustained low efficiency dialysis (SLED) in critically ill patients. By comparing a novel protocol for SLED using 30% cit...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-018-0879-4

    authors: Wen M,Küchle C,Steubl D,Satanovskji R,Heemann U,Suttmann Y,Angermann S,Kemmner S,Rehbehn L,Huber M,Hauser C,Schmaderer C,Reichelt AL,Haller B,Renders L

    更新日期:2018-04-03 00:00:00

  • Trends in anemia care in non-dialysis-dependent chronic kidney disease (CKD) patients in the United States (2006-2015).

    abstract:BACKGROUND:The objective of the study was to examine overall anemia management trends in non-dialysis patients with chronic kidney disease (CKD) from 2006 to 2015, and to evaluate the impact of Trial to Reduced Cardiovascular Events with Ananesp Therapy (TREAT)'s study results (October 2009) and the US Food and Drug Ad...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-018-1119-7

    authors: Park H,Liu X,Henry L,Harman J,Ross EA

    更新日期:2018-11-09 00:00:00

  • Effect of cool vs. warm dialysate on toxin removal: rationale and study design.

    abstract:BACKGROUND:Cool dialysate is often recommended for prevention of intra-dialytic hypotensive episodes in maintenance hemodialysis (HD) patients. However, its effect on toxin removal is not studied. It is known that inter-compartmental resistance is the main barrier for toxin removal. Cool dialysate can potentially incre...

    journal_title:BMC nephrology

    pub_type: 杂志文章,随机对照试验

    doi:10.1186/s12882-015-0017-5

    authors: Maheshwari V,Lau T,Samavedham L,Rangaiah GP

    更新日期:2015-02-27 00:00:00

  • Association between family members of dialysis patients and chronic kidney disease: a multicenter study in China.

    abstract:BACKGROUND:Family members of patients with end stage renal disease were reported to have an increased prevalence of chronic kidney disease (CKD). However, studies differentiated genetic and non-genetic family members are limited. We sought to investigate the prevalence of CKD among fist-degree relatives and spouses of ...

    journal_title:BMC nephrology

    pub_type: 杂志文章,多中心研究

    doi:10.1186/1471-2369-14-19

    authors: Kong X,Liu L,Zuo L,Yuan P,Li Z,Li W,Cai M,Chen X,Jiang A,Long G,Xu J,Lin H,Wang S,Huang W,Wang Y,Guo Y,Cao P,Wu H,Jia Q,Zhang L,Wang M,Wang H

    更新日期:2013-01-18 00:00:00

  • Chronic kidney disease of uncertain aetiology: prevalence and causative factors in a developing country.

    abstract:BACKGROUND:This study describes chronic kidney disease of uncertain aetiology (CKDu), which cannot be attributed to diabetes, hypertension or other known aetiologies, that has emerged in the North Central region of Sri Lanka. METHODS:A cross-sectional study was conducted, to determine the prevalence of and risk factor...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/1471-2369-14-180

    authors: Jayatilake N,Mendis S,Maheepala P,Mehta FR,CKDu National Research Project Team.

    更新日期:2013-08-27 00:00:00

  • Anti-neutrophil extracellular trap antibody in a patient with relapse of anti-neutrophil cytoplasmic antibody-associated vasculitis: a case report.

    abstract:BACKGROUND:Neutrophil extracellular traps (NETs) are web-like DNA decorated with antimicrobial proteins, such as myeloperoxidase (MPO), which are extruded from activated neutrophils. Although NETs are essential in innate immunity, an excessive formation of NETs has adverse effects, e.g., induction of anti-neutrophil cy...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-018-0953-y

    authors: Shida H,Hashimoto N,Kusunoki Y,Hattanda F,Ogawa Y,Hayashi T,Nakazawa D,Masuda S,Tomaru U,Ishizu A

    更新日期:2018-06-22 00:00:00

  • Effect of chitosan chewing gum on reducing serum phosphorus in hemodialysis patients: a multi-center, randomized, double-blind, placebo-controlled trial.

    abstract:BACKGROUND:HS219 (40 mg chitosan-loaded chewing gum) is designed to bind salivary phosphorus as an add-on to available phosphorus binders. We performed a randomized, placebo-controlled, double-blind study to evaluate the efficacy and safety of HS219 in hemodialysis (HD) patients with hyperphosphatemia as an add-on to p...

    journal_title:BMC nephrology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1186/1471-2369-15-98

    authors: Akizawa T,Tsuruta Y,Okada Y,Miyauchi Y,Suda A,Kasahara H,Sasaki N,Maeda Y,Suzuki T,Matsui N,Niwayama J,Suzuki T,Hara H,Asano Y,Komemushi S,Fukagawa M

    更新日期:2014-06-25 00:00:00

  • The lived experiences of patients undergoing hemodialysis with the concept of care: a phenomenological study.

    abstract:BACKGROUND:Providing patient-centered care needs in patients with chronic renal failure undergoing hemodialysis is important in inspiring their confidence to continue their treatment and promote their mental and social health. Therefore, recognizing the concept of care from the viewpoint of these patients can be helpfu...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-018-1138-4

    authors: Shahgholian N,Yousefi H

    更新日期:2018-11-26 00:00:00

  • The association of dialysis adequacy, body mass index, and mortality among hemodialysis patients.

    abstract:BACKGROUND:Although hemodialysis (HD) adequacy, single-pool Kt/Vurea (spKt/V), is inversely correlated with body size, each is known to affect patient survival in the same direction. Therefore, we sought to examine the relationship between HD adequacy and mortality according to body mass index (BMI) in HD patients and ...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-019-1570-0

    authors: Hong WP,Lee YJ

    更新日期:2019-10-22 00:00:00

  • Comparison of outcomes between emergent-start and planned-start peritoneal dialysis in incident ESRD patients: a prospective observational study.

    abstract:BACKGROUND:The clinical consequences of starting chronic peritoneal dialysis (PD) after emergent dialysis via a temporary hemodialysis (HD) catheter has rarely been evaluated within a full spectrum of treated end-stage renal disease (ESRD). We investigated the longer-term outcomes of patients undergoing emergent-start ...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-017-0764-6

    authors: Li WY,Wang YC,Hwang SJ,Lin SH,Wu KD,Chen YM

    更新日期:2017-12-11 00:00:00

  • Incidence of glomerulonephritis and non-diabetic end-stage renal disease in a developing middle-east region near armed conflict.

    abstract:BACKGROUND:Estimates of the incidence of glomerulonephritis (GN) and end-stage renal disease (ESRD) in an Iraqi population are compared with the United States (US) and Jordan. METHODS:The study set consist of renal biopsies performed in 2012 and 2013 in the Kurdish provinces of Northern Iraq. The age specific and age ...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-018-1062-7

    authors: Ali AA,Sharif DA,Almukhtar SE,Abd KH,Saleem ZSM,Hughson MD

    更新日期:2018-10-11 00:00:00

  • Unilateral renal artery stenosis presented with hyponatremic-hypertensive syndrome - case report and literature review.

    abstract:BACKGROUND:Renal artery stenosis is one of the secondary causes of pediatric hypertension. Cases with critical unilateral renal artery stenosis manifesting with the hyponatremic hypertensive syndrome are rare and a comprehensive description of this disorder in the pediatric population is lacking in the literature. CAS...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-019-1246-9

    authors: Ding JJ,Lin SH,Lai JY,Wu TW,Huang JL,Chung HT,Tseng MH

    更新日期:2019-02-21 00:00:00

  • A need-based approach to self-management education for adults with co-morbid diabetes and chronic kidney disease.

    abstract:BACKGROUND:Self-management education needs have not been assessed in patients with complex co-morbid conditions such as diabetes and chronic kidney disease (CKD). The objectives of this study were to 1) determine the self-management education needs for patients with co-morbid diabetes and CKD and 2) co-develop an educa...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-019-1296-z

    authors: Zimbudzi E,Lo C,Kerr PG,Zoungas S

    更新日期:2019-04-02 00:00:00

  • A novel model of reno-cardiac syndrome in the C57BL/ 6 mouse strain.

    abstract:BACKGROUND:The end stage renal disease population has a 20 fold higher incidence of cardiovascular mortality compared to the overall population. The development of reno-cardiac syndrome in these patients will result in cardiovascular events to be the cause of 50% of fatalities. There is therefore a need to research imp...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-018-1155-3

    authors: Kieswich JE,Chen J,Alliouachene S,Caton PW,McCafferty K,Thiemermann C,Yaqoob MM

    更新日期:2018-12-04 00:00:00

  • Effect of treatment on urinary kidney injury molecule-1 in IgA nephropathy.

    abstract:BACKGROUND:Kidney injury molecule-1 (KIM-1) is a biomarker useful for detecting early tubular damage and has been recently reported as a useful marker for evaluating kidney injury in IgA nephropathy (IgAN). We therefore investigated whether treatment decreases urinary KIM-1 excretion in IgAN. METHODS:We prospectively ...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/1471-2369-14-139

    authors: Seo MS,Park MY,Choi SJ,Jeon JS,Noh H,Kim JK,Han DC,Hwang SD,Jin SY,Kwon SH

    更新日期:2013-07-09 00:00:00

  • NGAL expression during cardiopulmonary bypass does not predict severity of postoperative acute kidney injury.

    abstract:BACKGROUND:Renal injury is a serious complication after cardiac surgery and therefore, early detection and much more prediction of postoperative kidney injury is desirable. Neutrophil gelatinase-associated lipocalin (NGAL) is a predictive biomarker of acute kidney injury and may increase after cardiopulmonary bypass (C...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-017-0479-8

    authors: Friedrich MG,Bougioukas I,Kolle J,Bireta C,Jebran FA,Placzek M,Tirilomis T

    更新日期:2017-02-21 00:00:00

  • Prevalence and associated factors of protein- energy wasting among patients with chronic kidney disease at Mulago hospital, Kampala-Uganda: a cross-sectional study.

    abstract:BACKGROUND:Chronic kidney disease (CKD) is global health concern and priority. It is the 12th leading cause of death worldwide. Protein Energy Wasting occurs in 20-25% of patients with chronic kidney disease and can lead to a high morbidity and mortality rate. We determined the prevalence of protein energy wasting and ...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-018-0920-7

    authors: Namuyimbwa L,Atuheire C,Okullo J,Kalyesubula R

    更新日期:2018-06-14 00:00:00

  • Rationale and design of the Sodium Lowering In Dialysate (SoLID) trial: a randomised controlled trial of low versus standard dialysate sodium concentration during hemodialysis for regression of left ventricular mass.

    abstract:BACKGROUND:The current literature recognises that left ventricular hypertrophy makes a key contribution to the high rate of premature cardiovascular mortality in dialysis patients. Determining how we might intervene to ameliorate left ventricular hypertrophy in dialysis populations has become a research priority. Reduc...

    journal_title:BMC nephrology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1186/1471-2369-14-149

    authors: Dunlop JL,Vandal AC,de Zoysa JR,Gabriel RS,Haloob IA,Hood CJ,Matheson PJ,McGregor DO,Rabindranath KS,Semple DJ,Marshall MR

    更新日期:2013-07-15 00:00:00