Abstract:
BACKGROUND:Group A streptococcus (GAS) is an etiological agent for the immune mediated sequela post streptococcal glomerulonephritis (PSGN). In some populations PSGN is recognized as a risk factor for chronic kidney disease (CKD) and end-stage renal disease (ESRD). It was found that a significantly greater proportion of subjects with past history of PSGN than without the history exhibited seroreactions to streptococcal antigens called streptococcal inhibitor of complement (SIC) and to distantly related SIC (DRS). These antigens are expressed by major PSGN-associated GAS types. We therefore predicted that in populations such as India, which is endemic for streptococcal diseases and which has high prevalence of CKD and ESRD, greater proportions of CKD and ESRD patients exhibit seroreaction to SIC and DRS than healthy controls. METHODS:To test this we conducted a SIC and DRS seroprevalence study in subjects from Mumbai area. We recruited 100 CKD, 70 ESRD and 70 healthy individuals. RESULTS:Nineteen and 35.7% of CKD and ESRD subjects respectively were SIC antibody-positive, whereas only 7% of healthy cohort was seropositive to SIC. Furthermore, significantly greater proportion of the ESRD patients than the CKD patients is seropositive to SIC (p=0.02; odds ratio 2.37). No association was found between the renal diseases and DRS-antibody-positivity. CONCLUSIONS:Past infection with SIC-positive GAS is a risk factor for CKD and ESRD in Mumbai population. Furthermore, SIC seropositivity is predictive of poor prognosis of CKD patients.
journal_name
BMC Nephroljournal_title
BMC nephrologyauthors
Karmarkar MG,Hule GP,Hase NK,Mehta PR,Walter SR,Sriprakash KSdoi
10.1186/1471-2369-14-101subject
Has Abstractpub_date
2013-05-06 00:00:00pages
101issn
1471-2369pii
1471-2369-14-101journal_volume
14pub_type
杂志文章相关文献
BMC Nephrology文献大全abstract:BACKGROUND:The prevalence of chronic kidney disease (CKD) is increasing worldwide and in Africa. Health related quality of life (QOL) has become an essential outcome measure for patients with CKD and end stage renal disease (ESRD). There is growing interest worldwide in QOL of CKD patients but paucity of data in Ghana....
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-019-1316-z
更新日期:2019-04-08 00:00:00
abstract:BACKGROUND:Primary hyperoxaluria type 1 is a rare autosomal recessive disease of glyoxylate metabolism caused by a defect in the liver-specific peroxisomal enzyme alanine:glyoxylate aminotransferase (AGT) that leads to hyperoxaluria, recurrent urolithiasis, and nephrocalcinosis. METHODS:Two unrelated patients with rec...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/1471-2369-15-92
更新日期:2014-06-17 00:00:00
abstract:BACKGROUND:Association between metabolic syndrome (MS) and mildly reduced estimated glomerular filtration rates (eGFRs) remains unclear. Therefore, we aimed to evaluate the association between MS and a mildly reduced eGFR in Chinese adults. METHODS:Anthropometric and biochemical examinations were performed in 2992 ind...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-017-0597-3
更新日期:2017-06-13 00:00:00
abstract:BACKGROUND:Chronic kidney disease (CKD) and coronary artery disease (CAD) are independently associated with increased vascular stiffness. We examined whether renal function contributes to vascular stiffness independently of CAD status. METHODS:We studied 160 patients with CAD and 169 subjects without CAD. The 4-variab...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/1471-2369-14-173
更新日期:2013-08-13 00:00:00
abstract:BACKGROUND:African Americans have an increased incidence and worse prognosis with chronic kidney disease (CKD--estimated glomerular filtration rate [eGFR] <60 ml/min/1.73 m2) than their counterparts of European-descent. Inflammation has been related to renal disease in non-Hispanic whites, but there are limited data on...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/1471-2369-11-1
更新日期:2010-01-15 00:00:00
abstract:BACKGROUND:This study tests the hypotheses that health-related quality of life (HRQOL) in prevalent dialysis patients with diabetes is lower than in dialysis patients without diabetes, and is at least as poor as diabetic patients with another severe complication, i.e. foot ulcers. This study also explores the mortality...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/1471-2369-13-78
更新日期:2012-08-03 00:00:00
abstract:BACKGROUND:Patients who start renal replacement therapy (RRT) for End-Stage Kidney Disease (ESKD) without having had timely access to specialist renal services have poor outcomes. At one NHS Trust in England, a community-wide CKD management system has led to a decline in the incident rate of RRT and the lowest percenta...
journal_title:BMC nephrology
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12882-017-0522-9
更新日期:2017-04-11 00:00:00
abstract:BACKGROUND:Bioimpedance analysis (BIA) has been reported as helpful in identifying hypervolemia. Observation data showed that hypervolemic maintenance hemodialysis (MHD) patients identified using BIA methods have higher mortality risk. However, it is not known if BIA-guided fluid management can improve MHD patients' su...
journal_title:BMC nephrology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/1471-2369-13-120
更新日期:2012-09-25 00:00:00
abstract:BACKGROUND:Age and number of recipients in need of kidney re-transplantation are increasing. Re-transplantation practices and outcomes in elderly recipients are not previously explored. We aimed to retrospectively evaluate the outcomes of recipients 65 years and older receiving their second deceased donor allograft. M...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-016-0426-0
更新日期:2017-01-11 00:00:00
abstract::Chronic kidney disease (CKD) is an inherently systemic disease that refers to a long-term loss of kidney function. The progression of CKD has repercussions for other organs, leading to many kinds of extrarenal complications. Intensive studies are now being undertaken to reveal the risk factors and pathophysiological m...
journal_title:BMC nephrology
pub_type: 杂志文章,评审
doi:10.1186/s12882-018-1094-z
更新日期:2018-10-22 00:00:00
abstract:BACKGROUND:Acute kidney injury (AKI) is common in hospitalized human immunodeficiency virus (HIV)-infected patients and is associated with hospital mortality. We aimed to evaluate the impact of AKI on long-term mortality of hospitalized HIV-infected patients. METHODS:Retrospective analysis of a cohort of 433 hospitali...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/1471-2369-14-32
更新日期:2013-02-11 00:00:00
abstract:BACKGROUND:Myeloperoxidase anti-neutrophil cytoplasmic antibody-associated glomerulonephritis (MPO-ANCA-GN) and concurrent membranous nephropathy (MN) are very rare combination. Their causal relationship has been suggested, but not determined. CASE PRESENTATION:A 73-years-old male with 5-year history of proteinuria un...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/1471-2369-14-73
更新日期:2013-03-28 00:00:00
abstract:BACKGROUND:Aluminium (Al) toxicity was frequent in the 1980s in patients ingesting Al containing phosphate binders (Alucaps) whilst having HD using water potentially contaminated with Al. The aim of this study was to determine the risk of Al toxicity in HD patients receiving Alucaps but never exposed to contaminated di...
journal_title:BMC nephrology
pub_type: 临床试验,杂志文章
doi:10.1186/1471-2369-12-55
更新日期:2011-10-12 00:00:00
abstract:BACKGROUND:Patients with advanced chronic kidney disease (CKD) exhibit higher prevalence of coronary artery calcification (CaC) than general population. CaC has been proposed as a risk factor for mortality in end-stage CKD, but most studies in the field are based on short-term follow-up. METHODS:We conducted a cohort,...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-019-1367-1
更新日期:2019-05-28 00:00:00
abstract:BACKGROUND:Serum cystatin C (ScysC) may help predicting cardiovascular outcome not only through its ability to detect renal dysfunction but also through its potential connection to others factors that are directly related to cardiovascular diseases. We explored the potential association of ScysC with arterial stiffness...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/1471-2369-15-196
更新日期:2014-12-11 00:00:00
abstract:BACKGROUND:To establish a model of chronic renal fibrosis following acute kidney injury (AKI) in BALB/c mice and to observe the effect of AKI on podocyte injury and chronic fibrosis of the kidney. Additional aims included using the model to explore the role of podocyte injury in AKI and post-injury fibrosis. METHODS:F...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-019-1298-x
更新日期:2019-03-28 00:00:00
abstract:BACKGROUND:Recipients of living donor renal transplantation are typically considered to have a relatively lower immunological risk. This retrospective study aimed to compare the therapeutic efficacy and safety between rabbit antithymocyte globulin (rATG) or interleukin-2 receptor antagonist (IL2-RA) induction therapies...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-019-1293-2
更新日期:2019-03-22 00:00:00
abstract:BACKGROUND:The possibility of clearing Cell-free Plasma Hemoglobin (CPH) from human plasma may appear attractive, especially when considering the noxious effects that CPH has on the immune function and the renal damage caused by its filtration. The existence of the so-called High Cut-Off (HCO) filters, possessing pores...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-018-1051-x
更新日期:2018-10-04 00:00:00
abstract:BACKGROUND:Acute kidney injury (AKI) is a common clinical problem. Studies have documented the incidence of AKI in a variety of populations but to date we do not believe the real incidence of AKI has been accurately documented in a district general hospital setting.The aim here was to describe the detected incidence of...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/1471-2369-15-95
更新日期:2014-06-21 00:00:00
abstract:BACKGROUND:In view of the prevalence of oxidative stress in chronic kidney disease (CKD) patients, the loss of low-molecular-weight biomolecules by hemodialysis and the antioxidant potential of some uremic solutes that accumulate in CKD, we used in vitro model systems to test the antioxidant potential of the following ...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-015-0029-1
更新日期:2015-04-11 00:00:00
abstract:BACKGROUND:Patients undergoing liver transplantation with preexisting renal dysfunction are prone to further renal impairment with the early postoperative use of Calcineurin-inhibitors. However, there is only little scientific evidence for the safety and efficacy of de novo CNI free "bottom-up" regimens in patients wit...
journal_title:BMC nephrology
pub_type: 临床试验,杂志文章
doi:10.1186/1471-2369-11-24
更新日期:2010-09-14 00:00:00
abstract:BACKGROUND:Transplant renal artery dissection is a rare and serious event that can cause allograft dysfunction and activation of the renin-mediated renovascular hypertension. Most cases are induced by percutaneous transluminal angioplasty, arteriosclerotic disease, or fibromuscular dysplasia. We observed a case of tran...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-020-1699-x
更新日期:2020-01-29 00:00:00
abstract:BACKGROUND:There is a high prevalence of cognitive impairment in dialysis patients. The prevalence of cognitive impairment after kidney transplantation is unknown. METHODS:Study Design: Cross-sectional study. SETTING AND PARTICIPANTS:Single center study of prevalent kidney transplant recipients from a transplant clin...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-017-0570-1
更新日期:2017-05-12 00:00:00
abstract:BACKGROUND:The extent to which smoking contributes to adverse outcomes among men and women of all ages undergoing dialysis is uncertain. The objective of this study was to determine the differential impact of smoking on risks of mortality and kidney transplantation by age and by sex at dialysis initiation. METHODS:We ...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-016-0311-x
更新日期:2016-07-26 00:00:00
abstract:BACKGROUND:The aims of this study are to find the prevalence of potential drug-drug interactions (DDIs) in patients with Hemodialysis and identify factors associated with these interactions if present. METHODS:The study was an observational- retrospective cohort study that was conducted in ten hemodialysis units in th...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-016-0317-4
更新日期:2016-07-26 00:00:00
abstract:BACKGROUND:Treatment of idiopathic membranous nephropathy with nephrotic syndrome is still controversial. There is currently little known about the clinical use of renal biomarkers which may explain contradictory results obtained from clinical trials. In order to assess whether IgG-uria can predict the outcome in membr...
journal_title:BMC nephrology
pub_type: 临床试验,杂志文章
doi:10.1186/1471-2369-15-74
更新日期:2014-05-08 00:00:00
abstract:BACKGROUND:Icodextrin is a starch-derived, water soluble glucose polymer, which is used as an alternative to glucose in order to enhance dialytic fluid removal in peritoneal dialysis patients. Although the safety and efficacy of icodextrin is well-established, its use in everyday clinical practice has been associated w...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-018-1071-6
更新日期:2018-10-25 00:00:00
abstract:BACKGROUND:The presence of glutathione transferase (GST) M1 null genotype (GSTM1-null) in end-stage renal disease (ESRD) patients is associated with lower overall survival rate in comparison to those with GSTM1-active variants. We examined association between GSTM1 and GSTT1 deletion polymorphisms as well as SNPs in GS...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/1471-2369-15-12
更新日期:2014-01-14 00:00:00
abstract:BACKGROUND:Physical inactivity and sedentary behaviour (too much sitting) can contribute to renal dysfunction. However, the potential benefits of behavioural change (e.g. replacing sedentary behaviour with physical activity) on renal function are not well understood. We used isotemporal substitution to model potential ...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-020-01869-8
更新日期:2020-06-03 00:00:00
abstract:BACKGROUND:Annual decline in kidney function is a widely applied surrogate outcome of renal failure. It is important to understand the relationships between known risk factors and the annual decline in estimated glomerular filtration rate (eGFR) according to baseline age; however, these remain unclear. METHODS:A commu...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-020-02121-z
更新日期:2020-11-13 00:00:00