Prevalence and correlates of cognitive impairment in kidney transplant recipients.

Abstract:

BACKGROUND:There is a high prevalence of cognitive impairment in dialysis patients. The prevalence of cognitive impairment after kidney transplantation is unknown. METHODS:Study Design: Cross-sectional study. SETTING AND PARTICIPANTS:Single center study of prevalent kidney transplant recipients from a transplant clinic in a large academic center. INTERVENTION:Assessment of cognition using the Montreal Cognitive Assessment (MoCA). Demographic and clinical variables associated with cognitive impairment were also examined. Outcomes and Measurements: a) Prevalence of cognitive impairment defined by a MoCA score of <26. b) Multivariable linear and logistic regression to examine the association of demographic and clinical factors with cognitive impairment. RESULTS:Data from 226 patients were analyzed. Mean (SD) age was 54 (13.4) years, 73% were white, 60% were male, 37% had diabetes, 58% had an education level of college or above, and the mean (SD) time since kidney transplant was 3.4 (4.1) years. The prevalence of cognitive impairment was 58.0%. Multivariable linear regression demonstrated that older age, male gender and absence of diabetes were associated with lower MoCA scores (p < 0.01 for all). Estimated glomerular filtration rate (eGFR) was not associated with level of cognition. The logistic regression analysis confirmed the association of older age with cognitive impairment. CONCLUSION:Cognitive impairment is common in prevalent kidney transplant recipients, at a younger age compared to general population, and is associated with certain demographic variables, but not level of eGFR.

journal_name

BMC Nephrol

journal_title

BMC nephrology

authors

Gupta A,Mahnken JD,Johnson DK,Thomas TS,Subramaniam D,Polshak T,Gani I,John Chen G,Burns JM,Sarnak MJ

doi

10.1186/s12882-017-0570-1

subject

Has Abstract

pub_date

2017-05-12 00:00:00

pages

158

issue

1

issn

1471-2369

pii

10.1186/s12882-017-0570-1

journal_volume

18

pub_type

杂志文章
  • Vitamin D deficiency may predict a poorer outcome of IgA nephropathy.

    abstract:BACKGROUND:Experimental studies showed that 25-hydroxy-vitamin D [25(OH)D] deficiency (defined as 25-hydroxy-vitamin D < 15 ng/ml) has been associated with CKD progression. Patients with IgA nephropathy have an exceptionally high rate of severe 25(OH)D deficiency; however, it is not known whether this deficiency is a r...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-016-0378-4

    authors: Li XH,Huang XP,Pan L,Wang CY,Qin J,Nong FW,Luo YZ,Wu Y,Huang YM,Peng X,Yang ZH,Liao YH

    更新日期:2016-11-02 00:00:00

  • Association of vitamin D and FGF23 with serum ferritin in hypoparathyroid thalassemia: a case control study.

    abstract:BACKGROUND:FGF23 controls serum l,25(OH)2D3 levels and phosphate homeostasis. This study evaluates the effects of ferritin on intact PTH, FGF23, and l,25(OH)2D3 in patients with major thalassemia. It also evaluates FGF23 changes in patients with hypoparathyroidism to clarify the interaction between FGF23 and PTH in the...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-020-02101-3

    authors: Saki F,Salehifar A,Kassaee SR,Omrani GR

    更新日期:2020-11-16 00:00:00

  • Association of platelet function with depression and its treatment with sertraline in patients with chronic kidney disease: analysis of a randomized trial.

    abstract:BACKGROUND:Major Depressive Disorder (MDD) can lead to adverse cardiovascular outcomes in patients with chronic kidney disease (CKD). Although one of the proposed mechanisms is heightened platelet activation, effects of MDD and its treatment with a selective serotonin reuptake inhibitor (SSRI) on platelet function in p...

    journal_title:BMC nephrology

    pub_type: 杂志文章,随机对照试验

    doi:10.1186/s12882-019-1576-7

    authors: Jain N,Wan F,Kothari M,Adelodun A,Ware J,Sarode R,Hedayati SS

    更新日期:2019-10-29 00:00:00

  • Dose selection method for pharmacokinetic study in hemodialysis patients using a subpharmacological dose: oseltamivir as a model drug.

    abstract:BACKGROUND:Dose selection is an important step in pharmacokinetic (PK) studies of hemodialysis patients. We propose a simulation-based dose-selection method for PK studies of hemodialysis patients using a subpharmacological dose of oseltamivir as a model drug. METHODS:The concentrations of oseltamivir and its active m...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/1471-2369-15-46

    authors: Kim DK,Lee JW,Shin KH,Kim S,Oh KH,Kim M,Yu KS,Lee JP,Lim CS,Kim YS,Joo KW

    更新日期:2014-03-17 00:00:00

  • A comparison of temporal artery thermometers with internal blood monitors to measure body temperature during hemodialysis.

    abstract:BACKGROUND:Thermometers that measure core (internal) body temperature are the gold standard for monitoring temperature. Despite that most modern hemodialysis machines are equipped with an internal blood monitor that measures core body temperature, current practice is to use peripheral thermometers. A better understandi...

    journal_title:BMC nephrology

    pub_type: 杂志文章,多中心研究

    doi:10.1186/s12882-018-0938-x

    authors: Lunney M,Tonelli B,Lewis R,Wiebe N,Thomas C,MacRae J,Tonelli M

    更新日期:2018-06-14 00:00:00

  • Increased blood pressure in adult offspring of families with Balkan endemic nephropathy: a prospective study.

    abstract:BACKGROUND:Previous studies have linked smaller kidney dimensions to increased blood pressure. However, patients with Balkan Endemic Nephropathy (BEN), whose kidneys shrink during the course of the disease, do not manifest increased blood pressure. The authors evaluated the relationship between kidney cortex width, kid...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/1471-2369-7-12

    authors: Dimitrov PS,Simeonov VA,Tsolova SD,Bonev AG,Georgieva RB,Karmaus WJ

    更新日期:2006-08-23 00:00:00

  • Independent risk factors and long-term outcomes for acute kidney injury in pediatric patients undergoing hematopoietic stem cell transplantation: a retrospective cohort study.

    abstract:BACKGROUND:Acute kidney injury (AKI) remains a frequent complication in children undergoing hematopoietic stem cell transplantation (HSCT) and an independent risk factor of the patient's survival and a prognostic factor of progression to chronic kidney disease (CKD). However, the causes of these complications are diver...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-020-02045-8

    authors: Hirano D,Kakegawa D,Miwa S,Umeda C,Takemasa Y,Tokunaga A,Kawakami Y,Ito A

    更新日期:2020-08-27 00:00:00

  • Dementia is a risk factor for major adverse cardiac and cerebrovascular events in elderly Korean patients initiating hemodialysis: a Korean national population-based study.

    abstract:BACKGROUND:Dementia is common in end-stage renal disease (ESRD) patients on hemodialysis (HD) and is associated with worse outcomes. This study aimed to investigate the risk of major adverse cardiac and cerebrovascular event (MACCE) in elderly patients with dementia initiating HD. METHODS:Using the database from the H...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-017-0547-0

    authors: Jung SM,Kim CT,Kang EW,Kim KH,Lee S,Oh HJ,Kim SJ,Kang DH,Choi KB,Ryu DR,Kim H

    更新日期:2017-04-06 00:00:00

  • Temporal validation of the CT-PIRP prognostic model for mortality and renal replacement therapy initiation in chronic kidney disease patients.

    abstract:BACKGROUND:A classification tree model (CT-PIRP) was developed in 2013 to predict the annual renal function decline of patients with chronic kidney disease (CKD) participating in the PIRP (Progetto Insufficienza Renale Progressiva) project, which involves thirteen Nephrology Hospital Units in Emilia-Romagna (Italy). Th...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-019-1345-7

    authors: Gibertoni D,Rucci P,Mandreoli M,Corradini M,Martelli D,Russo G,Mancini E,Santoro A

    更新日期:2019-05-17 00:00:00

  • The role of klotho in chronic kidney disease.

    abstract::Chronic kidney disease (CKD) is an inherently systemic disease that refers to a long-term loss of kidney function. The progression of CKD has repercussions for other organs, leading to many kinds of extrarenal complications. Intensive studies are now being undertaken to reveal the risk factors and pathophysiological m...

    journal_title:BMC nephrology

    pub_type: 杂志文章,评审

    doi:10.1186/s12882-018-1094-z

    authors: Zou D,Wu W,He Y,Ma S,Gao J

    更新日期:2018-10-22 00:00:00

  • The reverse remodeling of the aorta in patients after renal transplantation - the value of aortic stiffness index: prospective echocardiographic study.

    abstract:BACKGROUND:Atherosclerosis is regarded as a combination of two major separate diseases: atherosis and sclerosis. Sclerotic component depends on deterioration of elastic properties of the aortic wall and is called aortic stiffness. The most valuable, non-invasive method of aortic stiffness assessment is echocardiography...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-017-0453-5

    authors: Zapolski T,Furmaga J,Jaroszyński A,Wysocka A,Rudzki S,Wysokiński AP

    更新日期:2017-01-23 00:00:00

  • Effects of uremic solutes on reactive oxygen species in vitro model systems as a possibility of support the renal function management.

    abstract:BACKGROUND:In view of the prevalence of oxidative stress in chronic kidney disease (CKD) patients, the loss of low-molecular-weight biomolecules by hemodialysis and the antioxidant potential of some uremic solutes that accumulate in CKD, we used in vitro model systems to test the antioxidant potential of the following ...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-015-0029-1

    authors: Assis RP,Castro JF,Gutierres VO,Arcaro CA,Brotto RS,Oliveira OM,Baviera AM,Brunetti IL

    更新日期:2015-04-11 00:00:00

  • The relation of C--reactive protein to chronic kidney disease in African Americans: the Jackson Heart Study.

    abstract:BACKGROUND:African Americans have an increased incidence and worse prognosis with chronic kidney disease (CKD--estimated glomerular filtration rate [eGFR] <60 ml/min/1.73 m2) than their counterparts of European-descent. Inflammation has been related to renal disease in non-Hispanic whites, but there are limited data on...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/1471-2369-11-1

    authors: Fox ER,Benjamin EJ,Sarpong DF,Nagarajarao H,Taylor JK,Steffes MW,Salahudeen AK,Flessner MF,Akylbekova EL,Fox CS,Garrison RJ,Taylor HA Jr

    更新日期:2010-01-15 00:00:00

  • Association of Frailty based on self-reported physical function with directly measured kidney function and mortality.

    abstract:BACKGROUND:Use of serum creatinine to estimate GFR may lead to underestimation of the association between self-reported frailty and kidney function. Our objectives were to evaluate the association of measured GFR (mGFR) with self-reported frailty among patients with CKD and to determine whether self-reported frailty wa...

    journal_title:BMC nephrology

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1186/s12882-015-0202-6

    authors: Delgado C,Grimes BA,Glidden DV,Shlipak M,Sarnak MJ,Johansen KL

    更新日期:2015-12-09 00:00:00

  • An association between time-varying serum albumin level and the mortality rate in maintenance haemodialysis patients: a five-year clinical cohort study.

    abstract:BACKGROUND:Until now, no long-term studies relating serum albumin level to mortality rate in prevalent haemodialysis (HD) patients have been conducted. We aimed to examine the association between serum albumin level and mortality over a 5-year period. METHODS:This study included 781 patients who received maintenance H...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-016-0332-5

    authors: Chen JB,Cheng BC,Yang CH,Hua MS

    更新日期:2016-08-20 00:00:00

  • Do oral aluminium phosphate binders cause accumulation of aluminium to toxic levels?

    abstract:BACKGROUND:Aluminium (Al) toxicity was frequent in the 1980s in patients ingesting Al containing phosphate binders (Alucaps) whilst having HD using water potentially contaminated with Al. The aim of this study was to determine the risk of Al toxicity in HD patients receiving Alucaps but never exposed to contaminated di...

    journal_title:BMC nephrology

    pub_type: 临床试验,杂志文章

    doi:10.1186/1471-2369-12-55

    authors: Pepper R,Campbell N,Yaqoob MM,Roberts NB,Fan SL

    更新日期:2011-10-12 00:00:00

  • Atherosclerotic vascular disease is more prevalent among black ESKD patients on long-term CAPD in South Africa.

    abstract:BACKGROUND:Occurrence of cardiovascular disease (CVD) in the setting of chronic kidney disease (CKD) can be described as a "cruel alliance", with CVD responsible for about half of all deaths among CKD patients. Chronic kidney disease patients are more likely to die from CVD than progress to end stage kidney disease (ES...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-019-1583-8

    authors: Oguntola SO,Hassan MO,Duarte R,Vachiat A,Manga P,Naicker S

    更新日期:2019-10-30 00:00:00

  • Induction therapy with thymoglobulin or interleukin-2 receptor antagonist for Chinese recipients of living donor renal transplantation: a retrospective study.

    abstract:BACKGROUND:Recipients of living donor renal transplantation are typically considered to have a relatively lower immunological risk. This retrospective study aimed to compare the therapeutic efficacy and safety between rabbit antithymocyte globulin (rATG) or interleukin-2 receptor antagonist (IL2-RA) induction therapies...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-019-1293-2

    authors: Qiu J,Li J,Chen G,Huang G,Fu Q,Wang C,Chen L

    更新日期:2019-03-22 00:00:00

  • PR3 vasculitis presenting with symptomatic splenic and renal infarction: a case report and literature review.

    abstract:BACKGROUND:ANCA-associated vasculitis is a life-threatening, systemic autoimmune disease. There is an increased risk of organ infarction but in many cases this is asymptomatic. We described here the first reported case of PR3 vasculitis presenting with symptomatic bilateral renal wedge infarction. CASE PRESENTATION:A ...

    journal_title:BMC nephrology

    pub_type: 杂志文章,评审

    doi:10.1186/s12882-019-1266-5

    authors: Bottomley MJ,Gibson M,Alchi B

    更新日期:2019-03-06 00:00:00

  • Health related quality of life among haemodialysis and kidney transplant recipients from Nepal: a cross sectional study using WHOQOL-BREF.

    abstract:BACKGROUND:Very less is known about health-related quality of life (HRQOL) among patients with kidney diseases in Nepal. This study examined HRQOL among haemodialysis and kidney transplant recipients in Nepal. METHODS:The Nepali version of World Health Organization Quality of Life Instruments -(WHOQOL-BREF) questionna...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-020-02085-0

    authors: Ranabhat K,Khanal P,Mishra SR,Khanal A,Tripathi S,Sigdel MR

    更新日期:2020-10-12 00:00:00

  • Unexpected presentation and surgical salvage of transplant renal artery dissection caused by vascular clamping: a case report.

    abstract:BACKGROUND:Transplant renal artery dissection is a rare and serious event that can cause allograft dysfunction and activation of the renin-mediated renovascular hypertension. Most cases are induced by percutaneous transluminal angioplasty, arteriosclerotic disease, or fibromuscular dysplasia. We observed a case of tran...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-020-1699-x

    authors: Hori S,Yoneda T,Tomizawa M,Ichikawa K,Morizawa Y,Nakai Y,Miyake M,Fujimoto K

    更新日期:2020-01-29 00:00:00

  • Soluble Klotho is associated with mortality and cardiovascular events in hemodialysis.

    abstract:BACKGROUND:Klotho is a transmembrane protein acting as a co-receptor for FGF-23 and thus exerts clinical actions on mineral metabolism. The association of secreted Klotho with outcomes in CKD patients is unclear. This study examined the relation between plasma Klotho and cardiovascular events in dialysis patients, acco...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-019-1391-1

    authors: Memmos E,Sarafidis P,Pateinakis P,Tsiantoulas A,Faitatzidou D,Giamalis P,Vasilikos V,Papagianni A

    更新日期:2019-06-11 00:00:00

  • Risk factors for chronic kidney disease in Japan: a community-based study.

    abstract:BACKGROUND:Chronic kidney disease (CKD) is increasingly being recognized as a predictor for both end-stage renal disease and cardiovascular disease. The present study, conducted on individuals from a community in Arita, Japan, was designed to evaluate biomarkers that can be used to determine the associated factors for ...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/1471-2369-10-34

    authors: Takamatsu N,Abe H,Tominaga T,Nakahara K,Ito Y,Okumoto Y,Kim J,Kitakaze M,Doi T

    更新日期:2009-10-27 00:00:00

  • Excessive diagnostic testing in acute kidney injury.

    abstract:BACKGROUND:The patterns, performance characteristics, and yield of diagnostic tests ordered for the evaluation of acute kidney injury (AKI) have not been rigorously evaluated. METHODS:We characterized the frequency of AKI diagnostic testing for urine, blood, radiology, and pathology tests in all adult inpatients who w...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-016-0224-8

    authors: Leaf DE,Srivastava A,Zeng X,McMahon GM,Croy HE,Mendu ML,Kachalia A,Waikar SS

    更新日期:2016-01-15 00:00:00

  • Effect of tolvaptan on renal water and sodium excretion and blood pressure during nitric oxide inhibition: a dose-response study in healthy subjects.

    abstract:BACKGROUND:Tolvaptan is a selective vasopressin receptor antagonist. Nitric Oxide (NO) promotes renal water and sodium excretion, but the effect is unknown in the nephron's principal cells. In a dose-response study, we measured the effect of tolvaptan on renal handling of water and sodium and systemic hemodynamics, dur...

    journal_title:BMC nephrology

    pub_type: 杂志文章,随机对照试验

    doi:10.1186/s12882-017-0501-1

    authors: Al Therwani S,Rosenbæk JB,Mose FH,Bech JN,Pedersen EB

    更新日期:2017-03-13 00:00:00

  • Hyperphosphatemia and risks of acute kidney injury, end-stage renal disease, and mortality in hospitalized patients.

    abstract:BACKGROUND:Hyperphosphatemia is associated with vascular calcification and bone mineral disorders and is a major concern among patients with chronic kidney disease (CKD). However, the relationship between hyperphosphatemia and renal outcome in non-CKD patients has not been studied. Furthermore, the clinical implication...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-019-1556-y

    authors: Moon H,Chin HJ,Na KY,Joo KW,Kim YS,Kim S,Han SS

    更新日期:2019-09-18 00:00:00

  • Pre-donation BMI and preserved kidney volume can predict the cohort with unfavorable renal functional compensation at 1-year after kidney donation.

    abstract:BACKGROUND:The magnitude of renal function recovery after kidney donation differs in donors with a heterogeneous background. Preoperative assessment of candidates with potentially unfavorable renal functional compensation is critical when baseline kidney function is marginal. We explored the significance of preserved k...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-019-1242-0

    authors: Shinoda K,Morita S,Akita H,Tamaki S,Takahashi R,Kono H,Asanuma H,Kikuchi E,Jinzaki M,Nakagawa K,Oya M

    更新日期:2019-02-08 00:00:00

  • Warfarin anticoagulation in hemodialysis patients with atrial fibrillation: comparison of nephrologist-led and anticoagulation clinic-led management.

    abstract:BACKGROUND:There is conflicting evidence of benefit versus harm for warfarin anticoagulation in hemodialysis patients with atrial fibrillation. This equipoise may be explained by suboptimal Time in Therapeutic Range (TTR), which correlates well with thromboembolic and bleeding complications. This study aimed to compare...

    journal_title:BMC nephrology

    pub_type: 杂志文章,多中心研究

    doi:10.1186/s12882-017-0809-x

    authors: Bahbahani H,AlTurki A,Dawas A,Lipman ML

    更新日期:2018-01-08 00:00:00

  • Evaluating the prevalence and opportunity for technology use in chronic kidney disease patients: a cross-sectional study.

    abstract:BACKGROUND:Chronic kidney disease (CKD) is increasing worldwide and early education to improve adherence to self-management is a key strategy to slow CKD progression. The use of the internet and mobile phone technologies (mHealth) to support patients is considered an effective tool in many other chronic disease populat...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-018-0830-8

    authors: Bonner A,Gillespie K,Campbell KL,Corones-Watkins K,Hayes B,Harvie B,Kelly JT,Havas K

    更新日期:2018-02-02 00:00:00

  • ANCA vasculitis in a patient with Alport syndrome: a difficult diagnosis but a treatable disease!

    abstract:BACKGROUND:Alport syndrome and ANCA-associated vasculitis are both rare diseases. The co-existence of these two conditions has never been reported. There is no obvious pathogenic link between these two glomerular diseases. The management of this case highlights the importance of a systematic approach when investigating...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-017-0527-4

    authors: Gillion V,Jadoul M,Aydin S,Godefroid N

    更新日期:2017-03-29 00:00:00