Dose selection method for pharmacokinetic study in hemodialysis patients using a subpharmacological dose: oseltamivir as a model drug.

abstract：BACKGROUND:This study tests the hypotheses that health-related quality of life (HRQOL) in prevalent dialysis patients with diabetes is lower than in dialysis patients without diabetes, and is at least as poor as diabetic patients with another severe complication, i.e. foot ulcers. This study also explores the mortality...

journal_title：BMC nephrology

authors： Osthus TB,von der Lippe N,Ribu L,Rustøen T,Leivestad T,Dammen T,Os I

更新日期：2012-08-03 00:00:00

abstract：BACKGROUND:Galectin-9 (Gal-9) induces apoptosis in activated T helper 1 (TH1) cells as a ligand for T cell immunoglobulin mucin-3 (Tim-3). Gal-9 also inhibits the G1 phase cell cycle arrest and hypertrophy in db/db mice, the hallmark of early diabetic nephropathy, by reversing the high glucose-induced up-regulation of ...

journal_title：BMC nephrology

authors： Kurose Y,Wada J,Kanzaki M,Teshigawara S,Nakatsuka A,Murakami K,Inoue K,Terami T,Katayama A,Watanabe M,Higuchi C,Eguchi J,Miyatake N,Makino H

更新日期：2013-01-22 00:00:00

abstract：BACKGROUND:Dietary and lifestyle factors may play an important role in the increasing prevalence of nephrolithiasis. We aimed to review and quantify the associations between lifestyle factors and incident nephrolithiasis and suggest lifestyle changes for the primary prevention of nephrolithiasis. METHODS:PubMed, EMBAS...

journal_title：BMC nephrology

authors： Lin BB,Lin ME,Huang RH,Hong YK,Lin BL,He XJ

更新日期：2020-07-11 00:00:00

abstract：BACKGROUND:Anemia is highly prevalent in chronic kidney disease (CKD). Elevated hepcidin concentrations are an important mediator of disordered iron metabolism, a key mechanism underlying anemia of CKD. Vitamin D was recently shown to reduce serum hepcidin concentrations in healthy individuals. We examined whether trea...

journal_title：BMC nephrology

authors： Panwar B,McCann D,Olbina G,Westerman M,Gutiérrez OM

更新日期：2018-02-09 00:00:00

abstract：BACKGROUND:Disagreements between clinic and ambulatory blood pressure (BP) measurements are well-described in the general population. Though hypertension is frequent in renal transplant recipients, only a few studies address the clinic-ambulatory discordance in this population. We aimed to describe the difference betwe...

journal_title：BMC nephrology

authors： Gluskin E,Tzukert K,Mor-Yosef Levi I,Gotsman O,Sagiv I,Abel R,Bloch A,Rubinger D,Aharon M,Dranitzki Elhalel M,Ben-Dov IZ

更新日期：2019-07-27 00:00:00

abstract：BACKGROUND:Patients with pre-existing impaired renal function are prone to develop acute contrast media induced nephropathy (CIN). Neutrophil gelatinase-associated lipocalin (NGAL), a new biomarker predictive for acute kidney injury (AKI), has been shown to be useful for earlier diagnosis of CIN; however, urinary NGAL ...

journal_title：BMC nephrology

authors： Schilcher G,Ribitsch W,Otto R,Portugaller RH,Quehenberger F,Truschnig-Wilders M,Zweiker R,Stiegler P,Brodmann M,Weinhandl K,Horina JH

更新日期：2011-08-17 00:00:00

abstract：BACKGROUND:Calcific Uremic Arteriolopathy (CUA) is a rare disease, causing painful skin ulcers in patients with end stage renal disease. Recommendations for CUA management and treatment are lacking. METHODS:We conducted a retrospective cohort study on CUA cases identified in western France, in order to describe its ma...

journal_title：BMC nephrology

authors： Gaisne R,Péré M,Menoyo V,Hourmant M,Larmet-Burgeot D

更新日期：2020-02-26 00:00:00

abstract：BACKGROUND:The predictive value of acute kidney injury (AKI) urinary biomarkers may depend on the time interval following tubular injury, thereby explaining in part the heterogeneous performance of these markers that has been reported in the literature. We studied the influence of timing on the predictive values of tub...

journal_title：BMC nephrology

authors： de Geus HR,Fortrie G,Betjes MG,van Schaik RH,Groeneveld AB

更新日期：2013-12-09 00:00:00

abstract：BACKGROUND:Patients with chronic kidney diseases (CKD) on haemodialysis (HD) have high morbidity and mortality rates, which are also due to the inherent risks associated with nephropathy. Non-adherence (NA) to the different demands of the treatment can have consequences for the outcome of patients undergoing HD; nevert...

journal_title：BMC nephrology

authors： Dantas LGG,de Seixas Rocha M,Junior JAM,Paschoalin EL,Paschoalin SRKP,Sampaio Cruz CM

更新日期：2019-11-06 00:00:00

abstract：BACKGROUND:The clinical consequences of starting chronic peritoneal dialysis (PD) after emergent dialysis via a temporary hemodialysis (HD) catheter has rarely been evaluated within a full spectrum of treated end-stage renal disease (ESRD). We investigated the longer-term outcomes of patients undergoing emergent-start ...

journal_title：BMC nephrology

authors： Li WY,Wang YC,Hwang SJ,Lin SH,Wu KD,Chen YM

更新日期：2017-12-11 00:00:00

abstract：BACKGROUND:Abdominal aortic calcification assessed by X-ray is recommended to evaluate vascular calcification in dialysis patients. It has been shown that abdominal aortic calcification score (AACS) is a predictor of adverse outcomes in hemodialysis patients, but evidence regarding its prognostic value in peritoneal di...

journal_title：BMC nephrology

authors： Ma D,Yan H,Yang X,Yu Z,Ni Z,Fang W

更新日期：2020-04-30 00:00:00

abstract：BACKGROUND:A large body mass index (BMI) has been considered as a relative contraindication for percutaneous catheter insertion, although this technique has many advantages. Up to now, there are few studies on peritoneal catheter placement and obesity. The aim of this study was to determine whether patients with large ...

journal_title：BMC nephrology

authors： Xie D,Zhou J,Cao X,Zhang Q,Sun Y,Tang L,Huang J,Zheng J,Lin L,Li Z,Cai G,Chen X

更新日期：2020-05-25 00:00:00

abstract：BACKGROUND:Sickle cell trait is not completely benign, and some renal complications can occur. The baseline rate of admission for gross hematuria in normal males carrying the sickle cell trait is 2%. CASE PRESENTATION:A 35-year-old non-smoking African man experienced a 2-week history of painless, profuse and persisten...

journal_title：BMC nephrology

authors： Le Joncour A,Mesnard L,Hertig A,Robert T

更新日期：2018-06-08 00:00:00

abstract：BACKGROUND:A marked reduction in serum levels of bioactive insulin-like growth factor-I (IGF-I) has been observed in fasting hemodialysis (HD) patients during a 4-h HD session. The aim of the present study was to investigate the beneficial effect of hyperinsulinemia during HD on bioactive IGF-I and inflammatory biomark...

journal_title：BMC nephrology

authors： Reinhard M,Frystyk J,Jespersen B,Bjerre M,Christiansen JS,Flyvbjerg A,Ivarsen P

更新日期：2013-04-04 00:00:00

abstract：BACKGROUND:Cystinuria is an inherited metabolic disease that is caused by defects in two genes, SLC3A1 and SLC7A9, which result in a renal reabsorptive defect of cystine and other dibasic amino acids, including ornithine, arginine, and lysine. Patients usually present with recurrent renal calculi and may develop renal ...

journal_title：BMC nephrology

authors： Obaid A,Nashabat M,Al Fakeeh K,Al Qahtani AT,Alfadhel M

更新日期：2017-02-06 00:00:00

abstract：BACKGROUND:Anaemia of chronic kidney disease increases the risk of death and adverse events, but can be managed using erythropoiesis stimulating agents (ESAs). However, recent evidence suggests that targeting a higher haemoglobin concentration ([Hb]) increases mortality risk, and both higher [Hb] targets and ESA doses ...

journal_title：BMC nephrology

authors： McMahon LP,Cai MX,Baweja S,Holt SG,Kent AB,Perkovic V,Leikis MJ,Becker GJ

更新日期：2012-06-15 00:00:00

abstract：BACKGROUND:Sclerostin is a paracrine acting factor, which is expressed in the osteocytes and articular chondrocytes. Sclerostin decreases the osteoblast-related bone formation through the inhibition of the Wnt/β-catenin pathway. Osteocytes also express the Calcium sensing receptor which is a target for cinacalcet. The ...

journal_title：BMC nephrology

authors： Kuczera P,Adamczak M,Więcek A

更新日期：2016-11-15 00:00:00

abstract：BACKGROUND:Chronic kidney disease (CKD) and end-stage renal disease (ESRD) represent worldwide health problems with an epidemic extent. Therefore, attention must be given to the optimisation of patient care, as gaps in the care of CKD and ESRD patients are well documented. As part of a multidisciplinary patient care st...

journal_title：BMC nephrology

authors： Stemer G,Lemmens-Gruber R

更新日期：2011-07-22 00:00:00

abstract：BACKGROUND:Rituximab is widely used in kidney transplantation. However, it is not clear whether the conventional doses of maintenance immunosuppressant in rituximab-treated kidney transplantation (KT) are appropriate. In our previous study, decreasing mycophenolate mofetil (MMF) dose due to infection did not increase t...

journal_title：BMC nephrology

authors： Baek CH,Kim H,Yu H,Shin E,Cho H,Yang WS,Han DJ,Park SK

更新日期：2015-12-04 00:00:00

abstract：BACKGROUND:Atherosclerosis is regarded as a combination of two major separate diseases: atherosis and sclerosis. Sclerotic component depends on deterioration of elastic properties of the aortic wall and is called aortic stiffness. The most valuable, non-invasive method of aortic stiffness assessment is echocardiography...

journal_title：BMC nephrology

authors： Zapolski T,Furmaga J,Jaroszyński A,Wysocka A,Rudzki S,Wysokiński AP

更新日期：2017-01-23 00:00:00

abstract：BACKGROUND:Patients with end-stage renal disease (ESRD) exhibit a premature aging phenotype of immune system, which is recently concerned as a significant factor for increased risk of various morbidities. Nevertheless, there are few dates explicating the relevancy of T cell senescence to mortality. In this study, we pr...

journal_title：BMC nephrology

authors： Xiang F,Chen R,Cao X,Shen B,Chen X,Ding X,Zou J

更新日期：2020-07-13 00:00:00

abstract：INTRODUCTION:Urinary biomarkers of kidney injury are presumed to reflect renal tubular damage. However, their concentrations may be influenced by other factors, such as hematuria or pyuria. We sought to examine what non-injury related urinalysis factors are associated with urinary biomarker levels. METHODS:We examined...

journal_title：BMC nephrology

authors： Nadkarni GN,Coca SG,Meisner A,Patel S,Kerr KF,Patel UD,Koyner JL,Garg AX,Philbrook HT,Edelstein CL,Shlipak M,El-Khoury J,Parikh CR,TRIBE-AKI Consortium Investigators.

更新日期：2017-07-06 00:00:00

abstract：BACKGROUND:Nephrotic syndrome (NS) is pathological condition characterized by heavy proteinuria. Our study investigates hypothesis that change in cell proliferation of proximal tubules influences primary cilia structure and function and promotes cystogenesis in congenital nephrotic syndrome of the Finnish type (CNF) an...

journal_title：BMC nephrology

authors： Saraga M,Vukojević K,Krželj V,Puretić Z,Bočina I,Durdov MG,Weber S,Dworniczak B,Ljubanović DG,Saraga-Babić M

更新日期：2014-01-08 00:00:00

abstract：BACKGROUND:Studies suggest 24-h blood pressure (BP) variability has prognostic value for cardiovascular disease. Several factors associated with high 24-h BP variability are also common among individuals with chronic kidney disease (CKD). We hypothesized 24-h BP variability would be higher for individuals with versus w...

journal_title：BMC nephrology

authors： Tanner RM,Shimbo D,Dreisbach AW,Carson AP,Fox ER,Muntner P

更新日期：2015-06-18 00:00:00

abstract：BACKGROUND:Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in patients with chronic kidney disease (CKD). Cardiovascular risk assessment in this population is hampered by the failure of traditional risk factors to fully account for the elevated CVD risk (reverse epidemiology effect) and the...

journal_title：BMC nephrology

authors： Junyent M,Martínez M,Borràs M,Coll B,Valdivielso JM,Vidal T,Sarró F,Roig J,Craver L,Fernández E

更新日期：2010-07-07 00:00:00

abstract：BACKGROUND:Membranous nephropathy (MN) has been recognized to occur in patients with human immunodeficiency virus (HIV) infection since the beginning of the HIV epidemic. The prevalence of phospholipase A2 receptor (PLA2R)-associated MN in this group has not been well studied. METHODS:We conducted a retrospective revi...

journal_title：BMC nephrology

authors： Charu V,Andeen N,Walavalkar V,Lapasia J,Kim JY,Lin A,Sibley R,Higgins J,Troxell M,Kambham N

更新日期：2020-09-18 00:00:00

abstract：BACKGROUND:Post transplantation diabetes mellitus (PTDM) is a common and serious complication after renal transplantation with significant morbidity and mortality. Metformin has proven benefits in the general population and might be advantageous in the prevention and management of PTDM. METHODS:Transplantation and Dia...

journal_title：BMC nephrology

authors： Alnasrallah B,Goh TL,Chan LW,Manley P,Pilmore H

更新日期：2019-04-29 00:00:00

abstract：BACKGROUND:TAFRO syndrome is a clinical subtype of idiopathic multicentric Castleman disease (iMCD) that is characterized by thrombocytopenia, anasarca, fever, reticulin myelofibrosis (or renal dysfunction), and organomegaly. TAFRO syndrome has only recently been described, and many clinicians are unaware of this disea...

journal_title：BMC nephrology

authors： Zhou Q,Zhang Y,Zhou G,Zhu J

更新日期：2020-11-23 00:00:00

abstract：BACKGROUND:About 1% of patients admitted to the Emergency Department (ED) have hypernatremia, a condition associated with a mortality rate of 20 to 60%. Management recommendations originate from intensive care unit studies, in which patients and medical diseases differ from those in ED. METHODS:We retrospectively stud...

journal_title：BMC nephrology

authors： Bataille S,Baralla C,Torro D,Buffat C,Berland Y,Alazia M,Loundou A,Michelet P,Vacher-Coponat H

更新日期：2014-02-21 00:00:00

abstract：BACKGROUND:Experimental studies showed that 25-hydroxy-vitamin D [25(OH)D] deficiency (defined as 25-hydroxy-vitamin D < 15 ng/ml) has been associated with CKD progression. Patients with IgA nephropathy have an exceptionally high rate of severe 25(OH)D deficiency; however, it is not known whether this deficiency is a r...

journal_title：BMC nephrology

authors： Li XH,Huang XP,Pan L,Wang CY,Qin J,Nong FW,Luo YZ,Wu Y,Huang YM,Peng X,Yang ZH,Liao YH

更新日期：2016-11-02 00:00:00