Indoleamine 2, 3-dioxygenase (IDO) increases during renal fibrogenesis and its inhibition potentiates TGF-β 1-induced epithelial to mesenchymal transition.

abstract：BACKGROUND:The presence of glutathione transferase (GST) M1 null genotype (GSTM1-null) in end-stage renal disease (ESRD) patients is associated with lower overall survival rate in comparison to those with GSTM1-active variants. We examined association between GSTM1 and GSTT1 deletion polymorphisms as well as SNPs in GS...

journal_title：BMC nephrology

authors： Suvakov S,Damjanovic T,Pekmezovic T,Jakovljevic J,Savic-Radojevic A,Pljesa-Ercegovac M,Radovanovic S,Simic DV,Pljesa S,Zarkovic M,Mimic-Oka J,Dimkovic N,Simic T

更新日期：2014-01-14 00:00:00

abstract：BACKGROUND:Primary hyperoxaluria type 1 is a rare autosomal recessive disease of glyoxylate metabolism caused by a defect in the liver-specific peroxisomal enzyme alanine:glyoxylate aminotransferase (AGT) that leads to hyperoxaluria, recurrent urolithiasis, and nephrocalcinosis. METHODS:Two unrelated patients with rec...

journal_title：BMC nephrology

authors： Li GM,Xu H,Shen Q,Gong YN,Fang XY,Sun L,Liu HM,An Y

更新日期：2014-06-17 00:00:00

abstract：BACKGROUND:Urinary albumin can be measured in 24 h or spot samples. The 24 h urinary albumin excretion rate is considered the gold standard, but is cumbersome to collect. Instead, often an overnight sample is collected, and adjusted for dilution. Proxies for 24 h excretion rate have been studied in diabetics, but seldo...

journal_title：BMC nephrology

authors： Fagerstrom P,Sallsten G,Akerstrom M,Haraldsson B,Barregard L

更新日期：2015-01-24 00:00:00

abstract：BACKGROUND:Transplant tourism entails movement of recipient, donor or both to a transplant centre outside their country of residence. This has been reported in many countries; and has variously been associated with organ trade. The objective of this study is to determine the frequency and pattern of transplant tourism ...

journal_title：BMC nephrology

authors： Okafor UH

更新日期：2017-07-05 00:00:00

abstract：BACKGROUND:Cardiovascular disease is the most common complication and leading cause of death in maintenance hemodialysis patients. The protection mechanism of hydrogen sulfide (H2S) and the specific role of conventional protein kinase C βII (cPKCβII)/Akt signaling pathway in the formation of atherosclerosis is still co...

journal_title：BMC nephrology

authors： Xiong R,Lu X,Song J,Li H,Wang S

更新日期：2019-09-14 00:00:00

abstract：BACKGROUND:During continuous venovenous haemofiltration (CVVH), regional anticoagulation with citrate may be superior to heparin in terms of biocompatibility, since heparin as opposed to citrate may activate complement (reflected by circulating C5a) and induce neutrophil degranulation in the filter and myeloperoxidase ...

journal_title：BMC nephrology

authors： Schilder L,Nurmohamed SA,ter Wee PM,Paauw NJ,Girbes AR,Beishuizen A,Beelen RH,Groeneveld AB

更新日期：2014-01-17 00:00:00

abstract：BACKGROUND:Autosomal dominant polycystic kidney disease (ADPKD) is the leading inheritable cause of end-stage renal disease (ESRD); however, the natural course of disease progression is heterogeneous between patients. This study aimed to develop a natural history model of ADPKD that predicted progression rates and long...

journal_title：BMC nephrology

authors： McEwan P,Bennett Wilton H,Ong ACM,Ørskov B,Sandford R,Scolari F,Cabrera MV,Walz G,O'Reilly K,Robinson P

更新日期：2018-02-13 00:00:00

abstract：BACKGROUND:Atypical hemolytic uremic syndrome (aHUS) is a rare, genetically-mediated systemic disease most often caused by chronic, uncontrolled complement activation that leads to systemic thrombotic microangiopathy (TMA) and renal and other end-organ damage. METHODS:The global aHUS Registry, initiated in April 2012,...

journal_title：BMC nephrology

authors： Licht C,Ardissino G,Ariceta G,Cohen D,Cole JA,Gasteyger C,Greenbaum LA,Johnson S,Ogawa M,Schaefer F,Vande Walle J,Frémeaux-Bacchi V

更新日期：2015-12-10 00:00:00

abstract：BACKGROUND:Renal injury is a serious complication after cardiac surgery and therefore, early detection and much more prediction of postoperative kidney injury is desirable. Neutrophil gelatinase-associated lipocalin (NGAL) is a predictive biomarker of acute kidney injury and may increase after cardiopulmonary bypass (C...

journal_title：BMC nephrology

authors： Friedrich MG,Bougioukas I,Kolle J,Bireta C,Jebran FA,Placzek M,Tirilomis T

更新日期：2017-02-21 00:00:00

abstract：BACKGROUND:Early recognition and management of chronic kidney disease (CKD) are associated with better outcomes. Internal medicine residency should prepare physicians to diagnose and manage CKD. METHODS:To examine whether residency training and program characteristics were associated with CKD knowledge and investigate...

journal_title：BMC nephrology

authors： Estrella MM,Sisson SD,Roth J,Choi MJ

更新日期：2012-09-27 00:00:00

abstract：BACKGROUND:Echocardiographic characteristics across the spectrum of chronic kidney disease (CKD) have not been well described. We assessed the echocardiographic characteristics of patients with preserved renal function and mild or moderate CKD referred for echocardiography and determined whether echocardiographic param...

journal_title：BMC nephrology

authors： Mavrakanas TA,Khattak A,Singh K,Charytan DM

更新日期：2018-07-11 00:00:00

abstract：BACKGROUND:Haemodialysis is the most common form of renal replacement therapy in Nigeria. The high cost of haemodialysis has made optimal therapy of end-stage renal disease difficult in Nigeria. This paper is a review of data collected over two years of provision of dialysis services in a new tertiary hospital in South...

journal_title：BMC nephrology

authors： Ekrikpo UE,Udo AI,Ikpeme EE,Effa EE

更新日期：2011-10-02 00:00:00

abstract：BACKGROUND:Serum phosphorus control is critical for chronic kidney disease (CKD) 5D patients. Currently, clinical profile for an oral phosphorus binder in the mainland Chinese population is not available. OBJECTIVE:To establish the efficacy, safety, and tolerability of lanthanum carbonate in CKD 5D patients. DESIGN:M...

journal_title：BMC nephrology

authors： Xu J,Zhang YX,Yu XQ,Liu ZH,Wang LN,Chen JH,Fan YP,Ni ZH,Wang M,Yuan FH,Ding GH,Chen XM,Zhang AP,Mei CL

更新日期：2013-02-04 00:00:00

abstract：BACKGROUND:A large body mass index (BMI) has been considered as a relative contraindication for percutaneous catheter insertion, although this technique has many advantages. Up to now, there are few studies on peritoneal catheter placement and obesity. The aim of this study was to determine whether patients with large ...

journal_title：BMC nephrology

authors： Xie D,Zhou J,Cao X,Zhang Q,Sun Y,Tang L,Huang J,Zheng J,Lin L,Li Z,Cai G,Chen X

更新日期：2020-05-25 00:00:00

abstract：BACKGROUND:Immunoglobulin light chains are classified as middle molecule uremic toxins able to interact with B lymphocyte membranes leading to the activation of transmembrane signaling. The ensuing impairment of neutrophil function can contribute to the chronic inflammation state of uremic patients, and the increased r...

journal_title：BMC nephrology

authors： Donati G,Moretti MI,Baraldi O,Spazzoli A,Capelli I,Comai G,Marchetti A,Sarma M,Mancini R,La Manna G

更新日期：2016-11-25 00:00:00

abstract：BACKGROUND:This retrospective study was undertaken to determine the incidence of kidney dysfunction (KD) and to identify potential risk factors contributing to development of KD in orthopaedic population following an elective or emergency surgery. METHODS:A total of 1025 patients were admitted in our institution over ...

journal_title：BMC nephrology

authors： Kateros K,Doulgerakis C,Galanakos SP,Sakellariou VI,Papadakis SA,Macheras GA

更新日期：2012-09-03 00:00:00

abstract：BACKGROUND:In patients with autosomal dominant polycystic kidney disease (ADPKD), malnutrition may develop as renal function declines and the abdominal organs become enlarged. We investigated the relationship of intra-abdominal mass with nutritional status. METHODS:This cross-sectional study was performed at a tertiar...

journal_title：BMC nephrology

authors： Ryu H,Kim H,Park HC,Kim H,Cho EJ,Lee KB,Chung W,Oh KH,Cho JY,Hwang YH,Ahn C

更新日期：2017-01-14 00:00:00

abstract：BACKGROUND:The predictive value of acute kidney injury (AKI) urinary biomarkers may depend on the time interval following tubular injury, thereby explaining in part the heterogeneous performance of these markers that has been reported in the literature. We studied the influence of timing on the predictive values of tub...

journal_title：BMC nephrology

authors： de Geus HR,Fortrie G,Betjes MG,van Schaik RH,Groeneveld AB

更新日期：2013-12-09 00:00:00

abstract：BACKGROUND:Chronic kidney disease (CKD) is global health concern and priority. It is the 12th leading cause of death worldwide. Protein Energy Wasting occurs in 20-25% of patients with chronic kidney disease and can lead to a high morbidity and mortality rate. We determined the prevalence of protein energy wasting and ...

journal_title：BMC nephrology

authors： Namuyimbwa L,Atuheire C,Okullo J,Kalyesubula R

更新日期：2018-06-14 00:00:00

abstract：BACKGROUND:Cool dialysate is often recommended for prevention of intra-dialytic hypotensive episodes in maintenance hemodialysis (HD) patients. However, its effect on toxin removal is not studied. It is known that inter-compartmental resistance is the main barrier for toxin removal. Cool dialysate can potentially incre...

journal_title：BMC nephrology

authors： Maheshwari V,Lau T,Samavedham L,Rangaiah GP

更新日期：2015-02-27 00:00:00

abstract：BACKGROUND:Nasal colonization with methicillin-resistant Staphylococcus aureus (MRSA) is a well defined risk factor for subsequent bacteremia and death in various groups of patients, but its impact on outcome in patients receiving long-term hemodialysis (HD) is under debate. METHODS:This prospective interventional coh...

journal_title：BMC nephrology

authors： Schmid H,Romanos A,Schiffl H,Lederer SR

更新日期：2013-04-23 00:00:00

abstract：BACKGROUND:Renal infarction (RI) is a rare disease with poor prognosis. Appropriate secondary prevention treatment is essential and requires an exhaustive etiological assessment. We aimed to determine whether invasive endovascular explorations may improve the diagnostic process and change the secondary prevention treat...

journal_title：BMC nephrology

authors： Ivanes F,Dewaele J,Touboul C,Gatault P,Sautenet B,Barbet C,Büchler M,Quilliet L,Angoulvant D,Halimi JM

更新日期：2020-07-14 00:00:00

abstract：BACKGROUND:Evidence suggests that alkaline phosphatase attenuates inflammatory response in sepsis by lipopolysaccharide detoxification and adenosine triphosphate dephosphorylation. We sought to determine changes in alkaline phosphatase (AP) activity during septic acute kidney injury (AKI) and clinical parameters associ...

journal_title：BMC nephrology

authors： Baek SD,Kang JY,Yu H,Shin S,Park HS,Kim MS,Lee EK,Kim SM,Chang JW

更新日期：2018-09-20 00:00:00

abstract：BACKGROUND:The risk of an individual to develop an acute kidney injury (AKI), or its severity, cannot be reliably predicted by common clinical risk factors. Whether genetic risk factors have an explanatory role poses an interesting question, however. Thus, we conducted a systematic literature review regarding genetic p...

journal_title：BMC nephrology

authors： Vilander LM,Kaunisto MA,Pettilä V

更新日期：2015-12-02 00:00:00

abstract：BACKGROUND:Several equations have been developed to estimate glomerular filtration rate (eGFR). The common equations used were derived from populations predominantly comprised of Caucasians with chronic kidney disease (CKD). Some of the equations provide a correction factor for African-Americans due to their relatively...

journal_title：BMC nephrology

authors： Omuse G,Maina D,Mwangi J,Wambua C,Kanyua A,Kagotho E,Amayo A,Ojwang P,Erasmus R

更新日期：2017-12-20 00:00:00

abstract：BACKGROUND:Patients with an impaired renal function show a high incidence of bone and mineral disturbances. These 'chronic kidney disease - mineral and bone disorders' (CKD-MBD) range from high turnover osteoporosis to adynamic bone disease. Currently, the histomorphometric analysis of a bone biopsy taken from the ilia...

journal_title：BMC nephrology

authors： Hiller RG,Patecki M,Neunaber C,Reifenrath J,Kielstein JT,Kielstein H

更新日期：2017-04-13 00:00:00

abstract：BACKGROUND:Dyspepsia is a common disorder in kidney transplant recipients, and the risk of post-transplant complications is increased in candidates with upper gastrointestinal disease. We evaluated gastrointestinal lesions of kidney transplant candidates on dialysis. METHODS:In this study, endoscopic and pathological ...

journal_title：BMC nephrology

authors： Usta M,Ersoy A,Ayar Y,Ocakoğlu G,Yuzbasioglu B,Erdem ED,Erdogan O

更新日期：2020-10-22 00:00:00

abstract：BACKGROUND:Nonadherence to medications by patients requiring hemodialysis (HD) leads to unfavorable clinical outcomes. Limited data exist to demonstrate the effect of incorporating patient-centered interventions using concepts of medication therapy management and motivational interview by pharmacists on pharmacoadheren...

journal_title：BMC nephrology

authors： Ismail S,Al-Subhi A,Youssif E,Ahmed M,Almalki A,Seger DL,Seger AC,Cook E

更新日期：2019-11-13 00:00:00

abstract：BACKGROUND:Sustained low efficiency dialysis (SLED) is increasingly used as a renal replacement modality in critically ill patients with acute kidney injury (AKI) and hemodynamic instability. SLED may reduce the hemodynamic perturbations of intermittent hemodialysis, while obviating the resource demands of CRRT. Althou...

journal_title：BMC nephrology

authors： Kitchlu A,Adhikari N,Burns KE,Friedrich JO,Garg AX,Klein D,Richardson RM,Wald R

更新日期：2015-08-04 00:00:00

abstract：BACKGROUND:Cisplatin is a well-known nephrotoxic antineoplastic drug. Chronic hypokalemic metabolic alkalosis with hypomagnesemia and hypocalciuria is one of the rare complications associated with its use. CASE PRESENTATION:A 42-year-old woman presented with a 20 year-history of hypokalemic metabolic alkalosis with hy...

journal_title：BMC nephrology

authors： Panichpisal K,Angulo-Pernett F,Selhi S,Nugent KM

更新日期：2006-05-24 00:00:00