Evaluation of potential drug- drug interactions among Palestinian hemodialysis patients.

Abstract:

BACKGROUND:The aims of this study are to find the prevalence of potential drug-drug interactions (DDIs) in patients with Hemodialysis and identify factors associated with these interactions if present. METHODS:The study was an observational- retrospective cohort study that was conducted in ten hemodialysis units in the West bank, Palestine, between June and August 2015. The data collection form was completed by interviewing the patients in addition to reviewing their medical records. Potential DDIs were reviewed. SPSS program was used for data analysis. RESULTS:The study included 275 patients, a total of 930 potential interactions were identified in 245 (89.1 %) patients. Patients were prescribed 1-15 drugs with a mean (± SD) of 7.87 ± 2.44, calcium carbonate was the most common drug prescribed. The most common potential interaction in 114 (41.5 %) patients was Calcium Carbonate/Amlodipine followed by Calcium Carbonate/Aspirin in 76 (27.6 %) cases. Most patients (89.9 %) of the patients had one or more comorbid diseases; hypertension, diabetes and gout were the most common. Univariate analysis showed that the number of potential DDIs were related to the number of diseases, the number of prescribed drugs (P value <0.0001) and the age of the patient (P value = 0.015). The results of multiple linear regression showed a significant positive association between number of potential DDIs with the total number of medications (r = 0.242; p < 0.001). CONCLUSION:The prevalence of potential drug- drug interactions among hemodialysis patients is very common; they are highly expected and depend on the number of drugs taken by the patients. Many of these potential interactions are considered as preventable drug- related problems, so screening for potential interactions and monitoring regularly is highly needed.

journal_name

BMC Nephrol

journal_title

BMC nephrology

authors

Al-Ramahi R,Raddad AR,Rashed AO,Bsharat A,Abu-Ghazaleh D,Yasin E,Shehab O

doi

10.1186/s12882-016-0317-4

subject

Has Abstract

pub_date

2016-07-26 00:00:00

pages

96

issn

1471-2369

pii

10.1186/s12882-016-0317-4

journal_volume

17

pub_type

杂志文章
  • Persistent hematuria in patients with antineutrophil cytoplasmic antibody-associated vasculitis during clinical remission: chronic glomerular lesion or low-grade active renal vasculitis?

    abstract:BACKGROUND:Whether persistent hematuria in patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) during clinical remission reflects active disease or chronic glomerular injury is uncertain. This study aimed to investigate the significance of persistent hematuria during clinical remission ...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-017-0763-7

    authors: Lv L,Chang DY,Li ZY,Chen M,Hu Z,Zhao MH

    更新日期:2017-12-06 00:00:00

  • Effect of tolvaptan on renal water and sodium excretion and blood pressure during nitric oxide inhibition: a dose-response study in healthy subjects.

    abstract:BACKGROUND:Tolvaptan is a selective vasopressin receptor antagonist. Nitric Oxide (NO) promotes renal water and sodium excretion, but the effect is unknown in the nephron's principal cells. In a dose-response study, we measured the effect of tolvaptan on renal handling of water and sodium and systemic hemodynamics, dur...

    journal_title:BMC nephrology

    pub_type: 杂志文章,随机对照试验

    doi:10.1186/s12882-017-0501-1

    authors: Al Therwani S,Rosenbæk JB,Mose FH,Bech JN,Pedersen EB

    更新日期:2017-03-13 00:00:00

  • Vitamin D deficiency may predict a poorer outcome of IgA nephropathy.

    abstract:BACKGROUND:Experimental studies showed that 25-hydroxy-vitamin D [25(OH)D] deficiency (defined as 25-hydroxy-vitamin D < 15 ng/ml) has been associated with CKD progression. Patients with IgA nephropathy have an exceptionally high rate of severe 25(OH)D deficiency; however, it is not known whether this deficiency is a r...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-016-0378-4

    authors: Li XH,Huang XP,Pan L,Wang CY,Qin J,Nong FW,Luo YZ,Wu Y,Huang YM,Peng X,Yang ZH,Liao YH

    更新日期:2016-11-02 00:00:00

  • Dementia is a risk factor for major adverse cardiac and cerebrovascular events in elderly Korean patients initiating hemodialysis: a Korean national population-based study.

    abstract:BACKGROUND:Dementia is common in end-stage renal disease (ESRD) patients on hemodialysis (HD) and is associated with worse outcomes. This study aimed to investigate the risk of major adverse cardiac and cerebrovascular event (MACCE) in elderly patients with dementia initiating HD. METHODS:Using the database from the H...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-017-0547-0

    authors: Jung SM,Kim CT,Kang EW,Kim KH,Lee S,Oh HJ,Kim SJ,Kang DH,Choi KB,Ryu DR,Kim H

    更新日期:2017-04-06 00:00:00

  • Effect of cool vs. warm dialysate on toxin removal: rationale and study design.

    abstract:BACKGROUND:Cool dialysate is often recommended for prevention of intra-dialytic hypotensive episodes in maintenance hemodialysis (HD) patients. However, its effect on toxin removal is not studied. It is known that inter-compartmental resistance is the main barrier for toxin removal. Cool dialysate can potentially incre...

    journal_title:BMC nephrology

    pub_type: 杂志文章,随机对照试验

    doi:10.1186/s12882-015-0017-5

    authors: Maheshwari V,Lau T,Samavedham L,Rangaiah GP

    更新日期:2015-02-27 00:00:00

  • Beyond dialysis decisions: a qualitative exploration of decision-making among culturally and linguistically diverse adults with chronic kidney disease on haemodialysis.

    abstract:BACKGROUND:To date, limited research has been dedicated to exploring the experience of decision-making for chronic kidney disease (CKD) patients who have initiated dialysis and have to make decisions in the context of managing multiple illnesses. Evidence about the experience of decision-making for minority or disadvan...

    journal_title:BMC nephrology

    pub_type: 杂志文章,多中心研究

    doi:10.1186/s12882-018-1131-y

    authors: Muscat DM,Kanagaratnam R,Shepherd HL,Sud K,McCaffery K,Webster A

    更新日期:2018-11-27 00:00:00

  • Duration of temporary catheter use for hemodialysis: an observational, prospective evaluation of renal units in Brazil.

    abstract:BACKGROUND:For chronic hemodialysis, the ideal permanent vascular access is the arteriovenous fistula (AVF). Temporary catheters should be reserved for acute dialysis needs. The AVF is associated with lower infection rates, better clinical results, and a higher quality of life and survival when compared to temporary ca...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/1471-2369-12-63

    authors: Bonfante GM,Gomes IC,Andrade EI,Lima EM,Acurcio FA,Cherchiglia ML

    更新日期:2011-11-17 00:00:00

  • Analysis of kidney dysfunction in orthopaedic patients.

    abstract:BACKGROUND:This retrospective study was undertaken to determine the incidence of kidney dysfunction (KD) and to identify potential risk factors contributing to development of KD in orthopaedic population following an elective or emergency surgery. METHODS:A total of 1025 patients were admitted in our institution over ...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/1471-2369-13-101

    authors: Kateros K,Doulgerakis C,Galanakos SP,Sakellariou VI,Papadakis SA,Macheras GA

    更新日期:2012-09-03 00:00:00

  • Factors associated with Health-Related Quality of Life in Kidney Transplant Recipients in France.

    abstract:BACKGROUND:Health-Related Quality of Life (HRQoL) assessment after kidney transplantation has become an important tool in evaluating outcomes. This study aims to identify the associated factors with HRQoL among a representative sample size of Kidney Transplant Recipients (KTR) at the time of their inclusion in the stud...

    journal_title:BMC nephrology

    pub_type: 杂志文章,多中心研究

    doi:10.1186/s12882-018-0893-6

    authors: Mouelhi Y,Jouve E,Alessandrini M,Pedinielli N,Moal V,Meurette A,Cassuto E,Mourad G,Durrbach A,Dussol B,Gentile S

    更新日期:2018-04-27 00:00:00

  • Prevalence of chronic kidney disease and associated factors among the Chinese population in Taian, China.

    abstract:BACKGROUND:This study was designed to assess the prevalence of chronic kidney disease (CKD) and associated risk factors among the Chinese population in Taian, China. METHODS:A primary care-based cross-sectional study was conducted in Taian, China, from September to December 2012. Participants selected by a multi-stage...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/1471-2369-15-205

    authors: Xue L,Lou Y,Feng X,Wang C,Ran Z,Zhang X

    更新日期:2014-12-21 00:00:00

  • Comparison of endoscopic and pathological findings of the upper gastrointestinal tract in transplant candidate patients undergoing hemodialysis or peritoneal dialysis treatment: a review of literature.

    abstract:BACKGROUND:Dyspepsia is a common disorder in kidney transplant recipients, and the risk of post-transplant complications is increased in candidates with upper gastrointestinal disease. We evaluated gastrointestinal lesions of kidney transplant candidates on dialysis. METHODS:In this study, endoscopic and pathological ...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-020-02108-w

    authors: Usta M,Ersoy A,Ayar Y,Ocakoğlu G,Yuzbasioglu B,Erdem ED,Erdogan O

    更新日期:2020-10-22 00:00:00

  • Age differences in the relationships between risk factors and loss of kidney function: a general population cohort study.

    abstract:BACKGROUND:Annual decline in kidney function is a widely applied surrogate outcome of renal failure. It is important to understand the relationships between known risk factors and the annual decline in estimated glomerular filtration rate (eGFR) according to baseline age; however, these remain unclear. METHODS:A commu...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-020-02121-z

    authors: Toyama T,Kitagawa K,Oshima M,Kitajima S,Hara A,Iwata Y,Sakai N,Shimizu M,Hashiba A,Furuichi K,Wada T

    更新日期:2020-11-13 00:00:00

  • Association between 24-hour blood pressure variability and chronic kidney disease: a cross-sectional analysis of African Americans participating in the Jackson heart study.

    abstract:BACKGROUND:Studies suggest 24-h blood pressure (BP) variability has prognostic value for cardiovascular disease. Several factors associated with high 24-h BP variability are also common among individuals with chronic kidney disease (CKD). We hypothesized 24-h BP variability would be higher for individuals with versus w...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-015-0085-6

    authors: Tanner RM,Shimbo D,Dreisbach AW,Carson AP,Fox ER,Muntner P

    更新日期:2015-06-18 00:00:00

  • A model to predict disease progression in patients with autosomal dominant polycystic kidney disease (ADPKD): the ADPKD Outcomes Model.

    abstract:BACKGROUND:Autosomal dominant polycystic kidney disease (ADPKD) is the leading inheritable cause of end-stage renal disease (ESRD); however, the natural course of disease progression is heterogeneous between patients. This study aimed to develop a natural history model of ADPKD that predicted progression rates and long...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-017-0804-2

    authors: McEwan P,Bennett Wilton H,Ong ACM,Ørskov B,Sandford R,Scolari F,Cabrera MV,Walz G,O'Reilly K,Robinson P

    更新日期:2018-02-13 00:00:00

  • Incidence and diagnosis of Acute kidney injury in hospitalized adult patients: a retrospective observational study in a tertiary teaching Hospital in Southeast China.

    abstract:BACKGROUND:Acute kidney injury (AKI) places a heavy burden on the healthcare system in China and is usually misdiagnosed. However, there are limited studies that have described the epidemiology and diagnosis of AKI in China. The aim of this study was to describe the incidence and diagnosis of AKI in hospitalized adult ...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-017-0622-6

    authors: Cheng X,Wu B,Liu Y,Mao H,Xing C

    更新日期:2017-06-24 00:00:00

  • Renal disease and accidental falls: a review of published evidence.

    abstract:BACKGROUND:The pathogenesis of falling is complex, and identification of risk factors may be essential for prevention. The relationship between renal disease and falls is unclear, and the goal of this study was to collect the available evidence and investigate the relationship between accidental falls and renal dysfunc...

    journal_title:BMC nephrology

    pub_type: 杂志文章,评审

    doi:10.1186/s12882-015-0173-7

    authors: López-Soto PJ,De Giorgi A,Senno E,Tiseo R,Ferraresi A,Canella C,Rodríguez-Borrego MA,Manfredini R,Fabbian F

    更新日期:2015-10-29 00:00:00

  • The association between geographic proximity to a dialysis facility and use of dialysis catheters.

    abstract:BACKGROUND:Residing remotely from health care resources appears to impact quality of care delivery. It remains unclear if there are differences in vascular access based on distance of one's residence to dialysis centre at time of dialysis initiation, and whether region or duration of pre-dialysis care are important eff...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/1471-2369-15-40

    authors: Miller LM,Vercaigne LM,Moist L,Lok CE,Tangri N,Komenda P,Rigatto C,Mojica J,Sood MM

    更新日期:2014-02-27 00:00:00

  • Risk scores to predict decreased glomerular filtration rate at 10 years in an Asian general population.

    abstract:BACKGROUND:Asians have among the highest prevalence of chronic kidney disease (CKD) or end-stage renal disease in the world. A risk score capable of identifying high risk individuals at the primary care level could allow targeted therapy to prevent future development of CKD. Risk scores for new CKD have been developed ...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-017-0653-z

    authors: Saranburut K,Vathesatogkit P,Thongmung N,Chittamma A,Vanavanan S,Tangstheanphan T,Sritara P,Kitiyakara C

    更新日期:2017-07-17 00:00:00

  • Understanding acute kidney injury in low resource settings: a step forward.

    abstract::Attention has recently been focused on addressing the problem of acute kidney injury in both the developed and developing world. Little information is actually available on the incidence and management of AKI in low resource settings. Thus, the paper by Bagasha in the current issue of BMC Nephrology makes an important...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/1471-2369-16-5

    authors: Anand S,Cruz DN,Finkelstein FO

    更新日期:2015-01-16 00:00:00

  • Warfarin anticoagulation in hemodialysis patients with atrial fibrillation: comparison of nephrologist-led and anticoagulation clinic-led management.

    abstract:BACKGROUND:There is conflicting evidence of benefit versus harm for warfarin anticoagulation in hemodialysis patients with atrial fibrillation. This equipoise may be explained by suboptimal Time in Therapeutic Range (TTR), which correlates well with thromboembolic and bleeding complications. This study aimed to compare...

    journal_title:BMC nephrology

    pub_type: 杂志文章,多中心研究

    doi:10.1186/s12882-017-0809-x

    authors: Bahbahani H,AlTurki A,Dawas A,Lipman ML

    更新日期:2018-01-08 00:00:00

  • Prevalence, clinical characteristics, and predictors of peripheral arterial disease in hemodialysis patients: a cross-sectional study.

    abstract:BACKGROUND:Peripheral arterial disease (PAD) is common in patients with end-stage renal disease on hemodialysis, but is frequently underdiagnosed. The risk factors for PAD are well known within the general population, but they differ somewhat in hemodialysis patients. This study aimed to determine the prevalence of PAD...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-019-1468-x

    authors: Ašćerić RR,Dimković NB,Trajković GŽ,Ristić BS,Janković AN,Durić PS,Ilijevski NS

    更新日期:2019-07-26 00:00:00

  • An association between time-varying serum albumin level and the mortality rate in maintenance haemodialysis patients: a five-year clinical cohort study.

    abstract:BACKGROUND:Until now, no long-term studies relating serum albumin level to mortality rate in prevalent haemodialysis (HD) patients have been conducted. We aimed to examine the association between serum albumin level and mortality over a 5-year period. METHODS:This study included 781 patients who received maintenance H...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-016-0332-5

    authors: Chen JB,Cheng BC,Yang CH,Hua MS

    更新日期:2016-08-20 00:00:00

  • Interaction between acyl-ghrelin and BMI predicts clinical outcomes in hemodialysis patients.

    abstract:BACKGROUND:Ghrelin, a gastric orexigenic peptide, and body mass index (BMI) are known as inversely associated to each other and are both linked to cardiovascular (CV) risk and mortality in maintenance hemodialysis (MHD) patients. However, it is unclear whether the interaction between ghrelin and BMI is associated with ...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-017-0442-8

    authors: Beberashvili I,Sinuani I,Azar A,Shapiro G,Feldman L,Doenyas-Barak K,Stav K,Efrati S

    更新日期:2017-01-18 00:00:00

  • Membranous nephropathy in patients with HIV: a report of 11 cases.

    abstract:BACKGROUND:Membranous nephropathy (MN) has been recognized to occur in patients with human immunodeficiency virus (HIV) infection since the beginning of the HIV epidemic. The prevalence of phospholipase A2 receptor (PLA2R)-associated MN in this group has not been well studied. METHODS:We conducted a retrospective revi...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-020-02042-x

    authors: Charu V,Andeen N,Walavalkar V,Lapasia J,Kim JY,Lin A,Sibley R,Higgins J,Troxell M,Kambham N

    更新日期:2020-09-18 00:00:00

  • Prognostic utility of plasma S100A12 levels to establish a novel scoring system for predicting mortality in maintenance hemodialysis patients: a two-year prospective observational study in Japan.

    abstract:BACKGROUND:S100A12 protein is an endogenous receptor ligand for advanced glycation end products. In this study, the plasma S100A12 level was assessed as an independent predictor of mortality, and its utility in clinical settings was examined. METHODS:In a previous cross-sectional study, plasma S100A12 levels were meas...

    journal_title:BMC nephrology

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1186/1471-2369-14-16

    authors: Shiotsu Y,Mori Y,Nishimura M,Hatta T,Imada N,Maki N,Iida K,Iwamoto N,Matsuoka E,Tamagaki K,Kosaki A

    更新日期:2013-01-16 00:00:00

  • Time of injury affects urinary biomarker predictive values for acute kidney injury in critically ill, non-septic patients.

    abstract:BACKGROUND:The predictive value of acute kidney injury (AKI) urinary biomarkers may depend on the time interval following tubular injury, thereby explaining in part the heterogeneous performance of these markers that has been reported in the literature. We studied the influence of timing on the predictive values of tub...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/1471-2369-14-273

    authors: de Geus HR,Fortrie G,Betjes MG,van Schaik RH,Groeneveld AB

    更新日期:2013-12-09 00:00:00

  • Genetic predisposition to acute kidney injury--a systematic review.

    abstract:BACKGROUND:The risk of an individual to develop an acute kidney injury (AKI), or its severity, cannot be reliably predicted by common clinical risk factors. Whether genetic risk factors have an explanatory role poses an interesting question, however. Thus, we conducted a systematic literature review regarding genetic p...

    journal_title:BMC nephrology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1186/s12882-015-0190-6

    authors: Vilander LM,Kaunisto MA,Pettilä V

    更新日期:2015-12-02 00:00:00

  • Atherosclerotic vascular disease is more prevalent among black ESKD patients on long-term CAPD in South Africa.

    abstract:BACKGROUND:Occurrence of cardiovascular disease (CVD) in the setting of chronic kidney disease (CKD) can be described as a "cruel alliance", with CVD responsible for about half of all deaths among CKD patients. Chronic kidney disease patients are more likely to die from CVD than progress to end stage kidney disease (ES...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-019-1583-8

    authors: Oguntola SO,Hassan MO,Duarte R,Vachiat A,Manga P,Naicker S

    更新日期:2019-10-30 00:00:00

  • Costs of care at the end of life among elderly patients with chronic kidney disease: patterns and predictors in a nationwide cohort study.

    abstract:BACKGROUND:Despite the urgent need for evidence to guide the end-of-life (EOL) care for patients with chronic kidney disease (CKD), we have limited knowledge of the costs and intensity of EOL care in this population. The present study examined patterns and predictors for EOL care intensity among elderly patients with C...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-017-0456-2

    authors: Chen B,Fan VY,Chou YJ,Kuo CC

    更新日期:2017-01-26 00:00:00

  • Citrate confers less filter-induced complement activation and neutrophil degranulation than heparin when used for anticoagulation during continuous venovenous haemofiltration in critically ill patients.

    abstract:BACKGROUND:During continuous venovenous haemofiltration (CVVH), regional anticoagulation with citrate may be superior to heparin in terms of biocompatibility, since heparin as opposed to citrate may activate complement (reflected by circulating C5a) and induce neutrophil degranulation in the filter and myeloperoxidase ...

    journal_title:BMC nephrology

    pub_type: 杂志文章,随机对照试验

    doi:10.1186/1471-2369-15-19

    authors: Schilder L,Nurmohamed SA,ter Wee PM,Paauw NJ,Girbes AR,Beishuizen A,Beelen RH,Groeneveld AB

    更新日期:2014-01-17 00:00:00