Genetic predisposition to acute kidney injury--a systematic review.

Abstract:

BACKGROUND:The risk of an individual to develop an acute kidney injury (AKI), or its severity, cannot be reliably predicted by common clinical risk factors. Whether genetic risk factors have an explanatory role poses an interesting question, however. Thus, we conducted a systematic literature review regarding genetic predisposition to AKI or outcome of AKI patients. METHODS:We searched Ovid SP (MEDLINE) and EMBASE databases and found 4027 references to AKI. Based on titles and abstracts, we approved 37 articles for further analysis. Nine were published only as abstracts, leaving 28 original articles in the final analysis. We extracted the first author, year of publication, study design, clinical setting, number of studied patients, patients with AKI, ethnicity of patients, studied polymorphisms, endpoints, AKI definition, phenotype, significant findings, and data for quality scoring from each article. We summarized the findings and scored the quality of articles. RESULTS:The articles were quite heterogeneous and of moderate quality (mean 6.4 of 10). CONCLUSIONS:Despite different gene polymorphisms with suggested associations with development or severity or outcome of AKI, definitive conclusions would require replication of associations in independent cohort studies and, preferably a hypothesis-free study design.

journal_name

BMC Nephrol

journal_title

BMC nephrology

authors

Vilander LM,Kaunisto MA,Pettilä V

doi

10.1186/s12882-015-0190-6

subject

Has Abstract

pub_date

2015-12-02 00:00:00

pages

197

issn

1471-2369

pii

10.1186/s12882-015-0190-6

journal_volume

16

pub_type

杂志文章,meta分析,评审
  • Mutational analysis of AGXT in two Chinese families with primary hyperoxaluria type 1.

    abstract:BACKGROUND:Primary hyperoxaluria type 1 is a rare autosomal recessive disease of glyoxylate metabolism caused by a defect in the liver-specific peroxisomal enzyme alanine:glyoxylate aminotransferase (AGT) that leads to hyperoxaluria, recurrent urolithiasis, and nephrocalcinosis. METHODS:Two unrelated patients with rec...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/1471-2369-15-92

    authors: Li GM,Xu H,Shen Q,Gong YN,Fang XY,Sun L,Liu HM,An Y

    更新日期:2014-06-17 00:00:00

  • An association between time-varying serum albumin level and the mortality rate in maintenance haemodialysis patients: a five-year clinical cohort study.

    abstract:BACKGROUND:Until now, no long-term studies relating serum albumin level to mortality rate in prevalent haemodialysis (HD) patients have been conducted. We aimed to examine the association between serum albumin level and mortality over a 5-year period. METHODS:This study included 781 patients who received maintenance H...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-016-0332-5

    authors: Chen JB,Cheng BC,Yang CH,Hua MS

    更新日期:2016-08-20 00:00:00

  • Serum osteoprotegerin is an independent marker of central arterial stiffness as assessed using carotid-femoral pulse wave velocity in hemodialysis patients: a cross sectional study.

    abstract:BACKGROUND:Cardiovascular morbidity and mortality are highly prevalent in patients with end-stage renal disease, and osteoprotegerin (OPG) may be an important link between bone loss and vascular calcification. This study was conducted to evaluate the relationship between central arterial stiffness and serum OPG levels ...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-019-1374-2

    authors: Hou JS,Lin YL,Wang CH,Lai YH,Kuo CH,Subeq YM,Hsu BG

    更新日期:2019-05-23 00:00:00

  • Periodontal disease, chronic kidney disease and mortality: results from the third National Health and Nutrition Examination Survey.

    abstract:BACKGROUND:Periodontal disease is associated with increased mortality in the general population, however its prognostic significance in chronic kidney disease (CKD) is not known. We evaluated the joint effect of periodontal disease and CKD on all-cause and cardiovascular mortality. METHODS:Prospective observational st...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-015-0101-x

    authors: Ricardo AC,Athavale A,Chen J,Hampole H,Garside D,Marucha P,Lash JP

    更新日期:2015-07-07 00:00:00

  • Icodextrin-associated generalized exfoliative skin rash in a CAPD patient: a case-report.

    abstract:BACKGROUND:Icodextrin is a starch-derived, water soluble glucose polymer, which is used as an alternative to glucose in order to enhance dialytic fluid removal in peritoneal dialysis patients. Although the safety and efficacy of icodextrin is well-established, its use in everyday clinical practice has been associated w...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-018-1071-6

    authors: Liakopoulos V,Georgianos PI,Demirtzi P,Vaios V,Kalathas T,Zebekakis PE

    更新日期:2018-10-25 00:00:00

  • Coronary calcification as a predictor of cardiovascular mortality in advanced chronic kidney disease: a prospective long-term follow-up study.

    abstract:BACKGROUND:Patients with advanced chronic kidney disease (CKD) exhibit higher prevalence of coronary artery calcification (CaC) than general population. CaC has been proposed as a risk factor for mortality in end-stage CKD, but most studies in the field are based on short-term follow-up. METHODS:We conducted a cohort,...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-019-1367-1

    authors: Cano-Megías M,Guisado-Vasco P,Bouarich H,de Arriba-de la Fuente G,de Sequera-Ortiz P,Álvarez-Sanz C,Rodríguez-Puyol D

    更新日期:2019-05-28 00:00:00

  • Independent risk factors and long-term outcomes for acute kidney injury in pediatric patients undergoing hematopoietic stem cell transplantation: a retrospective cohort study.

    abstract:BACKGROUND:Acute kidney injury (AKI) remains a frequent complication in children undergoing hematopoietic stem cell transplantation (HSCT) and an independent risk factor of the patient's survival and a prognostic factor of progression to chronic kidney disease (CKD). However, the causes of these complications are diver...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-020-02045-8

    authors: Hirano D,Kakegawa D,Miwa S,Umeda C,Takemasa Y,Tokunaga A,Kawakami Y,Ito A

    更新日期:2020-08-27 00:00:00

  • Prevalence and associated factors of protein- energy wasting among patients with chronic kidney disease at Mulago hospital, Kampala-Uganda: a cross-sectional study.

    abstract:BACKGROUND:Chronic kidney disease (CKD) is global health concern and priority. It is the 12th leading cause of death worldwide. Protein Energy Wasting occurs in 20-25% of patients with chronic kidney disease and can lead to a high morbidity and mortality rate. We determined the prevalence of protein energy wasting and ...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-018-0920-7

    authors: Namuyimbwa L,Atuheire C,Okullo J,Kalyesubula R

    更新日期:2018-06-14 00:00:00

  • Urine concentration ability is reduced to the same degree in adult dominant polycystic kidney disease compared with other chronic kidney diseases in the same CKD-stage and lower THAN in healthy control subjects - a CASE control study.

    abstract:BACKGROUND:Concentration of the urine is primarily regulated via vasopressin dependent aquaporin-2 water channels in the apical membrane of kidney principal cells. It is unclear whether urine concentration ability in ADPKD differs from other patients with similar degree of impaired renal function (non-ADPKD patients). ...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-020-02043-w

    authors: Malmberg MH,Mose FH,Pedersen EB,Bech JN

    更新日期:2020-08-31 00:00:00

  • A comparative study of bone biopsies from the iliac crest, the tibial bone, and the lumbar spine.

    abstract:BACKGROUND:Patients with an impaired renal function show a high incidence of bone and mineral disturbances. These 'chronic kidney disease - mineral and bone disorders' (CKD-MBD) range from high turnover osteoporosis to adynamic bone disease. Currently, the histomorphometric analysis of a bone biopsy taken from the ilia...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-017-0550-5

    authors: Hiller RG,Patecki M,Neunaber C,Reifenrath J,Kielstein JT,Kielstein H

    更新日期:2017-04-13 00:00:00

  • Identifying risk groups of infectious spondylitis in patients with end-stage renal disease under hemodialysis: a propensity score-matched case-control study.

    abstract:BACKGROUND:Patients with end-stage renal disease (ESRD) under hemodialysis (HD) are at greater risks of infectious spondylitis (IS), but there is no reliable predictor that facilitate early detection of this relatively rare and insidious disease. METHODS:A retrospective review of the medical records from patients with...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-019-1504-x

    authors: Lu KL,Huang WH,Lu YA,Lin CY,Wu HH,Hsu CW,Weng CH,Wu CY,Wu IW,Wu MY,Yen TH,Yang HY

    更新日期:2019-08-16 00:00:00

  • Unilateral renal artery stenosis presented with hyponatremic-hypertensive syndrome - case report and literature review.

    abstract:BACKGROUND:Renal artery stenosis is one of the secondary causes of pediatric hypertension. Cases with critical unilateral renal artery stenosis manifesting with the hyponatremic hypertensive syndrome are rare and a comprehensive description of this disorder in the pediatric population is lacking in the literature. CAS...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-019-1246-9

    authors: Ding JJ,Lin SH,Lai JY,Wu TW,Huang JL,Chung HT,Tseng MH

    更新日期:2019-02-21 00:00:00

  • Unexpected presentation and surgical salvage of transplant renal artery dissection caused by vascular clamping: a case report.

    abstract:BACKGROUND:Transplant renal artery dissection is a rare and serious event that can cause allograft dysfunction and activation of the renin-mediated renovascular hypertension. Most cases are induced by percutaneous transluminal angioplasty, arteriosclerotic disease, or fibromuscular dysplasia. We observed a case of tran...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-020-1699-x

    authors: Hori S,Yoneda T,Tomizawa M,Ichikawa K,Morizawa Y,Nakai Y,Miyake M,Fujimoto K

    更新日期:2020-01-29 00:00:00

  • Soluble Klotho is associated with mortality and cardiovascular events in hemodialysis.

    abstract:BACKGROUND:Klotho is a transmembrane protein acting as a co-receptor for FGF-23 and thus exerts clinical actions on mineral metabolism. The association of secreted Klotho with outcomes in CKD patients is unclear. This study examined the relation between plasma Klotho and cardiovascular events in dialysis patients, acco...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-019-1391-1

    authors: Memmos E,Sarafidis P,Pateinakis P,Tsiantoulas A,Faitatzidou D,Giamalis P,Vasilikos V,Papagianni A

    更新日期:2019-06-11 00:00:00

  • Relationship between early proteinuria and long term outcome of kidney transplanted patients from different decades of donor age.

    abstract:BACKGROUND:Proteinuria after kidney transplantation portends a worse graft survival. However the magnitude of proteinuria related to patient and graft survival and its correlation with donor and recipient characteristics are poorly explored. METHODS:This study investigated the impact of post transplant proteinuria in ...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-019-1635-0

    authors: Diena D,Messina M,De Biase C,Fop F,Scardino E,Rossetti MM,Barreca A,Verri A,Biancone L

    更新日期:2019-12-02 00:00:00

  • Lanthanum carbonate for the treatment of hyperphosphatemia in CKD 5D: multicenter, double blind, randomized, controlled trial in mainland China.

    abstract:BACKGROUND:Serum phosphorus control is critical for chronic kidney disease (CKD) 5D patients. Currently, clinical profile for an oral phosphorus binder in the mainland Chinese population is not available. OBJECTIVE:To establish the efficacy, safety, and tolerability of lanthanum carbonate in CKD 5D patients. DESIGN:M...

    journal_title:BMC nephrology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1186/1471-2369-14-29

    authors: Xu J,Zhang YX,Yu XQ,Liu ZH,Wang LN,Chen JH,Fan YP,Ni ZH,Wang M,Yuan FH,Ding GH,Chen XM,Zhang AP,Mei CL

    更新日期:2013-02-04 00:00:00

  • Validation of two prediction models of undiagnosed chronic kidney disease in mixed-ancestry South Africans.

    abstract:BACKGROUND:Chronic kidney disease (CKD) is a global challenge. Risk models to predict prevalent undiagnosed CKD have been published. However, none was developed or validated in an African population. We validated the Korean and Thai CKD prediction model in mixed-ancestry South Africans. METHODS:Discrimination and cali...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-015-0093-6

    authors: Mogueo A,Echouffo-Tcheugui JB,Matsha TE,Erasmus RT,Kengne AP

    更新日期:2015-07-04 00:00:00

  • Lactic acidosis associated with metformin in patients with moderate to severe chronic kidney disease: study protocol for a multicenter population-based case-control study using health databases.

    abstract:BACKGROUND:The use of metformin in patients with type 2 diabetes mellitus has been associated with lactic acidosis. However, the information available in patients with moderate-severe chronic kidney disease is scarce. METHODS:The ALIMAR-C2 study is a case-control study to assess the association between metformin and l...

    journal_title:BMC nephrology

    pub_type: 杂志文章,多中心研究

    doi:10.1186/s12882-019-1389-8

    authors: Pedrós C,Ávila M,Gómez-Lumbreras A,Manríquez M,Morros R,ALIMAR-C2 Study Group.

    更新日期:2019-05-30 00:00:00

  • Persistent nasal methicillin-resistant staphylococcus aureus carriage in hemodialysis outpatients: a predictor of worse outcome.

    abstract:BACKGROUND:Nasal colonization with methicillin-resistant Staphylococcus aureus (MRSA) is a well defined risk factor for subsequent bacteremia and death in various groups of patients, but its impact on outcome in patients receiving long-term hemodialysis (HD) is under debate. METHODS:This prospective interventional coh...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/1471-2369-14-93

    authors: Schmid H,Romanos A,Schiffl H,Lederer SR

    更新日期:2013-04-23 00:00:00

  • Induction therapy with thymoglobulin or interleukin-2 receptor antagonist for Chinese recipients of living donor renal transplantation: a retrospective study.

    abstract:BACKGROUND:Recipients of living donor renal transplantation are typically considered to have a relatively lower immunological risk. This retrospective study aimed to compare the therapeutic efficacy and safety between rabbit antithymocyte globulin (rATG) or interleukin-2 receptor antagonist (IL2-RA) induction therapies...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-019-1293-2

    authors: Qiu J,Li J,Chen G,Huang G,Fu Q,Wang C,Chen L

    更新日期:2019-03-22 00:00:00

  • Membranous nephropathy in patients with HIV: a report of 11 cases.

    abstract:BACKGROUND:Membranous nephropathy (MN) has been recognized to occur in patients with human immunodeficiency virus (HIV) infection since the beginning of the HIV epidemic. The prevalence of phospholipase A2 receptor (PLA2R)-associated MN in this group has not been well studied. METHODS:We conducted a retrospective revi...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-020-02042-x

    authors: Charu V,Andeen N,Walavalkar V,Lapasia J,Kim JY,Lin A,Sibley R,Higgins J,Troxell M,Kambham N

    更新日期:2020-09-18 00:00:00

  • Dietary and lifestyle factors for primary prevention of nephrolithiasis: a systematic review and meta-analysis.

    abstract:BACKGROUND:Dietary and lifestyle factors may play an important role in the increasing prevalence of nephrolithiasis. We aimed to review and quantify the associations between lifestyle factors and incident nephrolithiasis and suggest lifestyle changes for the primary prevention of nephrolithiasis. METHODS:PubMed, EMBAS...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-020-01925-3

    authors: Lin BB,Lin ME,Huang RH,Hong YK,Lin BL,He XJ

    更新日期:2020-07-11 00:00:00

  • Kidney biopsy findings in two patients with TAFRO syndrome: case presentations and review of the literature.

    abstract:BACKGROUND:TAFRO syndrome is a clinical subtype of idiopathic multicentric Castleman disease (iMCD) that is characterized by thrombocytopenia, anasarca, fever, reticulin myelofibrosis (or renal dysfunction), and organomegaly. TAFRO syndrome has only recently been described, and many clinicians are unaware of this disea...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-020-02119-7

    authors: Zhou Q,Zhang Y,Zhou G,Zhu J

    更新日期:2020-11-23 00:00:00

  • A model to predict disease progression in patients with autosomal dominant polycystic kidney disease (ADPKD): the ADPKD Outcomes Model.

    abstract:BACKGROUND:Autosomal dominant polycystic kidney disease (ADPKD) is the leading inheritable cause of end-stage renal disease (ESRD); however, the natural course of disease progression is heterogeneous between patients. This study aimed to develop a natural history model of ADPKD that predicted progression rates and long...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-017-0804-2

    authors: McEwan P,Bennett Wilton H,Ong ACM,Ørskov B,Sandford R,Scolari F,Cabrera MV,Walz G,O'Reilly K,Robinson P

    更新日期:2018-02-13 00:00:00

  • Reference values for glomerular filtration rate in healthy Brazilian adults.

    abstract:BACKGROUND:Glomerular filtration rate (GFR) is the best index of renal function, but age, gender and ethnicity can putatively affect its values. The aim of this study was to establish reference values for GFR in healthy Brazilian subjects while taking these factors into account. METHODS:In this cross-sectional study, ...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/1471-2369-14-54

    authors: Soares AA,Prates AB,Weinert LS,Veronese FV,de Azevedo MJ,Silveiro SP

    更新日期:2013-02-28 00:00:00

  • Renal disease and accidental falls: a review of published evidence.

    abstract:BACKGROUND:The pathogenesis of falling is complex, and identification of risk factors may be essential for prevention. The relationship between renal disease and falls is unclear, and the goal of this study was to collect the available evidence and investigate the relationship between accidental falls and renal dysfunc...

    journal_title:BMC nephrology

    pub_type: 杂志文章,评审

    doi:10.1186/s12882-015-0173-7

    authors: López-Soto PJ,De Giorgi A,Senno E,Tiseo R,Ferraresi A,Canella C,Rodríguez-Borrego MA,Manfredini R,Fabbian F

    更新日期:2015-10-29 00:00:00

  • Papulonodular mucinosis, Guillain-Barré syndrome and nephrotic syndrome in a patient with systemic lupus erythematosus: a case report.

    abstract:BACKGROUND:Awareness of the spectrum of clinical manifestations of systemic lupus erythematosus (SLE), especially uncommon changes, is essential for diagnosis and effective management of patients. CASE PRESENTATION:A 26-year-old Chinese man with SLE initially manifested cutaneous papulonodular mucinosis and developed ...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-017-0458-0

    authors: Su X,Qiao X,Li J,Gao L,Wang C,Wang L

    更新日期:2017-02-01 00:00:00

  • Protective effect of quinacrine against glycerol-induced acute kidney injury in rats.

    abstract:BACKGROUND:Acute kidney injury (AKI) is a serious clinical problem with high rate of mortality and morbidity. Currently used prophylactic and therapeutic strategies to address AKI are limited and warrant further studies. In the present study an attempt was made to investigate the effect of quinacrine, a phospholipase A...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-017-0450-8

    authors: Al Asmari AK,Al Sadoon KT,Obaid AA,Yesunayagam D,Tariq M

    更新日期:2017-01-28 00:00:00

  • Internet and social network users' profiles in Renal Transplant Recipients in France.

    abstract:BACKGROUND:The use of the Internet for searching and sharing health information and for health care interactions may have a great potential for Renal Transplant Recipients (RTR). This study aims to determine the characteristics associated with Internet and social network use in a representative sample of RTR at the tim...

    journal_title:BMC nephrology

    pub_type: 杂志文章,多中心研究

    doi:10.1186/s12882-017-0670-y

    authors: Mouelhi Y,Alessandrini M,Pauly V,Dussol B,Gentile S

    更新日期:2017-08-03 00:00:00

  • Do oral aluminium phosphate binders cause accumulation of aluminium to toxic levels?

    abstract:BACKGROUND:Aluminium (Al) toxicity was frequent in the 1980s in patients ingesting Al containing phosphate binders (Alucaps) whilst having HD using water potentially contaminated with Al. The aim of this study was to determine the risk of Al toxicity in HD patients receiving Alucaps but never exposed to contaminated di...

    journal_title:BMC nephrology

    pub_type: 临床试验,杂志文章

    doi:10.1186/1471-2369-12-55

    authors: Pepper R,Campbell N,Yaqoob MM,Roberts NB,Fan SL

    更新日期:2011-10-12 00:00:00