Abstract:
BACKGROUND:Icodextrin is a starch-derived, water soluble glucose polymer, which is used as an alternative to glucose in order to enhance dialytic fluid removal in peritoneal dialysis patients. Although the safety and efficacy of icodextrin is well-established, its use in everyday clinical practice has been associated with the appearance of skin rashes and other related skin reactions. CASE PRESENTATION:Herein, we report the rare case of a 91-year-old woman with a history of severe congestive heart failure, who initiated continuous ambulatory peritoneal dialysis with icodextrin-based dialysate solutions and 15 days after the initial exposure to icodextrin developed a generalized maculopapular and exfoliative skin rash extending over the back, torso and extremities. Discontinuation of icodextrin and oral therapy with low-dose methyl-prednisolone with quick dose tapering improved the skin lesions within the following days. CONCLUSIONS:This case report highlights that skin hypersensitivity is a rare icodextrin-related adverse event that should be suspected in patients manifesting skin reactions typically within a few days or weeks after the initial exposure.
journal_name
BMC Nephroljournal_title
BMC nephrologyauthors
Liakopoulos V,Georgianos PI,Demirtzi P,Vaios V,Kalathas T,Zebekakis PEdoi
10.1186/s12882-018-1071-6subject
Has Abstractpub_date
2018-10-25 00:00:00pages
293issue
1issn
1471-2369pii
10.1186/s12882-018-1071-6journal_volume
19pub_type
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