Abstract:
BACKGROUND:Peripheral arterial disease (PAD) is common in patients with end-stage renal disease on hemodialysis, but is frequently underdiagnosed. The risk factors for PAD are well known within the general population, but they differ somewhat in hemodialysis patients. This study aimed to determine the prevalence of PAD and its risk factors in patients on hemodialysis. METHODS:This cross-sectional study included 156 hemodialysis patients. Comorbidities and laboratory parameters were analyzed. Following clinical examinations, the ankle-brachial index was measured in all patients. PAD was diagnosed based on the clinical findings, ankle-brachial index < 0.9, and PAD symptoms. RESULTS:PAD was present in 55 of 156 (35.3%; 95% CI, 27.7-42.8%) patients. The patients with PAD were significantly older (67 ± 10 years vs. 62 ± 11 years, p = 0.014), more likely to have diabetes mellitus (p = 0.022), and anemia (p = 0.042), and had significantly lower serum albumin (p = 0.005), total cholesterol (p = 0.024), and iron (p = 0.004) levels, higher glucose (p = 0.002) and C-reactive protein (p < 0.001) levels, and lower dialysis adequacies (p = 0.040) than the patients without PAD. Multivariate analysis showed higher C-reactive protein level (odds ratio [OR], 1.03; 95% confidence interval [CI], 1.00-1.06; p = 0.030), vascular access by Hickman catheter (OR, 4.66; 95% CI, 1.03-21.0; p = 0.045), and symptoms of PAD (OR, 5.20; 95% CI, 2.60-10.4; p < 0.001) as independent factors associated with PAD in hemodialysis patients. CONCLUSION:The prevalence of PAD was high among patients with end-stage renal disease on hemodialysis. Symptoms of PAD, higher C-reactive protein levels, and Hickman vascular access were independent predictors of PAD in patients on hemodialysis.
journal_name
BMC Nephroljournal_title
BMC nephrologyauthors
Ašćerić RR,Dimković NB,Trajković GŽ,Ristić BS,Janković AN,Durić PS,Ilijevski NSdoi
10.1186/s12882-019-1468-xsubject
Has Abstractpub_date
2019-07-26 00:00:00pages
281issue
1issn
1471-2369pii
10.1186/s12882-019-1468-xjournal_volume
20pub_type
杂志文章相关文献
BMC Nephrology文献大全abstract:BACKGROUND:The risk of an individual to develop an acute kidney injury (AKI), or its severity, cannot be reliably predicted by common clinical risk factors. Whether genetic risk factors have an explanatory role poses an interesting question, however. Thus, we conducted a systematic literature review regarding genetic p...
journal_title:BMC nephrology
pub_type: 杂志文章,meta分析,评审
doi:10.1186/s12882-015-0190-6
更新日期:2015-12-02 00:00:00
abstract:BACKGROUND:Accurate estimation of glomerular filtration rate (GFR) is important for diagnosis and risk stratification in chronic kidney disease and for selection of living donors. Ethnic differences have required correction factors in the originally developed creatinine-based GFR estimation equations for populations ar...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-018-0813-9
更新日期:2018-02-01 00:00:00
abstract:BACKGROUND:As a result of difficulties related to their illness, diagnosis and treatment, patients with end-stage renal disease experience significant emotional and psychological problems, which untreated can have considerable negative impact on their health and wellbeing. Despite evidence that patients desire improved...
journal_title:BMC nephrology
pub_type: 杂志文章,多中心研究
doi:10.1186/s12882-016-0327-2
更新日期:2016-08-02 00:00:00
abstract:BACKGROUND:A positive pregnancy test in acute or chronically ill patients has implications for the use of potentially mutagenic or teratogenic products in urgent medical therapies such as the use of chemotherapies or therapies with immunosuppressants, for anesthesia, and for time-sensitive indications like urgent surge...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-020-01729-5
更新日期:2020-02-28 00:00:00
abstract:BACKGROUND:Glucocorticoids (GCs) are frequently used to treat glomerular diseases but are associated with multiple adverse effects including hypothalamic-pituitary-adrenal axis inhibition that can lead to adrenal insufficiency (AI) on withdrawal. There is no agreed GC tapering strategy to minimise this risk. METHODS:T...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-019-1354-6
更新日期:2019-05-06 00:00:00
abstract:BACKGROUND:Cystinosis is a rare autosomal recessive lysosomal disorder characterized by the accumulation of cystine in lysosomes. Cystinosis is much rarer in Asian than Caucasian populations. There are only 14 patients have with cystinosis alive in Japan. Most cystinosis is the nephropathic infantile form, as indicated...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-017-0721-4
更新日期:2017-09-26 00:00:00
abstract:BACKGROUND:Hemodiafiltration (HDF), as a convective blood purification technique, has been associated with favorable outcomes improved phosphate control, removal of middle-molecules such as Beta2-microglobulin and the occurrence of intradialytic hypotension (IDH) as compared to diffusive techniques. The aim of this ret...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/1471-2369-13-106
更新日期:2012-09-10 00:00:00
abstract:BACKGROUND:Almost all cases of renal hydatid cysts need surgical intervention for treatment. We report a case of isolated renal hydatid cyst treated successfully only with medical therapy. CASE PRESENTATION:This case is a 79-year-old veterinarian presented with right flank pain, hydatiduria and positive echinococcus g...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-020-02064-5
更新日期:2020-10-08 00:00:00
abstract:BACKGROUND:Neck of femur fractures are associated with high mortality and have increased prevalence in dialysis patients. Delays in operating on dialysis patients can occur as a result of logistical or medical issues; it has previously been shown that delays on operating on neck of femur fractures in the general popula...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-016-0234-6
更新日期:2016-03-03 00:00:00
abstract:BACKGROUND:Fibroblast growth factor 23 (FGF23) is a phosphaturic hormone that is secreted from bone and serum level increases as renal function declines. Higher levels of FGF23 are associated with increased mortality in hemodialysis-patients and in patients with chronic kidney disease (CKD) stage 2-4. The use of active...
journal_title:BMC nephrology
pub_type: 杂志文章,随机对照试验
doi:10.1186/1471-2369-13-49
更新日期:2012-06-28 00:00:00
abstract:BACKGROUND:Ghrelin, a gastric orexigenic peptide, and body mass index (BMI) are known as inversely associated to each other and are both linked to cardiovascular (CV) risk and mortality in maintenance hemodialysis (MHD) patients. However, it is unclear whether the interaction between ghrelin and BMI is associated with ...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-017-0442-8
更新日期:2017-01-18 00:00:00
abstract:BACKGROUND:This study will assess measures of vascular health and inflammation in Aboriginal Australian adults with chronic kidney disease (CKD), and determine if intensive periodontal intervention improves cardiovascular health, progression of renal disease and periodontal health over a 24-month follow-up. METHODS:Th...
journal_title:BMC nephrology
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12882-015-0169-3
更新日期:2015-10-31 00:00:00
abstract:BACKGROUND:Knowing how chronic kidney disease (CKD) patients talk about their encounters with providers (i.e., their discourse) can inform the important clinical goal of engaging patients in their chronic disease self-management. The aim of this study was to analyze patient discourse on ongoing CKD monitoring encounter...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-018-0981-7
更新日期:2018-07-19 00:00:00
abstract:BACKGROUND:FGF23 controls serum l,25(OH)2D3 levels and phosphate homeostasis. This study evaluates the effects of ferritin on intact PTH, FGF23, and l,25(OH)2D3 in patients with major thalassemia. It also evaluates FGF23 changes in patients with hypoparathyroidism to clarify the interaction between FGF23 and PTH in the...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-020-02101-3
更新日期:2020-11-16 00:00:00
abstract:BACKGROUND:Interleukin 17 is a proinflammatory cytokine involved in immune response after allograft transplantation. IL-17 family of proinflammatory cytokines includes IL-17A and IL-17F. Previous studies have demonstrated that the rs2275913 IL17A and the rs11465553 IL17F gene polymorphism are associated with kidney all...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-019-1308-z
更新日期:2019-04-08 00:00:00
abstract:BACKGROUND:Chronic kidney disease (CKD) is a global challenge. Risk models to predict prevalent undiagnosed CKD have been published. However, none was developed or validated in an African population. We validated the Korean and Thai CKD prediction model in mixed-ancestry South Africans. METHODS:Discrimination and cali...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-015-0093-6
更新日期:2015-07-04 00:00:00
abstract:BACKGROUND:The pathogenesis of falling is complex, and identification of risk factors may be essential for prevention. The relationship between renal disease and falls is unclear, and the goal of this study was to collect the available evidence and investigate the relationship between accidental falls and renal dysfunc...
journal_title:BMC nephrology
pub_type: 杂志文章,评审
doi:10.1186/s12882-015-0173-7
更新日期:2015-10-29 00:00:00
abstract:BACKGROUND:Sclerostin is a paracrine acting factor, which is expressed in the osteocytes and articular chondrocytes. Sclerostin decreases the osteoblast-related bone formation through the inhibition of the Wnt/β-catenin pathway. Osteocytes also express the Calcium sensing receptor which is a target for cinacalcet. The ...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-016-0392-6
更新日期:2016-11-15 00:00:00
abstract:BACKGROUND:Periodontal disease is associated with increased mortality in the general population, however its prognostic significance in chronic kidney disease (CKD) is not known. We evaluated the joint effect of periodontal disease and CKD on all-cause and cardiovascular mortality. METHODS:Prospective observational st...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-015-0101-x
更新日期:2015-07-07 00:00:00
abstract:BACKGROUND:Icodextrin is a starch-derived, water soluble glucose polymer, which is used as an alternative to glucose in order to enhance dialytic fluid removal in peritoneal dialysis patients. Although the safety and efficacy of icodextrin is well-established, its use in everyday clinical practice has been associated w...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-018-1071-6
更新日期:2018-10-25 00:00:00
abstract:BACKGROUND:Kidney impairment constitutes severe risk for cardiovascular disease, stroke and all-cause mortality, and early identification and prevention of kidney impairment is critical to effective management of prognostic risk in community residents. Previous studies have validated that carotid-femoral pulse wave vel...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-018-0897-2
更新日期:2018-05-02 00:00:00
abstract:BACKGROUND:Frailty is independently associated with worse health-related quality of life (HRQOL) in chronic kidney disease (CKD). However, the relationship between frailty and symptom experience is not well described in people living with CKD. This study's aim was to evaluate the relationship between frailty and sympto...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-020-02063-6
更新日期:2020-09-23 00:00:00
abstract:BACKGROUND:Age and number of recipients in need of kidney re-transplantation are increasing. Re-transplantation practices and outcomes in elderly recipients are not previously explored. We aimed to retrospectively evaluate the outcomes of recipients 65 years and older receiving their second deceased donor allograft. M...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-016-0426-0
更新日期:2017-01-11 00:00:00
abstract:BACKGROUND:Little is known about the changes in disease makers and risk factors in patients with chronic kidney disease (CKD) under nephrological care in Africa. This study aimed to evaluate the baseline level of markers of CKD and their 12-month time-trend in newly referred patients in a tertiary hospital in Cameroon....
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-020-01760-6
更新日期:2020-03-18 00:00:00
abstract:BACKGROUND:Group A streptococcus (GAS) is an etiological agent for the immune mediated sequela post streptococcal glomerulonephritis (PSGN). In some populations PSGN is recognized as a risk factor for chronic kidney disease (CKD) and end-stage renal disease (ESRD). It was found that a significantly greater proportion o...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/1471-2369-14-101
更新日期:2013-05-06 00:00:00
abstract:BACKGROUND:Early preparation for renal replacement therapy (RRT) is recommended for patients with advanced chronic kidney disease (CKD), yet many patients initiate RRT urgently and/or are inadequately prepared. METHODS:We conducted audio-recorded, qualitative, directed telephone interviews of nephrology health care pr...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-015-0020-x
更新日期:2015-03-28 00:00:00
abstract:BACKGROUND:Metabolic syndrome (MetS) has been established as a risk for cardiovascular diseases and mortality in hemodialysis patients. Energy intake (EI) is an important nutritional therapy for preventing MetS. We examined the association of self-reported dietary EI with metabolic abnormalities and MetS among hemodial...
journal_title:BMC nephrology
pub_type: 杂志文章,多中心研究
doi:10.1186/s12882-018-1041-z
更新日期:2018-09-19 00:00:00
abstract:BACKGROUND:The optimal revascularization strategy for patients with impaired glomerular filtration rate (IGFR) has not been established in acute coronary syndrome (ACS). We investigated the prognosis and impact of IGFR and invasive strategy on the cardiovascular outcomes in the ACS population. METHODS:In a Taiwan nati...
journal_title:BMC nephrology
pub_type: 杂志文章,多中心研究
doi:10.1186/1471-2369-15-66
更新日期:2014-04-23 00:00:00
abstract:BACKGROUND:The poorly differentiated renal cell carcinoma (RCC) with rhabdomyosarcomatous sarcomatoid differentiation shows a severely aggressive biological behavior characterized by rapid disease progression. Preoperative identification of the subtype with the prognostic factors and imaging features of sarcomatoid ren...
journal_title:BMC nephrology
pub_type: 杂志文章,评审
doi:10.1186/s12882-018-0884-7
更新日期:2018-04-10 00:00:00
abstract:BACKGROUND:Evidence suggests that exercise training for hemodialysis patients positively improves morbidity and mortality outcomes, yet exercise programs remain rare and are not systematically incorporated into care. We developed a research-based film, Fit for Dialysis, designed to introduce, motivate, and sustain exer...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-017-0454-4
更新日期:2017-01-26 00:00:00