Abstract:
BACKGROUND:The poorly differentiated renal cell carcinoma (RCC) with rhabdomyosarcomatous sarcomatoid differentiation shows a severely aggressive biological behavior characterized by rapid disease progression. Preoperative identification of the subtype with the prognostic factors and imaging features of sarcomatoid renal cell carcinoma (SRCC) would be of great clinical significance. CASE PRESENTATION:A 45-year-old male patient presented a nine day history of gross hematuria without any other symptoms. A computed tomography (CT) and a full-body fluorine-18 fluoro-2-deoxyglucose (FDG) positron emission tomography (PET) - computed tomography (CT) scan urogram were performed. An initial diagnosis identified a space-occupying lesion of the right kidney, retroperitoneal and right renal hulum lymph node metastases, as well as a space-occupying lesion of the third thoracic vertebra (T3). A right radical nephrectomy was performed. Pathologic analysis revealed poorly differentiated RCC with rhabdomyosarcomatous sarcomatoid differentiation that extends into the renal sinus and the ureteral (T3N1M1). Five days later, the Magnetic Resonance imaging (MRI) evidenced a diffused osseous metastatic disease in the thoracic and lumbar vertebra and multiple retroperitoneal lymph node metastases. The disease progressed quickly to multiple organ dysfunction syndrome (MODS) in half a month and the patient died of respiratory failure two days later. The patient refused any chemoradiotherapy in the hospital. CONCLUSIONS:Our case presents a SRCC with severe, aggressive, and rapid disease progression. Classifying SRCC imaging features by CT, MRI as well as PET-CT techniques could potentially be helpful for preoperative identification of the subtype. The prognostic factors of SRCC would be of great clinical interest.
journal_name
BMC Nephroljournal_title
BMC nephrologyauthors
Liang X,Liu Y,Ran P,Tang M,Xu C,Zhu Ydoi
10.1186/s12882-018-0884-7subject
Has Abstractpub_date
2018-04-10 00:00:00pages
84issue
1issn
1471-2369pii
10.1186/s12882-018-0884-7journal_volume
19pub_type
杂志文章,评审相关文献
BMC Nephrology文献大全abstract:BACKGROUND:TAFRO syndrome is a clinical subtype of idiopathic multicentric Castleman disease (iMCD) that is characterized by thrombocytopenia, anasarca, fever, reticulin myelofibrosis (or renal dysfunction), and organomegaly. TAFRO syndrome has only recently been described, and many clinicians are unaware of this disea...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-020-02119-7
更新日期:2020-11-23 00:00:00
abstract:BACKGROUND:Accurately determining renal function is essential for clinical management of HIV patients. Classically, it has been evaluated by estimating glomerular filtration rate (eGFR) with the MDRD-equation, but today there is evidence that the new Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation ...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-017-0470-4
更新日期:2017-02-10 00:00:00
abstract:BACKGROUND:Dialysis has long been a critical issue in the field of nephrology, though the burden this lifesaving technology places on society can be immense. Effectively increasing the health literacy of hemodialysis patients can be beneficial for their health outcomes and self-care abilities. Thus, the aims of this st...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-016-0266-y
更新日期:2016-05-31 00:00:00
abstract:BACKGROUND:The aim of this study was to investigate the characteristics and outcomes of patients receiving renal replacement therapy for end-stage kidney disease (ESKD) secondary to haemolytic uraemic syndrome (HUS). METHODS:The study included all patients with ESKD who commenced renal replacement therapy in Australia...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/1471-2369-13-164
更新日期:2012-12-03 00:00:00
abstract:BACKGROUND:Nasal colonization with methicillin-resistant Staphylococcus aureus (MRSA) is a well defined risk factor for subsequent bacteremia and death in various groups of patients, but its impact on outcome in patients receiving long-term hemodialysis (HD) is under debate. METHODS:This prospective interventional coh...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/1471-2369-14-93
更新日期:2013-04-23 00:00:00
abstract:BACKGROUND:The high cost, complexity of the available protocols, and metabolic complications are the major barriers that impede the clinical utilization of regional citrate anticoagulation (RCA) for sustained low efficiency dialysis (SLED) in critically ill patients. By comparing a novel protocol for SLED using 30% cit...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-018-0879-4
更新日期:2018-04-03 00:00:00
abstract:BACKGROUND:Data on radial access (RA) as an independent risk factor for acute kidney injury (AKI) in myocardial infarction (MI) patients are conflicting. Our aim was to assess how RA influences the incidence of AKI in MI patients undergoing percutaneous coronary intervention (PCI). METHODS:Data from 3842 MI patients u...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-019-1210-8
更新日期:2019-01-30 00:00:00
abstract:BACKGROUND:There is limited evidence on the relationship between social support and renal outcomes in African Americans. We sought to determine the association of social support with prevalent chronic kidney disease (CKD) and kidney function decline in an African American cohort. We also examined whether age modifies t...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-019-1432-9
更新日期:2019-07-15 00:00:00
abstract:BACKGROUND:About 1% of patients admitted to the Emergency Department (ED) have hypernatremia, a condition associated with a mortality rate of 20 to 60%. Management recommendations originate from intensive care unit studies, in which patients and medical diseases differ from those in ED. METHODS:We retrospectively stud...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/1471-2369-15-37
更新日期:2014-02-21 00:00:00
abstract:BACKGROUND:FGF23 controls serum l,25(OH)2D3 levels and phosphate homeostasis. This study evaluates the effects of ferritin on intact PTH, FGF23, and l,25(OH)2D3 in patients with major thalassemia. It also evaluates FGF23 changes in patients with hypoparathyroidism to clarify the interaction between FGF23 and PTH in the...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-020-02101-3
更新日期:2020-11-16 00:00:00
abstract:BACKGROUND:Although chronic kidney disease (CKD) affects a growing number of people, epidemiologic data on incident CKD in the general population are scarce. Screening strategies to increase early CKD detection have been developed. METHODS:From a community-based sample of 4,409 individuals residing in a well-defined g...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-016-0379-3
更新日期:2016-11-15 00:00:00
abstract:BACKGROUND:Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used and have been linked to acute kidney injury (AKI), chronic kidney disease (CKD) and cardiovascular disease (CVD). Patients who survive an AKI episode are at risk for future adverse kidney and cardiovascular outcomes. The objective of our study wa...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-016-0411-7
更新日期:2016-11-24 00:00:00
abstract:BACKGROUND:Chronic cyclosporine-(CsA)-mediated loss of kidney function is a major clinical problem in organ transplantation. We hypothesized that the mineralocorticoid receptor antagonist eplerenone (EPL) prevents chronic CsA-induced renal interstitial volume increase, tubule loss, and functional impairment in a rat mo...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/1471-2369-14-42
更新日期:2013-02-20 00:00:00
abstract:BACKGROUND:Aciduria caused by urinary excretion of acidic metabolic wastes produced in daily life is known to be augmented in patients with chronic kidney disease (CKD). To evaluate the reno-protective effect of oral alkalizing agents for the improvement of metabolic acidosis and neutralization of intratubular pH in th...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-020-01807-8
更新日期:2020-04-22 00:00:00
abstract:BACKGROUND:Patients undergoing haemodialysis (HD) are at higher risk of developing worse outcomes if they contract COVID-19. In our renal service we reduced HD frequency from thrice to twice-weekly in selected patients with the primary aim of reducing COVID 19 exposure and transmission between HD patients. METHODS:Dia...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-020-02172-2
更新日期:2020-12-07 00:00:00
abstract:BACKGROUND:Asians have among the highest prevalence of chronic kidney disease (CKD) or end-stage renal disease in the world. A risk score capable of identifying high risk individuals at the primary care level could allow targeted therapy to prevent future development of CKD. Risk scores for new CKD have been developed ...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-017-0653-z
更新日期:2017-07-17 00:00:00
abstract:BACKGROUND:Immunosuppressive treatment will predispose an idiopathic membranous nephropathy (iMN) patient to opportunistic infections. Disease severity is one of the main concerns for making the treatment decision. Urinary angiotensinogen (UAGT) level has been shown highly correlated with intrarenal renin-angiotensin s...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-018-1165-1
更新日期:2018-12-12 00:00:00
abstract:BACKGROUND:Adherence to phosphate binder treatment is important to prevent high serum phosphate level in chronic dialysis patients. We therefore wanted to investigate patient knowledge, beliefs about and adherence to phosphate binders among these patients and assess whether one-to-one pharmacist-led education and couns...
journal_title:BMC nephrology
pub_type: 临床试验,杂志文章
doi:10.1186/s12882-019-1334-x
更新日期:2019-05-17 00:00:00
abstract:BACKGROUND:Association between metabolic syndrome (MS) and mildly reduced estimated glomerular filtration rates (eGFRs) remains unclear. Therefore, we aimed to evaluate the association between MS and a mildly reduced eGFR in Chinese adults. METHODS:Anthropometric and biochemical examinations were performed in 2992 ind...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-017-0597-3
更新日期:2017-06-13 00:00:00
abstract:BACKGROUND:Obesity is a well-established risk factor for atherosclerosis. However, it is unknown which measure of adiposity best relates to atherosclerosis in relatively lean maintenance hemodialysis (MHD) patients. We aimed to explore and compare the associations between different adiposity indices reflecting general,...
journal_title:BMC nephrology
pub_type: 杂志文章,多中心研究
doi:10.1186/s12882-018-0996-0
更新日期:2018-08-16 00:00:00
abstract:BACKGROUND:The Reducing Disparities in Access to kidNey Transplantation Community Study (RaDIANT) was an End-Stage Renal Disease (ESRD) Network 6-developed, dialysis facility-level randomized trial testing the effectiveness of a 1-year multicomponent education and quality improvement intervention in increasing referral...
journal_title:BMC nephrology
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12882-017-0807-z
更新日期:2018-01-15 00:00:00
abstract:BACKGROUND:Patients with pre-existing impaired renal function are prone to develop acute contrast media induced nephropathy (CIN). Neutrophil gelatinase-associated lipocalin (NGAL), a new biomarker predictive for acute kidney injury (AKI), has been shown to be useful for earlier diagnosis of CIN; however, urinary NGAL ...
journal_title:BMC nephrology
pub_type: 杂志文章,随机对照试验
doi:10.1186/1471-2369-12-39
更新日期:2011-08-17 00:00:00
abstract::In a recent study published by the National Project Team on chronic kidney diseases of unknown origin in Sri Lanka, identified cadmium as a major risk factor but strong conclusions were not made as the identified environmental toxins were within the permissible levels.Sri Lankan food consumption pattern is different s...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-015-0211-5
更新日期:2015-12-23 00:00:00
abstract:BACKGROUND:Tissue derived biomarkers may offer utility as indicators of accumulated damage. Reduced thickness of retinal neuronal tissue and the vascular choroid have previously been associated with vascular damage and diabetes. We evaluated associations between retinal thickness, retinal microvascular and choroidal me...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-019-1679-1
更新日期:2020-01-31 00:00:00
abstract:BACKGROUND:Patients who start renal replacement therapy (RRT) for End-Stage Kidney Disease (ESKD) without having had timely access to specialist renal services have poor outcomes. At one NHS Trust in England, a community-wide CKD management system has led to a decline in the incident rate of RRT and the lowest percenta...
journal_title:BMC nephrology
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12882-017-0522-9
更新日期:2017-04-11 00:00:00
abstract:BACKGROUND:Evidence suggests that exercise training for hemodialysis patients positively improves morbidity and mortality outcomes, yet exercise programs remain rare and are not systematically incorporated into care. We developed a research-based film, Fit for Dialysis, designed to introduce, motivate, and sustain exer...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-017-0454-4
更新日期:2017-01-26 00:00:00
abstract:BACKGROUND:African Americans have an increased incidence and worse prognosis with chronic kidney disease (CKD--estimated glomerular filtration rate [eGFR] <60 ml/min/1.73 m2) than their counterparts of European-descent. Inflammation has been related to renal disease in non-Hispanic whites, but there are limited data on...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/1471-2369-11-1
更新日期:2010-01-15 00:00:00
abstract:BACKGROUND:Group A streptococcus (GAS) is an etiological agent for the immune mediated sequela post streptococcal glomerulonephritis (PSGN). In some populations PSGN is recognized as a risk factor for chronic kidney disease (CKD) and end-stage renal disease (ESRD). It was found that a significantly greater proportion o...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/1471-2369-14-101
更新日期:2013-05-06 00:00:00
abstract:BACKGROUND:Complementary and Alternative Medicines (CAMs) are increasingly practiced in the general population; it is estimated that over 30% of patients with chronic diseases use CAMs on a regular basis. CAMs are also used in hospital settings, suggesting a growing interest in individualized therapies. One potential f...
journal_title:BMC nephrology
pub_type: 杂志文章,评审
doi:10.1186/1471-2369-14-129
更新日期:2013-06-21 00:00:00
abstract:BACKGROUND:Immunoglobulin light chains are classified as middle molecule uremic toxins able to interact with B lymphocyte membranes leading to the activation of transmembrane signaling. The ensuing impairment of neutrophil function can contribute to the chronic inflammation state of uremic patients, and the increased r...
journal_title:BMC nephrology
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12882-016-0405-5
更新日期:2016-11-25 00:00:00