Angiotensin converting enzyme inhibition increases ADMA concentration in patients on maintenance hemodialysis--a randomized cross-over study.

Abstract:

BACKGROUND:Endothelial dysfunction occurs in patients with end-stage renal disease (ESRD) and is associated with increased cardiovascular morbidity and mortality. Asymmetric dimethylarginine (ADMA) contributes to endothelial dysfunction in ESRD. In the general population, angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARBs) decrease ADMA levels, but no study has compared the effect of these drugs in patients with ESRD on maintenance hemodialysis (MHD). METHODS:We evaluated the effect of 1-week treatment with ramipril (5 mg/d), valsartan (160 mg/d), and placebo on ADMA levels in 15 patients on MHD in a double-blind, placebo-controlled, three x three cross-over study. RESULTS:We found that ADMA levels were increased at baseline and throughout the dialysis session during ramipril treatment (p < 0.001 compared to both, placebo and valsartan). Ramipril did not increase ADMA levels in a study of patients without ESRD, suggesting that factors related to ESRD or hemodialysis contribute to the ACE inhibitor-induced increase in ADMA. We have previously shown that ACE inhibition increases bradykinin (BK) levels during hemodialysis. We therefore evaluated the effect of bradykinin on ADMA production in A549 cells; a cell line that expresses BK receptors. Incubation with BK increased intracellular ADMA concentration through BK B2-receptor stimulation. CONCLUSION:These data indicate that short-term ACE inhibition increases ADMA in patients on MHD whereas ARBs do not. In vitro studies further suggest that this may occur through BK-mediated increase in ADMA production during ACE inhibition. TRIAL REGISTRATION:Clinicaltrials.gov NCT00732069 August 6 2008 and NCT00607672 February 4 2008.

journal_name

BMC Nephrol

journal_title

BMC nephrology

authors

Gamboa JL,Pretorius M,Sprinkel KC,Brown NJ,Ikizler TA

doi

10.1186/s12882-015-0162-x

subject

Has Abstract

pub_date

2015-10-22 00:00:00

pages

167

issn

1471-2369

pii

10.1186/s12882-015-0162-x

journal_volume

16

pub_type

杂志文章,随机对照试验
  • Citrate confers less filter-induced complement activation and neutrophil degranulation than heparin when used for anticoagulation during continuous venovenous haemofiltration in critically ill patients.

    abstract:BACKGROUND:During continuous venovenous haemofiltration (CVVH), regional anticoagulation with citrate may be superior to heparin in terms of biocompatibility, since heparin as opposed to citrate may activate complement (reflected by circulating C5a) and induce neutrophil degranulation in the filter and myeloperoxidase ...

    journal_title:BMC nephrology

    pub_type: 杂志文章,随机对照试验

    doi:10.1186/1471-2369-15-19

    authors: Schilder L,Nurmohamed SA,ter Wee PM,Paauw NJ,Girbes AR,Beishuizen A,Beelen RH,Groeneveld AB

    更新日期:2014-01-17 00:00:00

  • Factors associated with Health-Related Quality of Life in Kidney Transplant Recipients in France.

    abstract:BACKGROUND:Health-Related Quality of Life (HRQoL) assessment after kidney transplantation has become an important tool in evaluating outcomes. This study aims to identify the associated factors with HRQoL among a representative sample size of Kidney Transplant Recipients (KTR) at the time of their inclusion in the stud...

    journal_title:BMC nephrology

    pub_type: 杂志文章,多中心研究

    doi:10.1186/s12882-018-0893-6

    authors: Mouelhi Y,Jouve E,Alessandrini M,Pedinielli N,Moal V,Meurette A,Cassuto E,Mourad G,Durrbach A,Dussol B,Gentile S

    更新日期:2018-04-27 00:00:00

  • Determination of vancomycin and gentamicin clearance in an in vitro, closed loop dialysis system.

    abstract:BACKGROUND:The purpose of this study was to evaluate the feasibility of utilizing an in-vitro, closed loop hemodialysis system as a method to assess drug clearance. Secondarily, this study tested the influence of variables (blood flow rate, dialysate flow rate, and type of filter) in the hemodialysis procedure on the c...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/1471-2369-15-204

    authors: Jang SM,Cardone KE,Nolin TD,Mason DL,Grabe DW

    更新日期:2014-12-20 00:00:00

  • Urine concentration ability is reduced to the same degree in adult dominant polycystic kidney disease compared with other chronic kidney diseases in the same CKD-stage and lower THAN in healthy control subjects - a CASE control study.

    abstract:BACKGROUND:Concentration of the urine is primarily regulated via vasopressin dependent aquaporin-2 water channels in the apical membrane of kidney principal cells. It is unclear whether urine concentration ability in ADPKD differs from other patients with similar degree of impaired renal function (non-ADPKD patients). ...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-020-02043-w

    authors: Malmberg MH,Mose FH,Pedersen EB,Bech JN

    更新日期:2020-08-31 00:00:00

  • Efficacy of an internet-based tool for improving physician knowledge of chronic kidney disease: an observational study.

    abstract:BACKGROUND:Early recognition and management of chronic kidney disease (CKD) are associated with better outcomes. Internal medicine residency should prepare physicians to diagnose and manage CKD. METHODS:To examine whether residency training and program characteristics were associated with CKD knowledge and investigate...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/1471-2369-13-126

    authors: Estrella MM,Sisson SD,Roth J,Choi MJ

    更新日期:2012-09-27 00:00:00

  • Fractional excretion of IgG in idiopathic membranous nephropathy with nephrotic syndrome: a predictive marker of risk and drug responsiveness.

    abstract:BACKGROUND:Treatment of idiopathic membranous nephropathy with nephrotic syndrome is still controversial. There is currently little known about the clinical use of renal biomarkers which may explain contradictory results obtained from clinical trials. In order to assess whether IgG-uria can predict the outcome in membr...

    journal_title:BMC nephrology

    pub_type: 临床试验,杂志文章

    doi:10.1186/1471-2369-15-74

    authors: Bazzi C,Rizza V,Casellato D,Tofik R,Berg AL,Gallieni M,D'Amico G,Bakoush O

    更新日期:2014-05-08 00:00:00

  • Polycystic kidney disease in patients on the renal transplant waiting list: trends in hematocrit and survival.

    abstract:BACKGROUND:The patient characteristics and mortality associated with autosomal dominant polycystic kidney disease (PKD) have not been characterized for a national sample of end stage renal disease (ESRD) patients on the renal transplant waiting list. METHODS:40,493 patients in the United States Renal Data System who w...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/1471-2369-3-7

    authors: Abbott KC,Agodoa LY

    更新日期:2002-08-23 00:00:00

  • Mutational analysis of AGXT in two Chinese families with primary hyperoxaluria type 1.

    abstract:BACKGROUND:Primary hyperoxaluria type 1 is a rare autosomal recessive disease of glyoxylate metabolism caused by a defect in the liver-specific peroxisomal enzyme alanine:glyoxylate aminotransferase (AGT) that leads to hyperoxaluria, recurrent urolithiasis, and nephrocalcinosis. METHODS:Two unrelated patients with rec...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/1471-2369-15-92

    authors: Li GM,Xu H,Shen Q,Gong YN,Fang XY,Sun L,Liu HM,An Y

    更新日期:2014-06-17 00:00:00

  • Low dose of mycophenolate mofetil is enough in desensitized kidney transplantation using rituximab.

    abstract:BACKGROUND:Rituximab is widely used in kidney transplantation. However, it is not clear whether the conventional doses of maintenance immunosuppressant in rituximab-treated kidney transplantation (KT) are appropriate. In our previous study, decreasing mycophenolate mofetil (MMF) dose due to infection did not increase t...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-015-0201-7

    authors: Baek CH,Kim H,Yu H,Shin E,Cho H,Yang WS,Han DJ,Park SK

    更新日期:2015-12-04 00:00:00

  • PR3 vasculitis presenting with symptomatic splenic and renal infarction: a case report and literature review.

    abstract:BACKGROUND:ANCA-associated vasculitis is a life-threatening, systemic autoimmune disease. There is an increased risk of organ infarction but in many cases this is asymptomatic. We described here the first reported case of PR3 vasculitis presenting with symptomatic bilateral renal wedge infarction. CASE PRESENTATION:A ...

    journal_title:BMC nephrology

    pub_type: 杂志文章,评审

    doi:10.1186/s12882-019-1266-5

    authors: Bottomley MJ,Gibson M,Alchi B

    更新日期:2019-03-06 00:00:00

  • Effect of 3% saline and furosemide on biomarkers of kidney injury and renal tubular function and GFR in healthy subjects - a randomized controlled trial.

    abstract:BACKGROUND:Chloride is speculated to have nephrotoxic properties. In healthy subjects we tested the hypothesis that acute chloride loading with 3% saline would induce kidney injury, which could be prevented with the loop-diuretic furosemide. METHODS:The study was designed as a randomized, placebo-controlled, crossover...

    journal_title:BMC nephrology

    pub_type: 杂志文章,随机对照试验

    doi:10.1186/s12882-019-1342-x

    authors: Mose FH,Jörgensen AN,Vrist MH,Ekelöf NP,Pedersen EB,Bech JN

    更新日期:2019-06-03 00:00:00

  • A novel model of reno-cardiac syndrome in the C57BL/ 6 mouse strain.

    abstract:BACKGROUND:The end stage renal disease population has a 20 fold higher incidence of cardiovascular mortality compared to the overall population. The development of reno-cardiac syndrome in these patients will result in cardiovascular events to be the cause of 50% of fatalities. There is therefore a need to research imp...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-018-1155-3

    authors: Kieswich JE,Chen J,Alliouachene S,Caton PW,McCafferty K,Thiemermann C,Yaqoob MM

    更新日期:2018-12-04 00:00:00

  • Serum cystatin C is a determinant of central pressure augmentation index measured by oscillometric method in renal transplant recipients.

    abstract:BACKGROUND:Serum cystatin C (ScysC) may help predicting cardiovascular outcome not only through its ability to detect renal dysfunction but also through its potential connection to others factors that are directly related to cardiovascular diseases. We explored the potential association of ScysC with arterial stiffness...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/1471-2369-15-196

    authors: Dinic M,Maillard N,Thibaudin D,Jannot M,Masson I,Alamartine E,Mariat C

    更新日期:2014-12-11 00:00:00

  • Designing a web-application to support home-based care of childhood CKD stages 3-5: qualitative study of family and professional preferences.

    abstract:BACKGROUND:There is a lack of online, evidence-based information and resources to support home-based care of childhood CKD stages 3-5. METHODS:Qualitative interviews were undertaken with parents, patients and professionals to explore their views on content of the proposed online parent information and support (OPIS) w...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/1471-2369-15-34

    authors: Swallow VM,Hall AG,Carolan I,Santacroce S,Webb NJ,Smith T,Hanif N

    更新日期:2014-02-18 00:00:00

  • Serum lactate level and mortality in metformin-associated lactic acidosis requiring renal replacement therapy: a systematic review of case reports and case series.

    abstract:BACKGROUND:The current practice concerning timing, mode, and dose of renal replacement therapy (RRT) in patients with metformin-associated lactic acidosis (MALA) with renal failure remains unknown. To investigate whether serum lactate level and prescription pattern of RRT are associated with mortality in patients with ...

    journal_title:BMC nephrology

    pub_type: 杂志文章,评审

    doi:10.1186/s12882-017-0640-4

    authors: Yeh HC,Ting IW,Tsai CW,Wu JY,Kuo CC

    更新日期:2017-07-10 00:00:00

  • Red urine, updated for the nephrologist: a case report.

    abstract:BACKGROUND:Sickle cell trait is not completely benign, and some renal complications can occur. The baseline rate of admission for gross hematuria in normal males carrying the sickle cell trait is 2%. CASE PRESENTATION:A 35-year-old non-smoking African man experienced a 2-week history of painless, profuse and persisten...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-018-0939-9

    authors: Le Joncour A,Mesnard L,Hertig A,Robert T

    更新日期:2018-06-08 00:00:00

  • Association between 24-hour blood pressure variability and chronic kidney disease: a cross-sectional analysis of African Americans participating in the Jackson heart study.

    abstract:BACKGROUND:Studies suggest 24-h blood pressure (BP) variability has prognostic value for cardiovascular disease. Several factors associated with high 24-h BP variability are also common among individuals with chronic kidney disease (CKD). We hypothesized 24-h BP variability would be higher for individuals with versus w...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-015-0085-6

    authors: Tanner RM,Shimbo D,Dreisbach AW,Carson AP,Fox ER,Muntner P

    更新日期:2015-06-18 00:00:00

  • IL17A and IL17F genes polymorphisms are associated with histopathological changes in transplanted kidney.

    abstract:BACKGROUND:Interleukin 17 is a proinflammatory cytokine involved in immune response after allograft transplantation. IL-17 family of proinflammatory cytokines includes IL-17A and IL-17F. Previous studies have demonstrated that the rs2275913 IL17A and the rs11465553 IL17F gene polymorphism are associated with kidney all...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-019-1308-z

    authors: Domanski L,Kłoda K,Patrzyk M,Wisniewska M,Safranow K,Sienko J,Sulikowski T,Staniszewska M,Pawlik A

    更新日期:2019-04-08 00:00:00

  • Lanthanum carbonate for the treatment of hyperphosphatemia in CKD 5D: multicenter, double blind, randomized, controlled trial in mainland China.

    abstract:BACKGROUND:Serum phosphorus control is critical for chronic kidney disease (CKD) 5D patients. Currently, clinical profile for an oral phosphorus binder in the mainland Chinese population is not available. OBJECTIVE:To establish the efficacy, safety, and tolerability of lanthanum carbonate in CKD 5D patients. DESIGN:M...

    journal_title:BMC nephrology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1186/1471-2369-14-29

    authors: Xu J,Zhang YX,Yu XQ,Liu ZH,Wang LN,Chen JH,Fan YP,Ni ZH,Wang M,Yuan FH,Ding GH,Chen XM,Zhang AP,Mei CL

    更新日期:2013-02-04 00:00:00

  • Gaps and barriers in health-care provision for co-morbid diabetes and chronic kidney disease: a cross-sectional study.

    abstract:BACKGROUND:Patients with diabetes and chronic kidney disease (CKD) are a complex subset of the growing number of patients with diabetes, due to multi-morbidity. Gaps between recommended and received care for diabetes and chronic kidney disease (CKD) are evident despite promulgation of guidelines. Here, we document gaps...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-017-0493-x

    authors: Lo C,Teede H,Fulcher G,Gallagher M,Kerr PG,Ranasinha S,Russell G,Walker R,Zoungas S

    更新日期:2017-02-28 00:00:00

  • Renal disease and accidental falls: a review of published evidence.

    abstract:BACKGROUND:The pathogenesis of falling is complex, and identification of risk factors may be essential for prevention. The relationship between renal disease and falls is unclear, and the goal of this study was to collect the available evidence and investigate the relationship between accidental falls and renal dysfunc...

    journal_title:BMC nephrology

    pub_type: 杂志文章,评审

    doi:10.1186/s12882-015-0173-7

    authors: López-Soto PJ,De Giorgi A,Senno E,Tiseo R,Ferraresi A,Canella C,Rodríguez-Borrego MA,Manfredini R,Fabbian F

    更新日期:2015-10-29 00:00:00

  • Effect of tolvaptan on renal water and sodium excretion and blood pressure during nitric oxide inhibition: a dose-response study in healthy subjects.

    abstract:BACKGROUND:Tolvaptan is a selective vasopressin receptor antagonist. Nitric Oxide (NO) promotes renal water and sodium excretion, but the effect is unknown in the nephron's principal cells. In a dose-response study, we measured the effect of tolvaptan on renal handling of water and sodium and systemic hemodynamics, dur...

    journal_title:BMC nephrology

    pub_type: 杂志文章,随机对照试验

    doi:10.1186/s12882-017-0501-1

    authors: Al Therwani S,Rosenbæk JB,Mose FH,Bech JN,Pedersen EB

    更新日期:2017-03-13 00:00:00

  • Risk factors for chronic kidney disease in Japan: a community-based study.

    abstract:BACKGROUND:Chronic kidney disease (CKD) is increasingly being recognized as a predictor for both end-stage renal disease and cardiovascular disease. The present study, conducted on individuals from a community in Arita, Japan, was designed to evaluate biomarkers that can be used to determine the associated factors for ...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/1471-2369-10-34

    authors: Takamatsu N,Abe H,Tominaga T,Nakahara K,Ito Y,Okumoto Y,Kim J,Kitakaze M,Doi T

    更新日期:2009-10-27 00:00:00

  • IgM monoclonal gammopathy with heavy-and-light-chain amyloidosis resembling fibrillary glomerulonephritis determined by tandem mass spectrometry: a case report.

    abstract:BACKGROUND:Fibrillary glomerulonephritis (FGN) is distinguished from amyloidosis by thicker fibrils and the lack of staining with histochemical dyes typically reactive with amyloid. However, congophilic FGN has been proposed recently and adding laser microdissection followed by mass spectrometry (LMD/MS) to conventiona...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-020-01851-4

    authors: Adachi M,Kitamura M,Muta K,Maekawa A,Uramatsu T,Tadokoro M,Funakoshi S,Hisano S,Kuwahara N,Shimizu A,Mukae H,Nishino T

    更新日期:2020-05-24 00:00:00

  • Acute bilateral emphysematous pyelonephritis successfully managed by medical therapy alone: a case report and review of the literature.

    abstract:BACKGROUND:Bilateral emphysematous pyelonephritis is a life threatening condition usually occurring in diabetics. Management of this condition has traditionally been aggressive and surgery is considered mandatory. However, this is itself a hazardous intervention in a septic, unstable patient with circulatory or liver f...

    journal_title:BMC nephrology

    pub_type: 杂志文章,评审

    doi:10.1186/1471-2369-3-4

    authors: Flores G,Nellen H,Magaña F,Calleja J

    更新日期:2002-06-03 00:00:00

  • Renal arteriography with endovascular ultrasound for the management of renal infarction patients.

    abstract:BACKGROUND:Renal infarction (RI) is a rare disease with poor prognosis. Appropriate secondary prevention treatment is essential and requires an exhaustive etiological assessment. We aimed to determine whether invasive endovascular explorations may improve the diagnostic process and change the secondary prevention treat...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-020-01929-z

    authors: Ivanes F,Dewaele J,Touboul C,Gatault P,Sautenet B,Barbet C,Büchler M,Quilliet L,Angoulvant D,Halimi JM

    更新日期:2020-07-14 00:00:00

  • Body weight definitions for evaluating a urinary diagnosis of acute kidney injury in patients with sepsis.

    abstract:BACKGROUND:We hypothesized that the use of actual body weight might lead to more frequent misdiagnosis of acute kidney injury (AKI) than when ideal body weight is used in underweight and/or obese patients. We examined which definition of body weight is most effective in establishing a urinary diagnosis of AKI in septic...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-018-0895-4

    authors: Katayama S,Koyama K,Goto Y,Koinuma T,Tonai K,Shima J,Wada M,Nunomiya S

    更新日期:2018-05-02 00:00:00

  • Increased blood pressure in adult offspring of families with Balkan endemic nephropathy: a prospective study.

    abstract:BACKGROUND:Previous studies have linked smaller kidney dimensions to increased blood pressure. However, patients with Balkan Endemic Nephropathy (BEN), whose kidneys shrink during the course of the disease, do not manifest increased blood pressure. The authors evaluated the relationship between kidney cortex width, kid...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/1471-2369-7-12

    authors: Dimitrov PS,Simeonov VA,Tsolova SD,Bonev AG,Georgieva RB,Karmaus WJ

    更新日期:2006-08-23 00:00:00

  • Health-related quality of life and all-cause mortality in patients with diabetes on dialysis.

    abstract:BACKGROUND:This study tests the hypotheses that health-related quality of life (HRQOL) in prevalent dialysis patients with diabetes is lower than in dialysis patients without diabetes, and is at least as poor as diabetic patients with another severe complication, i.e. foot ulcers. This study also explores the mortality...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/1471-2369-13-78

    authors: Osthus TB,von der Lippe N,Ribu L,Rustøen T,Leivestad T,Dammen T,Os I

    更新日期:2012-08-03 00:00:00

  • Inadequate dietary energy intake associates with higher prevalence of metabolic syndrome in different groups of hemodialysis patients: a clinical observational study in multiple dialysis centers.

    abstract:BACKGROUND:Metabolic syndrome (MetS) has been established as a risk for cardiovascular diseases and mortality in hemodialysis patients. Energy intake (EI) is an important nutritional therapy for preventing MetS. We examined the association of self-reported dietary EI with metabolic abnormalities and MetS among hemodial...

    journal_title:BMC nephrology

    pub_type: 杂志文章,多中心研究

    doi:10.1186/s12882-018-1041-z

    authors: Duong TV,Wong TC,Chen HH,Chen TW,Chen TH,Hsu YH,Peng SJ,Kuo KL,Liu HC,Lin ET,Wang CS,Tseng IH,Feng YW,Chang TY,Su CT,Yang SH

    更新日期:2018-09-19 00:00:00