Abstract:
BACKGROUND:Vancomycin is the first-line antibiotic for methicillin-resistant Staphylococcus aureus and coagulase-negative strains. The risk of vancomycin-induced acute kidney injury increases with plasma vancomycin levels. Vancomycin-induced acute kidney injury is histologically characterized by acute interstitial nephritis and/or acute tubular necrosis. However, only 12 biopsy-proven cases of vancomycin-induced acute kidney injury have been reported so far, as renal biopsy is rarely performed for such cases. Current recommendations for the prevention or treatment of vancomycin-induced acute kidney injury are drug monitoring of plasma vancomycin levels using trough level and drug withdrawal. Oral prednisone and high-flux haemodialysis have led to the successful recovery of renal function in some biopsy-proven cases. CASE PRESENTATION:We present the case of a 41-year-old man with type 1 diabetes mellitus, who developed vancomycin-induced acute kidney injury during treatment for Fournier gangrene. His serum creatinine level increased to 1020.1 μmol/L from a baseline of 79.6 μmol/L, and his plasma trough level of vancomycin peaked at 80.48 μg/mL. Vancomycin discontinuation and frequent haemodialysis with high-flux membrane were immediately performed following diagnosis. Renal biopsy showed acute tubular necrosis and focal acute interstitial nephritis, mainly in the medullary rays (medullary ray injury). There was no sign of glomerulonephritis, but mild diabetic changes were detected. He was discharged without continuing haemodialysis (serum creatinine level, 145.0 μmol/L) 49 days after initial vancomycin administration. CONCLUSIONS:This case suggests that frequent haemodialysis and renal biopsy could be useful for the treatment and assessment of vancomycin-induced acute kidney injury, particularly in high-risk cases or patients with other renal disorders.
journal_name
BMC Nephroljournal_title
BMC nephrologyauthors
Sawada A,Kawanishi K,Morikawa S,Nakano T,Kodama M,Mitobe M,Taneda S,Koike J,Ohara M,Nagashima Y,Nitta K,Mochizuki Tdoi
10.1186/s12882-018-0845-1subject
Has Abstractpub_date
2018-03-27 00:00:00pages
72issue
1issn
1471-2369pii
10.1186/s12882-018-0845-1journal_volume
19pub_type
杂志文章,评审相关文献
BMC Nephrology文献大全abstract:BACKGROUND:Bioimpedance analysis (BIA) has been reported as helpful in identifying hypervolemia. Observation data showed that hypervolemic maintenance hemodialysis (MHD) patients identified using BIA methods have higher mortality risk. However, it is not known if BIA-guided fluid management can improve MHD patients' su...
journal_title:BMC nephrology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/1471-2369-13-120
更新日期:2012-09-25 00:00:00
abstract:BACKGROUND:Primary nephrotic syndrome (PNS) is a common glomerular disease in children. T cell dysfunction plays a crucial role in the pathogenesis of PNS. Moreover, dysbiosis of gut microbiota contributes to immunological disorders. Whether the initial therapy of PNS affects gut microbiota remains an important questio...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-019-1615-4
更新日期:2019-11-26 00:00:00
abstract:BACKGROUND:The end stage renal disease population has a 20 fold higher incidence of cardiovascular mortality compared to the overall population. The development of reno-cardiac syndrome in these patients will result in cardiovascular events to be the cause of 50% of fatalities. There is therefore a need to research imp...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-018-1155-3
更新日期:2018-12-04 00:00:00
abstract:BACKGROUND:Early recognition and management of chronic kidney disease (CKD) are associated with better outcomes. Internal medicine residency should prepare physicians to diagnose and manage CKD. METHODS:To examine whether residency training and program characteristics were associated with CKD knowledge and investigate...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/1471-2369-13-126
更新日期:2012-09-27 00:00:00
abstract:BACKGROUND:The possibility of clearing Cell-free Plasma Hemoglobin (CPH) from human plasma may appear attractive, especially when considering the noxious effects that CPH has on the immune function and the renal damage caused by its filtration. The existence of the so-called High Cut-Off (HCO) filters, possessing pores...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-018-1051-x
更新日期:2018-10-04 00:00:00
abstract:BACKGROUND:Until now, no long-term studies relating serum albumin level to mortality rate in prevalent haemodialysis (HD) patients have been conducted. We aimed to examine the association between serum albumin level and mortality over a 5-year period. METHODS:This study included 781 patients who received maintenance H...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-016-0332-5
更新日期:2016-08-20 00:00:00
abstract:BACKGROUND:Nephrotic syndrome (NS) is pathological condition characterized by heavy proteinuria. Our study investigates hypothesis that change in cell proliferation of proximal tubules influences primary cilia structure and function and promotes cystogenesis in congenital nephrotic syndrome of the Finnish type (CNF) an...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/1471-2369-15-3
更新日期:2014-01-08 00:00:00
abstract:BACKGROUND:Membranous nephropathy (MN) has been recognized to occur in patients with human immunodeficiency virus (HIV) infection since the beginning of the HIV epidemic. The prevalence of phospholipase A2 receptor (PLA2R)-associated MN in this group has not been well studied. METHODS:We conducted a retrospective revi...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-020-02042-x
更新日期:2020-09-18 00:00:00
abstract:BACKGROUND:It remained lack of a kind of contrast-induced acute kidney injury (CI-AKI) model which was widely used in clinical practice and comparable to CI-AKI in humans. METHODS:Fifty Sprague-Dawley rats were divided into five groups of 10 rats each: (1) sham group (normal saline [NS] + NS); (2) NS plus low osmolali...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-019-1436-5
更新日期:2019-07-04 00:00:00
abstract:BACKGROUND:Hepatocyte growth factor (HGF) counteracts peritoneal fibrosis in animal models and in-vitro studies, but no study explored effluent HGF in peritoneal dialysis (PD) patients with ultrafiltration failure (UFF). Our aim was to assess the relationship between effluent HGF with UF profile, free water transport (...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/1471-2369-15-201
更新日期:2014-12-17 00:00:00
abstract:BACKGROUND:Hyperchloremia is common in critically ill septic patients. The impact of hyperchloremia on the incidence of acute kidney injury (AKI) is not well studied. We investigated the association between hyperchloremia and AKI within the first 72 h of intensive care unit (ICU) admission. METHODS:6490 ICU adult pati...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-017-0750-z
更新日期:2017-12-02 00:00:00
abstract:BACKGROUND:Icodextrin is a starch-derived, water soluble glucose polymer, which is used as an alternative to glucose in order to enhance dialytic fluid removal in peritoneal dialysis patients. Although the safety and efficacy of icodextrin is well-established, its use in everyday clinical practice has been associated w...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-018-1071-6
更新日期:2018-10-25 00:00:00
abstract:BACKGROUND:Studies suggest 24-h blood pressure (BP) variability has prognostic value for cardiovascular disease. Several factors associated with high 24-h BP variability are also common among individuals with chronic kidney disease (CKD). We hypothesized 24-h BP variability would be higher for individuals with versus w...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-015-0085-6
更新日期:2015-06-18 00:00:00
abstract:BACKGROUND:To identify patient and health system characteristics associated with late referral of patients with chronic kidney disease to nephrologists. METHODS:MEDLINE, CENTRAL, and CINAHL were searched using the appropriate MESH terms in March 2007. Two reviewers individually and in duplicate reviewed the abstracts ...
journal_title:BMC nephrology
pub_type: 杂志文章,评审
doi:10.1186/1471-2369-9-3
更新日期:2008-02-25 00:00:00
abstract:BACKGROUND:Severe renal manifestation of systemic lupus erythematosus (SLE) is not uncommon and is associated with an indeterminate prognosis. Complete remission can be obtained, however, at least in the young when chronic lesions are absent and adequate anti-inflammatory therapy is immediately initiated. CASE PRESENT...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/1471-2369-13-81
更新日期:2012-08-06 00:00:00
abstract:BACKGROUND:Combined peritoneal dialysis (PD) and hemodialysis (HD) therapy (combined therapy) has numerous clinical benefits and should be emphasized for PD patients encountering technique failure. METHODS:This 12-year nationwide retrospective study was conducted to compare long-term outcomes (including admission and ...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-020-01989-1
更新日期:2020-08-15 00:00:00
abstract:BACKGROUND:The aim of the study was to assess the association between chronic kidney disease (CKD) and obesity in predicting CKD among Chinese adults, distinguishing between 5 different adiposity indices: visceral fat index (VFI), percentage body fat (PBF), body mass index (BMI), waist circumference (WC) and waist-to-h...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-018-0837-1
更新日期:2018-02-17 00:00:00
abstract:BACKGROUND:To measure health-related and care-related quality of life among informal caregivers of older people with end-stage kidney disease (ESKD), and to determine the association between caregiver quality of life and care recipient's treatment type. METHODS:A prospective cross-sectional study was conducted. Three ...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-020-01830-9
更新日期:2020-05-04 00:00:00
abstract:BACKGROUND:Kidney impairment constitutes severe risk for cardiovascular disease, stroke and all-cause mortality, and early identification and prevention of kidney impairment is critical to effective management of prognostic risk in community residents. Previous studies have validated that carotid-femoral pulse wave vel...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-018-0897-2
更新日期:2018-05-02 00:00:00
abstract:BACKGROUND:Patients with an impaired renal function show a high incidence of bone and mineral disturbances. These 'chronic kidney disease - mineral and bone disorders' (CKD-MBD) range from high turnover osteoporosis to adynamic bone disease. Currently, the histomorphometric analysis of a bone biopsy taken from the ilia...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-017-0550-5
更新日期:2017-04-13 00:00:00
abstract:BACKGROUND:Lower serum bicarbonate, mainly due to the modern Western-style diet, and renal hyperfiltration (RHF) are both independently associated with higher mortality in the general population with preserved renal function. The objective of this study was to evaluate the association between serum bicarbonate and RHF....
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-015-0218-y
更新日期:2016-01-06 00:00:00
abstract:BACKGROUND:The optimal revascularization strategy for patients with impaired glomerular filtration rate (IGFR) has not been established in acute coronary syndrome (ACS). We investigated the prognosis and impact of IGFR and invasive strategy on the cardiovascular outcomes in the ACS population. METHODS:In a Taiwan nati...
journal_title:BMC nephrology
pub_type: 杂志文章,多中心研究
doi:10.1186/1471-2369-15-66
更新日期:2014-04-23 00:00:00
abstract:BACKGROUND:To establish a model of chronic renal fibrosis following acute kidney injury (AKI) in BALB/c mice and to observe the effect of AKI on podocyte injury and chronic fibrosis of the kidney. Additional aims included using the model to explore the role of podocyte injury in AKI and post-injury fibrosis. METHODS:F...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-019-1298-x
更新日期:2019-03-28 00:00:00
abstract:BACKGROUND:Transplant renal artery dissection is a rare and serious event that can cause allograft dysfunction and activation of the renin-mediated renovascular hypertension. Most cases are induced by percutaneous transluminal angioplasty, arteriosclerotic disease, or fibromuscular dysplasia. We observed a case of tran...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-020-1699-x
更新日期:2020-01-29 00:00:00
abstract:BACKGROUND:Complementary and Alternative Medicines (CAMs) are increasingly practiced in the general population; it is estimated that over 30% of patients with chronic diseases use CAMs on a regular basis. CAMs are also used in hospital settings, suggesting a growing interest in individualized therapies. One potential f...
journal_title:BMC nephrology
pub_type: 杂志文章,评审
doi:10.1186/1471-2369-14-129
更新日期:2013-06-21 00:00:00
abstract:BACKGROUND:FGF23 controls serum l,25(OH)2D3 levels and phosphate homeostasis. This study evaluates the effects of ferritin on intact PTH, FGF23, and l,25(OH)2D3 in patients with major thalassemia. It also evaluates FGF23 changes in patients with hypoparathyroidism to clarify the interaction between FGF23 and PTH in the...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-020-02101-3
更新日期:2020-11-16 00:00:00
abstract:BACKGROUND:Bordetella pertussis infection is a known trigger of atypical hemolytic uremic syndrome (HUS). For patients suspected of having atypical HUS, prompt plasma exchange/infusion (PE/PI) or eculizumab (ECZ) treatment is recommended. CASE PRESENTATION:We report a 1-month-old female infant who was admitted with a ...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-018-1168-y
更新日期:2018-12-17 00:00:00
abstract:BACKGROUND:Chronic kidney disease (CKD) with edema is a common clinical problem resulting from defects in water and solute excretion. Furosemide is the drug of choice for treatment. In theory, good perfusion and albumin are required for the furosemide to be secreted at the tubular lumen. Thus, in the situation of low g...
journal_title:BMC nephrology
pub_type: 杂志文章,随机对照试验
doi:10.1186/1471-2369-13-92
更新日期:2012-08-29 00:00:00
abstract:BACKGROUND:Accurately determining renal function is essential for clinical management of HIV patients. Classically, it has been evaluated by estimating glomerular filtration rate (eGFR) with the MDRD-equation, but today there is evidence that the new Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation ...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/s12882-017-0470-4
更新日期:2017-02-10 00:00:00
abstract:BACKGROUND:Polycystic Kidney Disease (PKD) kidneys exhibit increased extracellular matrix (ECM) collagen expression and metalloproteinases (MMPs) activity. We investigated the role of these increases on cystic disease progression in PKD kidneys. METHODS:We examined the role of type I collagen (collagen I) and membrane...
journal_title:BMC nephrology
pub_type: 杂志文章
doi:10.1186/1471-2369-13-109
更新日期:2012-09-11 00:00:00