Identification of biomarkers and pathways in hypertensive nephropathy based on the ceRNA regulatory network.

abstract：BACKGROUND:Klotho is a transmembrane protein acting as a co-receptor for FGF-23 and thus exerts clinical actions on mineral metabolism. The association of secreted Klotho with outcomes in CKD patients is unclear. This study examined the relation between plasma Klotho and cardiovascular events in dialysis patients, acco...

journal_title：BMC nephrology

authors： Memmos E,Sarafidis P,Pateinakis P,Tsiantoulas A,Faitatzidou D,Giamalis P,Vasilikos V,Papagianni A

更新日期：2019-06-11 00:00:00

abstract：BACKGROUND:The current practice concerning timing, mode, and dose of renal replacement therapy (RRT) in patients with metformin-associated lactic acidosis (MALA) with renal failure remains unknown. To investigate whether serum lactate level and prescription pattern of RRT are associated with mortality in patients with ...

journal_title：BMC nephrology

authors： Yeh HC,Ting IW,Tsai CW,Wu JY,Kuo CC

更新日期：2017-07-10 00:00:00

abstract：BACKGROUND:Cryofibrinogenemia is a rare disorder that mainly affects the skin and occasionally the kidney. However, there are few published reports of cryofibrinogenemia-associated renal pathology. We therefore report a patient with cryofibrinogen-associated glomerulonephritis. Samples from this patient were examined b...

journal_title：BMC nephrology

authors： Ibuki E,Shiraishi A,Sofue T,Kushida Y,Kadota K,Honda K,Kang D,Joh K,Minamino T,Haba R

更新日期：2020-01-29 00:00:00

abstract：BACKGROUND:The purpose of this study was to evaluate the feasibility of utilizing an in-vitro, closed loop hemodialysis system as a method to assess drug clearance. Secondarily, this study tested the influence of variables (blood flow rate, dialysate flow rate, and type of filter) in the hemodialysis procedure on the c...

journal_title：BMC nephrology

authors： Jang SM,Cardone KE,Nolin TD,Mason DL,Grabe DW

更新日期：2014-12-20 00:00:00

abstract：BACKGROUND:Liddle's syndrome is a rare monogenic form of hypertension caused by truncating or missense mutations in the C termini of the epithelial sodium channel (ENaC) β or γ subunits. Patients with this syndrome present with early onset of hypertension, hypokalemia, metabolic alkalosis, hyporeninemia and hypoaldoste...

journal_title：BMC nephrology

authors： Yamaguchi E,Yoshikawa K,Nakaya I,Kato K,Miyasato Y,Nakagawa T,Kakizoe Y,Mukoyama M,Soma J

更新日期：2018-05-23 00:00:00

abstract：BACKGROUND:Fabry disease (FD) is an X-linked lysosomal storage disorder caused by mutations of the GLA gene, followed by deficiency in α-galactosidase A (α-gal) activity. Nephrotic syndrome, as the renal phenotype of FD, is unusual. Here, we report the rare case of a patient with FD with nephrotic syndrome whose protei...

journal_title：BMC nephrology

authors： Fujisawa H,Nakayama Y,Nakao S,Yamamoto R,Kurokawa Y,Nakamura N,Nagata A,Tsukimura T,Togawa T,Sakuraba H,Fukami K

更新日期：2019-12-17 00:00:00

abstract：BACKGROUND:S100A12 protein is an endogenous receptor ligand for advanced glycation end products. In this study, the plasma S100A12 level was assessed as an independent predictor of mortality, and its utility in clinical settings was examined. METHODS:In a previous cross-sectional study, plasma S100A12 levels were meas...

journal_title：BMC nephrology

authors： Shiotsu Y,Mori Y,Nishimura M,Hatta T,Imada N,Maki N,Iida K,Iwamoto N,Matsuoka E,Tamagaki K,Kosaki A

更新日期：2013-01-16 00:00:00

abstract：BACKGROUND:Early recognition and management of chronic kidney disease (CKD) are associated with better outcomes. Internal medicine residency should prepare physicians to diagnose and manage CKD. METHODS:To examine whether residency training and program characteristics were associated with CKD knowledge and investigate...

journal_title：BMC nephrology

authors： Estrella MM,Sisson SD,Roth J,Choi MJ

更新日期：2012-09-27 00:00:00

abstract：BACKGROUND:Serum phosphorus control is critical for chronic kidney disease (CKD) 5D patients. Currently, clinical profile for an oral phosphorus binder in the mainland Chinese population is not available. OBJECTIVE:To establish the efficacy, safety, and tolerability of lanthanum carbonate in CKD 5D patients. DESIGN:M...

journal_title：BMC nephrology

authors： Xu J,Zhang YX,Yu XQ,Liu ZH,Wang LN,Chen JH,Fan YP,Ni ZH,Wang M,Yuan FH,Ding GH,Chen XM,Zhang AP,Mei CL

更新日期：2013-02-04 00:00:00

abstract：BACKGROUND:Inflammatory processes are very important in the development of kidney disease. Nevertheless, the association between white blood cell (WBC) count and the risk of renal dysfunction has not been well-established, especially in subjects without chronic kidney disease (CKD). Our study investigated the associati...

journal_title：BMC nephrology

authors： Fan F,Jia J,Li J,Huo Y,Zhang Y

更新日期：2017-06-07 00:00:00

abstract：BACKGROUND:Neutrophil gelatinase associated lipocalin (NGAL) is a highly predictive biomarker of acute kidney injury. To understand the role of NGAL in renal injury during sepsis, we investigated the temporal changes and biological sources of NGAL in a rat model of acute kidney injury, and explored the relationship bet...

journal_title：BMC nephrology

authors： Han M,Li Y,Liu M,Li Y,Cong B

更新日期：2012-06-27 00:00:00

abstract：BACKGROUND:Several equations have been developed to estimate glomerular filtration rate (eGFR). The common equations used were derived from populations predominantly comprised of Caucasians with chronic kidney disease (CKD). Some of the equations provide a correction factor for African-Americans due to their relatively...

journal_title：BMC nephrology

authors： Omuse G,Maina D,Mwangi J,Wambua C,Kanyua A,Kagotho E,Amayo A,Ojwang P,Erasmus R

更新日期：2017-12-20 00:00:00

abstract：BACKGROUND:Adult patients with minimal change nephrotic syndrome (MCNS) are often associated with acute kidney injury (AKI). To assess the mechanisms of AKI, we examined whether tubular cell injuries unique to MCNS patients exist. METHODS:We performed a retrospective analysis of clinical data and tubular cell changes ...

journal_title：BMC nephrology

authors： Fujigaki Y,Tamura Y,Nagura M,Arai S,Ota T,Shibata S,Kondo F,Yamaguchi Y,Uchida S

更新日期：2017-11-28 00:00:00

abstract：BACKGROUND:Depression and frailty contribute to the adverse clinical outcome of peritoneal dialysis (PD) patients. However, the interaction between depression and frailty in PD patients remains uncertain. We determined the prevalence of depression and frailty in prevalent Chinese PD patients, dissected the internal rel...

journal_title：BMC nephrology

authors： Chan GC,Ng JK,Chow KM,Kwan BC,Kwong VW,Pang WF,Cheng PM,Law MC,Leung CB,Li PK,Szeto CC

更新日期：2020-08-05 00:00:00

abstract：BACKGROUND:Membranous nephropathy (MN) has been recognized to occur in patients with human immunodeficiency virus (HIV) infection since the beginning of the HIV epidemic. The prevalence of phospholipase A2 receptor (PLA2R)-associated MN in this group has not been well studied. METHODS:We conducted a retrospective revi...

journal_title：BMC nephrology

authors： Charu V,Andeen N,Walavalkar V,Lapasia J,Kim JY,Lin A,Sibley R,Higgins J,Troxell M,Kambham N

更新日期：2020-09-18 00:00:00

abstract：BACKGROUND:To study the incidence of vancomycin-associated acute kidney injury (VA-AKI) in Hong Kong and identify risk factors for VA-AKI. METHOD:Patients with vancomycin prescription and blood level measurement in 2012-2016 were identified using the Hong Kong Hospital Authority Clinical Data Analysis and Reporting Sy...

journal_title：BMC nephrology

authors： Qin X,Tsoi MF,Zhao X,Zhang L,Qi Z,Cheung BMY

更新日期：2020-02-03 00:00:00

abstract：BACKGROUND:Previous studies have not described the relationship between reducing radial artery diameter as well as increasing age and functional maturation of the radio-cephalic arteriovenous fistula (RCAVF) and no data identify these as linear relationship. The objective of this study was to perform trend analysis to ...

journal_title：BMC nephrology

authors： Wan ZM,Hu B,Lai QQ,Gao XJ,Tu B,Zhou Y,Zhao WB

更新日期：2020-06-22 00:00:00

abstract：BACKGROUND:Reproductive function in women with end stage renal disease generally improves after kidney transplant. However, pregnancy remains challenging due to the risk of adverse clinical outcomes. METHODS:We searched PubMed/MEDLINE, Elsevier EMBASE, Scopus, BIOSIS Previews, ISI Science Citation Index Expanded, and ...

journal_title：BMC nephrology

authors： Shah S,Venkatesan RL,Gupta A,Sanghavi MK,Welge J,Johansen R,Kean EB,Kaur T,Gupta A,Grant TJ,Verma P

更新日期：2019-01-23 00:00:00

abstract：BACKGROUND:Metabolic acidosis leads to chronic kidney disease (CKD) progression. The guidelines recommend a lower limit of serum bicarbonate level, but no upper limit. For serum bicarbonate level to be clinically useful as a therapeutic target marker, it is necessary to investigate the target serum bicarbonate level wi...

journal_title：BMC nephrology

authors： Kanda E,Ai M,Yoshida M,Kuriyama R,Shiigai T

更新日期：2013-01-09 00:00:00

abstract：BACKGROUND:Hypertension is a public health problem with mostly unknown causes, and where strong hereditary genetic alterations have not been fully elucidated. However, the use of experimental models has provided valuable information. Recent evidences suggest that alterations in key nephrogenic factors, such as Wilms' t...

journal_title：BMC nephrology

authors： Mazzei L,García M,Calvo JP,Casarotto M,Fornés M,Abud MA,Cuello-Carrión D,Ferder L,Manucha W

更新日期：2016-03-24 00:00:00

abstract：BACKGROUND:Anaemia is common in haemodialysis (HD) patients and associated with significant morbidity and mortality. Intravenous (IV) iron combined with erythropoiesis-stimulating agents (ESA) is the mainstay treatment of anaemia in these patients. The comparative efficacy and risk of adverse events with IV iron prepar...

journal_title：BMC nephrology

authors： Jesus-Silva JA,Lamplugh A,Dhada S,Burton JO,Bhandari S

更新日期：2020-06-03 00:00:00

abstract：BACKGROUND:The current literature recognises that left ventricular hypertrophy makes a key contribution to the high rate of premature cardiovascular mortality in dialysis patients. Determining how we might intervene to ameliorate left ventricular hypertrophy in dialysis populations has become a research priority. Reduc...

journal_title：BMC nephrology

authors： Dunlop JL,Vandal AC,de Zoysa JR,Gabriel RS,Haloob IA,Hood CJ,Matheson PJ,McGregor DO,Rabindranath KS,Semple DJ,Marshall MR

更新日期：2013-07-15 00:00:00

abstract：BACKGROUND:Serum p-cresyl sulfate (PCS) associates with cardiovascular disease in patients with chronic kidney disease. PCS concentrations are determined by intestinal uptake of p-cresol, human metabolism to PCS and renal clearance. Whether intestinal uptake of p-cresol itself is directly associated with cardiovascular...

journal_title：BMC nephrology

authors： Poesen R,Viaene L,Verbeke K,Augustijns P,Bammens B,Claes K,Kuypers D,Evenepoel P,Meijers B

更新日期：2014-06-09 00:00:00

abstract：BACKGROUND:The effect of chronic hepatitis B virus (HBV) infection on the risk of chronic kidney disease (CKD) is controversial. We examined the prospective association between hepatitis B surface antigen (HBsAg) serology status and incident CKD in a large cohort of men and women. METHODS:Cohort study of 299,913 adult...

journal_title：BMC nephrology

authors： Hong YS,Ryu S,Chang Y,Caínzos-Achirica M,Kwon MJ,Zhao D,Shafi T,Lazo M,Pastor-Barriuso R,Shin H,Cho J,Guallar E

更新日期：2018-12-11 00:00:00

abstract：BACKGROUND:Lower serum bicarbonate, mainly due to the modern Western-style diet, and renal hyperfiltration (RHF) are both independently associated with higher mortality in the general population with preserved renal function. The objective of this study was to evaluate the association between serum bicarbonate and RHF....

journal_title：BMC nephrology

authors： Park M,So R,Joo KW,Yoon HJ

更新日期：2016-01-06 00:00:00

abstract：BACKGROUND:Adherence to phosphate binder treatment is important to prevent high serum phosphate level in chronic dialysis patients. We therefore wanted to investigate patient knowledge, beliefs about and adherence to phosphate binders among these patients and assess whether one-to-one pharmacist-led education and couns...

journal_title：BMC nephrology

authors： Hjemås BJ,Bøvre K,Mathiesen L,Lindstrøm JC,Bjerknes K

更新日期：2019-05-17 00:00:00

abstract：BACKGROUND:Endothelial dysfunction occurs in patients with end-stage renal disease (ESRD) and is associated with increased cardiovascular morbidity and mortality. Asymmetric dimethylarginine (ADMA) contributes to endothelial dysfunction in ESRD. In the general population, angiotensin-converting enzyme (ACE) inhibitors ...

journal_title：BMC nephrology

authors： Gamboa JL,Pretorius M,Sprinkel KC,Brown NJ,Ikizler TA

更新日期：2015-10-22 00:00:00

abstract：:This paper describes the 30-year experience on nutritional management of non-dialysis dependent chronic kidney disease (CKD) patients in a public outpatient clinic located in the city of São Paulo, Brazil. A team of specialized dietitians in renal nutrition is responsible to provide individual dietary counseling for p...

journal_title：BMC nephrology

authors： Cuppari L,Nerbass FB,Avesani CM,Kamimura MA

更新日期：2016-07-16 00:00:00

abstract：BACKGROUND:Diabetic nephropathy (DN) is a primary complication of diabetes mellitus (DM). The pathology of DN is still vague, and diagnostic accuracy is not enough. This study was performed to identify miRNAs and genes that have possibilities of being used as therapeutic targets for DN in type 2 DM. METHODS:Human miRN...

journal_title：BMC nephrology

authors： Yu Y,Jia YY,Wang M,Mu L,Li HJ

更新日期：2021-01-12 00:00:00

abstract：BACKGROUND:Local renal ischemia is regarded as an important factor in the development of contrast-induced nephropathy (CIN). Mannose-binding lectin (MBL) is involved in the tissue damage during experimental ischemia/reperfusion injury of the kidneys. The aim of the present study was to investigate the association of MB...

journal_title：BMC nephrology

authors： Osthoff M,Piezzi V,Klima T,Christ A,Marana I,Hartwiger S,Breidthardt T,Marenzi G,Trendelenburg M,Mueller C

更新日期：2012-09-03 00:00:00