The relationships between exogenous and endogenous antioxidants with the lipid profile and oxidative damage in hemodialysis patients.

Abstract:

BACKGROUND:We sought to investigate the relationships among the plasma levels of carotenoids, tocopherols, endogenous antioxidants, oxidative damage and lipid profiles and their possible effects on the cardiovascular risk associated with hemodialysis (HD) patients. METHODS:The study groups were divided into HD and healthy subjects. Plasma carotenoid, tocopherol and malondialdehyde (MDA) levels, as well as erythrocyte reduced glutathione (GSH), were measured by HPLC. Blood antioxidant enzymes, kidney function biomarkers and the lipid profiles were analyzed by spectrophotometric methods. RESULTS:Plasma lycopene levels and blood glutathione peroxidase (GPx) activity were significantly decreased in HD patients compared with healthy subjects. Total cholesterol, low-density lipoprotein cholesterol (LDL-c), creatinine, urea, MDA, GSH, superoxide dismutase (SOD) and catalase (CAT) were significantly increased in HD (p < 0.05). Lycopene levels were correlated with MDA (r = -0.50; p < 0.01), LDL-c (r = -0.38; p = 0.01) levels, the LDL-c/HDL-c index (r = -0.33; p = 0.03) and GPx activity (r = 0.30; p = 0.03). Regression models showed that lycopene levels were correlated with LDL-c (β estimated = -31.59; p = 0.04), while gender was correlated with the TC/HDL-c index and triglycerides. Age did not present a correlation with the parameters evaluated. GPx activity was negatively correlated with MDA levels and with the LDL-c/HDL-c and CT/HDL-c indexes. CONCLUSIONS:Lycopene may represent an additional factor that contributes to reduced lipid peroxidation and atherogenesis in hemodialysis patients.

journal_name

BMC Nephrol

journal_title

BMC nephrology

authors

Roehrs M,Valentini J,Paniz C,Moro A,Charão M,Bulcão R,Freitas F,Brucker N,Duarte M,Leal M,Burg G,Grune T,Garcia SC

doi

10.1186/1471-2369-12-59

subject

Has Abstract

pub_date

2011-10-26 00:00:00

pages

59

issn

1471-2369

pii

1471-2369-12-59

journal_volume

12

pub_type

杂志文章
  • Evaluation of potential drug- drug interactions among Palestinian hemodialysis patients.

    abstract:BACKGROUND:The aims of this study are to find the prevalence of potential drug-drug interactions (DDIs) in patients with Hemodialysis and identify factors associated with these interactions if present. METHODS:The study was an observational- retrospective cohort study that was conducted in ten hemodialysis units in th...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-016-0317-4

    authors: Al-Ramahi R,Raddad AR,Rashed AO,Bsharat A,Abu-Ghazaleh D,Yasin E,Shehab O

    更新日期:2016-07-26 00:00:00

  • Reference values for glomerular filtration rate in healthy Brazilian adults.

    abstract:BACKGROUND:Glomerular filtration rate (GFR) is the best index of renal function, but age, gender and ethnicity can putatively affect its values. The aim of this study was to establish reference values for GFR in healthy Brazilian subjects while taking these factors into account. METHODS:In this cross-sectional study, ...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/1471-2369-14-54

    authors: Soares AA,Prates AB,Weinert LS,Veronese FV,de Azevedo MJ,Silveiro SP

    更新日期:2013-02-28 00:00:00

  • Vitamin D deficiency may predict a poorer outcome of IgA nephropathy.

    abstract:BACKGROUND:Experimental studies showed that 25-hydroxy-vitamin D [25(OH)D] deficiency (defined as 25-hydroxy-vitamin D < 15 ng/ml) has been associated with CKD progression. Patients with IgA nephropathy have an exceptionally high rate of severe 25(OH)D deficiency; however, it is not known whether this deficiency is a r...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-016-0378-4

    authors: Li XH,Huang XP,Pan L,Wang CY,Qin J,Nong FW,Luo YZ,Wu Y,Huang YM,Peng X,Yang ZH,Liao YH

    更新日期:2016-11-02 00:00:00

  • Quality of life among patients with moderate to advanced chronic kidney disease in Ghana - a single centre study.

    abstract:BACKGROUND:The prevalence of chronic kidney disease (CKD) is increasing worldwide and in Africa. Health related quality of life (QOL) has become an essential outcome measure for patients with CKD and end stage renal disease (ESRD). There is growing interest worldwide in QOL of CKD patients but paucity of data in Ghana....

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-019-1316-z

    authors: Tannor EK,Norman BR,Adusei KK,Sarfo FS,Davids MR,Bedu-Addo G

    更新日期:2019-04-08 00:00:00

  • Prevalence and correlates of cognitive impairment in kidney transplant recipients.

    abstract:BACKGROUND:There is a high prevalence of cognitive impairment in dialysis patients. The prevalence of cognitive impairment after kidney transplantation is unknown. METHODS:Study Design: Cross-sectional study. SETTING AND PARTICIPANTS:Single center study of prevalent kidney transplant recipients from a transplant clin...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-017-0570-1

    authors: Gupta A,Mahnken JD,Johnson DK,Thomas TS,Subramaniam D,Polshak T,Gani I,John Chen G,Burns JM,Sarnak MJ

    更新日期:2017-05-12 00:00:00

  • Seroprevalence of Streptococcal Inhibitor of Complement (SIC) suggests association of streptococcal infection with chronic kidney disease.

    abstract:BACKGROUND:Group A streptococcus (GAS) is an etiological agent for the immune mediated sequela post streptococcal glomerulonephritis (PSGN). In some populations PSGN is recognized as a risk factor for chronic kidney disease (CKD) and end-stage renal disease (ESRD). It was found that a significantly greater proportion o...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/1471-2369-14-101

    authors: Karmarkar MG,Hule GP,Hase NK,Mehta PR,Walter SR,Sriprakash KS

    更新日期:2013-05-06 00:00:00

  • Genetic predisposition to acute kidney injury--a systematic review.

    abstract:BACKGROUND:The risk of an individual to develop an acute kidney injury (AKI), or its severity, cannot be reliably predicted by common clinical risk factors. Whether genetic risk factors have an explanatory role poses an interesting question, however. Thus, we conducted a systematic literature review regarding genetic p...

    journal_title:BMC nephrology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1186/s12882-015-0190-6

    authors: Vilander LM,Kaunisto MA,Pettilä V

    更新日期:2015-12-02 00:00:00

  • Validation of two prediction models of undiagnosed chronic kidney disease in mixed-ancestry South Africans.

    abstract:BACKGROUND:Chronic kidney disease (CKD) is a global challenge. Risk models to predict prevalent undiagnosed CKD have been published. However, none was developed or validated in an African population. We validated the Korean and Thai CKD prediction model in mixed-ancestry South Africans. METHODS:Discrimination and cali...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-015-0093-6

    authors: Mogueo A,Echouffo-Tcheugui JB,Matsha TE,Erasmus RT,Kengne AP

    更新日期:2015-07-04 00:00:00

  • High serum bicarbonate level within the normal range prevents the progression of chronic kidney disease in elderly chronic kidney disease patients.

    abstract:BACKGROUND:Metabolic acidosis leads to chronic kidney disease (CKD) progression. The guidelines recommend a lower limit of serum bicarbonate level, but no upper limit. For serum bicarbonate level to be clinically useful as a therapeutic target marker, it is necessary to investigate the target serum bicarbonate level wi...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/1471-2369-14-4

    authors: Kanda E,Ai M,Yoshida M,Kuriyama R,Shiigai T

    更新日期:2013-01-09 00:00:00

  • Icodextrin-associated generalized exfoliative skin rash in a CAPD patient: a case-report.

    abstract:BACKGROUND:Icodextrin is a starch-derived, water soluble glucose polymer, which is used as an alternative to glucose in order to enhance dialytic fluid removal in peritoneal dialysis patients. Although the safety and efficacy of icodextrin is well-established, its use in everyday clinical practice has been associated w...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-018-1071-6

    authors: Liakopoulos V,Georgianos PI,Demirtzi P,Vaios V,Kalathas T,Zebekakis PE

    更新日期:2018-10-25 00:00:00

  • Clinical pharmacy activities in chronic kidney disease and end-stage renal disease patients: a systematic literature review.

    abstract:BACKGROUND:Chronic kidney disease (CKD) and end-stage renal disease (ESRD) represent worldwide health problems with an epidemic extent. Therefore, attention must be given to the optimisation of patient care, as gaps in the care of CKD and ESRD patients are well documented. As part of a multidisciplinary patient care st...

    journal_title:BMC nephrology

    pub_type: 杂志文章,评审

    doi:10.1186/1471-2369-12-35

    authors: Stemer G,Lemmens-Gruber R

    更新日期:2011-07-22 00:00:00

  • End-stage kidney disease due to haemolytic uraemic syndrome--outcomes in 241 consecutive ANZDATA registry cases.

    abstract:BACKGROUND:The aim of this study was to investigate the characteristics and outcomes of patients receiving renal replacement therapy for end-stage kidney disease (ESKD) secondary to haemolytic uraemic syndrome (HUS). METHODS:The study included all patients with ESKD who commenced renal replacement therapy in Australia...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/1471-2369-13-164

    authors: Tang W,Mohandas J,McDonald SP,Hawley CM,Badve SV,Boudville N,Brown FG,Clayton PA,Wiggins KJ,Bannister KM,Campbell SB,Johnson DW

    更新日期:2012-12-03 00:00:00

  • The association of dialysis adequacy, body mass index, and mortality among hemodialysis patients.

    abstract:BACKGROUND:Although hemodialysis (HD) adequacy, single-pool Kt/Vurea (spKt/V), is inversely correlated with body size, each is known to affect patient survival in the same direction. Therefore, we sought to examine the relationship between HD adequacy and mortality according to body mass index (BMI) in HD patients and ...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-019-1570-0

    authors: Hong WP,Lee YJ

    更新日期:2019-10-22 00:00:00

  • Suboptimal medical care of patients with ST-elevation myocardial infarction and renal insufficiency: results from the Korea Acute Myocardial Infarction Registry.

    abstract:BACKGROUND:The clinical outcomes of ST-segment elevation myocardial infarction (STEMI) are poor in patients with renal insufficiency. This study investigated changes in the likelihood that patients received optimal medical care throughout the entire process of myocardial infarction management, on the basis of their glo...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/1471-2369-13-110

    authors: Choi JS,Kim CS,Bae EH,Ma SK,Jeong MH,Kim YJ,Cho MC,Kim CJ,Kim SW

    更新日期:2012-09-11 00:00:00

  • Prognostic utility of plasma S100A12 levels to establish a novel scoring system for predicting mortality in maintenance hemodialysis patients: a two-year prospective observational study in Japan.

    abstract:BACKGROUND:S100A12 protein is an endogenous receptor ligand for advanced glycation end products. In this study, the plasma S100A12 level was assessed as an independent predictor of mortality, and its utility in clinical settings was examined. METHODS:In a previous cross-sectional study, plasma S100A12 levels were meas...

    journal_title:BMC nephrology

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1186/1471-2369-14-16

    authors: Shiotsu Y,Mori Y,Nishimura M,Hatta T,Imada N,Maki N,Iida K,Iwamoto N,Matsuoka E,Tamagaki K,Kosaki A

    更新日期:2013-01-16 00:00:00

  • Estimation of renal function by CKD-EPI versus MDRD in a cohort of HIV-infected patients: a cross-sectional analysis.

    abstract:BACKGROUND:Accurately determining renal function is essential for clinical management of HIV patients. Classically, it has been evaluated by estimating glomerular filtration rate (eGFR) with the MDRD-equation, but today there is evidence that the new Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation ...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-017-0470-4

    authors: Cristelli MP,Cofán F,Rico N,Trullàs JC,Manzardo C,Agüero F,Bedini JL,Moreno A,Oppenheimer F,Miro JM,CKD-H. Clinic Investigators.

    更新日期:2017-02-10 00:00:00

  • Medical treatment for an isolated renal multilocular hydatid cyst in an elderly: a case report.

    abstract:BACKGROUND:Almost all cases of renal hydatid cysts need surgical intervention for treatment. We report a case of isolated renal hydatid cyst treated successfully only with medical therapy. CASE PRESENTATION:This case is a 79-year-old veterinarian presented with right flank pain, hydatiduria and positive echinococcus g...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-020-02064-5

    authors: Moghtadaie A,Yazdi SAM,Mohraz M,Asefi H,Razeghi E

    更新日期:2020-10-08 00:00:00

  • Patient's and physician's awareness of kidney disease in coronary heart disease patients - a cross-sectional analysis of the German subset of the EUROASPIRE IV survey.

    abstract:BACKGROUND:Chronic kidney disease (CKD) is a common comorbid condition in coronary heart disease (CHD). CKD predisposes the patient to acute kidney injury (AKI) during hospitalization. Data on awareness of kidney dysfunction among CHD patients and their treating physicians are lacking. In the current cross-sectional an...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-017-0730-3

    authors: Wagner M,Wanner C,Schich M,Kotseva K,Wood D,Hartmann K,Fette G,Rücker V,Oezkur M,Störk S,Heuschmann PU

    更新日期:2017-10-25 00:00:00

  • Relationship between history of coronary heart disease at dialysis initiation and onset of events associated with heart disease: a propensity-matched analysis of a prospective cohort study.

    abstract:BACKGROUND:Chronic kidney disease (CKD) is an independent risk factor for cardiovascular disease (CVD) events, and a number of reports have shown a relationship between CKD and CVD in pre-dialysis or maintenance dialysis patients. However, few studies have reported serial observations during dialysis initiation and mai...

    journal_title:BMC nephrology

    pub_type: 临床试验,杂志文章

    doi:10.1186/s12882-017-0495-8

    authors: Inaguma D,Koide S,Takahashi K,Hayashi H,Hasegawa M,Yuzawa Y

    更新日期:2017-02-28 00:00:00

  • Total kidney and liver volume is a major risk factor for malnutrition in ambulatory patients with autosomal dominant polycystic kidney disease.

    abstract:BACKGROUND:In patients with autosomal dominant polycystic kidney disease (ADPKD), malnutrition may develop as renal function declines and the abdominal organs become enlarged. We investigated the relationship of intra-abdominal mass with nutritional status. METHODS:This cross-sectional study was performed at a tertiar...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-016-0434-0

    authors: Ryu H,Kim H,Park HC,Kim H,Cho EJ,Lee KB,Chung W,Oh KH,Cho JY,Hwang YH,Ahn C

    更新日期:2017-01-14 00:00:00

  • Association of anaemia in primary care patients with chronic kidney disease: cross sectional study of quality improvement in chronic kidney disease (QICKD) trial data.

    abstract:BACKGROUND:Anaemia is a known risk factor for cardiovascular disease and treating anaemia in chronic kidney disease (CKD) may improve outcomes. However, little is known about the scope to improve primary care management of anaemia in CKD. METHODS:An observational study (N = 1,099,292) with a nationally representative ...

    journal_title:BMC nephrology

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1186/1471-2369-14-24

    authors: Dmitrieva O,de Lusignan S,Macdougall IC,Gallagher H,Tomson C,Harris K,Desombre T,Goldsmith D

    更新日期:2013-01-25 00:00:00

  • Periodontal disease and chronic kidney disease among Aboriginal adults; an RCT.

    abstract:BACKGROUND:This study will assess measures of vascular health and inflammation in Aboriginal Australian adults with chronic kidney disease (CKD), and determine if intensive periodontal intervention improves cardiovascular health, progression of renal disease and periodontal health over a 24-month follow-up. METHODS:Th...

    journal_title:BMC nephrology

    pub_type: 杂志文章,随机对照试验

    doi:10.1186/s12882-015-0169-3

    authors: Jamieson L,Skilton M,Maple-Brown L,Kapellas K,Askie L,Hughes J,Arrow P,Cherian S,Fernandes D,Pawar B,Brown A,Boffa J,Hoy W,Harris D,Mueller N,Cass A

    更新日期:2015-10-31 00:00:00

  • Understanding acute kidney injury in low resource settings: a step forward.

    abstract::Attention has recently been focused on addressing the problem of acute kidney injury in both the developed and developing world. Little information is actually available on the incidence and management of AKI in low resource settings. Thus, the paper by Bagasha in the current issue of BMC Nephrology makes an important...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/1471-2369-16-5

    authors: Anand S,Cruz DN,Finkelstein FO

    更新日期:2015-01-16 00:00:00

  • A comparative study of bone biopsies from the iliac crest, the tibial bone, and the lumbar spine.

    abstract:BACKGROUND:Patients with an impaired renal function show a high incidence of bone and mineral disturbances. These 'chronic kidney disease - mineral and bone disorders' (CKD-MBD) range from high turnover osteoporosis to adynamic bone disease. Currently, the histomorphometric analysis of a bone biopsy taken from the ilia...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-017-0550-5

    authors: Hiller RG,Patecki M,Neunaber C,Reifenrath J,Kielstein JT,Kielstein H

    更新日期:2017-04-13 00:00:00

  • Dietary acid load and chronic kidney disease among adults in the United States.

    abstract:BACKGROUND:Diet can markedly affect acid-base status and it significantly influences chronic kidney disease (CKD) and its progression. The relationship of dietary acid load (DAL) and CKD has not been assessed on a population level. We examined the association of estimated net acid excretion (NAE(es)) with CKD; and soci...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/1471-2369-15-137

    authors: Banerjee T,Crews DC,Wesson DE,Tilea A,Saran R,Rios Burrows N,Williams DE,Powe NR,Centers for Disease Control and Prevention Chronic Kidney Disease Surveillance Team.

    更新日期:2014-08-24 00:00:00

  • Post-hospitalization dialysis facility processes of care and hospital readmissions among hemodialysis patients: a retrospective cohort study.

    abstract:BACKGROUND:Both dialysis facilities and hospitals are accountable for 30-day hospital readmissions among U.S. hemodialysis patients. We examined the association of post-hospitalization processes of care at hemodialysis facilities with pulmonary edema-related and other readmissions. METHODS:In a retrospective cohort co...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-018-0983-5

    authors: Plantinga LC,Masud T,Lea JP,Burkart JM,O'Donnell CM,Jaar BG

    更新日期:2018-07-31 00:00:00

  • PR3 vasculitis presenting with symptomatic splenic and renal infarction: a case report and literature review.

    abstract:BACKGROUND:ANCA-associated vasculitis is a life-threatening, systemic autoimmune disease. There is an increased risk of organ infarction but in many cases this is asymptomatic. We described here the first reported case of PR3 vasculitis presenting with symptomatic bilateral renal wedge infarction. CASE PRESENTATION:A ...

    journal_title:BMC nephrology

    pub_type: 杂志文章,评审

    doi:10.1186/s12882-019-1266-5

    authors: Bottomley MJ,Gibson M,Alchi B

    更新日期:2019-03-06 00:00:00

  • Trends in anemia care in non-dialysis-dependent chronic kidney disease (CKD) patients in the United States (2006-2015).

    abstract:BACKGROUND:The objective of the study was to examine overall anemia management trends in non-dialysis patients with chronic kidney disease (CKD) from 2006 to 2015, and to evaluate the impact of Trial to Reduced Cardiovascular Events with Ananesp Therapy (TREAT)'s study results (October 2009) and the US Food and Drug Ad...

    journal_title:BMC nephrology

    pub_type: 杂志文章

    doi:10.1186/s12882-018-1119-7

    authors: Park H,Liu X,Henry L,Harman J,Ross EA

    更新日期:2018-11-09 00:00:00

  • Fractional excretion of IgG in idiopathic membranous nephropathy with nephrotic syndrome: a predictive marker of risk and drug responsiveness.

    abstract:BACKGROUND:Treatment of idiopathic membranous nephropathy with nephrotic syndrome is still controversial. There is currently little known about the clinical use of renal biomarkers which may explain contradictory results obtained from clinical trials. In order to assess whether IgG-uria can predict the outcome in membr...

    journal_title:BMC nephrology

    pub_type: 临床试验,杂志文章

    doi:10.1186/1471-2369-15-74

    authors: Bazzi C,Rizza V,Casellato D,Tofik R,Berg AL,Gallieni M,D'Amico G,Bakoush O

    更新日期:2014-05-08 00:00:00

  • Gitelman-like syndrome after cisplatin therapy: a case report and literature review.

    abstract:BACKGROUND:Cisplatin is a well-known nephrotoxic antineoplastic drug. Chronic hypokalemic metabolic alkalosis with hypomagnesemia and hypocalciuria is one of the rare complications associated with its use. CASE PRESENTATION:A 42-year-old woman presented with a 20 year-history of hypokalemic metabolic alkalosis with hy...

    journal_title:BMC nephrology

    pub_type: 杂志文章,评审

    doi:10.1186/1471-2369-7-10

    authors: Panichpisal K,Angulo-Pernett F,Selhi S,Nugent KM

    更新日期:2006-05-24 00:00:00