Abstract:
:We present three cases with anaphylaxis after injection of a depot corticosteroid. First, the steroid was suspected as the elicitor, but after evaluation the excipient macrogol was found to be the elicitor. One of the patients had reactions to several unrelated drugs. Increased awareness of anaphylaxis to excipients such as macrogols is needed, especially when allergy tests for the active drug is negative and in patients with a history of repeated anaphylaxis to seemingly unrelated drugs. To establish the correct diagnosis it is important to test with the exact formulation of the culprit drug, as well as all the ingredients including excipients.
journal_name
Clin Transl Allergyjournal_title
Clinical and translational allergyauthors
Brandt N,Garvey LH,Bindslev-Jensen U,Kjaer HF,Bindslev-Jensen C,Mortz CGdoi
10.1186/s13601-016-0138-3subject
Has Abstractpub_date
2017-01-10 00:00:00pages
2issn
2045-7022pii
138journal_volume
7pub_type
杂志文章abstract:BACKGROUND:Recently we reported the validation of the "Allergy-Control-SCORE© (ACS)" which assesses symptom severity as well as medication use on three dimensions lung, nose and eyes. The aim of this study was to test the validity of the score for eyes and nose. METHODS:One-hundred-twenty-one consenting subjects (age ...
journal_title:Clinical and translational allergy
pub_type: 杂志文章
doi:10.1186/2045-7022-2-17
更新日期:2012-09-19 00:00:00
abstract:BACKGROUND:Double-blind, placebo-controlled (DBPC) trials are the gold standard for demonstrating clinical efficacy and tolerability. The placebo effect, although an important feature in placebo-controlled studies, has never been systematically investigated in allergen-specific immunotherapy (SIT) studies. This study w...
journal_title:Clinical and translational allergy
pub_type: 杂志文章
doi:10.1186/2045-7022-3-42
更新日期:2013-12-21 00:00:00
abstract::Drug hypersensitivity reactions (DHR) have been present since the advent of drugs. In particular T-cell mediated delayed-type hypersensitivity reactions represent a heterogeneous clinical entity with a diverse pathogenesis and result in a considerable burden of morbidity and mortality not only driven by the reactions ...
journal_title:Clinical and translational allergy
pub_type: 杂志文章,评审
doi:10.1186/s13601-015-0073-8
更新日期:2015-09-03 00:00:00
abstract:Background:Chronic rhinosinusitis with nasal polyps (CRSwNP) is a heterogeneous inflammatory disease usually characterized by chronic eosinophilia in the sinonasal mucosa, which often requires glucocorticoid (GC) therapy. However, the therapeutic response varies markedly between individuals. The objective of this study...
journal_title:Clinical and translational allergy
pub_type: 杂志文章
doi:10.1186/s13601-018-0211-1
更新日期:2018-07-02 00:00:00
abstract:BACKGROUND:The European Academy of Allergy and Clinical Immunology (EAACI) is in the process of developing the EAACI Guidelines for Allergen Immunotherapy (AIT) for IgE-mediated food allergy. We seek to critically assess the effectiveness, cost-effectiveness and safety of AIT in IgE-mediated food allergy. METHODS:We w...
journal_title:Clinical and translational allergy
pub_type: 杂志文章
doi:10.1186/s13601-016-0113-z
更新日期:2016-07-05 00:00:00
abstract:BACKGROUND:With the aim of actively contributing to the ongoing 11(th) International Classification of Diseases (ICD) revision, an international collaboration led by the European Academy of Allergy and Clinical Immunology (EAACI) has decided to revise the classification of hypersensitivity/allergic diseases and to vali...
journal_title:Clinical and translational allergy
pub_type: 杂志文章
doi:10.1186/s13601-015-0063-x
更新日期:2015-06-03 00:00:00
abstract::[This corrects the article DOI: 10.1186/s13601-019-0303-6.]. ...
journal_title:Clinical and translational allergy
pub_type: 已发布勘误
doi:10.1186/s13601-020-00343-w
更新日期:2020-09-28 00:00:00
abstract:Background:In daily practice, one-third of sesame allergic patients, confirmed by clinical history or food challenge, do not show any detectable specific IgE using current diagnostics. Currently used sesame extracts are water-based and therefore lacking hydrophobic proteins like oleosins. Oleosins, the stabilizer of li...
journal_title:Clinical and translational allergy
pub_type: 杂志文章
doi:10.1186/s13601-019-0271-x
更新日期:2019-06-28 00:00:00
abstract:Background:Diagnostic workup of penicillin allergy comprises skin testing with penicillins, and patients are deemed allergic if skin test is positive. However, the literature suggests that skin test-positive patients may be challenge-negative, indicating that the skin test may be falsely positive. Objective:To investi...
journal_title:Clinical and translational allergy
pub_type: 杂志文章
doi:10.1186/s13601-017-0179-2
更新日期:2017-11-17 00:00:00
abstract::On March 29, 2017, a European Summit on the Prevention and Self-Management of Chronic Respiratory Diseases (CRD) was organized by the European Forum for Research and Education in Allergy and Airway Diseases. The event took place in the European Parliament of Brussels and was hosted by MEP David Borrelli and MEP Sirpa ...
journal_title:Clinical and translational allergy
pub_type: 杂志文章,评审
doi:10.1186/s13601-017-0186-3
更新日期:2017-12-27 00:00:00
abstract:BACKGROUND:Little is known about prevalence and risk factors of allergic rhinitis and chronic nasal symptoms among adults in Vietnam. We aimed to estimate the prevalence, risk factor patterns and co-morbidities of allergic rhinitis and chronic nasal symptoms in one urban and one rural area in northern Vietnam. METHODS...
journal_title:Clinical and translational allergy
pub_type: 杂志文章
doi:10.1186/2045-7022-1-7
更新日期:2011-08-11 00:00:00
abstract:Background:Asthma with atopy is often characterized by type 2 inflammation but less progress has been made in defining non-type 2 asthma. We have previously identified a subgroup of young non-atopic asthmatics with perceived food hypersensitivity and poor asthma control. Objective:Our aim was to further characterize t...
journal_title:Clinical and translational allergy
pub_type: 杂志文章
doi:10.1186/s13601-019-0250-2
更新日期:2019-02-22 00:00:00
abstract:BACKGROUND:Cow's milk allergy (CMA) is a common disease in infancy. Early environmental factors are likely to contribute to CMA. It is known that epigenetic gene regulation can be altered by environmental factors. We have set up a proof of concept study, aiming to detect epigenetic associations specific with CMA. METH...
journal_title:Clinical and translational allergy
pub_type: 杂志文章
doi:10.1186/s13601-016-0105-z
更新日期:2016-05-04 00:00:00
abstract::Oral allergy syndrome (OAS) is one of the most common IgE-mediated allergic reactions. It is characterized by a number of symptoms induced by the exposure of the oral and pharyngeal mucosa to allergenic proteins belonging to class 1 or to class 2 food allergens. OAS occurring when patients sensitized to pollens are ex...
journal_title:Clinical and translational allergy
pub_type: 杂志文章,评审
doi:10.1186/s13601-020-00329-8
更新日期:2020-06-17 00:00:00
abstract:Background:Evidence for distinct asthma phenotypes and their overlap is becoming increasingly relevant to identify personalized and targeted therapeutic strategies. In this study, we aimed to describe the overlap of five commonly reported asthma phenotypes in US adults with current asthma and assess its association wit...
journal_title:Clinical and translational allergy
pub_type: 杂志文章
doi:10.1186/s13601-018-0201-3
更新日期:2018-05-04 00:00:00
abstract:BACKGROUND:Indoleamine 2,3-dioxygenase (IDO) is a tryptophan catalyzing enzyme. It has been suggested that it has a role in lower airway allergic inflammations, but its role in allergic rhinitis has not been investigated. OBJECTIVE:Our aim was to evaluate the expression of IDO in the nasal mucosa of allergic rhinitis ...
journal_title:Clinical and translational allergy
pub_type: 杂志文章
doi:10.1186/2045-7022-1-17
更新日期:2011-12-12 00:00:00
abstract::Rhinitis and rhinosinusitis are the two major clinical entities of chronic upper airway disease. Chronic rhinosinusitis (CRS) and allergic rhinitis (AR) affect respectively up to 10 and 30% of the total population, hence being associated with an important socio-economic burden. Different phenotypes of rhinitis and CRS...
journal_title:Clinical and translational allergy
pub_type: 杂志文章,评审
doi:10.1186/s13601-017-0157-8
更新日期:2017-07-12 00:00:00
abstract:BACKGROUND:Suspected penicillin allergy (Pen-A) is often not verified by diagnostic testing. In third line penicillin allergy labels were associated with prescription of broad spectrum antibiotics, hospital stay duration and readmission. OBJECTIVE:Assess the impact of Pen-A labels on antibiotic and health care use in ...
journal_title:Clinical and translational allergy
pub_type: 杂志文章
doi:10.1186/s13601-017-0154-y
更新日期:2017-06-07 00:00:00
abstract::Cosmetics and skin care products for neonates and infants are considered as ''hypoallergenic'', "tested" or ''safe''. Nevertheless, the prevalence of haptens in these products is a matter of concern, since allergic contact dermatitis in children is gaining an importance. We aimed to assess the prevalence of haptens in...
journal_title:Clinical and translational allergy
pub_type: 杂志文章
doi:10.1186/s13601-019-0257-8
更新日期:2019-03-08 00:00:00
abstract:BACKGROUND:The efficacy of Lactobacillus paracasei NCC 2461 in modulating allergic rhinitis was previously evaluated in two exploratory clinical studies. Oral administration with NCC 2461 reduced specific subjective symptoms following nasal provocation tests with controlled grass pollen allergen concentrations. Our aim...
journal_title:Clinical and translational allergy
pub_type: 杂志文章
doi:10.1186/s13601-015-0085-4
更新日期:2015-12-09 00:00:00
abstract:Background:Susceptibility to pepsin digestion of candidate transgene products is regarded an important parameter in the weight-of-evidence approach for allergenicity risk assessment of genetically modified crops. It has been argued that protocols used for this assessment should better reflect physiological conditions e...
journal_title:Clinical and translational allergy
pub_type: 杂志文章
doi:10.1186/s13601-018-0216-9
更新日期:2018-08-10 00:00:00
abstract:BACKGROUND:Subcutaneous immunotherapy with high dose grass pollen (typically microgram quantities) was first described over 100 years ago. This treatment suppresses allergen-induced cutaneous late responses, with lesser effects on early responses. We previously reported that repeated 2-weekly intradermal injections of ...
journal_title:Clinical and translational allergy
pub_type: 杂志文章
doi:10.1186/2045-7022-3-27
更新日期:2013-08-21 00:00:00
abstract:BACKGROUND:For the development of forecasts for seasonal allergic rhinitis symptoms, it is essential to understand the relationship between grass pollen concentrations and the symptoms of grass pollen allergic patients. OBJECTIVE:The aim of this study was to delineate this relationship between seasonal allergic rhinit...
journal_title:Clinical and translational allergy
pub_type: 杂志文章
doi:10.1186/2045-7022-1-18
更新日期:2011-12-21 00:00:00
abstract:Background:Patients with chronic rhinosinusitis with nasal polyps (CRSwNP) and comorbid asthma have more severe disease and are difficult to treat. However, the molecular endotypes associated with CRSwNP with comorbid asthma (CRSwNP + AS) are not clear. This study aimed to investigate the characteristics of type 2 infl...
journal_title:Clinical and translational allergy
pub_type: 杂志文章
doi:10.1186/s13601-020-00332-z
更新日期:2020-07-03 00:00:00
abstract:Background:Pollen is a major cause of allergic respiratory diseases. In Qatar, data on the presence and prevalence of allergenic airborne types of pollen is quite limited. Methods:The study aimed to determine and correlate the most frequently implicated airborne pollen detected by aerobiological monitoring samplers in...
journal_title:Clinical and translational allergy
pub_type: 杂志文章
doi:10.1186/s13601-020-00339-6
更新日期:2020-08-10 00:00:00
abstract::[This corrects the article DOI: 10.1186/s13601-016-0116-9.]. ...
journal_title:Clinical and translational allergy
pub_type: 已发布勘误
doi:10.1186/s13601-016-0135-6
更新日期:2017-02-20 00:00:00
abstract:BACKGROUND:The introduction of whole new foods in a population may lead to sensitization and food allergy. This constitutes a potential public health problem and a challenge to risk assessors and managers as the existing understanding of the pathophysiological processes and the currently available biological tools for ...
journal_title:Clinical and translational allergy
pub_type: 杂志文章,评审
doi:10.1186/s13601-017-0152-0
更新日期:2017-05-12 00:00:00
abstract::Eosinophilic disorders represent a group of pathologic conditions with highly heterogeneous pathophysiology and clinical presentation and variable prognosis, ranging from asymptomatic or mild, to severe and complex cases, with fatal outcome. Interest in this group of disorders has increased during the last two decades...
journal_title:Clinical and translational allergy
pub_type: 杂志文章,评审
doi:10.1186/s13601-019-0277-4
更新日期:2019-07-25 00:00:00
abstract:BACKGROUND:The European Academy of Allergy and Clinical Immunology is developing guidelines about how to prevent and manage food allergy. As part of the guidelines development process, a systematic review is planned to examine published research about the prevention of food allergy. This systematic review is one of sev...
journal_title:Clinical and translational allergy
pub_type: 杂志文章
doi:10.1186/2045-7022-3-10
更新日期:2013-03-28 00:00:00
abstract:BACKGROUND:A drug reaction with eosinophilia and systemic symptoms (DRESS) is a severe T cell mediated hypersensitivity reaction. Relapses of symptoms in the recovery phase are frequent and linked to the reduction of the corticosteroid treatment, to viral reactivations or to the exposure to new drugs. Here, we analyzed...
journal_title:Clinical and translational allergy
pub_type: 杂志文章
doi:10.1186/s13601-020-00359-2
更新日期:2020-11-23 00:00:00