Abstract:
BACKGROUND:For the development of forecasts for seasonal allergic rhinitis symptoms, it is essential to understand the relationship between grass pollen concentrations and the symptoms of grass pollen allergic patients. OBJECTIVE:The aim of this study was to delineate this relationship between seasonal allergic rhinitis symptoms and grass pollen concentrations in the Netherlands. METHODS:Grass pollen allergic patients (n = 80 [2007] - 84 [2008]) were enrolled into the study. They were asked to enter their seasonal allergic rhinitis symptoms (runny nose, sneezing, blocked nose, post nasal drip, and eye symptoms) daily on a scale from 0 to 3 to the study centre either by short message service (SMS) or by internet from May-July 2007 and April-July 2008. Daily pollen counts were used to define the early and the late grass pollen season as the period 'before and during' respectively 'after' the first grass pollen peak (more than 150 pollen/m3). RESULTS:At similar grass pollen concentrations, the daily mean of the individual maximum symptom scores reported in the early season were higher as compared to that reported in the late season [differences of -0.41 (2007) and -0.30 (2008)]. This difference could not be explained by medication use by the patients nor by co-sensitization to birch. CONCLUSIONS:We conclude that seasonal allergic rhinitis symptoms at similar grass pollen concentrations are more severe in the early flowering season as compared to those in the late flowering season. This finding is not only relevant for development of forecasts for seasonal allergic rhinitis symptoms but also for understanding symptom development and planning and analysis of clinical studies.
journal_name
Clin Transl Allergyjournal_title
Clinical and translational allergyauthors
de Weger LA,Beerthuizen T,Gast-Strookman JM,van der Plas DT,Terreehorst I,Hiemstra PS,Sont JKdoi
10.1186/2045-7022-1-18subject
Has Abstractpub_date
2011-12-21 00:00:00pages
18issue
1issn
2045-7022pii
2045-7022-1-18journal_volume
1pub_type
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journal_title:Clinical and translational allergy
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journal_title:Clinical and translational allergy
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journal_title:Clinical and translational allergy
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