The association between airborne pollen monitoring and sensitization in the hot desert climate.

abstract：BACKGROUND:The FOXP3 gene is the master regulator for T regulatory cells and is under tight DNA methylation control at the Treg specific demethylated region (TSDR) in its first intron. This said, methylation of its promoter region, the significance of which is unknown, has also been associated with various immune-relat...

journal_title：Clinical and translational allergy

authors： Bégin P,Schulze J,Baron U,Olek S,Bauer RN,Passerini L,Baccheta R,Nadeau KC

更新日期：2015-10-20 00:00:00

abstract：BACKGROUND:While Health Related Quality of Life has been investigated among children with IgE-mediated food allergy, less is known about quality of life among children with other types of hypersensitivity to food. The aim of this study was to investigate Health Related Quality of Life (HRQL) in children with and withou...

journal_title：Clinical and translational allergy

authors： Strinnholm Å,Hedman L,Winberg A,Jansson SA,Lindh V,Rönmark E

更新日期：2017-07-03 00:00:00

abstract：:Rhinitis and rhinosinusitis are the two major clinical entities of chronic upper airway disease. Chronic rhinosinusitis (CRS) and allergic rhinitis (AR) affect respectively up to 10 and 30% of the total population, hence being associated with an important socio-economic burden. Different phenotypes of rhinitis and CRS...

journal_title：Clinical and translational allergy

authors： De Greve G,Hellings PW,Fokkens WJ,Pugin B,Steelant B,Seys SF

更新日期：2017-07-12 00:00:00

abstract：Background:Blood eosinophil count (BEC) and fractional exhaled nitric oxide (FeNO) concentration are established biomarkers in asthma, associated particularly with the risk of exacerbations. We evaluated the relationship of BEC and FeNO as complementary and independent biomarkers of severe asthma exacerbations. Method...

journal_title：Clinical and translational allergy

authors： Price DB,Bosnic-Anticevich S,Pavord ID,Roche N,Halpin DMG,Bjermer L,Usmani OS,Brusselle G,Ming SWY,Rastogi S

更新日期：2019-08-21 00:00:00

abstract：Background:Diagnostic workup of penicillin allergy comprises skin testing with penicillins, and patients are deemed allergic if skin test is positive. However, the literature suggests that skin test-positive patients may be challenge-negative, indicating that the skin test may be falsely positive. Objective:To investi...

journal_title：Clinical and translational allergy

authors： Tannert LK,Falkencrone S,Mortz CG,Bindslev-Jensen C,Skov PS

更新日期：2017-11-17 00:00:00

abstract：Background:Chronic rhinosinusitis with nasal polyps (CRSwNP) is a heterogeneous inflammatory disease usually characterized by chronic eosinophilia in the sinonasal mucosa, which often requires glucocorticoid (GC) therapy. However, the therapeutic response varies markedly between individuals. The objective of this study...

journal_title：Clinical and translational allergy

authors： Hong H,Wang D,Tan KS,Zheng R,Chen F,Gao W,He H,Shi J,Fan Y,Yang Q,Sun Y

更新日期：2018-07-02 00:00:00

abstract：UNLABELLED: BACKGROUND:The transition to adulthood can be particularly challenging for young people with severe allergies, who must learn to balance personal safety with independent living. Information and support for young people and their families are crucial to successfully managing this transition. We sought to: g...

journal_title：Clinical and translational allergy

authors： Worth A,Regent L,Levy M,Ledford C,East M,Sheikh A

更新日期：2013-01-22 00:00:00

abstract：:[This corrects the article DOI: 10.1186/s13601-019-0303-6.]. ...

journal_title：Clinical and translational allergy

authors： Hox V,Lourijsen E,Jordens A,Aasbjerg K,Agache I,Alobid I,Bachert C,Boussery K,Campo P,Fokkens W,Hellings P,Hopkins C,Klimek L,Mäkelä M,Mösges R,Mullol J,Pujols L,Rondon C,Rudenko M,Toppila-Salmi S,Scadding G,Sch

更新日期：2020-09-28 00:00:00

abstract：BACKGROUND:The European Academy of Allergy and Clinical Immunology is developing guidelines about how to prevent and manage food allergy. As part of the guidelines development process, a systematic review is planned to examine published research about the prevention of food allergy. This systematic review is one of sev...

journal_title：Clinical and translational allergy

authors： de Silva D,Panesar SS,Thusu S,Rader T,Halken S,Muraro A,Sheikh A

更新日期：2013-03-28 00:00:00

abstract：Background:Fungal and bacterial microbiota play an important role in development of asthma. We aim to characterize airway microbiome (mycobiome, bacteriome) and functional genes in asthmatics and controls. Methods:Sputum microbiome of controls, untreated asthma patients and inhaled corticosteroid (ICS) receiving patie...

journal_title：Clinical and translational allergy

authors： Huang C,Yu Y,Du W,Liu Y,Dai R,Tang W,Wang P,Zhang C,Shi G

更新日期：2020-10-22 00:00:00

abstract：Background:Patients with chronic rhinosinusitis with nasal polyps (CRSwNP) and comorbid asthma have more severe disease and are difficult to treat. However, the molecular endotypes associated with CRSwNP with comorbid asthma (CRSwNP + AS) are not clear. This study aimed to investigate the characteristics of type 2 infl...

journal_title：Clinical and translational allergy

authors： Wang M,Bu X,Luan G,Lin L,Wang Y,Jin J,Zhang L,Wang C

更新日期：2020-07-03 00:00:00

abstract：BACKGROUND:The European Academy of Allergy and Clinical Immunology (EAACI) is in the process of developing the EAACI Guidelines for Allergen Immunotherapy (AIT) for IgE-mediated food allergy. We seek to critically assess the effectiveness, cost-effectiveness and safety of AIT in IgE-mediated food allergy. METHODS:We w...

journal_title：Clinical and translational allergy

authors： Dhami S,Nurmatov U,Pajno GB,Fernandez-Rivas M,Muraro A,Roberts G,Akdis C,Alvaro-Lozano M,Beyer K,Bindslev-Jensen C,Burks W,du Toit G,Ebisawa M,Eigenmann P,Knol E,Makela M,Nadeau KC,O'Mahony L,Papadopoulos N,Poulsen

更新日期：2016-07-05 00:00:00

abstract：Background:Evidence for distinct asthma phenotypes and their overlap is becoming increasingly relevant to identify personalized and targeted therapeutic strategies. In this study, we aimed to describe the overlap of five commonly reported asthma phenotypes in US adults with current asthma and assess its association wit...

journal_title：Clinical and translational allergy

authors： Amaral R,Fonseca JA,Jacinto T,Pereira AM,Malinovschi A,Janson C,Alving K

更新日期：2018-05-04 00:00:00

abstract：BACKGROUND:Little is known about prevalence and risk factors of allergic rhinitis and chronic nasal symptoms among adults in Vietnam. We aimed to estimate the prevalence, risk factor patterns and co-morbidities of allergic rhinitis and chronic nasal symptoms in one urban and one rural area in northern Vietnam. METHODS...

journal_title：Clinical and translational allergy

authors： Lâm HT,Văn T Tng N,Ekerljung L,Rönmark E,Lundbäck B

更新日期：2011-08-11 00:00:00

abstract：BACKGROUND:Asthma is a frequent chronic respiratory disease in both children and adults. However, few data on asthma prevalence are available in Portugal. The Portuguese National Asthma Survey is the first nationwide study that uses standardized methods. We aimed to estimate the prevalence of current asthma in the Port...

journal_title：Clinical and translational allergy

authors： Sa-Sousa A,Morais-Almeida M,Azevedo LF,Carvalho R,Jacinto T,Todo-Bom A,Loureiro C,Bugalho-Almeida A,Bousquet J,Fonseca JA

更新日期：2012-08-29 00:00:00

abstract：Background:In severe asthma, high doses of inhaled corticosteroids (ICS) are used in order to achieve clinical and functional control. This study aimed to evaluate lung function in outpatients (children and adolescents) with severe asthma in Brazil, all of whom were treated with high doses of ICS. We evaluated all spir...

journal_title：Clinical and translational allergy

authors： Versiani Nunes Pinheiro de Queiroz M,Gonçalves Alvim C,Cruz ÁA,de Lima Belizário Facury Lasmar LM

更新日期：2017-12-15 00:00:00

abstract：BACKGROUND:Subcutaneous immunotherapy with high dose grass pollen (typically microgram quantities) was first described over 100 years ago. This treatment suppresses allergen-induced cutaneous late responses, with lesser effects on early responses. We previously reported that repeated 2-weekly intradermal injections of ...

journal_title：Clinical and translational allergy

authors： Slovick A,Douiri A,Kelly J,Guerra A,Muir R,Tsioulos K,Murphy C,Shamji MH,Ying S,Durham SR,Till SJ

更新日期：2013-08-21 00:00:00

abstract：BACKGROUND:A drug reaction with eosinophilia and systemic symptoms (DRESS) is a severe T cell mediated hypersensitivity reaction. Relapses of symptoms in the recovery phase are frequent and linked to the reduction of the corticosteroid treatment, to viral reactivations or to the exposure to new drugs. Here, we analyzed...

journal_title：Clinical and translational allergy

authors： Jörg L,Helbling A,Yerly D,Pichler WJ

更新日期：2020-11-23 00:00:00

abstract：BACKGROUND:With the aim of actively contributing to the ongoing 11(th) International Classification of Diseases (ICD) revision, an international collaboration led by the European Academy of Allergy and Clinical Immunology (EAACI) has decided to revise the classification of hypersensitivity/allergic diseases and to vali...

journal_title：Clinical and translational allergy

authors： Tanno LK,Calderon M,Papadopoulos NG,Demoly P,EAACI\/WAO Task force of a Global Classification of Hypersensitivity\/Allergic diseases.

更新日期：2015-06-03 00:00:00

abstract：BACKGROUND:Cow's milk allergy (CMA) is a common disease in infancy. Early environmental factors are likely to contribute to CMA. It is known that epigenetic gene regulation can be altered by environmental factors. We have set up a proof of concept study, aiming to detect epigenetic associations specific with CMA. METH...

journal_title：Clinical and translational allergy

authors： Petrus NCM,Henneman P,Venema A,Mul A,van Sinderen F,Haagmans M,Mook O,Hennekam RC,Sprikkelman AB,Mannens M

更新日期：2016-05-04 00:00:00

abstract：:[This corrects the article DOI: 10.1186/s13601-016-0116-9.]. ...

journal_title：Clinical and translational allergy

authors： Bousquet J,Farrell J,Crooks G,Hellings P,Bel EH,Bewick M,Chavannes NH,de Sousa JC,Cruz AA,Haahtela T,Joos G,Khaltaev N,Malva J,Muraro A,Nogues M,Palkonen S,Pedersen S,Robalo-Cordeiro C,Samolinski B,Strandberg T,Va

更新日期：2017-02-20 00:00:00

abstract：:Drug hypersensitivity reactions (DHR) have been present since the advent of drugs. In particular T-cell mediated delayed-type hypersensitivity reactions represent a heterogeneous clinical entity with a diverse pathogenesis and result in a considerable burden of morbidity and mortality not only driven by the reactions ...

journal_title：Clinical and translational allergy

authors： Schrijvers R,Gilissen L,Chiriac AM,Demoly P

更新日期：2015-09-03 00:00:00

abstract：Background:Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) and erythema multiforme (EM) are immunologically-mediated dermatological disorders commonly triggered by drug exposure and/or other external agents. We aimed to characterise SJS/TEN- and EM-drug-related hospitalisations in a nationwide administrat...

journal_title：Clinical and translational allergy

authors： Sousa-Pinto B,Araújo L,Freitas A,Correia O,Delgado L

更新日期：2018-01-22 00:00:00

abstract：Background:Rhinitis is a common problem within the population. Many subjects with rhinitis also have atopic multimorbidity, such as asthma and eczema. The purpose of this investigation was to compare subjects with only rhinitis to those that have rhinitis, asthma and/or eczema in relation to immunoglobulin E (IgE) sens...

journal_title：Clinical and translational allergy

authors： Blöndal V,Sundbom F,Borres MP,Högman M,Alving K,Malinovschi A,Janson C

更新日期：2020-02-21 00:00:00

abstract：Background:Evidence regarding the clinical effectiveness of mite allergen avoidance for the treatment of asthma is lacking. In previous meta-analyses on mite allergen control, the baseline data were not discussed in detail. This study updates and extends the existing Cochrane review by Gøtzsche and Johansen (Cochrane D...

journal_title：Clinical and translational allergy

authors： van Boven FE,de Jong NW,Braunstahl GJ,Gerth van Wijk R,Arends LR

更新日期：2020-01-06 00:00:00

abstract：BACKGROUND:Double-blind, placebo-controlled (DBPC) trials are the gold standard for demonstrating clinical efficacy and tolerability. The placebo effect, although an important feature in placebo-controlled studies, has never been systematically investigated in allergen-specific immunotherapy (SIT) studies. This study w...

journal_title：Clinical and translational allergy

authors： Narkus A,Lehnigk U,Haefner D,Klinger R,Pfaar O,Worm M

更新日期：2013-12-21 00:00:00

abstract：Background:Susceptibility to pepsin digestion of candidate transgene products is regarded an important parameter in the weight-of-evidence approach for allergenicity risk assessment of genetically modified crops. It has been argued that protocols used for this assessment should better reflect physiological conditions e...

journal_title：Clinical and translational allergy

authors： Akkerdaas J,Totis M,Barnett B,Bell E,Davis T,Edrington T,Glenn K,Graser G,Herman R,Knulst A,Ladics G,McClain S,Poulsen LK,Ranjan R,Rascle JB,Serrano H,Speijer D,Wang R,Pereira Mouriès L,Capt A,van Ree R

更新日期：2018-08-10 00:00:00

abstract：BACKGROUND:The efficacy of Lactobacillus paracasei NCC 2461 in modulating allergic rhinitis was previously evaluated in two exploratory clinical studies. Oral administration with NCC 2461 reduced specific subjective symptoms following nasal provocation tests with controlled grass pollen allergen concentrations. Our aim...

journal_title：Clinical and translational allergy

authors： Nembrini C,Singh A,De Castro CA,Mercenier A,Nutten S

更新日期：2015-12-09 00:00:00

abstract：:Crying combined with miscellaneous gastrointestinal symptoms are typical symptoms of infant with food allergy, but are also common among children with abnormal neurological development. Mutations in KAT6A gene is known to cause a syndrome characterized by developmental delay, hypotonia, cardiac defects, microcephaly, ...

journal_title：Clinical and translational allergy

authors： Elenius V,Lähdesmäki T,Hietala M,Jartti T

更新日期：2017-06-22 00:00:00

abstract：Background:Vitamin D has been reported to be associated with many allergic diseases. There are a limited number of the studies of vitamin D supplementation in patients with chronic spontaneous urticaria (CSU). This study aims to study the relationship between vitamin D and CSU in terms of serum vitamin D levels, and th...

journal_title：Clinical and translational allergy

authors： Tuchinda P,Kulthanan K,Chularojanamontri L,Arunkajohnsak S,Sriussadaporn S

更新日期：2018-12-04 00:00:00