Abstract:
Background:Chronic rhinosinusitis with nasal polyps (CRSwNP) is a heterogeneous inflammatory disease usually characterized by chronic eosinophilia in the sinonasal mucosa, which often requires glucocorticoid (GC) therapy. However, the therapeutic response varies markedly between individuals. The objective of this study was to evaluate the diagnostic values of sinus computed tomography (CT) for GC-sensitivity in patients with CRSwNP. Methods:We conducted a prospective, single-blinded study of 47 consecutive patients with CRSwNP. These patients were given a course of oral prednisone (30 mg daily for 14 days) and subsequently classified into objectively GC-sensitive and -insensitive subgroup according to the change in nasal polyp size score, or subjectively GC-sensitive and -insensitive subgroup according to the change in total nasal symptom score. The following parameters were compared between GC-sensitive and GC-insensitive subgroups: Lund-Mackay scores, olfactory cleft (OC) scores, and blood eosinophil counts and ratio (percentage of the total white blood cells). Results:25/47 (53.2%) and 29/47 (61.7%) patients were objectively and subjectively sensitive to GC therapy, respectively. The OC score and the blood eosinophil counts and ratio in GC-sensitive subgroup were significantly higher than those in GC-insensitive subgroup, defined either objectively or subjectively. Multivariate logistic regression revealed that OC score was independent risk factor for objective or subjective GC-sensitivity. The OC score exhibited comparable accuracy with the blood eosinophil ratio as predictor of objective and subjective GC-sensitivity (the OC score AUC = 0.775 and 0.829, respectively). A OC score of 3.5 could act as a reliable indicator for predicting the clinical response to GC therapy in CRSwNP. Conclusion:Our prospective findings validate the potential value of sinus CT scan in predicting GC-sensitivity in CRSwNP patients.
journal_name
Clin Transl Allergyjournal_title
Clinical and translational allergyauthors
Hong H,Wang D,Tan KS,Zheng R,Chen F,Gao W,He H,Shi J,Fan Y,Yang Q,Sun Ydoi
10.1186/s13601-018-0211-1subject
Has Abstractpub_date
2018-07-02 00:00:00pages
24issn
2045-7022pii
211journal_volume
8pub_type
杂志文章abstract:BACKGROUND:The FOXP3 gene is the master regulator for T regulatory cells and is under tight DNA methylation control at the Treg specific demethylated region (TSDR) in its first intron. This said, methylation of its promoter region, the significance of which is unknown, has also been associated with various immune-relat...
journal_title:Clinical and translational allergy
pub_type: 杂志文章
doi:10.1186/s13601-015-0079-2
更新日期:2015-10-20 00:00:00
abstract:Background:Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) and erythema multiforme (EM) are immunologically-mediated dermatological disorders commonly triggered by drug exposure and/or other external agents. We aimed to characterise SJS/TEN- and EM-drug-related hospitalisations in a nationwide administrat...
journal_title:Clinical and translational allergy
pub_type: 杂志文章
doi:10.1186/s13601-017-0188-1
更新日期:2018-01-22 00:00:00
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journal_title:Clinical and translational allergy
pub_type: 杂志文章
doi:10.1186/s13601-019-0257-8
更新日期:2019-03-08 00:00:00
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journal_title:Clinical and translational allergy
pub_type: 杂志文章,评审
doi:10.1186/s13601-017-0152-0
更新日期:2017-05-12 00:00:00
abstract:BACKGROUND:The European Academy of Allergy and Clinical Immunology (EAACI) is in the process of developing the EAACI Guidelines for Allergen Immunotherapy (AIT) for IgE-mediated food allergy. We seek to critically assess the effectiveness, cost-effectiveness and safety of AIT in IgE-mediated food allergy. METHODS:We w...
journal_title:Clinical and translational allergy
pub_type: 杂志文章
doi:10.1186/s13601-016-0113-z
更新日期:2016-07-05 00:00:00
abstract:BACKGROUND:Although efforts to improve the classification of hypersensitivity/allergic diseases have been made, they have not been considered a top-level category in the International Classification of Diseases (ICD)-10 and still are not in the ICD-11 beta phase linearization. ICD-10 is the most used classification sys...
journal_title:Clinical and translational allergy
pub_type: 杂志文章
doi:10.1186/2045-7022-4-42
更新日期:2014-11-28 00:00:00
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journal_title:Clinical and translational allergy
pub_type: 杂志文章
doi:10.1186/s13601-016-0138-3
更新日期:2017-01-10 00:00:00
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journal_title:Clinical and translational allergy
pub_type: 杂志文章
doi:10.1186/2045-7022-3-42
更新日期:2013-12-21 00:00:00
abstract:Background:Pollen is a major cause of allergic respiratory diseases. In Qatar, data on the presence and prevalence of allergenic airborne types of pollen is quite limited. Methods:The study aimed to determine and correlate the most frequently implicated airborne pollen detected by aerobiological monitoring samplers in...
journal_title:Clinical and translational allergy
pub_type: 杂志文章
doi:10.1186/s13601-020-00339-6
更新日期:2020-08-10 00:00:00
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journal_title:Clinical and translational allergy
pub_type: 杂志文章
doi:10.1186/s13601-018-0201-3
更新日期:2018-05-04 00:00:00
abstract:Background:In daily practice, one-third of sesame allergic patients, confirmed by clinical history or food challenge, do not show any detectable specific IgE using current diagnostics. Currently used sesame extracts are water-based and therefore lacking hydrophobic proteins like oleosins. Oleosins, the stabilizer of li...
journal_title:Clinical and translational allergy
pub_type: 杂志文章
doi:10.1186/s13601-019-0271-x
更新日期:2019-06-28 00:00:00
abstract:BACKGROUND:The 300IR (index of reactivity) 5-grass pollen tablet has favorable short-term and sustained clinical efficacy in patients with grass pollen-induced allergic rhinoconjunctivitis (ARC). Here, we report maintenance of efficacy and safety over 2 years following treatment discontinuation. METHODS:Randomized, do...
journal_title:Clinical and translational allergy
pub_type: 杂志文章
doi:10.1186/s13601-015-0057-8
更新日期:2015-05-22 00:00:00
abstract:Background:Evidence regarding the clinical effectiveness of mite allergen avoidance for the treatment of asthma is lacking. In previous meta-analyses on mite allergen control, the baseline data were not discussed in detail. This study updates and extends the existing Cochrane review by Gøtzsche and Johansen (Cochrane D...
journal_title:Clinical and translational allergy
pub_type: 杂志文章,评审
doi:10.1186/s13601-019-0306-3
更新日期:2020-01-06 00:00:00
abstract:BACKGROUND:A drug reaction with eosinophilia and systemic symptoms (DRESS) is a severe T cell mediated hypersensitivity reaction. Relapses of symptoms in the recovery phase are frequent and linked to the reduction of the corticosteroid treatment, to viral reactivations or to the exposure to new drugs. Here, we analyzed...
journal_title:Clinical and translational allergy
pub_type: 杂志文章
doi:10.1186/s13601-020-00359-2
更新日期:2020-11-23 00:00:00
abstract::Oral allergy syndrome (OAS) is one of the most common IgE-mediated allergic reactions. It is characterized by a number of symptoms induced by the exposure of the oral and pharyngeal mucosa to allergenic proteins belonging to class 1 or to class 2 food allergens. OAS occurring when patients sensitized to pollens are ex...
journal_title:Clinical and translational allergy
pub_type: 杂志文章,评审
doi:10.1186/s13601-020-00329-8
更新日期:2020-06-17 00:00:00
abstract::[This corrects the article DOI: 10.1186/s13601-016-0116-9.]. ...
journal_title:Clinical and translational allergy
pub_type: 已发布勘误
doi:10.1186/s13601-016-0135-6
更新日期:2017-02-20 00:00:00
abstract::Drug hypersensitivity reactions (DHR) have been present since the advent of drugs. In particular T-cell mediated delayed-type hypersensitivity reactions represent a heterogeneous clinical entity with a diverse pathogenesis and result in a considerable burden of morbidity and mortality not only driven by the reactions ...
journal_title:Clinical and translational allergy
pub_type: 杂志文章,评审
doi:10.1186/s13601-015-0073-8
更新日期:2015-09-03 00:00:00
abstract::On March 29, 2017, a European Summit on the Prevention and Self-Management of Chronic Respiratory Diseases (CRD) was organized by the European Forum for Research and Education in Allergy and Airway Diseases. The event took place in the European Parliament of Brussels and was hosted by MEP David Borrelli and MEP Sirpa ...
journal_title:Clinical and translational allergy
pub_type: 杂志文章,评审
doi:10.1186/s13601-017-0186-3
更新日期:2017-12-27 00:00:00
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journal_title:Clinical and translational allergy
pub_type: 杂志文章
doi:10.1186/s13601-019-0282-7
更新日期:2019-08-21 00:00:00
abstract:Background:Fungal and bacterial microbiota play an important role in development of asthma. We aim to characterize airway microbiome (mycobiome, bacteriome) and functional genes in asthmatics and controls. Methods:Sputum microbiome of controls, untreated asthma patients and inhaled corticosteroid (ICS) receiving patie...
journal_title:Clinical and translational allergy
pub_type: 杂志文章
doi:10.1186/s13601-020-00345-8
更新日期:2020-10-22 00:00:00
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journal_title:Clinical and translational allergy
pub_type: 杂志文章
doi:10.1186/s13601-020-00332-z
更新日期:2020-07-03 00:00:00
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journal_title:Clinical and translational allergy
pub_type: 杂志文章
doi:10.1186/2045-7022-2-17
更新日期:2012-09-19 00:00:00
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journal_title:Clinical and translational allergy
pub_type: 杂志文章
doi:10.1186/s13601-017-0179-2
更新日期:2017-11-17 00:00:00
abstract:BACKGROUND:The European Academy of Allergy and Clinical Immunology is developing guidelines about how to prevent and manage food allergy. As part of the guidelines development process, a systematic review is planned to examine published research about the prevention of food allergy. This systematic review is one of sev...
journal_title:Clinical and translational allergy
pub_type: 杂志文章
doi:10.1186/2045-7022-3-10
更新日期:2013-03-28 00:00:00
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journal_title:Clinical and translational allergy
pub_type: 杂志文章
doi:10.1186/2045-7022-3-27
更新日期:2013-08-21 00:00:00
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journal_title:Clinical and translational allergy
pub_type: 杂志文章
doi:10.1186/s13601-018-0234-7
更新日期:2018-12-04 00:00:00
abstract::[This corrects the article DOI: 10.1186/s13601-019-0303-6.]. ...
journal_title:Clinical and translational allergy
pub_type: 已发布勘误
doi:10.1186/s13601-020-00343-w
更新日期:2020-09-28 00:00:00
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journal_title:Clinical and translational allergy
pub_type: 杂志文章,评审
doi:10.1186/s13601-019-0277-4
更新日期:2019-07-25 00:00:00
abstract:BACKGROUND:With the aim of actively contributing to the ongoing 11(th) International Classification of Diseases (ICD) revision, an international collaboration led by the European Academy of Allergy and Clinical Immunology (EAACI) has decided to revise the classification of hypersensitivity/allergic diseases and to vali...
journal_title:Clinical and translational allergy
pub_type: 杂志文章
doi:10.1186/s13601-015-0063-x
更新日期:2015-06-03 00:00:00
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journal_title:Clinical and translational allergy
pub_type: 杂志文章
doi:10.1186/s13601-018-0216-9
更新日期:2018-08-10 00:00:00