Abstract:
BACKGROUND:The European Academy of Allergy and Clinical Immunology is developing guidelines about how to prevent and manage food allergy. As part of the guidelines development process, a systematic review is planned to examine published research about the prevention of food allergy. This systematic review is one of seven inter-linked evidence syntheses that are being undertaken in order to provide a state-of-the-art synopsis of the current evidence base in relation to epidemiology, prevention, diagnosis and clinical management, and impact on quality of life, which will be used to inform clinical recommendations. The aim of this systematic review will be to assess the effectiveness of approaches for the primary prevention of food allergy. METHODS:Seven bibliographic databases will be searched from their inception to September 30, 2012 for systematic reviews, randomized controlled trials, quasi-randomized controlled trials, controlled clinical trials, controlled before-and-after studies, interrupted time series and cohort studies. Cohort studies will be included due to an inability to randomize with interventions such as breastfeeding. Studies that focused on the development of either food sensitization (a proxy measure) or food allergy will also be eligible for inclusion. Studies will be critically appraised using the Critical Appraisal Skills Program and Cochrane Risk of Bias tools, as appropriate. DISCUSSION:There is a lack of rigorous evidence to support recommendations about how to prevent the development of food allergy. It would appear that it is important to see the prevention of food allergy in the context of individual, family and wider factors that may influence its development. There is much left to learn about preventing food allergy, and this is a priority given the high societal and healthcare costs involved. This systematic review will help to further this learning.
journal_name
Clin Transl Allergyjournal_title
Clinical and translational allergyauthors
de Silva D,Panesar SS,Thusu S,Rader T,Halken S,Muraro A,Sheikh Adoi
10.1186/2045-7022-3-10subject
Has Abstractpub_date
2013-03-28 00:00:00pages
10issue
1issn
2045-7022pii
2045-7022-3-10journal_volume
3pub_type
杂志文章abstract:Background:Asthma with atopy is often characterized by type 2 inflammation but less progress has been made in defining non-type 2 asthma. We have previously identified a subgroup of young non-atopic asthmatics with perceived food hypersensitivity and poor asthma control. Objective:Our aim was to further characterize t...
journal_title:Clinical and translational allergy
pub_type: 杂志文章
doi:10.1186/s13601-019-0250-2
更新日期:2019-02-22 00:00:00
abstract:Background:Fungal and bacterial microbiota play an important role in development of asthma. We aim to characterize airway microbiome (mycobiome, bacteriome) and functional genes in asthmatics and controls. Methods:Sputum microbiome of controls, untreated asthma patients and inhaled corticosteroid (ICS) receiving patie...
journal_title:Clinical and translational allergy
pub_type: 杂志文章
doi:10.1186/s13601-020-00345-8
更新日期:2020-10-22 00:00:00
abstract::Eosinophilic disorders represent a group of pathologic conditions with highly heterogeneous pathophysiology and clinical presentation and variable prognosis, ranging from asymptomatic or mild, to severe and complex cases, with fatal outcome. Interest in this group of disorders has increased during the last two decades...
journal_title:Clinical and translational allergy
pub_type: 杂志文章,评审
doi:10.1186/s13601-019-0277-4
更新日期:2019-07-25 00:00:00
abstract::Oral allergy syndrome (OAS) is one of the most common IgE-mediated allergic reactions. It is characterized by a number of symptoms induced by the exposure of the oral and pharyngeal mucosa to allergenic proteins belonging to class 1 or to class 2 food allergens. OAS occurring when patients sensitized to pollens are ex...
journal_title:Clinical and translational allergy
pub_type: 杂志文章,评审
doi:10.1186/s13601-020-00329-8
更新日期:2020-06-17 00:00:00
abstract::Rhinitis and rhinosinusitis are the two major clinical entities of chronic upper airway disease. Chronic rhinosinusitis (CRS) and allergic rhinitis (AR) affect respectively up to 10 and 30% of the total population, hence being associated with an important socio-economic burden. Different phenotypes of rhinitis and CRS...
journal_title:Clinical and translational allergy
pub_type: 杂志文章,评审
doi:10.1186/s13601-017-0157-8
更新日期:2017-07-12 00:00:00
abstract::[This corrects the article DOI: 10.1186/s13601-016-0116-9.]. ...
journal_title:Clinical and translational allergy
pub_type: 已发布勘误
doi:10.1186/s13601-016-0135-6
更新日期:2017-02-20 00:00:00
abstract:Background:Evidence regarding the clinical effectiveness of mite allergen avoidance for the treatment of asthma is lacking. In previous meta-analyses on mite allergen control, the baseline data were not discussed in detail. This study updates and extends the existing Cochrane review by Gøtzsche and Johansen (Cochrane D...
journal_title:Clinical and translational allergy
pub_type: 杂志文章,评审
doi:10.1186/s13601-019-0306-3
更新日期:2020-01-06 00:00:00
abstract:BACKGROUND:The efficacy of Lactobacillus paracasei NCC 2461 in modulating allergic rhinitis was previously evaluated in two exploratory clinical studies. Oral administration with NCC 2461 reduced specific subjective symptoms following nasal provocation tests with controlled grass pollen allergen concentrations. Our aim...
journal_title:Clinical and translational allergy
pub_type: 杂志文章
doi:10.1186/s13601-015-0085-4
更新日期:2015-12-09 00:00:00
abstract:BACKGROUND:Suspected penicillin allergy (Pen-A) is often not verified by diagnostic testing. In third line penicillin allergy labels were associated with prescription of broad spectrum antibiotics, hospital stay duration and readmission. OBJECTIVE:Assess the impact of Pen-A labels on antibiotic and health care use in ...
journal_title:Clinical and translational allergy
pub_type: 杂志文章
doi:10.1186/s13601-017-0154-y
更新日期:2017-06-07 00:00:00
abstract:BACKGROUND:The 300IR (index of reactivity) 5-grass pollen tablet has favorable short-term and sustained clinical efficacy in patients with grass pollen-induced allergic rhinoconjunctivitis (ARC). Here, we report maintenance of efficacy and safety over 2 years following treatment discontinuation. METHODS:Randomized, do...
journal_title:Clinical and translational allergy
pub_type: 杂志文章
doi:10.1186/s13601-015-0057-8
更新日期:2015-05-22 00:00:00
abstract:Background:Blood eosinophil count (BEC) and fractional exhaled nitric oxide (FeNO) concentration are established biomarkers in asthma, associated particularly with the risk of exacerbations. We evaluated the relationship of BEC and FeNO as complementary and independent biomarkers of severe asthma exacerbations. Method...
journal_title:Clinical and translational allergy
pub_type: 杂志文章
doi:10.1186/s13601-019-0282-7
更新日期:2019-08-21 00:00:00
abstract:Background:In severe asthma, high doses of inhaled corticosteroids (ICS) are used in order to achieve clinical and functional control. This study aimed to evaluate lung function in outpatients (children and adolescents) with severe asthma in Brazil, all of whom were treated with high doses of ICS. We evaluated all spir...
journal_title:Clinical and translational allergy
pub_type: 杂志文章
doi:10.1186/s13601-017-0183-6
更新日期:2017-12-15 00:00:00
abstract::Cosmetics and skin care products for neonates and infants are considered as ''hypoallergenic'', "tested" or ''safe''. Nevertheless, the prevalence of haptens in these products is a matter of concern, since allergic contact dermatitis in children is gaining an importance. We aimed to assess the prevalence of haptens in...
journal_title:Clinical and translational allergy
pub_type: 杂志文章
doi:10.1186/s13601-019-0257-8
更新日期:2019-03-08 00:00:00
abstract:Background:Susceptibility to pepsin digestion of candidate transgene products is regarded an important parameter in the weight-of-evidence approach for allergenicity risk assessment of genetically modified crops. It has been argued that protocols used for this assessment should better reflect physiological conditions e...
journal_title:Clinical and translational allergy
pub_type: 杂志文章
doi:10.1186/s13601-018-0216-9
更新日期:2018-08-10 00:00:00
abstract::Drug hypersensitivity reactions (DHR) have been present since the advent of drugs. In particular T-cell mediated delayed-type hypersensitivity reactions represent a heterogeneous clinical entity with a diverse pathogenesis and result in a considerable burden of morbidity and mortality not only driven by the reactions ...
journal_title:Clinical and translational allergy
pub_type: 杂志文章,评审
doi:10.1186/s13601-015-0073-8
更新日期:2015-09-03 00:00:00
abstract:Background:In daily practice, one-third of sesame allergic patients, confirmed by clinical history or food challenge, do not show any detectable specific IgE using current diagnostics. Currently used sesame extracts are water-based and therefore lacking hydrophobic proteins like oleosins. Oleosins, the stabilizer of li...
journal_title:Clinical and translational allergy
pub_type: 杂志文章
doi:10.1186/s13601-019-0271-x
更新日期:2019-06-28 00:00:00
abstract:Background:Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) and erythema multiforme (EM) are immunologically-mediated dermatological disorders commonly triggered by drug exposure and/or other external agents. We aimed to characterise SJS/TEN- and EM-drug-related hospitalisations in a nationwide administrat...
journal_title:Clinical and translational allergy
pub_type: 杂志文章
doi:10.1186/s13601-017-0188-1
更新日期:2018-01-22 00:00:00
abstract::Crying combined with miscellaneous gastrointestinal symptoms are typical symptoms of infant with food allergy, but are also common among children with abnormal neurological development. Mutations in KAT6A gene is known to cause a syndrome characterized by developmental delay, hypotonia, cardiac defects, microcephaly, ...
journal_title:Clinical and translational allergy
pub_type: 杂志文章
doi:10.1186/s13601-017-0155-x
更新日期:2017-06-22 00:00:00
abstract:BACKGROUND:Cow's milk allergy (CMA) is a common disease in infancy. Early environmental factors are likely to contribute to CMA. It is known that epigenetic gene regulation can be altered by environmental factors. We have set up a proof of concept study, aiming to detect epigenetic associations specific with CMA. METH...
journal_title:Clinical and translational allergy
pub_type: 杂志文章
doi:10.1186/s13601-016-0105-z
更新日期:2016-05-04 00:00:00
abstract:BACKGROUND:Double-blind, placebo-controlled (DBPC) trials are the gold standard for demonstrating clinical efficacy and tolerability. The placebo effect, although an important feature in placebo-controlled studies, has never been systematically investigated in allergen-specific immunotherapy (SIT) studies. This study w...
journal_title:Clinical and translational allergy
pub_type: 杂志文章
doi:10.1186/2045-7022-3-42
更新日期:2013-12-21 00:00:00
abstract:BACKGROUND:Asthma is a frequent chronic respiratory disease in both children and adults. However, few data on asthma prevalence are available in Portugal. The Portuguese National Asthma Survey is the first nationwide study that uses standardized methods. We aimed to estimate the prevalence of current asthma in the Port...
journal_title:Clinical and translational allergy
pub_type: 杂志文章
doi:10.1186/2045-7022-2-15
更新日期:2012-08-29 00:00:00
abstract:BACKGROUND:The introduction of whole new foods in a population may lead to sensitization and food allergy. This constitutes a potential public health problem and a challenge to risk assessors and managers as the existing understanding of the pathophysiological processes and the currently available biological tools for ...
journal_title:Clinical and translational allergy
pub_type: 杂志文章,评审
doi:10.1186/s13601-017-0152-0
更新日期:2017-05-12 00:00:00
abstract:Background:Diagnostic workup of penicillin allergy comprises skin testing with penicillins, and patients are deemed allergic if skin test is positive. However, the literature suggests that skin test-positive patients may be challenge-negative, indicating that the skin test may be falsely positive. Objective:To investi...
journal_title:Clinical and translational allergy
pub_type: 杂志文章
doi:10.1186/s13601-017-0179-2
更新日期:2017-11-17 00:00:00
abstract:BACKGROUND:Although efforts to improve the classification of hypersensitivity/allergic diseases have been made, they have not been considered a top-level category in the International Classification of Diseases (ICD)-10 and still are not in the ICD-11 beta phase linearization. ICD-10 is the most used classification sys...
journal_title:Clinical and translational allergy
pub_type: 杂志文章
doi:10.1186/2045-7022-4-42
更新日期:2014-11-28 00:00:00
abstract:Background:Evidence for distinct asthma phenotypes and their overlap is becoming increasingly relevant to identify personalized and targeted therapeutic strategies. In this study, we aimed to describe the overlap of five commonly reported asthma phenotypes in US adults with current asthma and assess its association wit...
journal_title:Clinical and translational allergy
pub_type: 杂志文章
doi:10.1186/s13601-018-0201-3
更新日期:2018-05-04 00:00:00
abstract:BACKGROUND:A drug reaction with eosinophilia and systemic symptoms (DRESS) is a severe T cell mediated hypersensitivity reaction. Relapses of symptoms in the recovery phase are frequent and linked to the reduction of the corticosteroid treatment, to viral reactivations or to the exposure to new drugs. Here, we analyzed...
journal_title:Clinical and translational allergy
pub_type: 杂志文章
doi:10.1186/s13601-020-00359-2
更新日期:2020-11-23 00:00:00
abstract:Background:Chronic rhinosinusitis with nasal polyps (CRSwNP) is a heterogeneous inflammatory disease usually characterized by chronic eosinophilia in the sinonasal mucosa, which often requires glucocorticoid (GC) therapy. However, the therapeutic response varies markedly between individuals. The objective of this study...
journal_title:Clinical and translational allergy
pub_type: 杂志文章
doi:10.1186/s13601-018-0211-1
更新日期:2018-07-02 00:00:00
abstract:BACKGROUND:With the aim of actively contributing to the ongoing 11(th) International Classification of Diseases (ICD) revision, an international collaboration led by the European Academy of Allergy and Clinical Immunology (EAACI) has decided to revise the classification of hypersensitivity/allergic diseases and to vali...
journal_title:Clinical and translational allergy
pub_type: 杂志文章
doi:10.1186/s13601-015-0063-x
更新日期:2015-06-03 00:00:00
abstract:Background:The relationship between smoking, household pollution, dual exposure and severity of asthma in adults has not been sufficiently studied. We examined and compared the effects of cigarette smoking, domestic wood burning pollution and dual exposure (tobacco and wood burning) upon asthma severity in adults. Met...
journal_title:Clinical and translational allergy
pub_type: 杂志文章
doi:10.1186/s13601-018-0235-6
更新日期:2018-12-10 00:00:00
abstract:BACKGROUND:Indoleamine 2,3-dioxygenase (IDO) is a tryptophan catalyzing enzyme. It has been suggested that it has a role in lower airway allergic inflammations, but its role in allergic rhinitis has not been investigated. OBJECTIVE:Our aim was to evaluate the expression of IDO in the nasal mucosa of allergic rhinitis ...
journal_title:Clinical and translational allergy
pub_type: 杂志文章
doi:10.1186/2045-7022-1-17
更新日期:2011-12-12 00:00:00