Correction to: Benefits and harm of systemic steroids for short- and long-term use in rhinitis and rhinosinusitis: an EAACI position paper.

abstract：Background:Susceptibility to pepsin digestion of candidate transgene products is regarded an important parameter in the weight-of-evidence approach for allergenicity risk assessment of genetically modified crops. It has been argued that protocols used for this assessment should better reflect physiological conditions e...

journal_title：Clinical and translational allergy

authors： Akkerdaas J,Totis M,Barnett B,Bell E,Davis T,Edrington T,Glenn K,Graser G,Herman R,Knulst A,Ladics G,McClain S,Poulsen LK,Ranjan R,Rascle JB,Serrano H,Speijer D,Wang R,Pereira Mouriès L,Capt A,van Ree R

更新日期：2018-08-10 00:00:00

abstract：Background:Evidence for distinct asthma phenotypes and their overlap is becoming increasingly relevant to identify personalized and targeted therapeutic strategies. In this study, we aimed to describe the overlap of five commonly reported asthma phenotypes in US adults with current asthma and assess its association wit...

journal_title：Clinical and translational allergy

authors： Amaral R,Fonseca JA,Jacinto T,Pereira AM,Malinovschi A,Janson C,Alving K

更新日期：2018-05-04 00:00:00

abstract：BACKGROUND:A drug reaction with eosinophilia and systemic symptoms (DRESS) is a severe T cell mediated hypersensitivity reaction. Relapses of symptoms in the recovery phase are frequent and linked to the reduction of the corticosteroid treatment, to viral reactivations or to the exposure to new drugs. Here, we analyzed...

journal_title：Clinical and translational allergy

authors： Jörg L,Helbling A,Yerly D,Pichler WJ

更新日期：2020-11-23 00:00:00

abstract：Background:Pollen is a major cause of allergic respiratory diseases. In Qatar, data on the presence and prevalence of allergenic airborne types of pollen is quite limited. Methods:The study aimed to determine and correlate the most frequently implicated airborne pollen detected by aerobiological monitoring samplers in...

journal_title：Clinical and translational allergy

authors： Al-Nesf MA,Gharbi D,Mobayed HM,Dason BR,Mohammed Ali R,Taha S,Tuffaha A,Adeli M,Sattar HA,Trigo MDM

更新日期：2020-08-10 00:00:00

abstract：UNLABELLED: BACKGROUND:The transition to adulthood can be particularly challenging for young people with severe allergies, who must learn to balance personal safety with independent living. Information and support for young people and their families are crucial to successfully managing this transition. We sought to: g...

journal_title：Clinical and translational allergy

authors： Worth A,Regent L,Levy M,Ledford C,East M,Sheikh A

更新日期：2013-01-22 00:00:00

abstract：Background:Rhinitis is a common problem within the population. Many subjects with rhinitis also have atopic multimorbidity, such as asthma and eczema. The purpose of this investigation was to compare subjects with only rhinitis to those that have rhinitis, asthma and/or eczema in relation to immunoglobulin E (IgE) sens...

journal_title：Clinical and translational allergy

authors： Blöndal V,Sundbom F,Borres MP,Högman M,Alving K,Malinovschi A,Janson C

更新日期：2020-02-21 00:00:00

abstract：BACKGROUND:The FOXP3 gene is the master regulator for T regulatory cells and is under tight DNA methylation control at the Treg specific demethylated region (TSDR) in its first intron. This said, methylation of its promoter region, the significance of which is unknown, has also been associated with various immune-relat...

journal_title：Clinical and translational allergy

authors： Bégin P,Schulze J,Baron U,Olek S,Bauer RN,Passerini L,Baccheta R,Nadeau KC

更新日期：2015-10-20 00:00:00

abstract：BACKGROUND:Cow's milk allergy (CMA) is a common disease in infancy. Early environmental factors are likely to contribute to CMA. It is known that epigenetic gene regulation can be altered by environmental factors. We have set up a proof of concept study, aiming to detect epigenetic associations specific with CMA. METH...

journal_title：Clinical and translational allergy

authors： Petrus NCM,Henneman P,Venema A,Mul A,van Sinderen F,Haagmans M,Mook O,Hennekam RC,Sprikkelman AB,Mannens M

更新日期：2016-05-04 00:00:00

abstract：:We present three cases with anaphylaxis after injection of a depot corticosteroid. First, the steroid was suspected as the elicitor, but after evaluation the excipient macrogol was found to be the elicitor. One of the patients had reactions to several unrelated drugs. Increased awareness of anaphylaxis to excipients s...

journal_title：Clinical and translational allergy

authors： Brandt N,Garvey LH,Bindslev-Jensen U,Kjaer HF,Bindslev-Jensen C,Mortz CG

更新日期：2017-01-10 00:00:00

abstract：BACKGROUND:The introduction of whole new foods in a population may lead to sensitization and food allergy. This constitutes a potential public health problem and a challenge to risk assessors and managers as the existing understanding of the pathophysiological processes and the currently available biological tools for ...

journal_title：Clinical and translational allergy

authors： van Bilsen JHM,Sienkiewicz-Szłapka E,Lozano-Ojalvo D,Willemsen LEM,Antunes CM,Molina E,Smit JJ,Wróblewska B,Wichers HJ,Knol EF,Ladics GS,Pieters RHH,Denery-Papini S,Vissers YM,Bavaro SL,Larré C,Verhoeckx KCM,Roggen EL

更新日期：2017-05-12 00:00:00

abstract：BACKGROUND:Suspected penicillin allergy (Pen-A) is often not verified by diagnostic testing. In third line penicillin allergy labels were associated with prescription of broad spectrum antibiotics, hospital stay duration and readmission. OBJECTIVE:Assess the impact of Pen-A labels on antibiotic and health care use in ...

journal_title：Clinical and translational allergy

authors： Su T,Broekhuizen BDL,Verheij TJM,Rockmann H

更新日期：2017-06-07 00:00:00

abstract：Background:In severe asthma, high doses of inhaled corticosteroids (ICS) are used in order to achieve clinical and functional control. This study aimed to evaluate lung function in outpatients (children and adolescents) with severe asthma in Brazil, all of whom were treated with high doses of ICS. We evaluated all spir...

journal_title：Clinical and translational allergy

authors： Versiani Nunes Pinheiro de Queiroz M,Gonçalves Alvim C,Cruz ÁA,de Lima Belizário Facury Lasmar LM

更新日期：2017-12-15 00:00:00

abstract：Background:Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) and erythema multiforme (EM) are immunologically-mediated dermatological disorders commonly triggered by drug exposure and/or other external agents. We aimed to characterise SJS/TEN- and EM-drug-related hospitalisations in a nationwide administrat...

journal_title：Clinical and translational allergy

authors： Sousa-Pinto B,Araújo L,Freitas A,Correia O,Delgado L

更新日期：2018-01-22 00:00:00

abstract：Background:Diagnostic workup of penicillin allergy comprises skin testing with penicillins, and patients are deemed allergic if skin test is positive. However, the literature suggests that skin test-positive patients may be challenge-negative, indicating that the skin test may be falsely positive. Objective:To investi...

journal_title：Clinical and translational allergy

authors： Tannert LK,Falkencrone S,Mortz CG,Bindslev-Jensen C,Skov PS

更新日期：2017-11-17 00:00:00

abstract：:Cosmetics and skin care products for neonates and infants are considered as ''hypoallergenic'', "tested" or ''safe''. Nevertheless, the prevalence of haptens in these products is a matter of concern, since allergic contact dermatitis in children is gaining an importance. We aimed to assess the prevalence of haptens in...

journal_title：Clinical and translational allergy

authors： Dumycz K,Kunkiel K,Feleszko W

更新日期：2019-03-08 00:00:00

abstract：BACKGROUND:Although efforts to improve the classification of hypersensitivity/allergic diseases have been made, they have not been considered a top-level category in the International Classification of Diseases (ICD)-10 and still are not in the ICD-11 beta phase linearization. ICD-10 is the most used classification sys...

journal_title：Clinical and translational allergy

authors： Tanno LK,Calderon MA,Goldberg BJ,Akdis CA,Papadopoulos NG,Demoly P

更新日期：2014-11-28 00:00:00

abstract：BACKGROUND:The efficacy of Lactobacillus paracasei NCC 2461 in modulating allergic rhinitis was previously evaluated in two exploratory clinical studies. Oral administration with NCC 2461 reduced specific subjective symptoms following nasal provocation tests with controlled grass pollen allergen concentrations. Our aim...

journal_title：Clinical and translational allergy

authors： Nembrini C,Singh A,De Castro CA,Mercenier A,Nutten S

更新日期：2015-12-09 00:00:00

abstract：BACKGROUND:Double-blind, placebo-controlled (DBPC) trials are the gold standard for demonstrating clinical efficacy and tolerability. The placebo effect, although an important feature in placebo-controlled studies, has never been systematically investigated in allergen-specific immunotherapy (SIT) studies. This study w...

journal_title：Clinical and translational allergy

authors： Narkus A,Lehnigk U,Haefner D,Klinger R,Pfaar O,Worm M

更新日期：2013-12-21 00:00:00

abstract：BACKGROUND:Asthma is a frequent chronic respiratory disease in both children and adults. However, few data on asthma prevalence are available in Portugal. The Portuguese National Asthma Survey is the first nationwide study that uses standardized methods. We aimed to estimate the prevalence of current asthma in the Port...

journal_title：Clinical and translational allergy

authors： Sa-Sousa A,Morais-Almeida M,Azevedo LF,Carvalho R,Jacinto T,Todo-Bom A,Loureiro C,Bugalho-Almeida A,Bousquet J,Fonseca JA

更新日期：2012-08-29 00:00:00

abstract：:On March 29, 2017, a European Summit on the Prevention and Self-Management of Chronic Respiratory Diseases (CRD) was organized by the European Forum for Research and Education in Allergy and Airway Diseases. The event took place in the European Parliament of Brussels and was hosted by MEP David Borrelli and MEP Sirpa ...

journal_title：Clinical and translational allergy

authors： Hellings PW,Borrelli D,Pietikainen S,Agache I,Akdis C,Bachert C,Bewick M,Botjes E,Constantinidis J,Fokkens W,Haahtela T,Hopkins C,Illario M,Joos G,Lund V,Muraro A,Pugin B,Seys S,Somekh D,Stjärne P,Valiulis A,Val

更新日期：2017-12-27 00:00:00

abstract：Background:Chronic rhinosinusitis with nasal polyps (CRSwNP) is a heterogeneous inflammatory disease usually characterized by chronic eosinophilia in the sinonasal mucosa, which often requires glucocorticoid (GC) therapy. However, the therapeutic response varies markedly between individuals. The objective of this study...

journal_title：Clinical and translational allergy

authors： Hong H,Wang D,Tan KS,Zheng R,Chen F,Gao W,He H,Shi J,Fan Y,Yang Q,Sun Y

更新日期：2018-07-02 00:00:00

abstract：Background:Asthma with atopy is often characterized by type 2 inflammation but less progress has been made in defining non-type 2 asthma. We have previously identified a subgroup of young non-atopic asthmatics with perceived food hypersensitivity and poor asthma control. Objective:Our aim was to further characterize t...

journal_title：Clinical and translational allergy

authors： Tsolakis N,Nordvall L,Janson C,Rydell N,Malinovschi A,Alving K

更新日期：2019-02-22 00:00:00

abstract：Background:Patients with chronic rhinosinusitis with nasal polyps (CRSwNP) and comorbid asthma have more severe disease and are difficult to treat. However, the molecular endotypes associated with CRSwNP with comorbid asthma (CRSwNP + AS) are not clear. This study aimed to investigate the characteristics of type 2 infl...

journal_title：Clinical and translational allergy

authors： Wang M,Bu X,Luan G,Lin L,Wang Y,Jin J,Zhang L,Wang C

更新日期：2020-07-03 00:00:00

abstract：:Crying combined with miscellaneous gastrointestinal symptoms are typical symptoms of infant with food allergy, but are also common among children with abnormal neurological development. Mutations in KAT6A gene is known to cause a syndrome characterized by developmental delay, hypotonia, cardiac defects, microcephaly, ...

journal_title：Clinical and translational allergy

authors： Elenius V,Lähdesmäki T,Hietala M,Jartti T

更新日期：2017-06-22 00:00:00

abstract：:[This corrects the article DOI: 10.1186/s13601-016-0116-9.]. ...

journal_title：Clinical and translational allergy

authors： Bousquet J,Farrell J,Crooks G,Hellings P,Bel EH,Bewick M,Chavannes NH,de Sousa JC,Cruz AA,Haahtela T,Joos G,Khaltaev N,Malva J,Muraro A,Nogues M,Palkonen S,Pedersen S,Robalo-Cordeiro C,Samolinski B,Strandberg T,Va

更新日期：2017-02-20 00:00:00

abstract：BACKGROUND:The 300IR (index of reactivity) 5-grass pollen tablet has favorable short-term and sustained clinical efficacy in patients with grass pollen-induced allergic rhinoconjunctivitis (ARC). Here, we report maintenance of efficacy and safety over 2 years following treatment discontinuation. METHODS:Randomized, do...

journal_title：Clinical and translational allergy

authors： Didier A,Malling HJ,Worm M,Horak F,Sussman GL

更新日期：2015-05-22 00:00:00

abstract：:Eosinophilic disorders represent a group of pathologic conditions with highly heterogeneous pathophysiology and clinical presentation and variable prognosis, ranging from asymptomatic or mild, to severe and complex cases, with fatal outcome. Interest in this group of disorders has increased during the last two decades...

journal_title：Clinical and translational allergy

authors： Leru PM

更新日期：2019-07-25 00:00:00

abstract：BACKGROUND:The European Academy of Allergy and Clinical Immunology (EAACI) is in the process of developing the EAACI Guidelines for Allergen Immunotherapy (AIT) for IgE-mediated food allergy. We seek to critically assess the effectiveness, cost-effectiveness and safety of AIT in IgE-mediated food allergy. METHODS:We w...

journal_title：Clinical and translational allergy

authors： Dhami S,Nurmatov U,Pajno GB,Fernandez-Rivas M,Muraro A,Roberts G,Akdis C,Alvaro-Lozano M,Beyer K,Bindslev-Jensen C,Burks W,du Toit G,Ebisawa M,Eigenmann P,Knol E,Makela M,Nadeau KC,O'Mahony L,Papadopoulos N,Poulsen

更新日期：2016-07-05 00:00:00

abstract：BACKGROUND:Subcutaneous immunotherapy with high dose grass pollen (typically microgram quantities) was first described over 100 years ago. This treatment suppresses allergen-induced cutaneous late responses, with lesser effects on early responses. We previously reported that repeated 2-weekly intradermal injections of ...

journal_title：Clinical and translational allergy

authors： Slovick A,Douiri A,Kelly J,Guerra A,Muir R,Tsioulos K,Murphy C,Shamji MH,Ying S,Durham SR,Till SJ

更新日期：2013-08-21 00:00:00

abstract：:Oral allergy syndrome (OAS) is one of the most common IgE-mediated allergic reactions. It is characterized by a number of symptoms induced by the exposure of the oral and pharyngeal mucosa to allergenic proteins belonging to class 1 or to class 2 food allergens. OAS occurring when patients sensitized to pollens are ex...

journal_title：Clinical and translational allergy

authors： Alessandri C,Ferrara R,Bernardi ML,Zennaro D,Tuppo L,Giangrieco I,Ricciardi T,Tamburrini M,Ciardiello MA,Mari A

更新日期：2020-06-17 00:00:00