Abstract:
Background:Diagnostic workup of penicillin allergy comprises skin testing with penicillins, and patients are deemed allergic if skin test is positive. However, the literature suggests that skin test-positive patients may be challenge-negative, indicating that the skin test may be falsely positive. Objective:To investigate real-time histamine release from a positive intracutaneous test induced by penicillin in patients with positive and negative challenges to penicillin. Methods:Skin microdialysis was performed in 21 penicillin-allergic patients with positive skin test, 13 non-allergic volunteers serving as negative controls, and 7 grass pollen-allergic patients serving as positive controls. Histamine was measured by microdialysis after skin test with penicillin/grass/NaCl. Penicillin challenge was subsequently performed in 12 of the patients. Results:Only 10/21 patients (47.6%) were skin test positive at microdialysis. During microdialysis 13 single intracutaneous tests were positive and histamine was detected in 4/13 occurring in four challenge positive patients. Thirteen/21 patients (61.9%) were deemed allergic to penicillin; eight had positive skin test. Two patients with positive skin test were challenge negative. In grass pollen allergic patients, 7/7 had a positive intracutaneous test to grass and all released histamine in the wheals. All 13 negative controls had negative intracutaneous test to penicillin and no histamine release. Conclusion:Histamine was only detected in the minority of positive intracutaneous tests with penicillin in penicillin-allergic patients. Other mediators may be involved.
journal_name
Clin Transl Allergyjournal_title
Clinical and translational allergyauthors
Tannert LK,Falkencrone S,Mortz CG,Bindslev-Jensen C,Skov PSdoi
10.1186/s13601-017-0179-2subject
Has Abstractpub_date
2017-11-17 00:00:00pages
40issn
2045-7022pii
179journal_volume
7pub_type
杂志文章abstract:Background:Patients with chronic rhinosinusitis with nasal polyps (CRSwNP) and comorbid asthma have more severe disease and are difficult to treat. However, the molecular endotypes associated with CRSwNP with comorbid asthma (CRSwNP + AS) are not clear. This study aimed to investigate the characteristics of type 2 infl...
journal_title:Clinical and translational allergy
pub_type: 杂志文章
doi:10.1186/s13601-020-00332-z
更新日期:2020-07-03 00:00:00
abstract::Cosmetics and skin care products for neonates and infants are considered as ''hypoallergenic'', "tested" or ''safe''. Nevertheless, the prevalence of haptens in these products is a matter of concern, since allergic contact dermatitis in children is gaining an importance. We aimed to assess the prevalence of haptens in...
journal_title:Clinical and translational allergy
pub_type: 杂志文章
doi:10.1186/s13601-019-0257-8
更新日期:2019-03-08 00:00:00
abstract::On March 29, 2017, a European Summit on the Prevention and Self-Management of Chronic Respiratory Diseases (CRD) was organized by the European Forum for Research and Education in Allergy and Airway Diseases. The event took place in the European Parliament of Brussels and was hosted by MEP David Borrelli and MEP Sirpa ...
journal_title:Clinical and translational allergy
pub_type: 杂志文章,评审
doi:10.1186/s13601-017-0186-3
更新日期:2017-12-27 00:00:00
abstract:Background:Blood eosinophil count (BEC) and fractional exhaled nitric oxide (FeNO) concentration are established biomarkers in asthma, associated particularly with the risk of exacerbations. We evaluated the relationship of BEC and FeNO as complementary and independent biomarkers of severe asthma exacerbations. Method...
journal_title:Clinical and translational allergy
pub_type: 杂志文章
doi:10.1186/s13601-019-0282-7
更新日期:2019-08-21 00:00:00
abstract:BACKGROUND:Suspected penicillin allergy (Pen-A) is often not verified by diagnostic testing. In third line penicillin allergy labels were associated with prescription of broad spectrum antibiotics, hospital stay duration and readmission. OBJECTIVE:Assess the impact of Pen-A labels on antibiotic and health care use in ...
journal_title:Clinical and translational allergy
pub_type: 杂志文章
doi:10.1186/s13601-017-0154-y
更新日期:2017-06-07 00:00:00
abstract:BACKGROUND:Little is known about prevalence and risk factors of allergic rhinitis and chronic nasal symptoms among adults in Vietnam. We aimed to estimate the prevalence, risk factor patterns and co-morbidities of allergic rhinitis and chronic nasal symptoms in one urban and one rural area in northern Vietnam. METHODS...
journal_title:Clinical and translational allergy
pub_type: 杂志文章
doi:10.1186/2045-7022-1-7
更新日期:2011-08-11 00:00:00
abstract:Background:Pollen is a major cause of allergic respiratory diseases. In Qatar, data on the presence and prevalence of allergenic airborne types of pollen is quite limited. Methods:The study aimed to determine and correlate the most frequently implicated airborne pollen detected by aerobiological monitoring samplers in...
journal_title:Clinical and translational allergy
pub_type: 杂志文章
doi:10.1186/s13601-020-00339-6
更新日期:2020-08-10 00:00:00
abstract:BACKGROUND:Although efforts to improve the classification of hypersensitivity/allergic diseases have been made, they have not been considered a top-level category in the International Classification of Diseases (ICD)-10 and still are not in the ICD-11 beta phase linearization. ICD-10 is the most used classification sys...
journal_title:Clinical and translational allergy
pub_type: 杂志文章
doi:10.1186/2045-7022-4-42
更新日期:2014-11-28 00:00:00
abstract:Background:Evidence regarding the clinical effectiveness of mite allergen avoidance for the treatment of asthma is lacking. In previous meta-analyses on mite allergen control, the baseline data were not discussed in detail. This study updates and extends the existing Cochrane review by Gøtzsche and Johansen (Cochrane D...
journal_title:Clinical and translational allergy
pub_type: 杂志文章,评审
doi:10.1186/s13601-019-0306-3
更新日期:2020-01-06 00:00:00
abstract:BACKGROUND:Asthma is a frequent chronic respiratory disease in both children and adults. However, few data on asthma prevalence are available in Portugal. The Portuguese National Asthma Survey is the first nationwide study that uses standardized methods. We aimed to estimate the prevalence of current asthma in the Port...
journal_title:Clinical and translational allergy
pub_type: 杂志文章
doi:10.1186/2045-7022-2-15
更新日期:2012-08-29 00:00:00
abstract:BACKGROUND:For the development of forecasts for seasonal allergic rhinitis symptoms, it is essential to understand the relationship between grass pollen concentrations and the symptoms of grass pollen allergic patients. OBJECTIVE:The aim of this study was to delineate this relationship between seasonal allergic rhinit...
journal_title:Clinical and translational allergy
pub_type: 杂志文章
doi:10.1186/2045-7022-1-18
更新日期:2011-12-21 00:00:00
abstract:BACKGROUND:Subcutaneous immunotherapy with high dose grass pollen (typically microgram quantities) was first described over 100 years ago. This treatment suppresses allergen-induced cutaneous late responses, with lesser effects on early responses. We previously reported that repeated 2-weekly intradermal injections of ...
journal_title:Clinical and translational allergy
pub_type: 杂志文章
doi:10.1186/2045-7022-3-27
更新日期:2013-08-21 00:00:00
abstract:BACKGROUND:The European Academy of Allergy and Clinical Immunology (EAACI) is in the process of developing the EAACI Guidelines for Allergen Immunotherapy (AIT) for IgE-mediated food allergy. We seek to critically assess the effectiveness, cost-effectiveness and safety of AIT in IgE-mediated food allergy. METHODS:We w...
journal_title:Clinical and translational allergy
pub_type: 杂志文章
doi:10.1186/s13601-016-0113-z
更新日期:2016-07-05 00:00:00
abstract:BACKGROUND:The European Academy of Allergy and Clinical Immunology is developing guidelines about how to prevent and manage food allergy. As part of the guidelines development process, a systematic review is planned to examine published research about the prevention of food allergy. This systematic review is one of sev...
journal_title:Clinical and translational allergy
pub_type: 杂志文章
doi:10.1186/2045-7022-3-10
更新日期:2013-03-28 00:00:00
abstract:BACKGROUND:While Health Related Quality of Life has been investigated among children with IgE-mediated food allergy, less is known about quality of life among children with other types of hypersensitivity to food. The aim of this study was to investigate Health Related Quality of Life (HRQL) in children with and withou...
journal_title:Clinical and translational allergy
pub_type: 杂志文章
doi:10.1186/s13601-017-0156-9
更新日期:2017-07-03 00:00:00
abstract::Drug hypersensitivity reactions (DHR) have been present since the advent of drugs. In particular T-cell mediated delayed-type hypersensitivity reactions represent a heterogeneous clinical entity with a diverse pathogenesis and result in a considerable burden of morbidity and mortality not only driven by the reactions ...
journal_title:Clinical and translational allergy
pub_type: 杂志文章,评审
doi:10.1186/s13601-015-0073-8
更新日期:2015-09-03 00:00:00
abstract:BACKGROUND:Recently we reported the validation of the "Allergy-Control-SCORE© (ACS)" which assesses symptom severity as well as medication use on three dimensions lung, nose and eyes. The aim of this study was to test the validity of the score for eyes and nose. METHODS:One-hundred-twenty-one consenting subjects (age ...
journal_title:Clinical and translational allergy
pub_type: 杂志文章
doi:10.1186/2045-7022-2-17
更新日期:2012-09-19 00:00:00
abstract:Background:Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) and erythema multiforme (EM) are immunologically-mediated dermatological disorders commonly triggered by drug exposure and/or other external agents. We aimed to characterise SJS/TEN- and EM-drug-related hospitalisations in a nationwide administrat...
journal_title:Clinical and translational allergy
pub_type: 杂志文章
doi:10.1186/s13601-017-0188-1
更新日期:2018-01-22 00:00:00
abstract:Background:Susceptibility to pepsin digestion of candidate transgene products is regarded an important parameter in the weight-of-evidence approach for allergenicity risk assessment of genetically modified crops. It has been argued that protocols used for this assessment should better reflect physiological conditions e...
journal_title:Clinical and translational allergy
pub_type: 杂志文章
doi:10.1186/s13601-018-0216-9
更新日期:2018-08-10 00:00:00
abstract:Background:Rhinitis is a common problem within the population. Many subjects with rhinitis also have atopic multimorbidity, such as asthma and eczema. The purpose of this investigation was to compare subjects with only rhinitis to those that have rhinitis, asthma and/or eczema in relation to immunoglobulin E (IgE) sens...
journal_title:Clinical and translational allergy
pub_type: 杂志文章
doi:10.1186/s13601-020-0311-6
更新日期:2020-02-21 00:00:00
abstract:UNLABELLED: BACKGROUND:The transition to adulthood can be particularly challenging for young people with severe allergies, who must learn to balance personal safety with independent living. Information and support for young people and their families are crucial to successfully managing this transition. We sought to: g...
journal_title:Clinical and translational allergy
pub_type: 杂志文章
doi:10.1186/2045-7022-3-2
更新日期:2013-01-22 00:00:00
abstract:Background:Fungal and bacterial microbiota play an important role in development of asthma. We aim to characterize airway microbiome (mycobiome, bacteriome) and functional genes in asthmatics and controls. Methods:Sputum microbiome of controls, untreated asthma patients and inhaled corticosteroid (ICS) receiving patie...
journal_title:Clinical and translational allergy
pub_type: 杂志文章
doi:10.1186/s13601-020-00345-8
更新日期:2020-10-22 00:00:00
abstract:Background:Asthma with atopy is often characterized by type 2 inflammation but less progress has been made in defining non-type 2 asthma. We have previously identified a subgroup of young non-atopic asthmatics with perceived food hypersensitivity and poor asthma control. Objective:Our aim was to further characterize t...
journal_title:Clinical and translational allergy
pub_type: 杂志文章
doi:10.1186/s13601-019-0250-2
更新日期:2019-02-22 00:00:00
abstract:Background:The relationship between smoking, household pollution, dual exposure and severity of asthma in adults has not been sufficiently studied. We examined and compared the effects of cigarette smoking, domestic wood burning pollution and dual exposure (tobacco and wood burning) upon asthma severity in adults. Met...
journal_title:Clinical and translational allergy
pub_type: 杂志文章
doi:10.1186/s13601-018-0235-6
更新日期:2018-12-10 00:00:00
abstract:BACKGROUND:The FOXP3 gene is the master regulator for T regulatory cells and is under tight DNA methylation control at the Treg specific demethylated region (TSDR) in its first intron. This said, methylation of its promoter region, the significance of which is unknown, has also been associated with various immune-relat...
journal_title:Clinical and translational allergy
pub_type: 杂志文章
doi:10.1186/s13601-015-0079-2
更新日期:2015-10-20 00:00:00
abstract:Background:In daily practice, one-third of sesame allergic patients, confirmed by clinical history or food challenge, do not show any detectable specific IgE using current diagnostics. Currently used sesame extracts are water-based and therefore lacking hydrophobic proteins like oleosins. Oleosins, the stabilizer of li...
journal_title:Clinical and translational allergy
pub_type: 杂志文章
doi:10.1186/s13601-019-0271-x
更新日期:2019-06-28 00:00:00
abstract::[This corrects the article DOI: 10.1186/s13601-019-0303-6.]. ...
journal_title:Clinical and translational allergy
pub_type: 已发布勘误
doi:10.1186/s13601-020-00343-w
更新日期:2020-09-28 00:00:00
abstract:BACKGROUND:The introduction of whole new foods in a population may lead to sensitization and food allergy. This constitutes a potential public health problem and a challenge to risk assessors and managers as the existing understanding of the pathophysiological processes and the currently available biological tools for ...
journal_title:Clinical and translational allergy
pub_type: 杂志文章,评审
doi:10.1186/s13601-017-0152-0
更新日期:2017-05-12 00:00:00
abstract::Rhinitis and rhinosinusitis are the two major clinical entities of chronic upper airway disease. Chronic rhinosinusitis (CRS) and allergic rhinitis (AR) affect respectively up to 10 and 30% of the total population, hence being associated with an important socio-economic burden. Different phenotypes of rhinitis and CRS...
journal_title:Clinical and translational allergy
pub_type: 杂志文章,评审
doi:10.1186/s13601-017-0157-8
更新日期:2017-07-12 00:00:00
abstract::Oral allergy syndrome (OAS) is one of the most common IgE-mediated allergic reactions. It is characterized by a number of symptoms induced by the exposure of the oral and pharyngeal mucosa to allergenic proteins belonging to class 1 or to class 2 food allergens. OAS occurring when patients sensitized to pollens are ex...
journal_title:Clinical and translational allergy
pub_type: 杂志文章,评审
doi:10.1186/s13601-020-00329-8
更新日期:2020-06-17 00:00:00