Abstract:
BACKGROUND:The efficacy of Lactobacillus paracasei NCC 2461 in modulating allergic rhinitis was previously evaluated in two exploratory clinical studies. Oral administration with NCC 2461 reduced specific subjective symptoms following nasal provocation tests with controlled grass pollen allergen concentrations. Our aim was to confirm the anti-allergic effect of NCC 2461 in grass pollen allergic subjects exposed to natural doses of allergens during the pollen season. FINDINGS:A double-blind, randomized, placebo-controlled, parallel study was conducted with 131 grass pollen allergic subjects from May to July 2012 in concomitance with the pollen season in Berlin. NCC 2461 or placebo was administered daily for an 8-week period to adult subjects with clinical history of allergic rhinitis to grass pollen, positive skin prick test and IgE to grass pollen. During the 8 weeks, symptoms and quality of life questionnaires were filled out, and plasma was collected for IgE analysis at screening and at the end of the intervention. All subjects were included within a 5-day interval, ensuring exposure to similar air pollen counts for each individual during the trial period. The results obtained show that symptoms increased with pollen loads, confirming a natural exposure to the allergen and presence of pollen-induced allergic rhinitis in the subjects. However, no significant differences were observed in allergic rhinitis symptoms scores, quality of life, or specific IgE levels between subjects receiving NCC 2461 as compared to placebo administration. CONCLUSION:In contrast to previous findings, oral administration of NCC 2461 did not show a beneficial effect on allergic rhinitis in a field trial. The influence of study design, allergen exposure and intervention window on the efficacy of NCC 2461 in modulating respiratory allergy should be further evaluated.
journal_name
Clin Transl Allergyjournal_title
Clinical and translational allergyauthors
Nembrini C,Singh A,De Castro CA,Mercenier A,Nutten Sdoi
10.1186/s13601-015-0085-4subject
Has Abstractpub_date
2015-12-09 00:00:00pages
41issn
2045-7022pii
85journal_volume
5pub_type
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journal_title:Clinical and translational allergy
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journal_title:Clinical and translational allergy
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journal_title:Clinical and translational allergy
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journal_title:Clinical and translational allergy
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doi:10.1186/s13601-018-0201-3
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pub_type: 杂志文章
doi:10.1186/2045-7022-2-15
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journal_title:Clinical and translational allergy
pub_type: 杂志文章,评审
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更新日期:2019-07-25 00:00:00
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journal_title:Clinical and translational allergy
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更新日期:2019-03-08 00:00:00
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journal_title:Clinical and translational allergy
pub_type: 杂志文章,评审
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更新日期:2015-09-03 00:00:00
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journal_title:Clinical and translational allergy
pub_type: 杂志文章
doi:10.1186/2045-7022-3-2
更新日期:2013-01-22 00:00:00