Abstract：
BACKGROUND:Molecular strain typing of tuberculosis isolates has led to increased understanding of the epidemiological characteristics of the disease and improvements in its control, diagnosis and treatment. However, molecular cluster investigations, which aim to detect previously unidentified cases, remain challenging. Interactive dot mapping is a simple approach which could aid investigations by highlighting cases likely to share epidemiological links. Current tools generally require technical expertise or lack interactivity. RESULTS:We designed a flexible application for producing disease dot maps using Shiny, a web application framework for the statistical software, R. The application displays locations of cases on an interactive map colour coded according to levels of categorical variables such as demographics and risk factors. Cases can be filtered by selecting combinations of these characteristics and by notification date. It can be used to rapidly identify geographic patterns amongst cases in molecular clusters of tuberculosis in space and time; generate hypotheses about disease transmission; identify outliers, and guide targeted control measures. CONCLUSIONS:DotMapper is a user-friendly application which enables rapid production of maps displaying locations of cases and their epidemiological characteristics without the need for specialist training in geographic information systems. Enhanced understanding of tuberculosis transmission using this application could facilitate improved detection of cases with epidemiological links and therefore lessen the public health impacts of the disease. It is a flexible system and also has broad international potential application to other investigations using geo-coded health information.
journal_name
BMC Infect Disjournal_title
BMC infectious diseasesauthors
Smith CM,Hayward ACdoi
10.1186/s12879-016-1475-5subject
Has Abstractpub_date
2016-04-12 00:00:00pages
145issn
1471-2334pii
10.1186/s12879-016-1475-5journal_volume
16pub_type
杂志文章abstract：BACKGROUND:Acinetobacter species are associated with increasing mortality due to emerging drug-resistance. Pediatric Acinetobacter infections are largely undefined in developed countries and clinical laboratory identification methods do not reliably differentiate between members of the Acinetobacter calcoaceticus-bauma...
journal_title：BMC infectious diseases
pub_type： 杂志文章
doi：10.1186/s12879-016-1678-9
更新日期：2016-07-22 00:00:00
abstract：BACKGROUND:Levels of non-neutralising antibodies (AB) to the C5 domain of HIV Env gp120 are inversely related to progression of HIV infection. In this phase I/II clinical study we investigated safety of Vacc-C5, a peptide-based therapeutic vaccine candidate corresponding to C5/gp41732-744 as well as the effects on pre-...
journal_title：BMC infectious diseases
pub_type： 杂志文章,随机对照试验
doi：10.1186/s12879-017-2316-x
更新日期：2017-03-24 00:00:00
abstract：BACKGROUND:Pertussis diagnosis may go unrecognized when other pathogens, such as respiratory syncytial virus (RSV) circulate. METHODS:A prospective cross-sectional study was conducted in Lima, Peru from January 2009 to September 2010. A total of 596 children under 5 years old admitted with clinical diagnoses of acute ...
journal_title：BMC infectious diseases
pub_type： 杂志文章
doi：10.1186/s12879-015-1287-z
更新日期：2015-12-02 00:00:00
abstract：BACKGROUND:Acute respiratory tract infections (ARTI) are an important public health problem. Improved identification of risk factors might enable targeted intervention. Therefore we carried out a case-control study with the aim of identifying environmental risk factors for ARTI consultations in the Dutch general popula...
journal_title：BMC infectious diseases
pub_type： 杂志文章
doi：10.1186/1471-2334-7-35
更新日期：2007-04-27 00:00:00
abstract：BACKGROUND:Rosacea is an inflammatory disease affecting the central part of face characterized by persistent or recurrent episodes of erythema, papules, pustules and telangiectasias of unknown etiology. Helicobacter pylori (H. pylori) is a gram-negative bacillus, which is one of the main causes of chronic gastritis, ga...
journal_title：BMC infectious diseases
pub_type： 杂志文章,评审
doi：10.1186/s12879-018-3232-4
更新日期：2018-07-11 00:00:00
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journal_title：BMC infectious diseases
pub_type： 杂志文章
doi：10.1186/s12879-020-4891-5
更新日期：2020-03-14 00:00:00
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journal_title：BMC infectious diseases
pub_type： 杂志文章
doi：10.1186/s12879-020-05607-1
更新日期：2020-11-19 00:00:00
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journal_title：BMC infectious diseases
pub_type： 杂志文章
doi：10.1186/s12879-019-4033-0
更新日期：2019-05-10 00:00:00
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journal_title：BMC infectious diseases
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doi：10.1186/s12879-019-4027-y
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更新日期：2019-01-29 00:00:00
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journal_title：BMC infectious diseases
pub_type： 杂志文章
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更新日期：2020-11-25 00:00:00
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journal_title：BMC infectious diseases
pub_type： 杂志文章
doi：10.1186/1471-2334-1-15
更新日期：2001-01-01 00:00:00
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journal_title：BMC infectious diseases
pub_type： 杂志文章
doi：10.1186/s12879-017-2674-4
更新日期：2017-08-18 00:00:00
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journal_title：BMC infectious diseases
pub_type： 杂志文章
doi：10.1186/s12879-015-0837-8
更新日期：2015-02-26 00:00:00
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pub_type： 杂志文章
doi：10.1186/s12879-019-3815-8
更新日期：2019-02-20 00:00:00
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pub_type： 杂志文章
doi：10.1186/s12879-015-0766-6
更新日期：2015-02-03 00:00:00
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journal_title：BMC infectious diseases
pub_type： 杂志文章
doi：10.1186/1471-2334-9-110
更新日期：2009-07-11 00:00:00
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journal_title：BMC infectious diseases
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doi：10.1186/s12879-016-2096-8
更新日期：2017-01-03 00:00:00
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更新日期：2017-09-25 00:00:00
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pub_type： 杂志文章
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更新日期：2016-05-20 00:00:00
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journal_title：BMC infectious diseases
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doi：10.1186/s12879-016-2059-0
更新日期：2016-12-01 00:00:00
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更新日期：2017-02-07 00:00:00
abstract：BACKGROUND:Brucella abortus is a highly pathogenic zoonotic agent, tempting for the development of a rapid diagnostic method to enable adequate treatment and prevent further spread. Enrichment of the bacteria is often used as a first step in diagnostics to increase the bacterial number above the detection limit of the ...
journal_title：BMC infectious diseases
pub_type： 杂志文章
doi：10.1186/s12879-018-3134-5
更新日期：2018-06-05 00:00:00
abstract：BACKGROUND:HIV infection induces chronic immune activation which is associated with accelerated disease progression; the causes of this activation, however, are incompletely understood. We investigated the activation status of CD4+ T cells specific for chronic herpes viruses and the non-persistent antigen tetanus toxoi...
journal_title：BMC infectious diseases
pub_type： 杂志文章
doi：10.1186/1471-2334-13-100
更新日期：2013-02-25 00:00:00
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journal_title：BMC infectious diseases
pub_type： 杂志文章
doi：10.1186/1471-2334-6-11
更新日期：2006-01-24 00:00:00
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journal_title：BMC infectious diseases
pub_type： 杂志文章
doi：10.1186/1471-2334-5-102
更新日期：2005-11-08 00:00:00
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journal_title：BMC infectious diseases
pub_type： 杂志文章,随机对照试验
doi：10.1186/s12879-017-2502-x
更新日期：2017-06-07 00:00:00
abstract：BACKGROUND:Hepatitis B (HBV) and C (HCV) infections are a serious global and national public health problem. Earlier studies have reported increasing rates of hepatitis infection in Pakistan, particularly in rural areas. Pakistan has no active surveillance program to monitor trends of these infections. The objective of...
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doi：10.1186/1471-2334-8-43
更新日期：2008-04-10 00:00:00
